KEGG   ORTHOLOGY: K00682
Entry
K00682                      KO                                     

Name
GGCT
Definition
gamma-glutamylcyclotransferase [EC:4.3.2.9]
Pathway
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K00682  GGCT; gamma-glutamylcyclotransferase
Enzymes [BR:ko01000]
 4. Lyases
  4.3  Carbon-nitrogen lyases
   4.3.2  Amidine-lyases
    4.3.2.9  gamma-glutamylcyclotransferase
     K00682  GGCT; gamma-glutamylcyclotransferase
Other DBs
RN: R02743 R03749
GO: 0003839
Genes
HSA: 79017(GGCT)
PTR: 463327(GGCT)
PPS: 100984104(GGCT)
GGO: 101138956(GGCT)
PON: 100444244(GGCT)
NLE: 100600608(GGCT)
MCC: 695547(GGCT)
MCF: 102142709(GGCT)
CSAB: 103226276(GGCT)
RRO: 104668447(GGCT)
RBB: 108533407(GGCT)
CJC: 100389077(GGCT)
SBQ: 101033297(GGCT)
MMU: 110175(Ggct)
MCAL: 110296364(Ggct)
MPAH: 110316963(Ggct)
RNO: 362368(Ggct)
MUN: 110555071(Ggct)
CGE: 100774679(Ggct)
NGI: 103740842(Ggct)
HGL: 101723887(Ggct)
CCAN: 109701127(Ggct)
OCU: 100337901(GGCT)
TUP: 102497631(GGCT)
CFA: 611603(GGCT)
VVP: 112935405(GGCT)
AML: 100475961(GGCT)
UMR: 103658939(GGCT)
UAH: 113262388(GGCT)
ORO: 101381331(GGCT)
ELK: 111147302
FCA: 101087219(GGCT)
PTG: 102972301(GGCT)
PPAD: 109263921(GGCT)
AJU: 106968672(GGCT)
BTA: 533374(GGCT)
BOM: 102265622(GGCT)
BIU: 109557476(GGCT)
BBUB: 102412357(GGCT)
CHX: 102187188(GGCT)
OAS: 101102474(GGCT)
SSC: 100512447(GGCT)
CFR: 102512131(GGCT)
CDK: 105095846(GGCT)
BACU: 102997196(GGCT)
LVE: 103085194(GGCT)
OOR: 101278558(GGCT)
DLE: 111180063(GGCT)
PCAD: 102983283(GGCT)
ECB: 100069874(GGCT)
EPZ: 103552750
EAI: 106831060(GGCT)
MYB: 102257993(GGCT)
MYD: 102766806(GGCT)
MNA: 107544417(GGCT)
HAI: 109381318(GGCT)
DRO: 112306962(GGCT)
PALE: 102887499(GGCT)
RAY: 107499554(GGCT)
MJV: 108410147(GGCT)
LAV: 100673070(GGCT)
TMU: 101349289
MDO: 100032519(GGCT)
SHR: 100919793(GGCT)
PCW: 110213108(GGCT)
OAA: 100081401(GGCT)
GGA: 420676(GGCT)
MGP: 100550241(GGCT)
CJO: 107309325(GGCT)
NMEL: 110394942(GGCT)
APLA: 101805349(GGCT)
ACYG: 106046640(GGCT)
TGU: 100190607(GGCT)
LSR: 110468221(GGCT)
SCAN: 103813162(GGCT)
GFR: 102039424(GGCT)
FAB: 101818892(GGCT)
PHI: 102099497(GGCT)
PMAJ: 107200351(GGCT)
CCAE: 111923889(GGCT)
CCW: 104689028(GGCT)
ETL: 114064384(GGCT)
FPG: 101921074(GGCT)
FCH: 102047880(GGCT)
CLV: 102083440(GGCT)
EGZ: 104127521(GGCT)
