KEGG   ORTHOLOGY: K00506
Entry
K00506                      KO                                     

Name
TYRP1
Definition
tyrosinase-related protein 1 [EC:1.14.18.-]
Pathway
ko00350  Tyrosine metabolism
ko01100  Metabolic pathways
ko04916  Melanogenesis
Disease
H00168  Oculocutaneous albinism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K00506  TYRP1; tyrosinase-related protein 1
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K00506  TYRP1; tyrosinase-related protein 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K00506  TYRP1; tyrosinase-related protein 1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.-  
     K00506  TYRP1; tyrosinase-related protein 1
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of melanoma cells
   K00506  TYRP1; tyrosinase-related protein 1
Other DBs
RN: R08965
Genes
HSA: 7306(TYRP1)
PTR: 464994(TYRP1)
PPS: 100991083(TYRP1)
GGO: 101138123(TYRP1)
PON: 100460406(TYRP1)
NLE: 100590830(TYRP1)
MCC: 714646(TYRP1)
MCF: 102120654(TYRP1)
CSAB: 103219447(TYRP1)
RRO: 104677984(TYRP1)
RBB: 108526440(TYRP1)
SBQ: 101050337(TYRP1)
MMU: 22178(Tyrp1)
MCAL: 110292114(Tyrp1)
MPAH: 110323788(Tyrp1)
RNO: 298182(Tyrp1)
MUN: 110565274(Tyrp1)
CGE: 100774614(Tyrp1)
NGI: 103746568(Tyrp1)
HGL: 101704615(Tyrp1)
CCAN: 109700723(Tyrp1)
OCU: 100342170(TYRP1)
TUP: 102498188(TYRP1)
CFA: 403479(TYRP1)
VVP: 112921931(TYRP1)
AML: 100470200(TYRP1)
UMR: 103662187(TYRP1)
UAH: 113260303(TYRP1)
ORO: 101369584(TYRP1)
ELK: 111156610
FCA: 554339(TYRP1)
PTG: 102972453(TYRP1)
PPAD: 109247101(TYRP1)
AJU: 106976833(TYRP1)
BTA: 282105(TYRP1)
BOM: 102278123(TYRP1)
BIU: 109562884(TYRP1)
BBUB: 102405492(TYRP1)
CHX: 100861390(TYRP1)
OAS: 100034666(TYRP1)
SSC: 574065(TYRP1)
CFR: 102517744(TYRP1)
CDK: 105095964(TYRP1)
BACU: 103014179(TYRP1)
LVE: 103079248(TYRP1)
OOR: 101282745(TYRP1)
DLE: 111174675(TYRP1)
PCAD: 102987022(TYRP1)
ECB: 100033886(TYRP1)
EPZ: 103560390(TYRP1)
EAI: 106832673(TYRP1)
MYB: 102255278(TYRP1)
MYD: 102769919(TYRP1)
MNA: 107545566(TYRP1)
HAI: 109373396(TYRP1)
DRO: 112302856(TYRP1)
PALE: 102897782(TYRP1)
RAY: 107519850(TYRP1)
MJV: 108402438(TYRP1)
LAV: 100670218(TYRP1)
TMU: 101342071
MDO: 100019721(TYRP1)
SHR: 100934501(TYRP1)
PCW: 110196476(TYRP1)
OAA: 100075631(TYRP1)
GGA: 395913(TYRP1)
MGP: 100550878(TYRP1)
CJO: 107306127(TYRP1)
NMEL: 110390048(TYRP1)
APLA: 101796800(TYRP1)
ACYG: 106043821(TYRP1)
TGU: 100218715(TYRP1)
LSR: 110468040(TYRP1)
SCAN: 103819457(TYRP1)
GFR: 102044625(TYRP1)
FAB: 101815694(TYRP1)
PHI: 102108746(TYRP1)
PMAJ: 107215772(TYRP1)
CCAE: 111940756(TYRP1)
CCW: 104685189(TYRP1)
ETL: 114057440(TYRP1)
FPG: 101918530(TYRP1)
FCH: 102052493(TYRP1)
CLV: 102092996(TYRP1)
EGZ: 104127370(TYRP1)
NNI: 104013995(TYRP1)
ACUN: 113490066(TYRP1)
PADL: 103920349(TYRP1)
AAM: 106496066(TYRP1)
ASN: 102367949(TYRP1)
AMJ: 102564561(TYRP1)
PSS: 102450145(TYRP1)
CMY: 102936404(TYRP1)
CPIC: 101947683(TYRP1)
ACS: 100556822(tyrp1)
PVT: 110073569(TYRP1)
PBI: 103066366(TYRP1)
PMUR: 107288227(TYRP1)
TSR: 106538421(TYRP1)
PMUA: 114587614(TYRP1)
GJA: 107106637(TYRP1)
XLA: 108706951(tyrp1.S) 380184(tyrp1.L)
XTR: 549230(tyrp1)
DRE: 100333145(tyrp1a) 437022(tyrp1b)
IPU: 108260967
PHYP: 113544389 113545792(tyrp1)
EEE: 113582223(tyrp1)
TRU: 101077827(tyrp1)
LCO: 104930927 104933847(tyrp1)
NCC: 104943247(tyrp1) 104960336
MZE: 101463840(tyrp1) 101483045
ONL: 100711224 100711312(tyrp1)
OLA: 101161292 101166337(tyrp1)
XMA: 102219238 102238399(tyrp1)
XCO: 114145089 114157693(tyrp1)
PRET: 103469120 103480674(tyrp1)
CVG: 107090593(tyrp1)
KMR: 108234822(tyrp1) 108241576
ALIM: 106514842(tyrp1)
AOCE: 111564118(tyrp1) 111574879
POV: 109634673(tyrp1) 109637815
LCF: 108892363(tyrp1) 108896421
SDU: 111231526 111231621(tyrp1)
SLAL: 111664495 111665957(tyrp1)
MALB: 109958459 109966528(tyrp1)
SASA: 100136925(tyrp-1) 100137726(tyrp-1b)
ELS: 105006137 105020622(tyrp1)
SFM: 108938702(tyrp1)
PKI: 111842599(tyrp1)
LCM: 102359571(TYRP1)
CMK: 103187149(tyrp1)
RTP: 109927747(tyrp1)
CIN: 100185647
 » show all
Reference
PMID:7813420
  Authors
Kobayashi T, Urabe K, Winder A, Jimenez-Cervantes C, Imokawa G, Brewington T, Solano F, Garcia-Borron JC, Hearing VJ
  Title
Tyrosinase related protein 1 (TRP1) functions as a DHICA oxidase in melanin biosynthesis.
  Journal
EMBO J 13:5818-25 (1994)
DOI:10.1002/j.1460-2075.1994.tb06925.x
  Sequence
[mmu:22178]
LinkDB

KEGG   REACTION: R08965
Entry
R08965                      Reaction                               

Name
5,6-Dihydroxyindole-2-carboxylate:oxygen oxidoreductase
Definition
2 5,6-Dihydroxyindole-2-carboxylate + Oxygen <=> 2 5,6-Indolequinone-2-carboxylic acid + 2 H2O
Equation
2 C04185 + C00007 <=> 2 C17938 + 2 C00001
Comment
5,6-dihydroxyindole-2-carboxylate oxidase
Reaction class
RC00180  C04185_C17938
Enzyme
1.14.18.-
Pathway
rn00350  Tyrosine metabolism
rn01100  Metabolic pathways
Orthology
K00506  tyrosinase-related protein 1 [EC:1.14.18.-]
LinkDB

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