KEGG   ORTHOLOGY: K00907
Entry
K00907                      KO                                     

Name
MYLK
Definition
myosin-light-chain kinase [EC:2.7.11.18]
Pathway
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04510  Focal adhesion
map04611  Platelet activation
map04810  Regulation of actin cytoskeleton
map04921  Oxytocin signaling pathway
map04971  Gastric acid secretion
Disease
H00801  Familial thoracic aortic aneurysm and dissection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K00907  MYLK; myosin-light-chain kinase
   04020 Calcium signaling pathway
    K00907  MYLK; myosin-light-chain kinase
   04022 cGMP-PKG signaling pathway
    K00907  MYLK; myosin-light-chain kinase
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K00907  MYLK; myosin-light-chain kinase
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K00907  MYLK; myosin-light-chain kinase
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K00907  MYLK; myosin-light-chain kinase
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K00907  MYLK; myosin-light-chain kinase
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K00907  MYLK; myosin-light-chain kinase
  09154 Digestive system
   04971 Gastric acid secretion
    K00907  MYLK; myosin-light-chain kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K00907  MYLK; myosin-light-chain kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.18  myosin-light-chain kinase
     K00907  MYLK; myosin-light-chain kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  MLCK family
   K00907  MYLK; myosin-light-chain kinase
Other DBs
GO: 0004687
Genes
HSA: 340156(MYLK4) 4638(MYLK) 85366(MYLK2) 91807(MYLK3)
PTR: 101057233(MYLK) 465143(MYLK3) 471840(MYLK4) 742591(MYLK2)
PPS: 100974667(MYLK3) 100978891(MYLK2) 100979422(MYLK) 100995666(MYLK4)
GGO: 101142619(MYLK3) 101143745(MYLK2) 101151517(MYLK) 101151667(MYLK4)
PON: 100171951(MYLK3) 100444714(MYLK4) 100452913(MYLK) 100453783(MYLK2)
NLE: 100585981(MYLK2) 100591151(MYLK) 100594745(MYLK4) 100604194 115831086(MYLK3)
MCC: 707361(MYLK4) 712830(MYLK2) 715422(MYLK) 716132(MYLK3)
MCF: 102122026(MYLK4) 102130711(MYLK) 102132754(MYLK3) 102145766(MYLK2)
CSAB: 103222295(MYLK4) 103228167(MYLK) 103232215(MYLK3) 103248051(MYLK2)
CATY: 105582238(MYLK2) 105589245(MYLK3) 105589789(MYLK) 105596420(MYLK4)
PANU: 101007177(MYLK4) 101012839(MYLK3) 101016979(MYLK) 101018714(MYLK2)
RRO: 104653717(MYLK2) 104655407(MYLK) 104655430(MYLK3) 104661238(MYLK4)
RBB: 108514260(MYLK4) 108517416(MYLK) 108524142(MYLK2) 108534775(MYLK3)
TFN: 117068620(MYLK2) 117083396(MYLK) 117086614(MYLK4) 117087736(MYLK3)
