KEGG   ORTHOLOGY: K00503
Entry
K00503                      KO                                     

Name
DBH
Definition
dopamine beta-monooxygenase [EC:1.14.17.1]
Pathway
ko00350  Tyrosine metabolism
ko01100  Metabolic pathways
Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Disease
H01005  Dopamine beta-hydroxylase deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00503  DBH; dopamine beta-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.17  With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.17.1  dopamine beta-monooxygenase
     K00503  DBH; dopamine beta-monooxygenase
Other DBs
RN: R02535
GO: 0004500
Genes
HSA: 1621(DBH)
PTR: 464827(DBH)
PPS: 100985587(DBH)
GGO: 101154486(DBH)
PON: 100461514(DBH)
NLE: 100597609(DBH)
MCC: 574105(DBH)
MCF: 102139527(DBH)
CSAB: 103239676(DBH)
RRO: 104669786(DBH)
RBB: 108513277(DBH)
CJC: 100406041(DBH)
SBQ: 101046079(DBH)
MMU: 13166(Dbh)
MCAL: 110290214(Dbh)
MPAH: 110319201(Dbh)
RNO: 25699(Dbh)
MUN: 110557516(Dbh)
CGE: 100761411(Dbh)
NGI: 103742818(Dbh)
HGL: 101724312(Dbh)
CCAN: 109677868(Dbh)
OCU: 103347199(DBH)
TUP: 102468703(DBH)
CFA: 448806(DBH)
VVP: 112906947(DBH)
AML: 100480347(DBH)
UMR: 103679922(DBH)
UAH: 113266575(DBH)
ORO: 101362871(DBH)
ELK: 111146214
FCA: 101082957(DBH)
PTG: 102961078(DBH)
PPAD: 109258287(DBH)
AJU: 106988258(DBH)
BTA: 280758(DBH)
BOM: 102286194(DBH)
BIU: 109566610(DBH)
BBUB: 102409301(DBH)
CHX: 102176244(DBH)
OAS: 114113851(DBH)
SSC: 733609(DBH)
CFR: 102523816(DBH)
CDK: 105106327(DBH)
BACU: 103001548(DBH)
LVE: 103082302(DBH)
OOR: 101269198(DBH)
DLE: 111177039(DBH)
PCAD: 102990638(DBH)
ECB: 791247(DBH)
EPZ: 103564043(DBH)
EAI: 106845350(DBH)
MYB: 102264141(DBH)
MYD: 102763656(DBH)
MNA: 107524669(DBH)
HAI: 109381156(DBH)
DRO: 112306436(DBH)
PALE: 102882740(DBH)
RAY: 107506265(DBH)
MJV: 108398386(DBH)
LAV: 100675803(DBH)
TMU: 101344432
MDO: 100018814(DBH)
SHR: 100925655(DBH)
PCW: 110205374(DBH)
OAA: 100073905(DBH)
GGA: 395549(DBH)
MGP: 100544779(DBH)
CJO: 107321868(DBH)
NMEL: 110406867(DBH)
APLA: 101793381(DBH)
ACYG: 106044068(DBH)
TGU: 100224356(DBH)
LSR: 110477727(DBH)
SCAN: 103818963(DBH)
GFR: 102038113(DBH)
FAB: 101810825(DBH)
PHI: 102100810(DBH)
PMAJ: 107211985(DBH)
CCAE: 111937045(DBH)
CCW: 104688340(DBH)
ETL: 114059130(DBH)
FPG: 101923335(DBH)
FCH: 102048380(DBH)
CLV: 102097674(DBH)
EGZ: 104129357(DBH)
NNI: 104023198(DBH)
ACUN: 113486646(DBH)
PADL: 103915345(DBH)
AAM: 106484479(DBH)
ASN: 102377750(DBH)
AMJ: 102562465(DBH)
PSS: 102455557(DBH)
CMY: 102935981(DBH)
CPIC: 101944381(DBH)
ACS: 100566843(dbh)
PVT: 110089291(DBH)
PBI: 103050577(DBH)
PMUR: 107291028(DBH)
TSR: 106552853(DBH)
PMUA: 114588914(DBH)
GJA: 107106563(DBH)
XLA: 108698178(dbh.L) 108699900(dbh.S)
XTR: 100492247(dbh)
NPR: 108792841(DBH)
DRE: 30505(dbh)
SGH: 107595570(dbh) 107597665
IPU: 108276829(dbh)
PHYP: 113544042(dbh)
AMEX: 103038160(dbh)
EEE: 113576331(dbh)
TRU: 101066621(dbh)
LCO: 104923914(dbh)
NCC: 104968179(dbh)
MZE: 101464817(dbh)
ONL: 100708156(dbh)
OLA: 101157870(dbh)
