KEGG   ORTHOLOGY: K00922
Entry
K00922                      KO                                     

Name
PIK3CA_B_D
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04360  Axon guidance
ko04361  Axon regeneration
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04611  Platelet activation
ko04620  Toll-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04668  TNF signaling pathway
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04926  Relaxin signaling pathway
ko04929  GnRH secretion
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04935  Growth hormone synthesis, secretion and action
ko04960  Aldosterone-regulated sodium reabsorption
ko04973  Carbohydrate digestion and absorption
ko05010  Alzheimer disease
ko05017  Spinocerebellar ataxia
ko05020  Prion disease
ko05100  Bacterial invasion of epithelial cells
ko05131  Shigellosis
ko05132  Salmonella infection
ko05135  Yersinia infection
ko05142  Chagas disease
ko05146  Amoebiasis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05171  Coronavirus disease - COVID-19
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00027  Ovarian cancer
H00031  Breast cancer
H00048  Hepatocellular carcinoma
H01102  Pituitary adenomas
H01222  Cowden syndrome
H01387  Activated PI3K-delta syndrome
H01431  Cushing syndrome
H01912  Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi
H01985  Desmoplastic small round cell tumor
H02153  Megalencephaly-capillary malformation syndrome
H02297  CLAPO syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04014 Ras signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04015 Rap1 signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04370 VEGF signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04630 JAK-STAT signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04668 TNF signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04066 HIF-1 signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04068 FoxO signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04070 Phosphatidylinositol signaling system
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04072 Phospholipase D signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04071 Sphingolipid signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04024 cAMP signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04151 PI3K-Akt signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04152 AMPK signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04150 mTOR signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09143 Cell growth and death
   04210 Apoptosis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04218 Cellular senescence
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04550 Signaling pathways regulating pluripotency of stem cells
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04620 Toll-like receptor signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04625 C-type lectin receptor signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04650 Natural killer cell mediated cytotoxicity
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04660 T cell receptor signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04662 B cell receptor signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04664 Fc epsilon RI signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04666 Fc gamma R-mediated phagocytosis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04670 Leukocyte transendothelial migration
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04062 Chemokine signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04923 Regulation of lipolysis in adipocytes
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04929 GnRH secretion
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04915 Estrogen signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04914 Progesterone-mediated oocyte maturation
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04917 Prolactin signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04926 Relaxin signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04935 Growth hormone synthesis, secretion and action
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04919 Thyroid hormone signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09156 Nervous system
   04725 Cholinergic synapse
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04722 Neurotrophin signaling pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09158 Development and regeneration
   04360 Axon guidance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04361 Axon regeneration
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04380 Osteoclast differentiation
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09149 Aging
   04211 Longevity regulating pathway
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04212 Longevity regulating pathway - worm
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04213 Longevity regulating pathway - multiple species
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05206 MicroRNAs in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05205 Proteoglycans in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05203 Viral carcinogenesis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05230 Central carbon metabolism in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05231 Choline metabolism in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09162 Cancer: specific types
   05210 Colorectal cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05212 Pancreatic cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05225 Hepatocellular carcinoma
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05226 Gastric cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05214 Glioma
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05221 Acute myeloid leukemia
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05220 Chronic myeloid leukemia
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05218 Melanoma