PTEH: 111524418(MYLK3) 111533516 111548207(MYLK2) 111548560(MYLK4)
CJC: 100391801(MYLK2) 100392653(MYLK3) 100392656(MYLK4) 100409440(MYLK)
SBQ: 101029220(MYLK) 101038668(MYLK2) 101049056(MYLK4) 101050910(MYLK3)
MMUR: 105866079(MYLK2) 105873493(MYLK4) 105876221(MYLK3) 105879866(MYLK)
MMU: 107589(Mylk) 213435(Mylk3) 228785(Mylk2) 238564(Mylk4)
MCAL: 110290127(Mylk2) 110300419(Mylk3) 110308670(Mylk4) 110311174(Mylk)
MPAH: 110319274(Mylk2) 110329346(Mylk) 110334129(Mylk4) 110337577(Mylk3)
RNO: 100911165(Mylk4) 117558(Mylk2) 288057(Mylk) 291926(Mylk3)
MCOC: 116069762(Mylk3) 116081489(Mylk4) 116085852(Mylk) 116091182(Mylk2)
MUN: 110547228(Mylk) 110550095(Mylk2) 110552995(Mylk3) 110558635(Mylk4)
CGE: 100755963(Mylk2) 100756400(Mylk4) 100758406(Mylk) 100766446(Mylk3)
PLEU: 114702188(Mylk4) 114704843(Mylk) 114705574(Mylk2) 114709967(Mylk3)
NGI: 103731078(Mylk2) 103737011(Mylk4) 103741992(Mylk)
HGL: 101701713(Mylk4) 101704236(Mylk) 101712444(Mylk2)
CCAN: 109677703 109691764(Mylk2) 109700226(Mylk4)
OCU: 100009051(MYLK2) 100353972(MYLK4)
TUP: 102476504(MYLK) 102489117(MYLK2) 102498032(MYLK4)
CFA: 475345(MYLK3) 477187(MYLK2) 488012(MYLK) 488190
VVP: 112907401(MYLK4) 112909931(MYLK2) 112913506(MYLK) 112914947(MYLK3)
VLG: 121478392(MYLK2) 121481492(MYLK3) 121499771(MYLK4) 121500652(MYLK)
AML: 100469244(MYLK2) 100473453(MYLK4) 100474254(MYLK3) 100481263(MYLK)
UMR: 103665161(MYLK4) 103673818(MYLK3) 103674343(MYLK2) 103678824(MYLK)
UAH: 113252202(MYLK3) 113252350(MYLK) 113258196(MYLK2) 113264229(MYLK4)
ORO: 101368074(MYLK4) 101370711(MYLK3) 101378973(MYLK) 101381609(MYLK2)
MPUF: 101673442(MYLK3) 101673644(MYLK2) 101681427(MYLK4)
EJU: 114199360(MYLK3) 114199417(MYLK) 114220792(MYLK2) 114223891(MYLK4)
MLX: 118007012(MYLK) 118011350(MYLK2) 118023826(MYLK3) 118027388(MYLK4)
FCA: 101088408(MYLK4) 101091744(MYLK3) 101095813(MYLK2)
PTG: 102951994(MYLK2) 102962607(MYLK3) 102968305(MYLK4) 102972928(MYLK)
PPAD: 109249481(MYLK4) 109266499(MYLK) 109270987(MYLK3) 109272590(MYLK2)
AJU: 106965987(MYLK3) 106976155(MYLK4) 106984088(MYLK) 106986013(MYLK2)
HHV: 120235452(MYLK2) 120237364(MYLK) 120238194(MYLK3) 120241448(MYLK4)
BTA: 338037(MYLK) 518025(MYLK4) 526379(MYLK3) 533378(MYLK2)
BOM: 102264349(MYLK4) 102269080(MYLK) 102275601(MYLK3) 102276600(MYLK2)
BIU: 109567347(MYLK2) 109572727(MYLK3) 109577322(MYLK4)
BBUB: 102395214(MYLK3) 102402899(MYLK) 102412646(MYLK4) 102415047(MYLK2)
CHX: 102181454(MYLK4) 102181980(MYLK3) 102182147(MYLK2) 102190641(MYLK)
OAS: 101111897(MYLK2) 101113784(MYLK3) 105603910 443334(MYLK)