XMA: 102218690(dbh)
XCO: 114149436(dbh)
PRET: 103473626(dbh)
CVG: 107088692(dbh)
NFU: 107372400(dbh)
KMR: 108232649(dbh)
ALIM: 106514559(dbh)
AOCE: 111567020(dbh)
CSEM: 103389065(dbh)
POV: 109626136(dbh)
LCF: 108879254(dbh)
SDU: 111238762(dbh)
SLAL: 111666075(dbh)
HCQ: 109517071(dbh)
BPEC: 110174164(dbh)
MALB: 109963454(dbh)
SASA: 106568424(dbh)
OTW: 112257386
SALP: 111980057
ELS: 105014776(dbh)
SFM: 108934136(dbh)
PKI: 111854168(dbh)
LCM: 102359119(DBH)
CMK: 103182970(dbh)
BFO: 118421819
CIN: 100176680
APLC: 110976390
SKO: 102804261
DME: Dmel_CG1543(Tbh)
DER: 6551562
DSE: 6620197
DSI: Dsimw501_GD16874(Dsim_Tbh)
DAN: 6503980
DSR: 110178084
DPE: 6600415
DMN: 108165110
DWI: 6641182
DAZ: 108620140
DNV: 115564952
DHE: 111598821
DVI: 6633815
MDE: 101897009
LCQ: 111684501
AAG: 5574019
AME: 751102(Tbh)
BIM: 100743458
BTER: 100649446
CCAL: 108629262
OBB: 114880623
SOC: 105201088
MPHA: 105837371
AEC: 105145835
ACEP: 105618961
PBAR: 105434118
VEM: 105570585
HST: 105182135
DQU: 106743489
CFO: 105258572
LHU: 105668349
PGC: 109857916
OBO: 105277857
PCF: 106792493
NVI: 100119029
CSOL: 105359023
MDL: 103579714
TCA: 663011(TcTBH)
ATD: 109600593
NVL: 108563606
BMOR: 100862766(Tbh)
BMAN: 114239450
PMAC: 106717834
PRAP: 110994553
HAW: 110383622
TNL: 113501985
API: 100166363
DNX: 107169334
AGS: 114121829
RMD: 113558464
BTAB: 109037049
CLEC: 106667484
ZNE: 110838985
FCD: 110851639
TUT: 107360804
DPTE: 113793264
CSCU: 111615103
PTEP: 107447331
CEL: CELE_H13N06.6(tbh-1)
CBR: CBG07714(Cbr-tbh-1)
OBI: 106875923
 » show all
Reference
PMID:3443096
  Authors
Lamouroux A, Vigny A, Faucon Biguet N, Darmon MC, Franck R, Henry JP, Mallet J
  Title
The primary structure of human dopamine-beta-hydroxylase: insights into the relationship between the soluble and the membrane-bound forms of the enzyme.
  Journal
EMBO J 6:3931-7 (1987)
DOI:10.1002/j.1460-2075.1987.tb02734.x
  Sequence
[hsa:1621]
LinkDB

KEGG   ENZYME: 1.14.17.1
Entry
EC 1.14.17.1                Enzyme                                 

Name
dopamine beta-monooxygenase;
dopamine beta-hydroxylase;
MDBH (membrane-associated dopamine beta-monooxygenase);
SDBH (soluble dopamine beta-monooxygenase);
dopamine-B-hydroxylase;
3,4-dihydroxyphenethylamine beta-oxidase;
4-(2-aminoethyl)pyrocatechol beta-oxidase;
dopa beta-hydroxylase;
dopamine beta-oxidase;
dopamine hydroxylase;
phenylamine beta-hydroxylase;
(3,4-dihydroxyphenethylamine)beta-mono-oxygenase;
DbetaM (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced ascorbate as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
Reaction(IUBMB)
dopamine + 2 ascorbate + O2 = noradrenaline + 2 monodehydroascorbate + H2O [RN:R02535]
Reaction(KEGG)
R02535
Substrate
dopamine [CPD:C03758];
ascorbate [CPD:C00072];
O2 [CPD:C00007]
Product
noradrenaline [CPD:C00547];
monodehydroascorbate [CPD:C01041];
H2O [CPD:C00001]
Comment
A copper protein. The enzyme, found in animals, binds two copper ions with distinct roles during catalysis. Stimulated by fumarate.
