KEGG   ORTHOLOGY: K00722Help
Entry
K00722                      KO                                     

Name
GBGT1
Definition
globoside alpha-N-acetylgalactosaminyltransferase [EC:2.4.1.88]
Pathway
ko00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00603 Glycosphingolipid biosynthesis - globo and isoglobo series
    K00722  GBGT1; globoside alpha-N-acetylgalactosaminyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00722  GBGT1; globoside alpha-N-acetylgalactosaminyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.88  globoside alpha-N-acetylgalactosaminyltransferase
     K00722  GBGT1; globoside alpha-N-acetylgalactosaminyltransferase
Glycosyltransferases [BR:ko01003]
 Glycan extension
  FORS blood group (Forssman antigen)
   K00722  GBGT1; globoside alpha-N-acetylgalactosaminyltransferase
BRITE hierarchy
Other DBs
RN: R05965 R11322
GO: 0047277
CAZy: GT6
Genes
HSA: 26301(GBGT1)
PTR: 464823(GBGT1)
PPS: 100978291(GBGT1)
GGO: 101145846(GBGT1)
PON: 100453106(GBGT1)
NLE: 100590023(GBGT1)
MCC: 106993582(GBGT1)
MCF: 102119767(GBGT1)
CSAB: 103239703(GBGT1)
RRO: 104669732(GBGT1)
RBB: 108513510(GBGT1)
CJC: 103795439(GBGT1)
SBQ: 104652637(GBGT1)
MMU: 227671(Gbgt1)
MCAL: 110290105(Gbgt1)
MPAH: 110319298(Gbgt1)
RNO: 499764
MUN: 110549880(Gbgt1)
CGE: 100771256(Gbgt1)
HGL: 101726516(Gbgt1)
CCAN: 109690998(Gbgt1)
TUP: 102477690(GBGT1)
CFA: 403833(GBGT1)
VVP: 112928011(GBGT1)
AML: 100479644(GBGT1)
UMR: 103670247(GBGT1)
UAH: 113266556(GBGT1)
ORO: 101386326(GBGT1)
ELK: 111146249
FCA: 101090810(GBGT1)
PTG: 102954717(GBGT1)
PPAD: 109249974(GBGT1)
AJU: 106985321(GBGT1)
BTA: 618517(GBGT1)
BOM: 102282202(GBGT1)
BIU: 109566575(GBGT1) 109566576
BBUB: 102405974(GBGT1)
CHX: 102180325(GBGT1)
OAS: 101112039(GBGT1)
SSC: 110256486(GBGT1)
CDK: 105085187(GBGT1)
BACU: 103008412
LVE: 103086807(GBGT1)
OOR: 105747968(GBGT1)
DLE: 111177084(GBGT1)
PCAD: 102993265(GBGT1)
ECB: 100069388(GBGT1)
EPZ: 103553672(GBGT1)
EAI: 106845361(GBGT1)
MYB: 102239613(GBGT1)
MYD: 102767739(GBGT1)
MNA: 107524628(GBGT1)
HAI: 109381005(GBGT1)
DRO: 112306338(GBGT1)
PALE: 102880609(GBGT1)
RAY: 107504585(GBGT1)
MJV: 108388221(GBGT1)
LAV: 100665584(GBGT1)
TMU: 101349194
MDO: 100017839(GBGT1)
SHR: 100918940(GBGT1)
PCW: 110205392(GBGT1)
OAA: 100090987(GBGT1)
GGA: 417163(GBGT1)
MGP: 100540036(CCDC180)
CJO: 107321913(GBGT1)
NMEL: 110406850
APLA: 101799653(GBGT1)
ACYG: 106044126(GBGT1)
TGU: 100225394
LSR: 110477722(GBGT1)
SCAN: 103818975(GBGT1)
GFR: 102040147(GBGT1)
FAB: 101806513(GBGT1)
PHI: 102103511(ABO)
PMAJ: 107212008(GBGT1)
CCAE: 111937029(GBGT1)
CCW: 104688481(GBGT1)
ETL: 114059121
FPG: 101921547(GBGT1)
FCH: 102050463(GBGT1)
CLV: 102095912(GBGT1)
EGZ: 104129328
NNI: 104023282(GBGT1)
ACUN: 113486511(GBGT1)
PADL: 103915270(GBGT1)
AAM: 106483758(GBGT1)
ASN: 102388459(GBGT1)
AMJ: 102565956(GBGT1)
PSS: 102455930(GBGT1)
CMY: 102938627(GBGT1)
CPIC: 101945380(GBGT1)
PVT: 110079644(GBGT1)
PMUA: 114589368(GBGT1)
GJA: 107124818(GBGT1)
DRE: 387303(gbgt1l4)
AMEX: 103028363
TRU: 101067861
CSEM: 103386423
HCQ: 109522118
CMK: 103178422 103183073(glt6d1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Xu H, Storch T, Yu M, Elliott SP, Haslam DB
  Title
Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions.
  Journal
J Biol Chem 274:29390-8 (1999)
DOI:10.1074/jbc.274.41.29390
  Sequence
[hsa:26301]
LinkDB All DBs