ODA: 120868758(MYLK2) 120869929 120870611(MYLK) 120872918(MYLK3)
SSC: 100157526(MYLK4) 100524288(MYLK2) 110260971(MYLK3) 396848(MYLK)
CFR: 102505869(MYLK2) 102511426(MYLK3) 102515628(MYLK4) 102518144(MYLK)
CDK: 105086549(MYLK4) 105090282(MYLK) 105091178(MYLK3) 105100824(MYLK2)
BACU: 103005866(MYLK3) 103008421(MYLK) 103017148(MYLK2) 103020477(MYLK4)
LVE: 103077707(MYLK4) 103079981(MYLK2) 103083551(MYLK3) 103090456(MYLK)
OOR: 101275794(MYLK4) 101282343(MYLK) 101287286(MYLK3) 101289244(MYLK2)
DLE: 111165019(MYLK3) 111171109 111171669(MYLK) 111184432(MYLK2)
PCAD: 102982196(MYLK3) 102982293(MYLK2) 102982405(MYLK) 102984346(MYLK4)
ECB: 100050092(MYLK4) 100053698(MYLK2) 100056559(MYLK3) 100070482(MYLK)
EPZ: 103547465(MYLK) 103548123(MYLK4) 103559162(MYLK2)
EAI: 106823711(MYLK) 106833720(MYLK2) 106842841(MYLK4) 106848229(MYLK3)
MYB: 102259949(MYLK2) 102262704(MYLK4)
MYD: 102755283(MYLK2) 102759237(MYLK) 102765242(MYLK4)
MMYO: 118663442(MYLK2) 118674227(MYLK3) 118675928(MYLK) 118677237(MYLK4)
MNA: 107527759(MYLK2) 107535858(MYLK3) 107542256(MYLK4)
HAI: 109383050(MYLK3) 109384471(MYLK2) 109388085
DRO: 112296778(MYLK3) 112297606(MYLK4) 112303707(MYLK2) 112320512(MYLK)
SHON: 118985341(MYLK2) 118990733(MYLK) 119001158(MYLK3) 119003468(MYLK4)
AJM: 119036780(MYLK4) 119039481(MYLK) 119047724(MYLK2) 119049053(MYLK3)
MMF: 118617212(MYLK) 118618547(MYLK2) 118626541(MYLK4) 118639281(MYLK3)
PALE: 102890778(MYLK) 102891799(MYLK2) 102894361(MYLK4)
RAY: 107512864(MYLK2) 107516607(MYLK4) 107518034(MYLK)
MJV: 108385316 108393093(MYLK2) 108396719(MYLK) 108402114(MYLK3)
TOD: 119249184(MYLK3) 119251054(MYLK4) 119253977(MYLK2) 119257453(MYLK)
LAV: 100656405(MYLK2) 100665634(MYLK4) 100677183(MYLK)
MDO: 100015876(MYLK3) 100019648(MYLK) 100021377(MYLK4)
SHR: 100918090(MYLK4) 100925131(MYLK3)
PCW: 110196726(MYLK4) 110207445(MYLK3) 110208127(MYLK)
OAA: 100079091(MYLK4) 100091283(MYLK) 100092442(MYLK3)
GGA: 396356(MYLK2) 396445(MYLK) 415748(MYLK3) 420893(MYLK4) 428278(MYLKSML)
PCOC: 116227380(MYLK) 116227766(MYLK2) 116233855 116243997(MYLK3)
MGP: 100538449 100542497(MYLK2) 100543918(MYLK4) 100547989(MYLK) 100551067(MYLK3) 104914090
CJO: 107309576(MYLK4) 107316813(MYLK) 107319273(MYLK3) 107323244(MYLK2) 107325036
NMEL: 110388525 110393482(MYLK4) 110400604(MYLK) 110404229(MYLK3) 110408280(MYLK2)
APLA: 101793167(MYLK3) 101799935(MYLK4) 101800032 101803931(MYLK2)
ACYG: 106029897(MYLK) 106039596(MYLK3) 106046900 106048980(MYLK4)
TGU: 100218159(MYLK2) 100222880(MYLK4) 100226590(MYLK) 100232455(MYLK3) 115490676
LSR: 110468290(MYLK) 110469015(MYLK2) 110470711(MYLK4) 110475603 110475887(MYLK3)