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05211 Renal cell carcinoma
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05215 Prostate cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05213 Endometrial cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05224 Breast cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05222 Small cell lung cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05223 Non-small cell lung cancer
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05017 Spinocerebellar ataxia
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05020 Prion disease
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04932 Non-alcoholic fatty liver disease
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04931 Insulin resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   04933 AGE-RAGE signaling pathway in diabetic complications
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05131 Shigellosis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05135 Yersinia infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05100 Bacterial invasion of epithelial cells
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05170 Human immunodeficiency virus 1 infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05161 Hepatitis B
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05160 Hepatitis C
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05171 Coronavirus disease - COVID-19
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05164 Influenza A
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05162 Measles
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05168 Herpes simplex virus 1 infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05163 Human cytomegalovirus infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05169 Epstein-Barr virus infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05165 Human papillomavirus infection
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   05142 Chagas disease
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   01524 Platinum drug resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
   01522 Endocrine resistance
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K00922  PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta
Other DBs
RN: R04545
GO: 0046934
Genes
HSA: 5290(PIK3CA) 5291(PIK3CB) 5293(PIK3CD)
PTR: 457922(PIK3CD) 460858(PIK3CA) 471079(PIK3CB)
PPS: 100989732(PIK3CD) 100990108(PIK3CB) 100990828(PIK3CA)
GGO: 101143811(PIK3CA) 101146434(PIK3CD) 101152123(PIK3CB)
PON: 100432846(PIK3CB) 100453779(PIK3CA) 103889133(PIK3CD)
NLE: 100580872(PIK3CD) 100584384(PIK3CB) 100588218(PIK3CA)
MCC: 709959(PIK3CA) 710552(PIK3CD) 716098(PIK3CB)
MCF: 102122725(PIK3CA) 102142026(PIK3CB) 102143464(PIK3CD)
CSAB: 103221212(PIK3CA) 103225637(PIK3CD) 103241599(PIK3CB)
RRO: 104663050(PIK3CD) 104665061(PIK3CB) 104670605(PIK3CA)
RBB: 108532960(PIK3CA) 108539355(PIK3CD) 108544591(PIK3CB)
CJC: 100391655(PIK3CB) 100398849(PIK3CD) 100403494(PIK3CA)
SBQ: 101027982(PIK3CB) 101029768(PIK3CA) 101052779(PIK3CD)
MMU: 18706(Pik3ca) 18707(Pik3cd) 74769(Pik3cb)
MCAL: 110290798(Pik3ca) 110292183(Pik3cd) 110301355(Pik3cb)
MPAH: 110319750(Pik3ca) 110323448(Pik3cd) 110327251(Pik3cb)
RNO: 170911(Pik3ca) 366508(Pik3cd) 685590 85243(Pik3cb)
MUN: 110548394(Pik3cb) 110556252(Pik3ca) 110565112(Pik3cd)
CGE: 100689251(Pik3ca) 100689252(Pik3cb) 100769225(Pik3cd)
NGI: 103733121(Pik3cd) 103738596(Pik3ca) 103742946(Pik3cb)
HGL: 101711934(Pik3ca) 101712941(Pik3cd) 101715249(Pik3cb)
CCAN: 109681900(Pik3cd) 109689664(Pik3ca)
OCU: 100337822(PIK3CA) 100345181(PIK3CB) 100348663(PIK3CD)
TUP: 102483329(PIK3CA) 102500530(PIK3CD) 102502163(PIK3CB) 106736453
CFA: 477085(PIK3CB) 488084(PIK3CA) 489644(PIK3CD)
VVP: 112924665(PIK3CD) 112926217(PIK3CA) 112934961(PIK3CB)
AML: 100463775(PIK3CB) 100479294(PIK3CA) 100479580(PIK3CD)
UMR: 103666874(PIK3CD) 103676125(PIK3CA) 103678592(PIK3CB)
UAH: 113253989(PIK3CB) 113254799(PIK3CA) 113270537(PIK3CD)
ORO: 101370689(PIK3CA) 101385241(PIK3CB) 101385267(PIK3CD)
FCA: 101091892(PIK3CB) 101094274(PIK3CD) 101097413(PIK3CA)
PTG: 102953082(PIK3CD) 102965070(PIK3CA) 102972487(PIK3CB)
PPAD: 109259912(PIK3CB) 109274075(PIK3CD) 109275159(PIK3CA)
AJU: 106973880(PIK3CA) 106984265(PIK3CB) 106984896(PIK3CD)
BTA: 282306(PIK3CA) 504531(PIK3CD) 517948(PIK3CB)
BOM: 102274461(PIK3CD) 102274553(PIK3CA) 102277548(PIK3CB)
BIU: 109557823(PIK3CA) 109559805(PIK3CB) 109570415(PIK3CD)
BBUB: 102400519(PIK3CA) 102404165(PIK3CB) 102404610(PIK3CD)
CHX: 102168391(PIK3CA) 102177551(PIK3CD) 102185042(PIK3CB)
OAS: 101109759(PIK3CB) 101110015(PIK3CA) 101117348(PIK3CD)
SSC: 100518131(PIK3CD) 100621789(PIK3CA) 100622559(PIK3CB)
CFR: 102518643(PIK3CD) 102519994(PIK3CB) 102523502(PIK3CA)
CDK: 105085928(PIK3CA) 105086305(PIK3CB) 105107003(PIK3CD)
BACU: 103012691(PIK3CA) 103012931(PIK3CB) 103014043(PIK3CD)
LVE: 103085303(PIK3CA) 103088756(PIK3CB) 103089257(PIK3CD)
OOR: 101278075(PIK3CA) 101278974(PIK3CD) 101283011(PIK3CB)
DLE: 111173839(PIK3CA) 111179235(PIK3CB) 111187262(PIK3CD)
PCAD: 102977108(PIK3CB) 102978952(PIK3CD) 102986098(PIK3CA)
ECB: 100051623(PIK3CD) 100051753(PIK3CB) 100058141(PIK3CA)
EPZ: 103549076(PIK3CD) 103552150(PIK3CA) 103554655
EAI: 106829313(PIK3CA) 106836695(PIK3CD) 106838100(PIK3CB)
MYB: 102239669(PIK3CA) 102252921(PIK3CD) 102260487(PIK3CB)
MYD: 102758951(PIK3CA) 102764343(PIK3CB) 102766356(PIK3CD)
MNA: 107532628(PIK3CB) 107538463(PIK3CD) 107541106(PIK3CA)
HAI: 109372681(PIK3CA) 109381238(PIK3CD) 109394108(PIK3CB)
DRO: 112299448(PIK3CD) 112307667(PIK3CA) 112310002(PIK3CB)
PALE: 102880320(PIK3CB) 102889227(PIK3CA) 102889576(PIK3CD)
RAY: 107513958(PIK3CB) 107517828(PIK3CA) 107520152(PIK3CD)
MJV: 108390365(PIK3CD) 108400388(PIK3CB) 108406544(PIK3CA)
LAV: 100657948(PIK3CA) 100658340(PIK3CB) 100666266(PIK3CD)
MDO: 100010412(PIK3CA) 100017332(PIK3CB) 100024769(PIK3CD)
SHR: 100929811(PIK3CB) 100932099(PIK3CA) 105749979(PIK3CD)
PCW: 110199476(PIK3CD) 110204454(PIK3CA) 110208219(PIK3CB)