NNI: 104018492(GGCT)
ACUN: 113477173(GGCT)
PADL: 103917094(GGCT)
AAM: 106491250(GGCT)
ASN: 102385482(GGCT)
AMJ: 102567732(GGCT)
PSS: 102455884(GGCT)
CMY: 102934944(GGCT)
CPIC: 101951537(GGCT)
ACS: 100558545(ggct)
PVT: 110082168(GGCT)
PBI: 103053081(GGCT)
PMUR: 107294022(GGCT)
TSR: 106545488(GGCT)
PMUA: 114607207(GGCT)
GJA: 107111522(GGCT)
XTR: 613056(ggct)
NPR: 108791133(GGCT)
DRE: 100149204(ggcta) 406278(ggctb)
CCAR: 109102943 109107899(ggct)
IPU: 100528263(ggct) 108256920(ggct)
PHYP: 113525565 113536025(ggct)
LCO: 104937169(ggct)
NCC: 104963997(ggct)
AOCE: 111563780 111569446(ggct)
CSEM: 103388762(ggct) 103394438
HCQ: 109516380 109521920(ggct)
MALB: 109963956(ggct)
SFM: 108942523
LCM: 102345575 102348398(GGCT)
CMK: 103176267(ggct)
RTP: 109924666(ggct)
BFO: 118417214
DSI: Dsimw501_GD12343(Dsim_GD12343) Dsimw501_GD12344(Dsim_GD12344)
DVI: 6622212
AAG: 5570054
AALB: 109405475
AME: 725055
BIM: 100745685
BTER: 100643954
CCAL: 108629753
OBB: 114876242
SOC: 105196864
MPHA: 105835327
AEC: 105150314
ACEP: 105621528
PBAR: 105431273
VEM: 105566080
HST: 105183396
DQU: 106751798
LHU: 105674071
PGC: 109853083
OBO: 105279351
PCF: 106793959
CSOL: 105361426
TCA: 657379
DPA: 109535153
NVL: 108569857
API: 100160827
DNX: 107167438
AGS: 114123987
RMD: 113560882
BTAB: 109031362
ZNE: 110832632
FCD: 110862377
PVM: 113828393
TUT: 107359593
CSCU: 111625598
PTEP: 107456735
CEL: CELE_C44B7.7(C44B7.7)
CBR: CBG11175
PCAN: 112576588
CRG: 105327160
LAK: 106170080
SHX: MS3_00069
NVE: 5518185
ADF: 107327495
HMG: 101238967
AQU: 100640069
MAW: MAC_04864
MAJ: MAA_00851
MRR: Moror_842
ABP: AGABI1DRAFT111071(AGABI1DRAFT_111071) AGABI1DRAFT117923(AGABI1DRAFT_117923) AGABI1DRAFT124916(AGABI1DRAFT_124916)
ABV: AGABI2DRAFT133726(AGABI2DRAFT_133726) AGABI2DRAFT176448(AGABI2DRAFT_176448)
CPS: CPS_2442
PHA: PSHAa0334
PART: PARC_a3561
FBL: Fbal_2422
NOC: Noc_2712
TEE: Tel_14445
HHA: Hhal_0424
BCT: GEM_5817
ADE: Adeh_4028
MXA: MXAN_3680
SPKC: KC8_09770
BBA: Bd1350
COO: CCU_03970
CCT: CC1_08810
AMR: AM1_4771
DET: DET1452
DEH: cbdbA1418
DMC: btf_1329
DMD: dcmb_1310
DMG: GY50_1283
MIN: Minf_0575
RUL: UC8_32080
 » show all
Reference
  Authors
Oakley AJ, Yamada T, Liu D, Coggan M, Clark AG, Board PG
  Title
The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle.
