KEGG   ORTHOLOGY: K00497Help
Entry
K00497                      KO                                     

Name
CYP11B1
Definition
steroid 11beta-monooxygenase [EC:1.14.15.4]
Pathway
ko00140  Steroid hormone biosynthesis
ko01100  Metabolic pathways
ko04927  Cortisol synthesis and secretion
ko04934  Cushing syndrome
Module
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
M00109  C21-Steroid hormone biosynthesis, progesterone => cortisol/cortisone
Disease
H00216  Congenital adrenal hyperplasia
H00602  Glucocorticoid-remediable aldosteronism (GRA)
H01603  Primary aldosteronism
H01633  High blood pressure
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00497  CYP11B1; steroid 11beta-monooxygenase
 09150 Organismal Systems
  09152 Endocrine system
   04927 Cortisol synthesis and secretion
    K00497  CYP11B1; steroid 11beta-monooxygenase
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00497  CYP11B1; steroid 11beta-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00497  CYP11B1; steroid 11beta-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4  steroid 11beta-monooxygenase
     K00497  CYP11B1; steroid 11beta-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP11 family
   K00497  CYP11B1; steroid 11beta-monooxygenase
BRITE hierarchy
Other DBs
RN: R02218 R02725 R02843 R03329 R03851 R04850 R08949
GO: 0004507
Genes
HSA: 1584(CYP11B1)
PTR: 464437(CYP11B1)
PPS: 100971586
GGO: 101142418
PON: 100459910
NLE: 100605657
MCC: 695793(CYP11B1)
MCF: 102136659
CSAB: 103237546(CYP11B1)
RRO: 104679773 104679810
RBB: 108536535
CJC: 100415667(CYP11B1)
MMU: 13072(Cyp11b2)
RNO: 24294(Cyp11b2) 353498(Cyp11b3)
CFA: 482071(CYP11B2)
VVP: 112911200
AML: 100478197
ORO: 101364874
FCA: 101097790
PTG: 102972244
PPAD: 109258417
AJU: 106989683
BTA: 282422(CYP11B1) 787628
OAS: 101102377 767576(CYP11B1)
SSC: 110260194
CFR: 102517728
CDK: 105106427
LVE: 103089121
OOR: 101286768
DLE: 111165107
PCAD: 102988484
EAI: 106827552
MYB: 102249727
MYD: 102752229
MNA: 107542744
HAI: 109390820
DRO: 112315587
PALE: 102881458
RAY: 107507877
MJV: 108400067
LAV: 100654178
TMU: 101354125
MDO: 100032885
SHR: 100930767
PCW: 110214194
OAA: 100082065
LSR: 110479458
PHI: 102113159
FPG: 101918505
FCH: 102046275
ASN: 102375758
AMJ: 102575737(CYP11B1)
CPIC: 101950678
ACS: 100560890
PVT: 110084842
PBI: 103058342
PMUR: 107300041
TSR: 106545562
PMUA: 114600140
GJA: 107116366
XLA: 108718624(CYP11B1)
XTR: 101731070
DRE: 791124(cyp11c1)
SRX: 107745157
SANH: 107698185
SGH: 107570796
CCAR: 109110857
IPU: 108263488
PHYP: 113525473
AMEX: 103026652
EEE: 113574779
TRU: 101075863
LCO: 104920541
NCC: 104944920
MZE: 101463871
ONL: 100533461(cyp11b)
OLA: 100125822(cyp11b)
XMA: 102236274
XCO: 114139300
PRET: 103478110
CVG: 107088793
NFU: 107379700
KMR: 108235361
ALIM: 106515094
CSEM: 103388284
POV: 109633048
LCF: 108885901
SDU: 111230014
SLAL: 111652162
HCQ: 109522775
BPEC: 110163163
MALB: 109970182
SALP: 112074060
ELS: 105018961
SFM: 108925533
PKI: 111853322
LCM: 102345423
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2592361
  Authors
Mornet E, Dupont J, Vitek A, White PC
  Title
Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).
  Journal
J Biol Chem 264:20961-7 (1989)
  Sequence
[hsa:1584]
Reference
PMID:3485096
  Authors
Yanagibashi K, Haniu M, Shively JE, Shen WH, Hall P
  Title
The synthesis of aldosterone by the adrenal cortex. Two zones (fasciculata and glomerulosa) possess one enzyme for 11 beta-, 18-hydroxylation, and aldehyde synthesis.
  Journal
J Biol Chem 261:3556-62 (1986)
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