OAA: 100073788(PIK3CA) 100074273(PIK3CD) 100086270(PIK3CB)
GGA: 419444(PIK3CD) 424826(PIK3CB) 424971(PIK3CA)
MGP: 100543492(PIK3CD) 100546867(PIK3CA)
CJO: 107317945(PIK3CB) 107318114(PIK3CA) 107323497(PIK3CD)
NMEL: 110397252(PIK3CB) 110398160(PIK3CA) 110408755(PIK3CD)
APLA: 101796183(PIK3CA) 101800900(PIK3CB) 101802796(PIK3CD)
ACYG: 106032026(PIK3CA) 106040311(PIK3CB) 106044285(PIK3CD)
TGU: 100219602(PIK3CB) 100224188(PIK3CD) 100229768(PIK3CA)
LSR: 110474406(PIK3CD) 110478031(PIK3CA) 110484828(PIK3CB)
SCAN: 103815304(PIK3CA) 103820781(PIK3CD) 103824201(PIK3CB)
GFR: 102040845(PIK3CB) 102040853(PIK3CD) 102042284(PIK3CA)
FAB: 101811931(PIK3CD) 101814811(PIK3CA) 101821801(PIK3CB)
PHI: 102099156(PIK3CA) 102103635(PIK3CD) 102106643(PIK3CB)
PMAJ: 107208827(PIK3CA) 107208852(PIK3CB) 107213667(PIK3CD)
CCAE: 111933356(PIK3CA) 111933753(PIK3CB) 111938683(PIK3CD)
CCW: 104688020(PIK3CA) 104693039(PIK3CB) 104693336(PIK3CD)
ETL: 114056876(PIK3CD) 114057709(PIK3CB) 114062399(PIK3CA)
FPG: 101911441(PIK3CA) 101919202(PIK3CD) 101923805(PIK3CB)
FCH: 102049197(PIK3CA) 102049812(PIK3CD) 102057414(PIK3CB)
CLV: 102083735(PIK3CB) 102084293(PIK3CA) 102095297(PIK3CD)
EGZ: 104129991(PIK3CA) 104133065(PIK3CD) 104135481(PIK3CB)
NNI: 104008980(PIK3CD) 104019595(PIK3CA) 104023668(PIK3CB)
ACUN: 113483286(PIK3CA) 113483483(PIK3CB) 113487938(PIK3CD)
PADL: 103914966(PIK3CA) 103917840(PIK3CB) 103917969(PIK3CD)
AAM: 106482245(PIK3CA) 106496183(PIK3CB) 106499152(PIK3CD)
ASN: 102372482(PIK3CB) 102387818(PIK3CA) 102388304(PIK3CD)
AMJ: 102564312(PIK3CD) 102571877(PIK3CB) 106737094(PIK3CA)
PSS: 102448624(PIK3CA) 102459577(PIK3CD) 102461096(PIK3CB) 102462482
CMY: 102929971(PIK3CA) 102932183(PIK3CD) 102936956(PIK3CB)
CPIC: 101934126(PIK3CD) 101935421(PIK3CA) 101940315(PIK3CB)
ACS: 100562345(pik3ca) 100567254(pik3cb) 100567364 100568252(pik3cd)
PVT: 110073252(PIK3CD) 110078719(PIK3CB) 110081909(PIK3CA) 110082359
PBI: 103049546(PIK3CB) 103050043(PIK3CA) 103061550(PIK3CD) 103063682
PMUR: 107284997 107285699(PIK3CA) 107292269(PIK3CB) 107292340(PIK3CD)
TSR: 106541175(PIK3CA) 106545691(PIK3CB)
PMUA: 114581855 114597773(PIK3CB) 114598008(PIK3CA) 114602471(PIK3CD)
GJA: 107107376(PIK3CD) 107110507(PIK3CB) 107110982(PIK3CA) 107118085
XLA: 108717120(pik3cb.L) 108718090 108718190(pik3cb.S) 373752(pik3ca.L)
XTR: 100144924(pik3ca) 780390(pik3cb)
NPR: 108785765(PIK3CA) 108796670(PIK3CB) 108798423(PIK3CD)
DRE: 100002263(pik3cb) 394174(pik3cd) 561737(pik3ca)
IPU: 108271155(pik3ca) 108275608 108276156(pik3cd) 108280664(pik3cb)
PHYP: 113525314 113530516(pik3cd) 113533072(pik3ca) 113543185(pik3cb)
AMEX: 103022173(pik3cb) 103032909 103041606(pik3ca) 103045036(pik3cd)
EEE: 113568728(pik3ca) 113581289(pik3cd) 113584997(pik3cb)
TRU: 101066166(pik3ca) 101067191 101068840(pik3cb) 101072152 101076867(pik3cd)
OLA: 101161626(pik3ca) 101161887(pik3cd) 101165660(pik3cb) 101168152
PRET: 103463230(pik3ca) 103467210(pik3cd) 103474947(pik3cb) 103475907 103479066
CVG: 107082599 107082662(pik3cb) 107086882(pik3cd) 107096583(pik3ca) 107102211
NFU: 107372394 107384477 107388064(pik3cb) 107390759(pik3cd) 107392966(pik3ca)
CSEM: 103378227(pik3cb) 103385041(pik3cd) 103396148 103396566(pik3ca)
SDU: 111216431(pik3ca) 111219094(pik3cd) 111228886 111232818(pik3cb) 111236831
MALB: 109951867(pik3cb) 109969865(pik3ca) 109971552(pik3cd) 109974067
ELS: 105009929 105025897(pik3ca) 105026926(pik3cd) 105028918 105029118(pik3cb)
SFM: 108921677 108923074 108932407(pik3cb) 108933929(pik3cd) 108937366(pik3ca)
PKI: 111836364 111853393(pik3cd) 111853566 111860453(pik3ca) 111860909(pik3cb)
LCM: 102350948(PIK3CA) 102351332 102351622(PIK3CD) 102359335(PIK3CB)
CMK: 103175241(pik3cb) 103175843(pik3ca) 103184230(pik3cd)
RTP: 109915713(pik3cd) 109915990(pik3cb) 109921900
DME: Dmel_CG4141(Pi3K92E)
DER: 6553598
DSE: 6619237
DSI: Dsimw501_GD20048(Dsim_GD20048)
DAN: 6501103
DSR: 110177240
DPE: 6598691
DMN: 108155590
DWI: 6649394
DAZ: 108620950
DNV: 108660257
DHE: 111600712
DVI: 6629966
MDE: 101900071
LCQ: 111678878
AAG: 5576468
AALB: 109397596
AME: 551500
BIM: 100748255
BTER: 100646352
CCAL: 108624026
OBB: 114875937
SOC: 105205485
AEC: 105149725
ACEP: 105620083
PBAR: 105432118
VEM: 105567336
HST: 105189236
DQU: 106746788
CFO: 105253109
LHU: 105678402
PGC: 109855345
OBO: 105281126
PCF: 106789415
NVI: 100115810
CSOL: 105365929
MDL: 103576066
TCA: 657286
DPA: 109538758
NVL: 108565087
BMOR: 101741278
BMAN: 114241881
PMAC: 106718395
PRAP: 110995586
HAW: 110372682
TNL: 113504471
PXY: 105394660
API: 100160001
DNX: 107164340
AGS: 114130020
RMD: 113551287
BTAB: 109034225
CLEC: 106672893
ZNE: 110828562
FCD: 110846541
CEL: CELE_B0334.8(age-1)
CBR: CBG02868(Cbr-age-1)
BMY: Bm1_55680
SHX: MS3_06635
EGL: EGR_03896
NVE: 5513857
ADF: 107327044
AMIL: 114970594
PDAM: 113668155
SPIS: 111332193
DGT: 114517978
AQU: 100640192
MBR: MONBRDRAFT_18656(PI3K-CA_alpha)
DDI: DDB_G0268548(pikF) DDB_G0275011(pikC) DDB_G0278727(pikA) DDB_G0282625(pikG) DDB_G0283081(pikB)
DFA: DFA_00682 DFA_02787(pikB) DFA_06196(pikC) DFA_10225(pikF) DFA_11886(pikA)
EHI: EHI_006130(83.t00026) EHI_095130(269.t00003) EHI_188970(67.t00015)
EHX: EMIHUDRAFT_632222(PI3K1)
 » show all
Reference
PMID:7713498
  Authors
Volinia S, Hiles I, Ormondroyd E, Nizetic D, Antonacci R, Rocchi M, Waterfield MD
  Title
Molecular cloning, cDNA sequence, and chromosomal localization of the human phosphatidylinositol 3-kinase p110 alpha (PIK3CA) gene.
  Journal
Genomics 24:472-7 (1994)
DOI:10.1006/geno.1994.1655
  Sequence
[hsa:5290]
Reference
PMID:8246984
  Authors
Hu P, Mondino A, Skolnik EY, Schlessinger J
  Title
Cloning of a novel, ubiquitously expressed human phosphatidylinositol 3-kinase and identification of its binding site on p85.
  Journal
Mol Cell Biol 13:7677-88 (1993)
DOI:10.1128/MCB.13.12.7677
  Sequence
[hsa:5291]
Reference
PMID:9113989
  Authors
Vanhaesebroeck B, Welham MJ, Kotani K, Stein R, Warne PH, Zvelebil MJ, Higashi K, Volinia S, Downward J, Waterfield MD
  Title
P110delta, a novel phosphoinositide 3-kinase in leukocytes.
