| Entry |
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| Name |
catechol 2,3-dioxygenase;
2,3-pyrocatechase;
catechol 2,3-oxygenase;
catechol oxygenase;
metapyrocatechase;
pyrocatechol 2,3-dioxygenase;
xylE (gene name);
catechol:oxygen 2,3-oxidoreductase (decyclizing)
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| Class |
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
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| Sysname |
catechol:oxygen 2,3-oxidoreductase (ring-opening)
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| Reaction(IUBMB) |
catechol + O2 = 2-hydroxymuconate-6-semialdehyde [RN: R00816]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
2-hydroxymuconate-6-semialdehyde [CPD: C00682]
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| Comment |
Requires FeII. The enzyme initiates the meta-cleavage pathway of catechol degradation.
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| History |
EC 1.13.11.2 created 1965 as EC 1.13.1.2, transferred 1972 to EC 1.13.11.2, modified 1999, modified 2013
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| Pathway |
| ec00361 | Chlorocyclohexane and chlorobenzene degradation |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K00446 | catechol 2,3-dioxygenase |
| K07104 | catechol 2,3-dioxygenase |
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| Genes |
» show all
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| Reference |
1 |
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| Authors |
Hayaishi, O. |
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| Title |
Direct oxygenation by O2, oxygenases. |
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| Journal |
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 8, Academic Press, New York, 1963, p. 353-371. |
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| Reference |
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| Authors |
KOJIMA Y, ITADA N, HAYAISHI O. |
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| Title |
Metapyrocatachase: a new catechol-cleaving enzyme. |
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| Journal |
J Biol Chem 236:2223-8 (1961) |
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| Reference |
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| Authors |
NOZAKI M, KAGAMIYAMA H, HAYAISHI O. |
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| Title |
METAPYROCATECHASE. I. PURIFICATION, CRYSTALLIZATION AND SOME PROPERTIES. |
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| Journal |
Biochem Z 338:582-90 (1963) |
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| Reference |
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| Authors |
Nakai C, Hori K, Kagamiyama H, Nakazawa T, Nozaki M |
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| Title |
Purification, subunit structure, and partial amino acid sequence of metapyrocatechase. |
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| Journal |
J Biol Chem 258:2916-22 (1983) |
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| Reference |
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| Authors |
Junker F, Field JA, Bangerter F, Ramsteiner K, Kohler HP, Joannou CL, Mason JR, Leisinger T, Cook AM. |
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| Title |
Oxygenation and spontaneous deamination of 2-aminobenzenesulphonic acid in Alcaligenes sp. strain O-1 with subsequent meta ring cleavage and spontaneous desulphonation to 2-hydroxymuconic acid. |
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| Journal |
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| Reference |
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| Authors |
Junker F, Leisinger T, Cook AM |
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| Title |
3-Sulphocatechol 2,3-dioxygenase and other dioxygenases (EC 1.13.11.2 and EC 1.14.12.-) in the degradative pathways of 2-aminobenzenesulphonic, benzenesulphonic and 4-toluenesulphonic acids in Alcaligenes sp. strain O-1. |
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| Journal |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.13.11.2 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.13.11.2 |
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| LinkDB |
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