SCAN: 103814310(MYLK) 103816608(MYLK3) 103818174(MYLK4) 103818839(MYLK2) 103821775
PMOA: 120497241(MYLK4) 120498294 120499105(MYLK) 120507140(MYLK2) 120508049(MYLK3)
GFR: 102037734(MYLK4) 102037824(MYLK2) 102038683(MYLK3) 102044716(MYLK)
FAB: 101807258(MYLK) 101807804 101809550(MYLK3) 101813259(MYLK2) 101819869(MYLK4)
PHI: 102101059 102104582(MYLK2) 102106790(MYLK) 102111091(MYLK4) 102112254(MYLK3)
PMAJ: 107207555(MYLK) 107209810(MYLK3) 107213081(MYLK2) 107213960(MYLK4) 107215054
CCAE: 111923845(MYLK4) 111932252(MYLK) 111934649(MYLK3) 111938138(MYLK2) 111940063
CCW: 104687441(MYLK3) 104687839(MYLK2) 104694020(MYLK) 104698150(MYLK4) 104698538
ETL: 114058107(MYLK) 114060388(MYLK3) 114063040(MYLK2) 114070606 114071985
FPG: 101910574 101917440(MYLK3) 101922032(MYLK2) 101922066 101922502(MYLK)
FCH: 102050025(MYLK) 102051042(MYLK2) 102051053 102058744(MYLK3)
CLV: 102088141 102093425(MYLK2) 102094050(MYLK4) 102095697(MYLK3)
EGZ: 104122823(MYLK4) 104125557(MYLK3) 104128132(MYLK) 104132337
NNI: 104011279(MYLK3) 104018366(MYLK2) 104018798(MYLK) 104018914 104021845(MYLK4)
ACUN: 113476670(MYLK4) 113482370(MYLK) 113484301(MYLK3) 113489147
PADL: 103913791(MYLK3) 103919008(MYLK4) 103919603(MYLK) 103921929
AAM: 106482002(MYLK4) 106483357(MYLK3) 106495651 106497378(MYLK2) 106499178(MYLK)
ASN: 102369318(MYLK2) 102371849(MYLK3) 102381743(MYLK) 102384108(MYLK4) 102387857
AMJ: 102557905 102561520(MYLK) 102568638(MYLK3) 102574082(MYLK4)
CPOO: 109310558(MYLK3) 109313073(MYLK2) 109314959(MYLK4) 109322804(MYLK)
GGN: 109289569 109292519(MYLK2) 109300981(MYLK4) 109301415(MYLK)
PSS: 102448460(MYLK4) 102458914(MYLK3) 102461616(MYLK)
CMY: 102929389(MYLK4) 102929671(MYLK) 102943339(MYLK3) 102943755
CPIC: 101934934(MYLK4) 101935997(MYLK3) 101945225 101950238(MYLK2)
TST: 117869384 117873146(MYLK4) 117885275(MYLK) 117886013(MYLK2) 117886754(MYLK3)
CABI: 116816818(MYLK2) 116823503(MYLK3) 116832025 116834662 116834732(MYLK)
ACS: 100557929(mylk) 100559335(mylk3) 100562117(mylk2) 100567803(mylk4)
PVT: 110076324(MYLK3) 110083010(MYLK) 110086708(MYLK2) 110090626(MYLK4)
PBI: 103059391(MYLK3) 103060340(MYLK) 112540892
PMUR: 107284832(MYLK4) 107290115(MYLK3)
TSR: 106543664(MYLK)
PGUT: 117657250(MYLK2) 117668851(MYLK) 117670916(MYLK3) 117672422(MYLK4)
PMUA: 114599828(MYLK2) 114600967(MYLK4) 114602252(MYLK3) 114603926(MYLK)
ZVI: 118086713(MYLK3) 118088799(MYLK2) 118090072 118091777(MYLK)
GJA: 107106205 107108885(MYLK3) 107113908(MYLK)
XLA: 108700969 108701256(mylk.L) 108701763(mylkl.L) 108702240(mylk.S) 108714133 108715487 108719107(mylk4.L) 108720081(mylk4.S)