  Journal
Proc Natl Acad Sci U S A 94:4330-5 (1997)
DOI:10.1073/pnas.94.9.4330
  Sequence
[hsa:5293]
LinkDB

KEGG   ORTHOLOGY: K02649
Entry
K02649                      KO                                     

Name
PIK3R1_2_3
Definition
phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04070  Phosphatidylinositol signaling system
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04380  Osteoclast differentiation
ko04510  Focal adhesion
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04611  Platelet activation
ko04620  Toll-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04630  JAK-STAT signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko04668  TNF signaling pathway
ko04670  Leukocyte transendothelial migration
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04926  Relaxin signaling pathway
ko04929  GnRH secretion
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04935  Growth hormone synthesis, secretion and action
ko04960  Aldosterone-regulated sodium reabsorption
ko04973  Carbohydrate digestion and absorption
ko05010  Alzheimer disease
ko05017  Spinocerebellar ataxia
ko05020  Prion disease
ko05100  Bacterial invasion of epithelial cells
ko05131  Shigellosis
ko05135  Yersinia infection
ko05142  Chagas disease
ko05146  Amoebiasis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05171  Coronavirus disease - COVID-19
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H01370  SHORT syndrome
H01885  Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04014 Ras signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04015 Rap1 signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04370 VEGF signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04630 JAK-STAT signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04668 TNF signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04066 HIF-1 signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04068 FoxO signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04070 Phosphatidylinositol signaling system
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04072 Phospholipase D signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04071 Sphingolipid signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04024 cAMP signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04151 PI3K-Akt signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04152 AMPK signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04150 mTOR signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09143 Cell growth and death
   04210 Apoptosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04218 Cellular senescence
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04550 Signaling pathways regulating pluripotency of stem cells
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04620 Toll-like receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04625 C-type lectin receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04650 Natural killer cell mediated cytotoxicity
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04660 T cell receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04662 B cell receptor signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04664 Fc epsilon RI signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04666 Fc gamma R-mediated phagocytosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04670 Leukocyte transendothelial migration
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04062 Chemokine signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04923 Regulation of lipolysis in adipocytes
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04929 GnRH secretion
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04915 Estrogen signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04914 Progesterone-mediated oocyte maturation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04917 Prolactin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04926 Relaxin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04935 Growth hormone synthesis, secretion and action
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04919 Thyroid hormone signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09156 Nervous system
   04725 Cholinergic synapse
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04722 Neurotrophin signaling pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09158 Development and regeneration
   04360 Axon guidance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04380 Osteoclast differentiation
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09149 Aging
   04211 Longevity regulating pathway
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04213 Longevity regulating pathway - multiple species
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05206 MicroRNAs in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05205 Proteoglycans in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05203 Viral carcinogenesis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05230 Central carbon metabolism in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05231 Choline metabolism in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05212 Pancreatic cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05225 Hepatocellular carcinoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05226 Gastric cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05214 Glioma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05221 Acute myeloid leukemia
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05220 Chronic myeloid leukemia
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05218 Melanoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05211 Renal cell carcinoma
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05215 Prostate cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05213 Endometrial cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05224 Breast cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05222 Small cell lung cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05223 Non-small cell lung cancer
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05017 Spinocerebellar ataxia
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05020 Prion disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04932 Non-alcoholic fatty liver disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04931 Insulin resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05135 Yersinia infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05100 Bacterial invasion of epithelial cells
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05170 Human immunodeficiency virus 1 infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05161 Hepatitis B
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05160 Hepatitis C
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05171 Coronavirus disease - COVID-19
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05164 Influenza A
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05162 Measles
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05168 Herpes simplex virus 1 infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05163 Human cytomegalovirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05169 Epstein-Barr virus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05165 Human papillomavirus infection
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   05142 Chagas disease
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   01524 Platinum drug resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
   01522 Endocrine resistance
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K02649  PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
