KEGG   ORTHOLOGY: K00665Help
Entry
K00665                      KO                                     

Name
FASN
Definition
fatty acid synthase, animal type [EC:2.3.1.85]
Pathway
ko00061  Fatty acid biosynthesis
ko01100  Metabolic pathways
ko01212  Fatty acid metabolism
ko04152  AMPK signaling pathway
ko04910  Insulin signaling pathway
Module
M00082  Fatty acid biosynthesis, initiation
M00083  Fatty acid biosynthesis, elongation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    K00665  FASN; fatty acid synthase, animal type
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K00665  FASN; fatty acid synthase, animal type
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K00665  FASN; fatty acid synthase, animal type
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K00665  FASN; fatty acid synthase, animal type
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K00665  FASN; fatty acid synthase, animal type
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.85  fatty-acid synthase system
     K00665  FASN; fatty acid synthase, animal type
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Animal type
   K00665  FASN; fatty acid synthase, animal type
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K00665  FASN; fatty acid synthase, animal type
  Exosomal proteins of breast milk
   K00665  FASN; fatty acid synthase, animal type
  Exosomal proteins of colorectal cancer cells
   K00665  FASN; fatty acid synthase, animal type
  Exosomal proteins of bladder cancer cells
   K00665  FASN; fatty acid synthase, animal type
BRITE hierarchy
Other DBs
RN: R01404 R01624 R01626 R01706 R04355 R04428 R04430 R04533 R04534 R04535 R04536 R04537 R04543 R04544 R04566 R04568 R04725 R04726 R04952 R04953 R04954 R04956 R04957 R04959 R04960 R04962 R04963 R04964 R04965 R04967 R04968 R04970 R05188 R08159
GO: 0004312
Genes
HSA: 2194(FASN)
PTR: 454986(FASN)
PPS: 100985873(FASN)
GGO: 101151060(FASN)
PON: 100456558(FASN)
NLE: 100596750 100597701(FASN)
MCC: 715708(FASN)
MCF: 102119674(FASN)
CSAB: 103243754(FASN)
RRO: 104654984(FASN)
RBB: 108525064 108534089(FASN)
CJC: 100402953(FASN)
SBQ: 101045175(FASN)
MMU: 14104(Fasn)
MCAL: 110305254(Fasn)
MPAH: 110332500(Fasn)
RNO: 50671(Fasn)
MUN: 110548829(Fasn)
CGE: 100689207(Fasn)
NGI: 103730050(Fasn)
HGL: 101698314(Fasn)
CCAN: 109702407(Fasn)
TUP: 102481635(FASN)
CFA: 483378(FASN)
VVP: 112920917(FASN)
AML: 100468470(FASN)
UMR: 103666012(FASN)
UAH: 113244480(FASN)
ORO: 101372296(FASN)
FCA: 100270775(FASN)
PTG: 102956933(FASN)
PPAD: 109276748(FASN)
AJU: 106986313(FASN)
BTA: 281152(FASN)
BOM: 102278267(FASN)
BIU: 109573330(FASN)
CHX: 100861286(FASN)
OAS: 100170327(FASN)
SSC: 397561(FASN)
CFR: 102509439(FASN)
CDK: 105102220(FASN)
BACU: 103017465
LVE: 103077747(FASN)
OOR: 101279575(FASN)
DLE: 111182671(FASN)
PCAD: 102976967(FASN)
ECB: 100057311(FASN)
EPZ: 103545808 103551124(FASN)
EAI: 106846150
MYB: 102251003(FASN)
MYD: 102761714(FASN)
MNA: 107539079(FASN)
HAI: 109393056(FASN)
DRO: 112298725(FASN)
PALE: 102887167(FASN)
RAY: 107520266(FASN)
MJV: 108387187(FASN)
LAV: 100674176(FASN)
TMU: 101361851
MDO: 100025176(FASN)
SHR: 100924144(FASN)
PCW: 110218312(FASN)
OAA: 100091954(FASN)
GGA: 396061(FASN)
MGP: 100542651(FASN)
CJO: 107322058(FASN)
NMEL: 110407258(FASN)
APLA: 101796973(FASN)
ACYG: 106046771(FASN)
TGU: 100226957(FASN)
LSR: 110472404(FASN)
SCAN: 103819722(FASN)
GFR: 102043163(FASN)
FAB: 101820764(FASN)
PHI: 102102393(FASN)
PMAJ: 107212310(FASN)
CCAE: 111937506(FASN)
CCW: 104698180(FASN)
ETL: 114060364(FASN)
FPG: 101924649(FASN)
FCH: 102046127(FASN)
CLV: 102086015(FASN)
EGZ: 104131108(FASN)
NNI: 104014322(FASN)
ACUN: 113486868(FASN)
PADL: 103917422(FASN)
AAM: 106487141(FASN)
ASN: 102384493(FASN)
AMJ: 102571811(FASN)
PSS: 102458578(FASN)
CMY: 102933656(FASN)
CPIC: 101942965(FASN)
ACS: 100563002(fasn)
PVT: 110090820(FASN)
PBI: 103062560(FASN)
PMUR: 107288857(FASN) 107301574
TSR: 106542096(FASN)
PMUA: 114589796(FASN) 114590238
GJA: 107118129(FASN)
XLA: 108701000
XTR: 100487052(fasn)
NPR: 108791330(FASN)
DRE: 559001(fasn)
SRX: 107722180 107755500(fasn)
IPU: 108273998(fasn)
PHYP: 113527148(fasn)
AMEX: 103030617(fasn)
EEE: 113568104(fasn) 113569579
TRU: 101069108
LCO: 104927028(fasn)
ONL: 100534502(fasn)
OLA: 101171365(fasn)
XMA: 102232393(fasn)
XCO: 114151265(fasn)
PRET: 103482177(fasn)
CVG: 107087621(fasn) 107104039
NFU: 107396699(fasn)
KMR: 108248335(fasn)
ALIM: 106530206(fasn)
AOCE: 111564925(fasn)
CSEM: 103381833(fasn)
SDU: 111237039(fasn)
SLAL: 111664335(fasn)
HCQ: 109513269(fasn)
BPEC: 110154166(fasn)
MALB: 109965115(fasn)
OTW: 112224492(fasn)
ELS: 105021150(fasn)
SFM: 108939982(fasn)
PKI: 111849631(fasn)
LCM: 102352909(FASN)
CMK: 103175468(fasn)
RTP: 109913760 109914699(fasn)
CIN: 100181277
SPU: 105440011
DME: Dmel_CG17374(FASN3) Dmel_CG3523(FASN1) Dmel_CG3524(FASN2)
DSI: Dsimw501_GD17693(Dsim_GD17693) Dsimw501_GD23206(Dsim_GD23206) Dsimw501_GD23207(Dsim_GD23207)
PVM: 113815940
CSCU: 111635849
CEL: CELE_F32H2.5(fasn-1)
CBR: CBG12408(Cbr-fasn-1)
BMY: Bm1_35180
TSP: Tsp_06638
EPA: 110240069
ADF: 107350794
AMIL: 114969596
PDAM: 113669115
SPIS: 111339547
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2717611
  Authors
Amy CM, Witkowski A, Naggert J, Williams B, Randhawa Z, Smith S
  Title
Molecular cloning and sequencing of cDNAs encoding the entire rat fatty acid synthase.
  Journal
Proc Natl Acad Sci U S A 86:3114-8 (1989)
DOI:10.1073/pnas.86.9.3114
  Sequence
[rno:50671]
LinkDB All DBs