  Journal
J Biol Chem 283:22031-42 (2008)
DOI:10.1074/jbc.M803623200
  Sequence
[hsa:79017]
LinkDB

KEGG   ORTHOLOGY: K22596
Entry
K22596                      KO                                     

Name
GGCT
Definition
gamma-glutamylcyclotransferase, plant [EC:4.3.2.9]
Pathway
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K22596  GGCT; gamma-glutamylcyclotransferase, plant
Enzymes [BR:ko01000]
 4. Lyases
  4.3  Carbon-nitrogen lyases
   4.3.2  Amidine-lyases
    4.3.2.9  gamma-glutamylcyclotransferase
     K22596  GGCT; gamma-glutamylcyclotransferase, plant
Other DBs
RN: R02743 R03749
GO: 0003839
Genes
ATH: AT1G44790 AT4G31290 AT5G26220
ALY: 9305409 9310372 9327358
CRB: 17878856 17882261 17898278
CSAT: 104706945 104717066 104721711 104730170 104736648 104757964 104771108 109124741
EUS: EUTSA_v10004888mg EUTSA_v10011803mg EUTSA_v10026164mg
BRP: 103834622 103837115 103847733 103851987
BNA: 106354720 106364013 106375433 106381093 106386242 106397053 106424106 106424107 106444452 106444453
BOE: 106296270 106303209 106316472 106332741 106342556
RSZ: 108821926 108821932 108825773 108825774 108828905 108844319
THJ: 104811222 104813146 104819923
LJA: Lj1g3v1991800.1(Lj1g3v1991800.1) Lj1g3v4314270.1(Lj1g3v4314270.1)
DOSA: Os02t0465900-01(Os02g0465900) Os04t0448600-01(Os04g0448600)
ATS: 109743898(LOC109743898) 109782856(LOC109782856)
APRO: F751_4836
 » show all
Reference
  Authors
Paulose B, Chhikara S, Coomey J, Jung HI, Vatamaniuk O, Dhankher OP
  Title
A gamma-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis.
  Journal
Plant Cell 25:4580-95 (2013)
DOI:10.1105/tpc.113.111815
  Sequence
[ath:AT5G26220]
LinkDB

KEGG   ENZYME: 4.3.2.9
Entry
EC 4.3.2.9                  Enzyme                                 

Name
gamma-glutamylcyclotransferase;
gamma-glutamyl-amino acid cyclotransferase;
gamma-L-glutamylcyclotransferase;
L-glutamic cyclase;
(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing);
GGCT
Class
Lyases;
Carbon-nitrogen lyases;
Amidine-lyases
Sysname
alpha-(gamma-L-glutamyl)-L-amino-acid gamma-glutamyl cyclotransferase (5-oxo-L-proline producing)
Reaction(IUBMB)
alpha-(gamma-L-glutamyl)-L-amino acid = alpha-L-amino acid + 5-oxo-L-proline [RN:R03749]
Reaction(KEGG)
R03749;
(other) R02743
Substrate
alpha-(gamma-L-glutamyl)-L-amino acid [CPD:C03740]
Product
alpha-L-amino acid;
5-oxo-L-proline [CPD:C01879]
Comment
The enzyme, found in animals and plants, acts on derivatives of L-glutamate, L-2-aminobutanoate, L-alanine and glycine. The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
History
EC 4.3.2.9 created 1972 as EC 2.3.2.4, transferred 2017 to EC 4.3.2.9
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K00682  gamma-glutamylcyclotransferase
K22596  gamma-glutamylcyclotransferase, plant
Genes
HSA: 79017(GGCT)
PTR: 463327(GGCT)
PPS: 100984104(GGCT)
GGO: 101138956(GGCT)
PON: 100444244(GGCT)
NLE: 100600608(GGCT)
MCC: 695547(GGCT)
MCF: 102142709(GGCT)