Other DBs
RN: R03362 R04545 R05795
Genes
HSA: 5295(PIK3R1) 5296(PIK3R2) 8503(PIK3R3)
PTR: 455855(PIK3R2) 456565(PIK3R3) 461836(PIK3R1)
PPS: 100969981(PIK3R2) 100986080(PIK3R3) 100994315(PIK3R1)
GGO: 101129336(PIK3R3) 101130978(PIK3R1) 101135298(PIK3R2)
PON: 100173589(PIK3R1) 100174298(PIK3R3) 100437617(PIK3R2)
NLE: 100591270(PIK3R3) 100599301(PIK3R2) 100605788(PIK3R1)
MCC: 698996(PIK3R1) 707310(PIK3R3) 719367(PIK3R2)
MCF: 101866246(PIK3R1) 102124804(PIK3R2) 102137291(PIK3R3)
CSAB: 103222594(PIK3R1) 103224900(PIK3R3) 103234391(PIK3R2)
RRO: 104662124(PIK3R3) 104675620(PIK3R1) 104680672(PIK3R2)
RBB: 108534276(PIK3R2) 108535636(PIK3R3) 108541175(PIK3R1)
CJC: 100392639(PIK3R1) 100406689(PIK3R2) 100414659(PIK3R3)
SBQ: 101032496(PIK3R1) 101033359(PIK3R2) 101050592(PIK3R3)
MMU: 18708(Pik3r1) 18709(Pik3r2) 18710(Pik3r3)
MCAL: 110292624 110299855(Pik3r2) 110308009(Pik3r1)
MPAH: 110322865(Pik3r3) 110328811(Pik3r1) 110336420(Pik3r2)
RNO: 25513(Pik3r1) 29741(Pik3r2) 60664(Pik3r3)
MUN: 110549145(Pik3r2) 110553683(Pik3r1) 110563512(Pik3r3)
CGE: 100750761(Pik3r1) 100771181(Pik3r2) 100774067
NGI: 103726879(Pik3r2) 103730305(Pik3r3) 103738715(Pik3r1)
HGL: 101703691(Pik3r1) 101717096(Pik3r3) 101718815(Pik3r2)
CCAN: 109682432(Pik3r3) 109682554 109694666(Pik3r1)
OCU: 100345250(PIK3R3) 100357841(PIK3R1)
TUP: 102469401(PIK3R2) 102484444(PIK3R3) 102484500(PIK3R1)
CFA: 100856339(PIK3R3) 487235(PIK3R1) 609956(PIK3R2)
VVP: 112913170(PIK3R2) 112914774 112935820(PIK3R1)
AML: 100467916(PIK3R3) 100475291(PIK3R2) 100483828(PIK3R1)
UMR: 103663617(PIK3R1) 103670766(PIK3R3) 103675162(PIK3R2)
UAH: 113254730(PIK3R3) 113255266(PIK3R1) 113256705(PIK3R2)
ORO: 101370100(PIK3R1) 101371800(PIK3R2) 101374787(PIK3R3)
FCA: 100271864(PIK3R1) 101093286(PIK3R3) 101093586(PIK3R2)
PTG: 102949853(PIK3R3) 102952993(PIK3R1) 102967709(PIK3R2)
PPAD: 109247606(PIK3R2) 109266953(PIK3R3) 109275060(PIK3R1)
AJU: 106969150(PIK3R2) 106973297(PIK3R3) 106976917(PIK3R1)
BTA: 282307(PIK3R1) 282308(PIK3R2) 286865(PIK3R3)
BOM: 102266922(PIK3R1) 102280296(PIK3R3) 102286868(PIK3R2)
BIU: 109556345 109561418(PIK3R2) 109574805(PIK3R1)
BBUB: 102395384 102404517(PIK3R2) 102415109(PIK3R1)
CHX: 102170135(PIK3R2) 102179343(PIK3R3) 102188710(PIK3R1)
OAS: 101111546(PIK3R2) 101121455(PIK3R1) 101123247(PIK3R3)
SSC: 100511937 100623707(PIK3R1) 100739510(PIK3R2)
CFR: 102505690 102513205(PIK3R2) 102520923(PIK3R1)
CDK: 105084758(PIK3R1) 105092913 105101867(PIK3R2)
BACU: 103007464(PIK3R1) 103008077(PIK3R3) 103009307(PIK3R2)
LVE: 103070370(PIK3R1) 103078725(PIK3R3) 103083960(PIK3R2)
OOR: 101277568(PIK3R3) 101281352(PIK3R2) 101285437(PIK3R1)
DLE: 111166652(PIK3R2) 111175760 111185984(PIK3R1)
PCAD: 102975555(PIK3R3) 102991192(PIK3R1) 102991779(PIK3R2)
ECB: 100050227(PIK3R1) 100052122 100146348(PIK3R2)
EPZ: 103548220(PIK3R1) 103551868(PIK3R3) 103561550(PIK3R2)
EAI: 106822593(PIK3R3) 106824993(PIK3R2) 106840141(PIK3R1)
MYB: 102242302(PIK3R1) 102253405(PIK3R2) 102258430(PIK3R3)
MYD: 102753036(PIK3R1) 102760468(PIK3R3) 102763670(PIK3R2)
MNA: 107526728(PIK3R3) 107529317(PIK3R1) 107535325(PIK3R2)
HAI: 109373811(PIK3R3) 109382484(PIK3R2) 109395865(PIK3R1)
DRO: 112305224(PIK3R2) 112314466 112321016(PIK3R1)
PALE: 102879163(PIK3R1) 102879453(PIK3R2) 102891637
RAY: 107498704(PIK3R1) 107517899(PIK3R3) 107521668(PIK3R2)
MJV: 108383561(PIK3R2) 108390475(PIK3R1) 108395975(PIK3R3)
LAV: 100653731(PIK3R1) 100665045(PIK3R2) 100675496(PIK3R3)
MDO: 100019317(PIK3R1) 100032726(PIK3R2) 100616957(PIK3R3)
SHR: 100924976(PIK3R1) 100926892(PIK3R2) 100935230(PIK3R3)
PCW: 110209293(PIK3R3) 110216530(PIK3R1) 110223395(PIK3R2)
OAA: 100080187(PIK3R2) 100082075(PIK3R3) 103167126(PIK3R1)
GGA: 427171(PIK3R1) 429096(PIK3R3) 771142(PIK3R2)
CJO: 107305909(PIK3R1) 107317608 107325533(PIK3R2)
NMEL: 110388756(PIK3R2) 110389564(PIK3R1) 110402756(PIK3R3)
APLA: 101795759 101799717(PIK3R1) 101803461(PIK3R2)
ACYG: 106033049(PIK3R3) 106042106(PIK3R1) 106045000(PIK3R2)
TGU: 100221185 100223949(PIK3R1) 100226234(PIK3R2)
LSR: 110469696 110472594(PIK3R1) 110478008(PIK3R2)
SCAN: 103814989 103821918(PIK3R2) 103823133(PIK3R1) 115483908
GFR: 102032353(PIK3R1) 102035891(PIK3R2) 102039817(PIK3R3)
FAB: 101811808(PIK3R2) 101812251(PIK3R3) 101820843(PIK3R1)
PHI: 102106897(PIK3R2) 102112482(PIK3R3) 102114750(PIK3R1)
PMAJ: 107208273(PIK3R3) 107215603(PIK3R2) 107216262(PIK3R1)
CCAE: 111933104(PIK3R3) 111940405(PIK3R2) 111941370(PIK3R1)
CCW: 104686712(PIK3R1) 104695234(PIK3R3) 104696977(PIK3R2)
FPG: 101913266(PIK3R3) 101915242(PIK3R2) 101924523(PIK3R1)
FCH: 102056135(PIK3R1) 102057083(PIK3R2) 102059517
CLV: 102084272(PIK3R3) 102084904(PIK3R2) 102092838(PIK3R1)
EGZ: 104124880(PIK3R1) 104126253(PIK3R3) 104135641(PIK3R2)
NNI: 104015409(PIK3R3) 104018715(PIK3R2)
ACUN: 113483193 113489298(PIK3R2) 113489600(PIK3R1)
PADL: 103919124(PIK3R3) 103919717(PIK3R1) 103926435(PIK3R2)
AAM: 106485939(PIK3R3) 106495610(PIK3R2) 106499441(PIK3R1)
ASN: 102377899(PIK3R2) 102380057 102382060(PIK3R1)
AMJ: 102567863(PIK3R2) 102570922(PIK3R1) 106737141(PIK3R3)
PSS: 102449585(PIK3R1) 102457516
CMY: 102933845(PIK3R2) 102941819(PIK3R3) 102945631(PIK3R1)
CPIC: 101945673(PIK3R2) 101947423(PIK3R3) 101953817(PIK3R1)
ACS: 100554618(pik3r3) 100555182(pik3r2) 100556883(pik3r1)
PVT: 110072561(PIK3R2) 110073778(PIK3R3) 110073951(PIK3R1)
PBI: 103055280(PIK3R2) 103065132 103065975(PIK3R1)
PMUR: 107282273(PIK3R2) 107283596 107286152(PIK3R1)
TSR: 106538977(PIK3R1) 106543200(PIK3R3) 106552169
PMUA: 114588236(PIK3R2) 114599062 114606162(PIK3R1)
GJA: 107108905(PIK3R1) 107119473(PIK3R3) 107121678(PIK3R2)
XLA: 108706884 108713027 399202(pik3r1.L) 443964(pik3r1.S) 446786(pik3r2) 447594(pik3r3.L)
XTR: 100486835(pik3r1) 100497001(pik3r2) 549983(pik3r3)
NPR: 108789013(PIK3R2) 108797628(PIK3R1) 108802963
DRE: 100000252(pik3r3b) 404211(pik3r2) 557176(pik3r1)
IPU: 108260231(pik3r1) 108272037(pik3r3)
PHYP: 113531632(pik3r1) 113538265
AMEX: 103029972(pik3r3) 103035767 103046618(pik3r1) 111190801
PRET: 103463201(pik3r3) 103463319 103470780 103473324(pik3r1) 103478998 103479173(pik3r2)
MALB: 109957384 109965201(pik3r3) 109966856 109969301(pik3r2) 109969763(pik3r1) 109970672
PKI: 111834821(pik3r3) 111835615(pik3r1) 111847640 111856594 111860386(pik3r2)
LCM: 102348007(PIK3R3) 102353218(PIK3R1)
CMK: 103177781(pik3r1) 103182064(pik3r2) 103182762(pik3r3)
BFO: 118432571
CIN: 100184893
SPU: 588766
APLC: 110977729
SKO: 100372481
DME: Dmel_CG2699(Pi3K21B)
DER: 6543312
DSE: 6621105
DSI: Dsimw501_GD23016(Dsim_GD23016)
DSR: 110187562
DPE: 6593764
DMN: 108163765
DWI: 6651829
DAZ: 108609449
DNV: 108650034
DHE: 111602464
DVI: 6628686
MDE: 101896300
LCQ: 111686430
AAG: 5578257
AALB: 109409609
AME: 408577
BIM: 100743083
BTER: 100643962
CCAL: 108629871
OBB: 114871807
SOC: 105195470
MPHA: 105831984
AEC: 105151922
ACEP: 105620878
PBAR: 105430848
VEM: 105567561
HST: 105192434
DQU: 106748226
CFO: 105255336
LHU: 105667777
PGC: 109854747
OBO: 105284404
PCF: 106792271
NVI: 100122747
CSOL: 105361583
MDL: 103580680
TCA: 100141888
DPA: 109540864
ATD: 109595073
NVL: 108559788
BMOR: 100158253(Pi3k60)
BMAN: 114245941
PMAC: 106714800
PRAP: 110992252
HAW: 110370679
TNL: 113497575
PXY: 105388447
AGS: 114129704
RMD: 113553291
BTAB: 109032766
CLEC: 106664096
FCD: 110845224
PVM: 113810630
DPTE: 113798240
CEL: CELE_Y110A7A.10(aap-1)
CBR: CBG10815(Cbr-aap-1)
BMY: Bm1_37505
TSP: Tsp_02388
CRG: 105321629
OBI: 106879157
SHX: MS3_06277
EGL: EGR_06563
NVE: 5520340
EPA: 110239539
ADF: 107335159
AMIL: 114952874
PDAM: 113679985
SPIS: 111326832
DGT: 114527321
HMG: 100197475
 » show all
Reference
PMID:1849461
  Authors
Skolnik EY, Margolis B, Mohammadi M, Lowenstein E, Fischer R, Drepps A, Ullrich A, Schlessinger J
  Title
Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.
