KEGG   ORTHOLOGY: K00498
Entry
K00498                      KO                                     

Name
CYP11A
Definition
cholesterol monooxygenase (side-chain-cleaving) [EC:1.14.15.6]
Pathway
ko00140  Steroid hormone biosynthesis
ko01100  Metabolic pathways
ko04913  Ovarian steroidogenesis
ko04925  Aldosterone synthesis and secretion
ko04927  Cortisol synthesis and secretion
ko04934  Cushing syndrome
Module
M00107  Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone
Disease
H02314  Adrenal insufficiency, congenital, with 46XY sex reversal, partial or complete
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
   04925 Aldosterone synthesis and secretion
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
   04927 Cortisol synthesis and secretion
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.6  cholesterol monooxygenase (side-chain-cleaving)
     K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP11 family
   K00498  CYP11A; cholesterol monooxygenase (side-chain-cleaving)
Other DBs
RN: R01454 R02723 R03933 R04676 R04854 R04855
GO: 0008386
Genes
HSA: 1583(CYP11A1)
PTR: 748998(CYP11A1)
PPS: 100979902
GGO: 101124697
PON: 100433169
NLE: 100595981
MCC: 708065
MCF: 102120640(CYP11A)
CSAB: 103245339(CYP11A1)
RRO: 104672245
RBB: 108531466
CJC: 100389930(CYP11A1)
SBQ: 101039906
MMU: 13070(Cyp11a1)
MCAL: 110301893
MPAH: 110328464
RNO: 29680(Cyp11a1)
CGE: 100752606
NGI: 103736867
HGL: 101704598
CCAN: 109687652
OCU: 100345737(CYP11A1)
TUP: 102487565
CFA: 478365(CYP11A1)
VVP: 112917406
AML: 100474049
UMR: 103678997
UAH: 113240963
ORO: 101384815
ELK: 111153362
FCA: 101085980
PTG: 102964439
PPAD: 109262704
AJU: 106979451
BTA: 338048(CYP11A1)
BOM: 102282116
BIU: 109575664
BBUB: 102400151
CHX: 102173131(CYP11A1)
OAS: 100048994(CYP11A1)
SSC: 403329(CYP11A1)
CFR: 102516700
CDK: 105087270
BACU: 103011342
LVE: 103068564
OOR: 101284598
DLE: 111177811
PCAD: 102978389
ECB: 100034229(CYP11A1)
EPZ: 103567309
EAI: 106842692
MYB: 102241006
MYD: 102765728
MNA: 107535212
HAI: 109396248
DRO: 112301926
PALE: 102894190
RAY: 107510545
MJV: 108390538
LAV: 100665050
TMU: 101357207
MDO: 100029519
SHR: 100923284
PCW: 110214023
GGA: 414838(CYP11A1)
MGP: 100543260
CJO: 107318663
NMEL: 110403743
APLA: 101796693
ACYG: 106044184
TGU: 100151695(CYP11A1)
GFR: 102043993
FAB: 101810676
PHI: 102109180
PMAJ: 107209117
ETL: 114059742
FPG: 101916429
FCH: 102049639
CLV: 102096337
EGZ: 104130717
NNI: 104016802
ACUN: 113483867
PADL: 103922056
AAM: 106487382
ASN: 102381626
AMJ: 102569028(CYP11A1)
PSS: 102455057
CMY: 102939633
CPIC: 101950099
PVT: 110084450
PBI: 103056955
PMUR: 107291917
TSR: 106553315
PMUA: 114604069
GJA: 107111326
XLA: 108712986(cyp11a1.S)
XTR: 100495360(cyp11a1)
NPR: 108785561
DRE: 563363(cyp11a2) 80374(cyp11a1)
SRX: 107751280
SANH: 107703186
SGH: 107589342
CCAR: 109044858
IPU: 100313513(cyp11a)
PHYP: 113530122
AMEX: 103021835
EEE: 113573160
TRU: 101063139
LCO: 104924331
NCC: 104966693
MZE: 101471001
ONL: 100692956
OLA: 100302421(cyp11a)
XMA: 102235384
XCO: 114151402
PRET: 103466560
CVG: 107101674
NFU: 107388733
KMR: 108229950
ALIM: 106514397
AOCE: 111587899
CSEM: 103380225
POV: 109624184
LCF: 108886266
SDU: 111228419
SLAL: 111666903
HCQ: 109519394
BPEC: 110163820
MALB: 109971254
SASA: 106561846(P450scc)
OTW: 112218957
SALP: 112071531
ELS: 105007422
SFM: 108926637
PKI: 111846669
LCM: 102360223
CMK: 103188165
 » show all
Reference
PMID:3024157
  Authors
Chung BC, Matteson KJ, Voutilainen R, Mohandas TK, Miller WL
  Title
Human cholesterol side-chain cleavage enzyme, P450scc: cDNA cloning, assignment of the gene to chromosome 15, and expression in the placenta.
  Journal
Proc Natl Acad Sci U S A 83:8962-6 (1986)
DOI:10.1073/pnas.83.23.8962
  Sequence
[hsa:1583]
Reference
  Authors
Seals RC, Urban RJ, Sekar N, Veldhuis JD
  Title
Up-regulation of basal transcriptional activity of the cytochrome P450 cholesterol side-chain cleavage (CYP11A) gene by isoform-specific calcium-calmodulin-dependent protein kinase in primary cultures of ovarian granulosa cells.
  Journal
Endocrinology 145:5616-22 (2004)
DOI:10.1210/en.2003-1528
Reference
  Authors
Mast N, Annalora AJ, Lodowski DT, Palczewski K, Stout CD, Pikuleva IA
  Title
Structural basis for three-step sequential catalysis by the cholesterol side chain cleavage enzyme CYP11A1.
  Journal
J Biol Chem 286:5607-13 (2011)
DOI:10.1074/jbc.M110.188433
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