KEGG   ENZYME: 2.4.1.88Help
Entry
EC 2.4.1.88                 Enzyme                                 

Name
globoside alpha-N-acetylgalactosaminyltransferase;
uridine diphosphoacetylgalactosamine-globoside alpha-acetylgalactosaminyltransferase;
Forssman synthase;
globoside acetylgalactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D-galactosyl-1,4-D-galactosyl-1,4-D-glucosylceramide alpha-N-acetyl-D-galactosaminyltransferase;
UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-(1->3)-D-galactosyl-(1->4)-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
BRITE hierarchy
Sysname
UDP-N-acetyl-alpha-D-galactosamine:N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide alpha-N-acetyl-D-galactosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-galactosamine + N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide = UDP + N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide [RN:R04182 R05965]
Reaction(KEGG)
R04182 R05965(G);
(other) R11322(G)
Show
Substrate
UDP-N-acetyl-alpha-D-galactosamine [CPD:C00203];
N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Product
UDP [CPD:C00015];
N-acetyl-alpha-D-galactosaminyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
History
EC 2.4.1.88 created 1976
Pathway
ec00603  Glycosphingolipid biosynthesis - globo and isoglobo series
ec01100  Metabolic pathways
Orthology
K00722  globoside alpha-N-acetylgalactosaminyltransferase
Genes
HSA: 26301(GBGT1)
PTR: 464823(GBGT1)
PPS: 100978291(GBGT1)
GGO: 101145846(GBGT1)
PON: 100453106(GBGT1)
NLE: 100590023(GBGT1)
MCC: 106993582(GBGT1)
MCF: 102119767(GBGT1)
CSAB: 103239703(GBGT1)
RRO: 104669732(GBGT1)
RBB: 108513510(GBGT1)
CJC: 103795439(GBGT1)
SBQ: 104652637(GBGT1)
MMU: 227671(Gbgt1)
MCAL: 110290105(Gbgt1)
MPAH: 110319298(Gbgt1)
RNO: 499764
MUN: 110549880(Gbgt1)
CGE: 100771256(Gbgt1)
HGL: 101726516(Gbgt1)
CCAN: 109690998(Gbgt1)
TUP: 102477690(GBGT1)
CFA: 403833(GBGT1)
VVP: 112928011(GBGT1)
AML: 100479644(GBGT1)
UMR: 103670247(GBGT1)
UAH: 113266556(GBGT1)
ORO: 101386326(GBGT1)
ELK: 111146249
FCA: 101090810(GBGT1)
PTG: 102954717(GBGT1)
PPAD: 109249974(GBGT1)
AJU: 106985321(GBGT1)
BTA: 618517(GBGT1)
BOM: 102282202(GBGT1)
BIU: 109566575(GBGT1) 109566576
BBUB: 102405974(GBGT1)
CHX: 102180325(GBGT1)
OAS: 101112039(GBGT1)
SSC: 110256486(GBGT1)
CDK: 105085187(GBGT1)
BACU: 103008412
LVE: 103086807(GBGT1)
OOR: 105747968(GBGT1)
DLE: 111177084(GBGT1)
PCAD: 102993265(GBGT1)
ECB: 100069388(GBGT1)
EPZ: 103553672(GBGT1)
EAI: 106845361(GBGT1)
MYB: 102239613(GBGT1)
MYD: 102767739(GBGT1)
MNA: 107524628(GBGT1)
HAI: 109381005(GBGT1)
DRO: 112306338(GBGT1)
PALE: 102880609(GBGT1)
RAY: 107504585(GBGT1)
MJV: 108388221(GBGT1)
LAV: 100665584(GBGT1)
TMU: 101349194
MDO: 100017839(GBGT1)
SHR: 100918940(GBGT1)
PCW: 110205392(GBGT1)
OAA: 100090987(GBGT1)
GGA: 417163(GBGT1)
MGP: 100540036(CCDC180)
CJO: 107321913(GBGT1)
NMEL: 110406850
APLA: 101799653(GBGT1)
ACYG: 106044126(GBGT1)
TGU: 100225394
LSR: 110477722(GBGT1)
SCAN: 103818975(GBGT1)
GFR: 102040147(GBGT1)
FAB: 101806513(GBGT1)
PHI: 102103511(ABO)
PMAJ: 107212008(GBGT1)
CCAE: 111937029(GBGT1)
CCW: 104688481(GBGT1)
ETL: 114059121
FPG: 101921547(GBGT1)
FCH: 102050463(GBGT1)
CLV: 102095912(GBGT1)
EGZ: 104129328
NNI: 104023282(GBGT1)
ACUN: 113486511(GBGT1)
PADL: 103915270(GBGT1)
AAM: 106483758(GBGT1)
ASN: 102388459(GBGT1)
AMJ: 102565956(GBGT1)
PSS: 102455930(GBGT1)
CMY: 102938627(GBGT1)
CPIC: 101945380(GBGT1)
PVT: 110079644(GBGT1)
PMUA: 114589368(GBGT1)
GJA: 107124818(GBGT1)
DRE: 387303(gbgt1l4)
AMEX: 103028363
TRU: 101067861
CSEM: 103386423
HCQ: 109522118
CMK: 103178422 103183073(glt6d1)
 » show all
Taxonomy
Reference
1  [PMID:4823436]
  Authors
Kijimoto S, Ishibashi T, Makita A.
  Title
Biosynthesis of Forssman hapten from globoside by alpha-N-acetylgalactosaminyltransferase of guinea pig tissues.
  Journal
Biochem Biophys Res Commun 56:177-84 (1974)
DOI:10.1016/S0006-291X(74)80331-1
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.88
IUBMB Enzyme Nomenclature: 2.4.1.88
ExPASy - ENZYME nomenclature database: 2.4.1.88
BRENDA, the Enzyme Database: 2.4.1.88
CAS: 52037-97-5
LinkDB All DBs

KEGG   REACTION: R05965Help
Entry
R05965                      Reaction                               

Definition
UDP-N-acetyl-D-galactosamine + Globoside <=> UDP + Forssman antigen, IV3GalNAca-Gb4Cer
Equation
Remark
Same as: R04182
Enzyme
Pathway
rn00603  Glycosphingolipid biosynthesis - globo and isoglobo series
rn01100  Metabolic pathways
Orthology
K00722  globoside alpha-N-acetylgalactosaminyltransferase [EC:2.4.1.88]
LinkDB All DBs

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