  Journal
Cell 65:83-90 (1991)
DOI:10.1016/0092-8674(91)90410-Z
  Sequence
[hsa:5295]
Reference
PMID:9582025
  Authors
Janssen JW, Schleithoff L, Bartram CR, Schulz AS
  Title
An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme.
  Journal
Oncogene 16:1767-72 (1998)
DOI:10.1038/sj.onc.1201695
  Sequence
[hsa:5296]
Reference
PMID:9524259
  Authors
Dey BR, Furlanetto RW, Nissley SP
  Title
Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor.
  Journal
Gene 209:175-83 (1998)
DOI:10.1016/S0378-1119(98)00045-6
  Sequence
[hsa:8503]
LinkDB

KEGG   ORTHOLOGY: K21289
Entry
K21289                      KO                                     

Name
PIK3CG
Definition
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]
Pathway
ko00562  Inositol phosphate metabolism
ko01100  Metabolic pathways
ko04022  cGMP-PKG signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04371  Apelin signaling pathway
ko04611  Platelet activation
ko04725  Cholinergic synapse
ko04921  Oxytocin signaling pathway
ko05132  Salmonella infection
ko05145  Toxoplasmosis
ko05167  Kaposi sarcoma-associated herpesvirus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
   04072 Phospholipase D signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
   04022 cGMP-PKG signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
   04151 PI3K-Akt signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
   04062 Chemokine signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  09156 Nervous system
   04725 Cholinergic synapse
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.153  phosphatidylinositol-4,5-bisphosphate 3-kinase
     K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K21289  PIK3CG; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma
Other DBs
RN: R04545
GO: 0046934
Genes
HSA: 5294(PIK3CG)
PTR: 463649(PIK3CG)
PPS: 100988420(PIK3CG)
GGO: 101153738(PIK3CG)
PON: 100453085(PIK3CG)
NLE: 100586512(PIK3CG)
MCC: 698857(PIK3CG)
MCF: 102146644(PIK3CG)
CSAB: 103226710(PIK3CG)
RRO: 104677402(PIK3CG)
RBB: 108540484(PIK3CG)
CJC: 100394268(PIK3CG)
SBQ: 101028650(PIK3CG)
MMU: 30955(Pik3cg)
MCAL: 110306848(Pik3cg)
MPAH: 110324300(Pik3cg)
RNO: 298947(Pik3cg)
MUN: 110565083(Pik3cg)
CGE: 100765862(Pik3cg)
NGI: 103732179(Pik3cg)
HGL: 101707055(Pik3cg)
CCAN: 109687395(Pik3cg)
OCU: 100344144(PIK3CG)
TUP: 102472442(PIK3CG)
CFA: 483266(PIK3CG)
VVP: 112908560(PIK3CG)
AML: 100470322(PIK3CG)
UMR: 103674633(PIK3CG)
UAH: 113258627(PIK3CG)
ORO: 101362272(PIK3CG)
ELK: 111155215
FCA: 101096215(PIK3CG)
PTG: 102953306(PIK3CG)
PPAD: 109268077(PIK3CG)
AJU: 106987833(PIK3CG)
BTA: 530001(PIK3CG)
BOM: 102277419(PIK3CG)
BIU: 109557383(PIK3CG)
BBUB: 102413532(PIK3CG)
CHX: 102173256(PIK3CG)
OAS: 101102896(PIK3CG)
SSC: 396979(PIK3CG)
CFR: 102503674(PIK3CG)
CDK: 105093031(PIK3CG)
BACU: 103004888(PIK3CG)
LVE: 103069455(PIK3CG)
OOR: 101281782(PIK3CG)
DLE: 111164603(PIK3CG)
PCAD: 102983371(PIK3CG)
ECB: 100050532(PIK3CG)
EPZ: 103557800(PIK3CG)
EAI: 106825232(PIK3CG)
MYB: 102241723(PIK3CG)
MYD: 102773870(PIK3CG)
MNA: 107530834(PIK3CG)
HAI: 109375969(PIK3CG)
DRO: 112303039(PIK3CG)
PALE: 102884972(PIK3CG)
RAY: 107511488(PIK3CG)
MJV: 108409197(PIK3CG)
LAV: 100673566(PIK3CG)
TMU: 101354532
MDO: 100009879(PIK3CG)
SHR: 100925455(PIK3CG)
PCW: 110207004(PIK3CG)
OAA: 100078046(PIK3CG)
GGA: 417706(PIK3CG)
MGP: 104914241
CJO: 107306688(PIK3CG)
NMEL: 110392374(PIK3CG)
APLA: 101796856(PIK3CG)
ACYG: 106042023(PIK3CG)
TGU: 100229232(PIK3CG)
LSR: 110472720(PIK3CG)
SCAN: 103813517(PIK3CG)
GFR: 102044692(PIK3CG)
FAB: 101811117(PIK3CG)
PHI: 102102611(PIK3CG)
PMAJ: 107204901(PIK3CG)
CCAE: 111922996(PIK3CG)
CCW: 104686866(PIK3CG)
ETL: 114060540(PIK3CG)
FPG: 101910831(PIK3CG)
FCH: 102051392(PIK3CG)
CLV: 102090627(PIK3CG)
EGZ: 104123774(PIK3CG)
NNI: 104010725(PIK3CG)
ACUN: 113490925(PIK3CG)
PADL: 103920571(PIK3CG)
AAM: 106487739(PIK3CG)
ASN: 102381149(PIK3CG)
AMJ: 102559272(PIK3CG)
PSS: 102460136(PIK3CG)
CMY: 102945282(PIK3CG)
CPIC: 101948128(PIK3CG)
ACS: 100561444(pik3cg)
PVT: 110089784(PIK3CG)
PBI: 103057875(PIK3CG)
PMUR: 107297786(PIK3CG)
TSR: 106544873
PMUA: 114605819(PIK3CG)
GJA: 107108982(PIK3CG)
XLA: 108711184 108713077(pik3cg.S)
XTR: 100158519(pik3cg)
NPR: 108797066(PIK3CG)
DRE: 406598(pik3cg) 564261(si:rp71-17i16.5)
CCAR: 109060929(pik3cg)
IPU: 108276435 108279798(pik3cg)
PHYP: 113530762 113531896(pik3cg)
