KEGG   ORTHOLOGY: K00739
Entry
K00739                      KO                                     

Name
B3GNT6
Definition
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase [EC:2.4.1.147]
Pathway
ko00512  Mucin type O-glycan biosynthesis
ko01100  Metabolic pathways
Module
M00056  O-glycan biosynthesis, mucin type core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09107 Glycan biosynthesis and metabolism
   00512 Mucin type O-glycan biosynthesis
    K00739  B3GNT6; acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K00739  B3GNT6; acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.147  acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
     K00739  B3GNT6; acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
Glycosyltransferases [BR:ko01003]
 Glycan extension
  Type 2 chain/Poly-N-acetyllactosamine
   K00739  B3GNT6; acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
Other DBs
RN: R05909
GO: 0047224
CAZy: GT31
Genes
HSA: 192134(B3GNT6)
PTR: 451437(B3GNT6)
PPS: 100976514(B3GNT6)
GGO: 101135837(B3GNT6)
PON: 100447110(B3GNT6)
NLE: 100590559(B3GNT6)
MCC: 697946(B3GNT6)
MCF: 102140679(B3GNT6)
CSAB: 103248086(B3GNT6)
RRO: 104665081(B3GNT6)
RBB: 108543201(B3GNT6)
CJC: 100395512(B3GNT6)
MMU: 272411(B3gnt6)
MCAL: 110299476(B3gnt6)
MPAH: 110338661(B3gnt6)
RNO: 292325(B3gnt6)
MUN: 110547309(B3gnt6)
CGE: 100768656(B3gnt6)
NGI: 103743061(B3gnt6)
HGL: 101709961(B3gnt6)
CCAN: 109688563(B3gnt6)
OCU: 100351306(B3GNT6)
TUP: 102471967(B3GNT6)
CFA: 485176(B3GNT6)
VVP: 112928597(B3GNT6)
AML: 100477436(B3GNT6)
UAH: 113269347(B3GNT6)
ORO: 101364432(B3GNT6)
ELK: 111140080
FCA: 101088357(B3GNT6)
PPAD: 109267243(B3GNT6)
AJU: 113593724(B3GNT6)
BTA: 540848(B3GNT6)
BOM: 102281875(B3GNT6)
BIU: 109569036(B3GNT6) 109569038
BBUB: 102404962(B3GNT6)
CHX: 102177179(B3GNT6)
OAS: 101110268(B3GNT6)
SSC: 100524328(B3GNT6)
CFR: 102514253(B3GNT6)
CDK: 105098256(B3GNT6)
BACU: 103008870(B3GNT6)
LVE: 103070939(B3GNT6)
PCAD: 102977665(B3GNT6)
ECB: 100146508(B3GNT6)
EPZ: 103548238(B3GNT6)
EAI: 106840415(B3GNT6)
MJV: 108387058(B3GNT6)
LAV: 100655490(B3GNT6)
TMU: 101342607
OAA: 100074637(B3GNT6)
PSS: 102450449
PBI: 112542604
XLA: 108703688
HST: 105192701
RMD: 113548355
PVM: 113829124
 » show all
Reference
  Authors
Iwai T, Inaba N, Naundorf A, Zhang Y, Gotoh M, Iwasaki H, Kudo T, Togayachi A, Ishizuka Y, Nakanishi H, Narimatsu H.
  Title
Molecular cloning and characterization of a novel UDP-GlcNAc:GalNAc-peptide beta1,3-N-acetylglucosaminyltransferase (beta 3Gn-T6), an enzyme synthesizing the core 3 structure of O-glycans.
  Journal
J Biol Chem 277:12802-9 (2002)
DOI:10.1074/jbc.M112457200
  Sequence
[hsa:192134]
LinkDB