History
EC 1.14.17.1 created 1965 as EC 1.14.2.1, transferred 1972 to EC 1.14.17.1, modified 2020
Pathway
ec00350  Tyrosine metabolism
ec01100  Metabolic pathways
Orthology
K00503  dopamine beta-monooxygenase
Genes
HSA: 1621(DBH)
PTR: 464827(DBH)
PPS: 100985587(DBH)
GGO: 101154486(DBH)
PON: 100461514(DBH)
NLE: 100597609(DBH)
MCC: 574105(DBH)
MCF: 102139527(DBH)
CSAB: 103239676(DBH)
RRO: 104669786(DBH)
RBB: 108513277(DBH)
CJC: 100406041(DBH)
SBQ: 101046079(DBH)
MMU: 13166(Dbh)
MCAL: 110290214(Dbh)
MPAH: 110319201(Dbh)
RNO: 25699(Dbh)
MUN: 110557516(Dbh)
CGE: 100761411(Dbh)
NGI: 103742818(Dbh)
HGL: 101724312(Dbh)
CCAN: 109677868(Dbh)
OCU: 103347199(DBH)
TUP: 102468703(DBH)
CFA: 448806(DBH)
VVP: 112906947(DBH)
AML: 100480347(DBH)
UMR: 103679922(DBH)
UAH: 113266575(DBH)
ORO: 101362871(DBH)
ELK: 111146214
FCA: 101082957(DBH)
PTG: 102961078(DBH)
PPAD: 109258287(DBH)
AJU: 106988258(DBH)
BTA: 280758(DBH)
BOM: 102286194(DBH)
BIU: 109566610(DBH)
BBUB: 102409301(DBH)
CHX: 102176244(DBH)
OAS: 114113851(DBH)
SSC: 733609(DBH)
CFR: 102523816(DBH)
CDK: 105106327(DBH)
BACU: 103001548(DBH)
LVE: 103082302(DBH)
OOR: 101269198(DBH)
DLE: 111177039(DBH)
PCAD: 102990638(DBH)
ECB: 791247(DBH)
EPZ: 103564043(DBH)
EAI: 106845350(DBH)
MYB: 102264141(DBH)
MYD: 102763656(DBH)
MNA: 107524669(DBH)
HAI: 109381156(DBH)
DRO: 112306436(DBH)
PALE: 102882740(DBH)
RAY: 107506265(DBH)
MJV: 108398386(DBH)
LAV: 100675803(DBH)
TMU: 101344432
MDO: 100018814(DBH)
SHR: 100925655(DBH)
PCW: 110205374(DBH)
OAA: 100073905(DBH)
GGA: 395549(DBH)
MGP: 100544779(DBH)
CJO: 107321868(DBH)
NMEL: 110406867(DBH)
APLA: 101793381(DBH)
ACYG: 106044068(DBH)
TGU: 100224356(DBH)
LSR: 110477727(DBH)
SCAN: 103818963(DBH)
GFR: 102038113(DBH)
FAB: 101810825(DBH)
PHI: 102100810(DBH)
PMAJ: 107211985(DBH)
CCAE: 111937045(DBH)
CCW: 104688340(DBH)
ETL: 114059130(DBH)
FPG: 101923335(DBH)
FCH: 102048380(DBH)
CLV: 102097674(DBH)
EGZ: 104129357(DBH)
NNI: 104023198(DBH)
ACUN: 113486646(DBH)
PADL: 103915345(DBH)
AAM: 106484479(DBH)
ASN: 102377750(DBH)
AMJ: 102562465(DBH)
PSS: 102455557(DBH)
CMY: 102935981(DBH)
CPIC: 101944381(DBH)
ACS: 100566843(dbh)
PVT: 110089291(DBH)
PBI: 103050577(DBH)
PMUR: 107291028(DBH)
TSR: 106552853(DBH)
PMUA: 114588914(DBH)
GJA: 107106563(DBH)
XLA: 108698178(dbh.L) 108699900(dbh.S)
XTR: 100492247(dbh)
NPR: 108792841(DBH)
DRE: 30505(dbh)
SGH: 107595570(dbh) 107597665
IPU: 108276829(dbh)
PHYP: 113544042(dbh)
AMEX: 103038160(dbh)
EEE: 113576331(dbh)
TRU: 101066621(dbh)
LCO: 104923914(dbh)
NCC: 104968179(dbh)
MZE: 101464817(dbh)
ONL: 100708156(dbh)
OLA: 101157870(dbh)
XMA: 102218690(dbh)
XCO: 114149436(dbh)
PRET: 103473626(dbh)
CVG: 107088692(dbh)
NFU: 107372400(dbh)
KMR: 108232649(dbh)
ALIM: 106514559(dbh)
AOCE: 111567020(dbh)
CSEM: 103389065(dbh)
POV: 109626136(dbh)
LCF: 108879254(dbh)
SDU: 111238762(dbh)
SLAL: 111666075(dbh)
HCQ: 109517071(dbh)
BPEC: 110174164(dbh)
MALB: 109963454(dbh)