XTR: 100489678(mylkl) 100497991(mylk4) 100498081(xkr7) 100498243(mylk3) 101730432(mylk)
NPR: 108785969 108787381(MYLK4) 108802964(MYLK3)
DRE: 100003770(mylk5) 449707(mylk4b) 492576(mylkb) 558685(mylk2) 561635(mylk3) 566845(mylk4a) 569510(mylka)
ELY: 117247106(mylk4b) 117251242(mylka) 117268957(mylk5) 117272282(mylk4a)
PLEP: 121951941(mylk4a) 121956704(mylk5) 121963547(mylk4b)
SLUC: 116038187(mylk4b) 116046022(mylk4a) 116059339(mylk5) 116064213(mylkb)
ECRA: 117950394(mylk4b) 117954407(mylk4a) 117957953(mylk5)
GAT: 120816425 120824084(mylk4b) 120827945(mylk5) 120833692(mylkb)
MSAM: 119892236(mylk5) 119900283(mylk4b) 119902037(mylk4a) 119903747 119915526
CUD: 121503777(mylk5) 121512603(mylk4b) 121519648(mylk4a) 121522726(mylka)
OAU: 116312478(mylk5) 116314400(mylk4b) 116318706(mylk4a) 116327386(mylka) 116327473
OML: 112138131(mylkb) 112146941(mylk5) 112147476(mylk4a) 112150925(mylk4b)
CTUL: 119777375(mylkb) 119778873(mylk5) 119787700(mylk4b) 119795685(mylk4a)
KMR: 108239577(mylk4a) 108243578(mylk4b) 108243749(mylk5) 108251559
CSEM: 103392366(mylk) 103393163 103396270(mylk4)
XGL: 120788222(mylk5) 120791078(mylk4b) 120794678 120798572(mylk4a) 120801368
LOC: 102682466(mylk3) 102685356(mylk2) 102686027 102689935(mylk4) 102697050(mylk)
LCM: 102346967(MYLK3) 102352251
CMK: 103176059(mylk3) 103176418(mylk) 103188646
SPU: 581963
APLC: 110985015
SKO: 100313660
DME: Dmel_CG42347(sqa)
AAG: 5566696
AALB: 109425849
AME: 413190
ACER: 108001692
BIM: 100741566
BTER: 100649174
MGEN: 117221146
NMEA: 116429762
CGIG: 122399422
NVI: 100118913
TCA: 659444
BANY: 112045838
PXU: 106120759
PRAP: 110996706
ZCE: 119837503
TNL: 113500367
API: 100163829
RMD: 113552034
BTAB: 109031131
CLEC: 106664694
NLU: 111052189
CSEC: 111862018
PVM: 113830372
HAME: 121859756
RSAN: 119383249
VDE: 111251098
VJA: 111272050
TUT: 107363672
DPTE: 113799848
CSCU: 111630964
CEL: CELE_ZC373.4(mlck-1)
CBR: CBG01967
GAE: 121387359
OBI: 106880214
LAK: 106163548
NVE: 5521343
ATEN: 116299105
 » show all
Reference
PMID:8810874
  Authors
Kohama K, Ye LH, Hayakawa K, Okagaki T
  Title
Myosin light chain kinase: an actin-binding protein that regulates an ATP-dependent interaction with myosin.
  Journal
Trends Pharmacol Sci 17:284-7 (1996)
DOI:10.1016/0165-6147(96)10033-X
Reference
PMID:8575746
  Authors
Potier MC, Chelot E, Pekarsky Y, Gardiner K, Rossier J, Turnell WG
  Title
The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21.
  Journal
Genomics 29:562-70 (1995)
DOI:10.1006/geno.1995.9965
  Sequence
[hsa:4638]
LinkDB

DBGET integrated database retrieval system