KEGG   ENZYME: 2.4.1.147
Entry
EC 2.4.1.147                Enzyme                                 

Name
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase;
O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III;
uridine diphosphoacetylglucosamine-mucin beta(1->3)-acetylglucosaminyltransferase;
mucin core 3 beta3-GlcNAc-transferase;
Core 3beta-GlcNAc-transferase;
UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosaminyl-R) beta-1,3-N-acetyl-D-glucosaminyltransferase;
UDP-N-acetyl-D-glucosamine:N-acetyl-beta-D-galactosaminyl-R 3-beta-N-acetyl-D-glucosaminyltransferase (incorrect)
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-N-acetyl-alpha-D-glucosamine:O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] 3-beta-N-acetyl-D-glucosaminyltransferase
Reaction(IUBMB)
UDP-N-acetyl-alpha-D-glucosamine + O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] = UDP + O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein] [RN:R05909]
Reaction(KEGG)
R05909(G);
(other) R03513
Substrate
UDP-N-acetyl-alpha-D-glucosamine [CPD:C00043];
O3-[N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
Product
UDP [CPD:C00015];
O3-[N-acetyl-beta-D-glucosaminyl-(1->3)-N-acetyl-alpha-D-galactosaminyl]-L-threonyl/L-seryl-[protein]
Comment
The product of the enzyme is known as core 3, one of the eight core structures of mucin-type O-glycans. O-Linked glycans are polysaccharides or oligosaccharides that are linked to a protein via the oxygen atom in the side chain of an L-serine or L-threonine residue.
History
EC 2.4.1.147 created 1984, modified 2015
Pathway
ec00512  Mucin type O-glycan biosynthesis
ec01100  Metabolic pathways
Orthology
K00739  acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase
Genes
HSA: 192134(B3GNT6)
PTR: 451437(B3GNT6)
PPS: 100976514(B3GNT6)
GGO: 101135837(B3GNT6)
PON: 100447110(B3GNT6)
NLE: 100590559(B3GNT6)
MCC: 697946(B3GNT6)
MCF: 102140679(B3GNT6)
CSAB: 103248086(B3GNT6)
RRO: 104665081(B3GNT6)
RBB: 108543201(B3GNT6)
CJC: 100395512(B3GNT6)
MMU: 272411(B3gnt6)
MCAL: 110299476(B3gnt6)
MPAH: 110338661(B3gnt6)
RNO: 292325(B3gnt6)
MUN: 110547309(B3gnt6)
CGE: 100768656(B3gnt6)
NGI: 103743061(B3gnt6)
HGL: 101709961(B3gnt6)
CCAN: 109688563(B3gnt6)
OCU: 100351306(B3GNT6)
TUP: 102471967(B3GNT6)
CFA: 485176(B3GNT6)
VVP: 112928597(B3GNT6)
AML: 100477436(B3GNT6)
UAH: 113269347(B3GNT6)
ORO: 101364432(B3GNT6)
ELK: 111140080
FCA: 101088357(B3GNT6)
PPAD: 109267243(B3GNT6)
AJU: 113593724(B3GNT6)
BTA: 540848(B3GNT6)
BOM: 102281875(B3GNT6)
BIU: 109569036(B3GNT6) 109569038
BBUB: 102404962(B3GNT6)
CHX: 102177179(B3GNT6)
OAS: 101110268(B3GNT6)
SSC: 100524328(B3GNT6)
CFR: 102514253(B3GNT6)
CDK: 105098256(B3GNT6)
BACU: 103008870(B3GNT6)
LVE: 103070939(B3GNT6)
PCAD: 102977665(B3GNT6)
ECB: 100146508(B3GNT6)
EPZ: 103548238(B3GNT6)
EAI: 106840415(B3GNT6)
MJV: 108387058(B3GNT6)
LAV: 100655490(B3GNT6)
TMU: 101342607
OAA: 100074637(B3GNT6)
PSS: 102450449
PBI: 112542604
XLA: 108703688
HST: 105192701
RMD: 113548355
PVM: 113829124
 » show all
Reference
1  [PMID:6226356]
  Authors
Brockhausen I, Rachaman ES, Matta KL, Schachter H.
  Title
The separation by liquid chromatography (under elevated pressure) of phenyl, benzyl, and O-nitrophenyl glycosides of oligosaccharides. Analysis of substrates and products for four N-acetyl-D-glucosaminyl-transferases involved in mucin synthesis.
  Journal
Carbohydr Res 120:3-16 (1983)
DOI:10.1016/0008-6215(83)88002-1
Reference
2  [PMID:3160388]
  Authors
Brockhausen I, Matta KL, Orr J, Schachter H
  Title
Mucin synthesis. UDP-GlcNAc:GalNAc-R beta 3-N-acetylglucosaminyltransferase and UDP-GlcNAc:GlcNAc beta 1-3GalNAc-R (GlcNAc to GalNAc) beta 6-N-acetylglucosaminyltransferase from pig and rat colon mucosa.
  Journal
Biochemistry 24:1866-74 (1985)
DOI:10.1021/bi00329a010
Reference
3  [PMID:7655172]
  Authors
Vavasseur F, Yang JM, Dole K, Paulsen H, Brockhausen I
  Title
Synthesis of O-glycan core 3: characterization of UDP-GlcNAc: GalNAc-R beta 3-N-acetyl-glucosaminyltransferase activity from colonic mucosal tissues and lack of the activity in human cancer cell lines.
  Journal
Glycobiology 5:351-7 (1995)
DOI:10.1093/glycob/5.3.351
  Sequence
[hsa:192134]
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.147
IUBMB Enzyme Nomenclature: 2.4.1.147
ExPASy - ENZYME nomenclature database: 2.4.1.147
BRENDA, the Enzyme Database: 2.4.1.147
CAS: 87927-96-6
LinkDB

KEGG   REACTION: R05909
Entry
R05909                      Reaction                               

Definition
UDP-N-acetyl-D-glucosamine + Tn antigen <=> UDP + G00028
Equation
Enzyme
Pathway
rn00512  Mucin type O-glycan biosynthesis
rn01100  Metabolic pathways
Module
M00056  O-glycan biosynthesis, mucin type core
Orthology
K00739  acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase [EC:2.4.1.147]
Other DBs
RHEA: 46887
LinkDB

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