SASA: 106568424(dbh)
OTW: 112257386
SALP: 111980057
ELS: 105014776(dbh)
SFM: 108934136(dbh)
PKI: 111854168(dbh)
LCM: 102359119(DBH)
CMK: 103182970(dbh)
BFO: 118421819
CIN: 100176680
APLC: 110976390
SKO: 102804261
DME: Dmel_CG1543(Tbh)
DER: 6551562
DSE: 6620197
DSI: Dsimw501_GD16874(Dsim_Tbh)
DAN: 6503980
DSR: 110178084
DPE: 6600415
DMN: 108165110
DWI: 6641182
DAZ: 108620140
DNV: 115564952
DHE: 111598821
DVI: 6633815
MDE: 101897009
LCQ: 111684501
AAG: 5574019
AME: 751102(Tbh)
BIM: 100743458
BTER: 100649446
CCAL: 108629262
OBB: 114880623
SOC: 105201088
MPHA: 105837371
AEC: 105145835
ACEP: 105618961
PBAR: 105434118
VEM: 105570585
HST: 105182135
DQU: 106743489
CFO: 105258572
LHU: 105668349
PGC: 109857916
OBO: 105277857
PCF: 106792493
NVI: 100119029
CSOL: 105359023
MDL: 103579714
TCA: 663011(TcTBH)
ATD: 109600593
NVL: 108563606
BMOR: 100862766(Tbh)
BMAN: 114239450
PMAC: 106717834
PRAP: 110994553
HAW: 110383622
TNL: 113501985
API: 100166363
DNX: 107169334
AGS: 114121829
RMD: 113558464
BTAB: 109037049
CLEC: 106667484
ZNE: 110838985
FCD: 110851639
TUT: 107360804
DPTE: 113793264
CSCU: 111615103
PTEP: 107447331
CEL: CELE_H13N06.6(tbh-1)
CBR: CBG07714(Cbr-tbh-1)
OBI: 106875923
 » show all
Reference
1  [PMID:14416204]
  Authors
LEVIN EY, LEVENBERG B, KAUFMAN S.
  Title
The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine.
  Journal
J Biol Chem 235:2080-6 (1960)
Reference
2  [PMID:5846992]
  Authors
Friedman S, Kaufman S.
  Title
3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity.
  Journal
J Biol Chem 240:4763-73 (1965)
Reference
3  [PMID:7388045]
  Authors
Skotland T, Ljones T
  Title
Direct spectrophotometric detection of ascorbate free radical formed by dopamine  beta-monooxygenase and by ascorbate oxidase.
  Journal
Biochim Biophys Acta 630:30-5 (1980)
DOI:10.1016/0304-4165(80)90134-8
Reference
4  [PMID:12966104]
  Authors
Evans JP, Ahn K, Klinman JP
  Title
Evidence that dioxygen and substrate activation are tightly coupled in dopamine beta-monooxygenase. Implications for the reactive oxygen species.
  Journal
J Biol Chem 278:49691-8 (2003)
DOI:10.1074/jbc.M300797200
Other DBs
ExplorEnz - The Enzyme Database: 1.14.17.1
IUBMB Enzyme Nomenclature: 1.14.17.1
ExPASy - ENZYME nomenclature database: 1.14.17.1
BRENDA, the Enzyme Database: 1.14.17.1
CAS: 9013-38-1
LinkDB

KEGG   REACTION: R02535
Entry
R02535                      Reaction                               

Name
dopamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)
Definition
Dopamine + 2 Ascorbate + Oxygen <=> L-Noradrenaline + 2 Monodehydroascorbate + H2O
Equation
Reaction class
RC00741  C00547_C03758
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Module
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Orthology
K00503  dopamine beta-monooxygenase [EC:1.14.17.1]
Other DBs
RHEA: 19120
LinkDB

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