AMEX: 103035431 103041836(pik3cg)
EEE: 113570029 113575802(pik3cg)
TRU: 101071229(pik3cg) 101075343
LCO: 104931247 104933235(pik3cg)
MZE: 101471620 101474181(pik3cg)
ONL: 100697462(pik3cg) 100706781
OLA: 101159013 101173828(pik3cg)
XMA: 102225994 102229099(pik3cg)
XCO: 114148414 114161029(pik3cg)
PRET: 103459664(pik3cg) 103466897
CVG: 107087086(pik3cg) 107103487
NFU: 107382729(pik3cg) 107391427
KMR: 108233022 108249075(pik3cg)
ALIM: 106523004 106524588(pik3cg)
AOCE: 111570585 111578550(pik3cg)
CSEM: 103383124(pik3cg) 103384699
POV: 109630674 109632718(pik3cg)
LCF: 108884757 108888339(pik3cg)
SDU: 111224935(pik3cg) 111234739
SLAL: 111657680(pik3cg) 111661891
HCQ: 109513761 109528849(pik3cg)
BPEC: 110161421 110161763(pik3cg)
MALB: 109961003(pik3cg) 109970413
ELS: 105025656(pik3cg) 105027772
SFM: 108918751(pik3cg) 108925594
PKI: 111851191 111857863(pik3cg)
LCM: 102353565(PIK3CG) 102362971
CMK: 103175665 103176691(pik3cg)
CIN: 100180112
SPAR: SPRG_03711
 » show all
Reference
PMID:7624799
  Authors
Stoyanov B, Volinia S, Hanck T, Rubio I, Loubtchenkov M, Malek D, Stoyanova S, Vanhaesebroeck B, Dhand R, Nurnberg B, et al.
  Title
Cloning and characterization of a G protein-activated human phosphoinositide-3 kinase.
  Journal
Science 269:690-3 (1995)
DOI:10.1126/science.7624799
  Sequence
[hsa:5294]
LinkDB

KEGG   ORTHOLOGY: K21290
Entry
K21290                      KO                                     

Name
PIK3R5_6
Definition
phosphoinositide-3-kinase regulatory subunit 5/6
Pathway
ko04022  cGMP-PKG signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04371  Apelin signaling pathway
ko04611  Platelet activation
ko04725  Cholinergic synapse
ko04921  Oxytocin signaling pathway
ko05145  Toxoplasmosis
ko05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H00848  Ataxia with ocular apraxia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
   04072 Phospholipase D signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
   04022 cGMP-PKG signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
   04151 PI3K-Akt signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
   04062 Chemokine signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
  09156 Nervous system
   04725 Cholinergic synapse
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K21290  PIK3R5_6; phosphoinositide-3-kinase regulatory subunit 5/6
Genes
HSA: 146850(PIK3R6) 23533(PIK3R5)
PTR: 455085(PIK3R5) 746196(PIK3R6)
PPS: 100981656(PIK3R6) 100981987(PIK3R5)
GGO: 101128094(PIK3R6) 101128463(PIK3R5)
PON: 100455593(PIK3R5) 100455956(PIK3R6)
NLE: 100586095(PIK3R6) 100593257(PIK3R5)
MCC: 722023(PIK3R6) 722027(PIK3R5)
MCF: 102133347(PIK3R6) 102135867(PIK3R5)
CSAB: 103242366(PIK3R6) 103242368(PIK3R5)
RRO: 104658283(PIK3R5) 104658296(PIK3R6)
RBB: 108513498(PIK3R5) 108513507(PIK3R6)
CJC: 100400385(PIK3R5) 100402223(PIK3R6)
SBQ: 101031169(PIK3R5) 101033790(PIK3R6)
MMU: 104709(Pik3r6) 320207(Pik3r5)
MCAL: 110304507(Pik3r6) 110305901(Pik3r5)
MPAH: 110331970(Pik3r5) 110332042(Pik3r6)
RNO: 497931(Pik3r5) 497932(Pik3r6)
MUN: 110551705(Pik3r5) 110551706(Pik3r6)
CGE: 100751224(Pik3r5) 100751518(Pik3r6)
NGI: 103752079(Pik3r5) 103752080(Pik3r6)
HGL: 101721410(Pik3r6) 101721762(Pik3r5)
CCAN: 109697132(Pik3r6) 109700829(Pik3r5)
OCU: 100337757(PIK3R5) 100340526(PIK3R6)
TUP: 102470324(PIK3R5) 102485065(PIK3R6)
CFA: 608225(PIK3R6) 612805(PIK3R5)
VVP: 112924887(PIK3R6) 112924888(PIK3R5)
AML: 100477067(PIK3R5) 100477324(PIK3R6)
UMR: 103660496(PIK3R6) 103660497(PIK3R5)
UAH: 113271195(PIK3R6) 113271196(PIK3R5)
ORO: 101374579(PIK3R5) 101375062(PIK3R6)
FCA: 101082104(PIK3R6) 101082354(PIK3R5)
PTG: 102954383(PIK3R5) 102954665(PIK3R6)
PPAD: 109245881(PIK3R5) 109246080(PIK3R6)
AJU: 106972459(PIK3R6) 106972460(PIK3R5)
BTA: 515621(PIK3R6) 614838(PIK3R5)
BOM: 102279608(PIK3R6) 102282596(PIK3R5)
BIU: 109573250(PIK3R5) 109574415(PIK3R6)
BBUB: 102397321(PIK3R5) 102399362(PIK3R6)
CHX: 102172481(PIK3R6) 102172758(PIK3R5)
OAS: 101109720(PIK3R6) 101109983(PIK3R5)
SSC: 100034246(PIK3R6) 396851(PIK3R5)
CFR: 102506518(PIK3R6) 102506780(PIK3R5)
CDK: 105098995(PIK3R5) 105098997(PIK3R6)
BACU: 103014949(PIK3R5) 103015229(PIK3R6)
LVE: 103076642(PIK3R6) 103076917(PIK3R5)
OOR: 101275667(PIK3R5) 101275916(PIK3R6)
DLE: 111186004(PIK3R5) 111186025(PIK3R6)
PCAD: 102976409(PIK3R6) 102979209(PIK3R5)
ECB: 100062779(PIK3R6) 100062810(PIK3R5)