KEGG   ORTHOLOGY: K10781Help
Entry
K10781                      KO                                     

Name
FATB
Definition
fatty acyl-ACP thioesterase B [EC:3.1.2.14 3.1.2.21]
Pathway
ko00061  Fatty acid biosynthesis
ko01100  Metabolic pathways
ko01212  Fatty acid metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00061 Fatty acid biosynthesis
    K10781  FATB; fatty acyl-ACP thioesterase B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K10781  FATB; fatty acyl-ACP thioesterase B
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.14  oleoyl-[acyl-carrier-protein] hydrolase
     K10781  FATB; fatty acyl-ACP thioesterase B
    3.1.2.21  dodecanoyl-[acyl-carrier-protein] hydrolase
     K10781  FATB; fatty acyl-ACP thioesterase B
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Component type
   K10781  FATB; fatty acyl-ACP thioesterase B
BRITE hierarchy
Other DBs
RN: R01706 R04014 R08157 R08158 R08159 R12329
GO: 0016295 0016296 0047381
Genes
ATH: AT1G08510(FATB)
ALY: ARALYDRAFT_888084(FATB)
CRB: 17897852
CSAT: 104739442 104755032 104766704 104774512
EUS: EUTSA_v10007761mg
BRP: 103836386 103843393 103871592
BNA: 106346329 106362292 106362316 106377030 106383116 106383129 106415535 106420175
BOE: 106295830 106312522 106312734
RSZ: 108805233 108823083 108861314
THJ: 104809019 104826529
CPAP: 110823017
LJA: Lj0g3v0119999.1(Lj0g3v0119999.1) Lj1g3v1498440.1(Lj1g3v1498440.1) Lj1g3v1498440.2(Lj1g3v1498440.2)
JCU: 105634942(FAT-L2) 105634943(FAT-L3) 105639285
NNU: 104592290
DOSA: Os02t0644700-01(Os02g0644700) Os06t0143400-01(Os06g0143400) Os06t0596300-01(Os06g0596300) Os11t0659500-01(Os11g0659500)
ATS: 109747972(LOC109747972) 109761208(LOC109761208)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Salas JJ, Ohlrogge JB.
  Title
Characterization of substrate specificity of plant FatA and FatB acyl-ACP thioesterases.
  Journal
Arch Biochem Biophys 403:25-34 (2002)
DOI:10.1016/S0003-9861(02)00017-6
LinkDB All DBs

KEGG   REACTION: R01706Help
Entry
R01706                      Reaction                               

Name
hexadecanoyl-[acyl-carrier protein] hydrolase
Definition
Hexadecanoyl-[acp] + H2O <=> Acyl-carrier protein + Hexadecanoic acid
Equation
Comment
the last step (thioester-hydrolysing) of fatty-acid synthase (ec 2.3.1.85, see R05188, map00061)
Reaction class
RC00014  C00249_C05764
RC00039  C00229_C05764
Enzyme
2.3.1.85        3.1.2.14
Pathway
rn00061  Fatty acid biosynthesis
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Orthology
K00665  fatty acid synthase, animal type [EC:2.3.1.85]
K10781  fatty acyl-ACP thioesterase B [EC:3.1.2.14 3.1.2.21]
Other DBs
RHEA: 41935
LinkDB All DBs

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