CSAB: 103226276(GGCT)
RRO: 104668447(GGCT)
RBB: 108533407(GGCT)
CJC: 100389077(GGCT)
SBQ: 101033297(GGCT)
MMU: 110175(Ggct)
MCAL: 110296364(Ggct)
MPAH: 110316963(Ggct)
RNO: 362368(Ggct)
MUN: 110555071(Ggct)
CGE: 100774679(Ggct)
NGI: 103740842(Ggct)
HGL: 101723887(Ggct)
CCAN: 109701127(Ggct)
OCU: 100337901(GGCT)
TUP: 102497631(GGCT)
CFA: 611603(GGCT)
VVP: 112935405(GGCT)
AML: 100475961(GGCT)
UMR: 103658939(GGCT)
UAH: 113262388(GGCT)
ORO: 101381331(GGCT)
ELK: 111147302
FCA: 101087219(GGCT)
PTG: 102972301(GGCT)
PPAD: 109263921(GGCT)
AJU: 106968672(GGCT)
BTA: 533374(GGCT)
BOM: 102265622(GGCT)
BIU: 109557476(GGCT)
BBUB: 102412357(GGCT)
CHX: 102187188(GGCT)
OAS: 101102474(GGCT)
SSC: 100512447(GGCT)
CFR: 102512131(GGCT)
CDK: 105095846(GGCT)
BACU: 102997196(GGCT)
LVE: 103085194(GGCT)
OOR: 101278558(GGCT)
DLE: 111180063(GGCT)
PCAD: 102983283(GGCT)
ECB: 100069874(GGCT)
EPZ: 103552750
EAI: 106831060(GGCT)
MYB: 102257993(GGCT)
MYD: 102766806(GGCT)
MNA: 107544417(GGCT)
HAI: 109381318(GGCT)
DRO: 112306962(GGCT)
PALE: 102887499(GGCT)
RAY: 107499554(GGCT)
MJV: 108410147(GGCT)
LAV: 100673070(GGCT)
TMU: 101349289
MDO: 100032519(GGCT)
SHR: 100919793(GGCT)
PCW: 110213108(GGCT)
OAA: 100081401(GGCT)
GGA: 420676(GGCT)
MGP: 100550241(GGCT)
CJO: 107309325(GGCT)
NMEL: 110394942(GGCT)
APLA: 101805349(GGCT)
ACYG: 106046640(GGCT)
TGU: 100190607(GGCT)
LSR: 110468221(GGCT)
SCAN: 103813162(GGCT)
GFR: 102039424(GGCT)
FAB: 101818892(GGCT)
PHI: 102099497(GGCT)
PMAJ: 107200351(GGCT)
CCAE: 111923889(GGCT)
CCW: 104689028(GGCT)
ETL: 114064384(GGCT)
FPG: 101921074(GGCT)
FCH: 102047880(GGCT)
CLV: 102083440(GGCT)
EGZ: 104127521(GGCT)
NNI: 104018492(GGCT)
ACUN: 113477173(GGCT)
PADL: 103917094(GGCT)
AAM: 106491250(GGCT)
ASN: 102385482(GGCT)
AMJ: 102567732(GGCT)
PSS: 102455884(GGCT)
CMY: 102934944(GGCT)
CPIC: 101951537(GGCT)
ACS: 100558545(ggct)
PVT: 110082168(GGCT)
PBI: 103053081(GGCT)
PMUR: 107294022(GGCT)
TSR: 106545488(GGCT)
PMUA: 114607207(GGCT)
GJA: 107111522(GGCT)
XTR: 613056(ggct)
NPR: 108791133(GGCT)
DRE: 100149204(ggcta) 406278(ggctb)
CCAR: 109102943 109107899(ggct)
IPU: 100528263(ggct) 108256920(ggct)
PHYP: 113525565 113536025(ggct)
LCO: 104937169(ggct)
NCC: 104963997(ggct)
AOCE: 111563780 111569446(ggct)
CSEM: 103388762(ggct) 103394438
HCQ: 109516380 109521920(ggct)
MALB: 109963956(ggct)
SFM: 108942523
LCM: 102345575 102348398(GGCT)
CMK: 103176267(ggct)
RTP: 109924666(ggct)
BFO: 118417214
DSI: Dsimw501_GD12343(Dsim_GD12343) Dsimw501_GD12344(Dsim_GD12344)
DVI: 6622212
AAG: 5570054
AALB: 109405475
AME: 725055
BIM: 100745685
BTER: 100643954
CCAL: 108629753
OBB: 114876242
SOC: 105196864
MPHA: 105835327
AEC: 105150314
ACEP: 105621528
PBAR: 105431273
VEM: 105566080
HST: 105183396
DQU: 106751798
LHU: 105674071
PGC: 109853083
OBO: 105279351
PCF: 106793959
CSOL: 105361426
TCA: 657379
DPA: 109535153
NVL: 108569857
API: 100160827
DNX: 107167438
AGS: 114123987
RMD: 113560882
BTAB: 109031362
ZNE: 110832632
FCD: 110862377