EPZ: 103564501(PIK3R5) 103564503(PIK3R6)
EAI: 106845727(PIK3R6) 106845751(PIK3R5)
MYB: 102246179(PIK3R6) 102246489(PIK3R5)
MYD: 102755643(PIK3R6) 102755921(PIK3R5)
MNA: 107544506(PIK3R6) 107544531(PIK3R5)
HAI: 109395140(PIK3R6) 109395146(PIK3R5)
DRO: 112308643(PIK3R5) 112308895(PIK3R6)
PALE: 102878019(PIK3R6) 102878262(PIK3R5)
RAY: 107515658(PIK3R5) 107515659(PIK3R6)
MJV: 108387546(PIK3R6) 108392468(PIK3R5)
LAV: 100670067(PIK3R5) 100674744(PIK3R6)
MDO: 100012464(PIK3R5)
SHR: 100931238(PIK3R5)
PCW: 110194373(PIK3R5)
OAA: 100084050(PIK3R5) 103169312(PIK3R6)
GGA: 417319(PIK3R5) 769202(PIK3R6)
MGP: 100546841(PIK3R6) 100547150(PIK3R5)
CJO: 107322275(PIK3R5) 107322277(PIK3R6)
NMEL: 110407249(PIK3R5) 110407250(PIK3R6)
APLA: 101790494(PIK3R6) 101791074(PIK3R5)
ACYG: 106046698(PIK3R5) 106046720(PIK3R6)
TGU: 116809067(PIK3R6) 116809077(PIK3R5)
LSR: 110475146(PIK3R6) 110475153(PIK3R5)
SCAN: 103820021(PIK3R5) 103820022(PIK3R6)
GFR: 102042317(PIK3R5) 102042485(PIK3R6)
FAB: 101814689(PIK3R6) 101818925(PIK3R5)
PHI: 102100026(PIK3R5) 102100202(PIK3R6)
PMAJ: 107212546(PIK3R5) 107212547(PIK3R6)
CCAE: 111937183(PIK3R6) 111937185(PIK3R5)
CCW: 104695667(PIK3R6) 104695668(PIK3R5)
ETL: 114064103(PIK3R6) 114064104(PIK3R5)
FPG: 101916082(PIK3R6) 101916251(PIK3R5)
FCH: 102058572(PIK3R6) 102058745(PIK3R5)
CLV: 102084322(PIK3R6) 102085068(PIK3R5)
EGZ: 104133795(PIK3R6) 104133802(PIK3R5)
NNI: 104011006(PIK3R5) 104011017(PIK3R6)
ACUN: 113486876(PIK3R6) 113486892(PIK3R5)
PADL: 103925339(PIK3R6) 103925359(PIK3R5)
AAM: 106493184(PIK3R5) 106493186(PIK3R6)
ASN: 102375158(PIK3R5) 102376480(PIK3R6)
AMJ: 102559047(PIK3R5) 102566809(PIK3R6)
PSS: 102452954(PIK3R5) 102453204(PIK3R6)
CMY: 102931130(PIK3R6) 102931359(PIK3R5)
CPIC: 101945514(PIK3R6) 101945796(PIK3R5)
ACS: 100553495(pik3r6) 100553697(pik3r5)
PVT: 110080421(PIK3R5) 110080433(PIK3R6)
PBI: 103065452(PIK3R6) 103065866(PIK3R5)
PMUR: 107286775(PIK3R6) 107286790(PIK3R5)
TSR: 106540654(PIK3R6) 106551195(PIK3R5)
PMUA: 114590746(PIK3R5) 114590747(PIK3R6)
GJA: 107123847(PIK3R5) 107123852(PIK3R6)
XLA: 108701182(pik3r5.L) 108701183(pik3r6.L) 432272(pik3r5.S)
XTR: 733968(pik3r5) 780316(pik3r6)
NPR: 108796779(PIK3R6) 108796783(PIK3R5)
DRE: 100007492 101886666(pik3r6b) 323588(pik3r5)
PHYP: 113524565(pik3r5) 113528008(pik3r6)
EEE: 113573215 113584794(pik3r5) 113584796(pik3r6)
TRU: 101073983(pik3r6) 101074203(pik3r5) 115253365
NCC: 104955399 104964731(pik3r5) 104965306(pik3r6)
MZE: 101463967 101466926 101482173(pik3r6) 101482467(pik3r5)
ONL: 100690007 100696454(pik3r5) 102076215(pik3r6) 102078679
OLA: 101154923(pik3r6) 101155167(pik3r5) 101155772
XMA: 102225840 102232431(pik3r6) 102232697(pik3r5)
XCO: 114144896(pik3r6) 114145294(pik3r5) 114159701
PRET: 103467832(pik3r6) 103467846(pik3r5) 103468393
CVG: 107094634(pik3r5) 107099145 107099146(pik3r6)
NFU: 107376244 107382340(pik3r5) 107382343(pik3r6)
KMR: 108236216 108242695(pik3r6) 108242700(pik3r5)
ALIM: 106515181(pik3r6) 106515277(pik3r5) 106517875 106536898
AOCE: 111564223(pik3r5) 111564238(pik3r6) 111568188
CSEM: 103383581(pik3r6) 103383582(pik3r5) 103393693
POV: 109627211(pik3r5) 109627249(pik3r6) 109646425 109646901
SDU: 111236286(pik3r6) 111236324(pik3r5) 111238053
SLAL: 111659744(pik3r5) 111659789(pik3r6) 111673751 111673823
HCQ: 109508474 109511358(pik3r5) 109511359(pik3r6)
BPEC: 110172006 110172569 110172577(pik3r5) 110172636(pik3r6)
ELS: 105012280(pik3r5) 105012281(pik3r6) 105013165
PKI: 111833532(pik3r5) 111833591(pik3r6) 111856319
LCM: 102361229(PIK3R6) 102361486(PIK3R5)
CMK: 103175427(pik3r6) 103175428(pik3r5)
RTP: 109930167(pik3r5) 109930168(pik3r6)
CIN: 100183938
AQU: 109582644
 » show all
Reference
PMID:9094719
  Authors
Stephens LR, Eguinoa A, Erdjument-Bromage H, Lui M, Cooke F, Coadwell J, Smrcka AS, Thelen M, Cadwallader K, Tempst P, Hawkins PT
  Title
The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101.
  Journal
Cell 89:105-14 (1997)
DOI:10.1016/S0092-8674(00)80187-7
  Sequence
[ssc:396851]
Reference
  Authors
Voigt P, Dorner MB, Schaefer M
  Title
Characterization of p87PIKAP, a novel regulatory subunit of phosphoinositide 3-kinase gamma that is highly expressed in heart and interacts with PDE3B.
  Journal
J Biol Chem 281:9977-86 (2006)
DOI:10.1074/jbc.M512502200
  Sequence
[mmu:104709]
LinkDB

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