PVM: 113828393
TUT: 107359593
CSCU: 111625598
PTEP: 107456735
CEL: CELE_C44B7.7(C44B7.7)
CBR: CBG11175
PCAN: 112576588
CRG: 105327160
LAK: 106170080
SHX: MS3_00069
NVE: 5518185
ADF: 107327495
HMG: 101238967
AQU: 100640069
LJA: Lj1g3v1991800.1(Lj1g3v1991800.1) Lj1g3v4314270.1(Lj1g3v4314270.1)
DOSA: Os02t0465900-01(Os02g0465900) Os04t0448600-01(Os04g0448600)
ATS: 109743898(LOC109743898) 109782856(LOC109782856)
APRO: F751_4836
MAW: MAC_04864
MAJ: MAA_00851
MRR: Moror_842
ABP: AGABI1DRAFT111071(AGABI1DRAFT_111071) AGABI1DRAFT117923(AGABI1DRAFT_117923) AGABI1DRAFT124916(AGABI1DRAFT_124916)
ABV: AGABI2DRAFT133726(AGABI2DRAFT_133726) AGABI2DRAFT176448(AGABI2DRAFT_176448)
CPS: CPS_2442
PHA: PSHAa0334
PART: PARC_a3561
FBL: Fbal_2422
NOC: Noc_2712
TEE: Tel_14445
HHA: Hhal_0424
BCT: GEM_5817
ADE: Adeh_4028
MXA: MXAN_3680
SPKC: KC8_09770
BBA: Bd1350
COO: CCU_03970
CCT: CC1_08810
AMR: AM1_4771
DET: DET1452
DEH: cbdbA1418
DMC: btf_1329
DMD: dcmb_1310
DMG: GY50_1283
MIN: Minf_0575
RUL: UC8_32080
 » show all
Reference
1
  Authors
Bodnaryk, R.P. and McGirr, L.
  Title
Purification, properties and function of a unique gamma-glutamyl cyclotransferase from the housefly, Musca domestica L.
  Journal
Biochim Biophys Acta 315:352-362 (1973)
Reference
2  [PMID:5781001]
  Authors
Orlowski M, Richman PG, Meister A.
  Title
Isolation and properties of gamma-L-glutamylcyclotransferase from human brain.
  Journal
Biochemistry 8:1048-55 (1969)
DOI:10.1021/bi00831a036
Reference
3  [PMID:18515354]
  Authors
Oakley AJ, Yamada T, Liu D, Coggan M, Clark AG, Board PG
  Title
The identification and structural characterization of C7orf24 as gamma-glutamyl cyclotransferase. An essential enzyme in the gamma-glutamyl cycle.
  Journal
J Biol Chem 283:22031-42 (2008)
DOI:10.1074/jbc.M803623200
  Sequence
[hsa:79017]
Reference
4  [PMID:24214398]
  Authors
Paulose B, Chhikara S, Coomey J, Jung HI, Vatamaniuk O, Dhankher OP
  Title
A gamma-glutamyl cyclotransferase protects Arabidopsis plants from heavy metal toxicity by recycling glutamate to maintain glutathione homeostasis.
  Journal
Plant Cell 25:4580-95 (2013)
DOI:10.1105/tpc.113.111815
  Sequence
[ath:AT5G26220]
Other DBs
ExplorEnz - The Enzyme Database: 4.3.2.9
IUBMB Enzyme Nomenclature: 4.3.2.9
ExPASy - ENZYME nomenclature database: 4.3.2.9
BRENDA, the Enzyme Database: 4.3.2.9
CAS: 9045-44-7
LinkDB

KEGG   REACTION: R02743
Entry
R02743                      Reaction                               

Name
gamma-L-glutamyl-L-cysteine gamma-glutamyl cyclotransferase (5-oxoproline-forming)
Definition
gamma-L-Glutamyl-L-cysteine <=> 5-Oxoproline + L-Cysteine
Equation
Reaction class
RC00064  C00097_C00669
RC00777  C00669_C01879
Enzyme
Pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Orthology
K00682  gamma-glutamylcyclotransferase [EC:4.3.2.9]
K22596  gamma-glutamylcyclotransferase, plant [EC:4.3.2.9]
LinkDB

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