KEGG   ORTHOLOGY: K01060
Entry
K01060                      KO                                     

Name
cah
Definition
cephalosporin-C deacetylase [EC:3.1.1.41]
Pathway
ko00311  Penicillin and cephalosporin biosynthesis
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00311 Penicillin and cephalosporin biosynthesis
    K01060  cah; cephalosporin-C deacetylase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.41  cephalosporin-C deacetylase
     K01060  cah; cephalosporin-C deacetylase
Other DBs
RN: R03062
COG: COG3458
GO: 0047739
Genes
VAS: GT360_16360
CATE: C2869_07180
METU: GNH96_13140
MMT: Metme_1885
MDN: JT25_021245
MDH: AYM39_10145
MKO: MKLM6_2137
METL: U737_14500
MPSY: CEK71_05805
MMAI: sS8_2978 sS8_3683
TEE: Tel_08835
MLO: mlr6993
ARA: Arad_9051
RLE: RL2908
RLG: Rleg_2440
MGM: Mmc1_2518
BSU: BSU03180(cah)
BSR: I33_0363
BSL: A7A1_1880
BSH: BSU6051_03180(cah)
BSUT: BSUB_00367(cah)
BSUL: BSUA_00367(cah)
BSUS: Q433_01915
BSS: BSUW23_01625(cah)
BST: GYO_0523
BSO: BSNT_06647(cah)
BSQ: B657_03180(cah)
BSX: C663_0308(cah)
BLI: BL01713(cah)
BLD: BLi00379(cah)
BLH: BaLi_c03950(cah)
BAQ: BACAU_0285(cah)
BYA: BANAU_0284(cah)
BAMP: B938_01465
BAML: BAM5036_0301(cah)
BAMA: RBAU_0315(cah)
BAMN: BASU_0300(cah)
BAMB: BAPNAU_0285(cah)
BAMT: AJ82_01875
BAMY: V529_03050(cah)
BMP: NG74_00324(cah)
BAO: BAMF_0291(cah)
BAZ: BAMTA208_01460(cah)
BQL: LL3_00299(cah)
BXH: BAXH7_00302(cah)
BQY: MUS_0300(cah)
BAMI: KSO_017950
BAMC: U471_03020
BAMF: U722_01760
BPU: BPUM_0297
BPUM: BW16_01880
BPUS: UP12_01885
BJS: MY9_0327
BACW: QR42_01840
BACP: SB24_08095
BACB: OY17_04375
BACY: QF06_00545
BACL: BS34A_03730(cah)
BALM: BsLM_0331
BGY: BGLY_0386(cah)
BBEV: BBEV_0471(cah)
BHA: BH3326
BCL: ABC1769(cah)
AXL: AXY_21800(axe) AXY_22340(axe)
BSE: Bsel_0980
PPM: PPSC2_18660(cah3) PPSC2_24180(cah5)
PPO: PPM_3754(cah3) PPM_4801(cah5)
PSWU: SY83_03310
PBK: Back11_05030(axe1_1) Back11_30500(axe1_2)
COHN: KCTCHS21_15190(cah) KCTCHS21_52180(axe1)
LLK: LLKF_1447(axe)
LLX: NCDO2118_1409(axe)
LLR: llh_7440
LLI: uc509_1372(axe)
LLW: kw2_1343
LLJ: LG36_1029(axe)
SPN: SP_1695
SPD: SPD_1506
SPR: spr1538(axe1)
SPW: SPCG_1668(axe1)
SJJ: SPJ_1589
SPX: SPG_1602(axe1)
SPV: SPH_1800
SPP: SPP_1712
SNP: SPAP_1703
SAG: SAG0041
SAN: gbs0040
SAK: SAK_0074
SGC: A964_0040
SAGM: BSA_740
SAGI: MSA_780
SAGR: SAIL_770
SAGE: EN72_00375
SAGG: EN73_00375
SAGN: W903_0076(axe1)
SSA: SSA_0070(axe1)
SEZ: Sez_0253
SEQ: SZO_17040
SEQU: Q426_07955
SUB: SUB1651
SGT: SGGB_0215(axe1)
SMB: smi_0600
SOR: SOR_0547
STB: SGPB_0158(axe1)
SCF: Spaf_1050
SMN: SMA_192(cah)
STRN: SNAG_0541(axeA)
EFA: EF1236
EFL: EF62_1680
EFS: EFS1_1059
EFQ: DR75_300
ENE: ENT_06680
CPE: CPE1596
CPF: CPF_1848(axe1)
CBV: U729_2266(axe1)
CTH: Cthe_3063
HSC: HVS_10845(cah)
CCE: Ccel_0210
CSS: Cst_c14440(cah)
CSD: Clst_1394
CCEL: CCDG5_2025
BPRO: PMF13cell1_02357(cah)
ACEL: acsn021_44380(axeA)
DSY: DSY0351
DHD: Dhaf_0284
SGY: Sgly_0270
TIT: Thit_0191
CSC: Csac_2436
ATE: Athe_0152
SCO: SCO7057(SC4G1.23c)
SALB: XNR_3892
SMA: SAVERM_1302(axe1) SAVERM_1457(axe2)
SGB: WQO_23395
SHY: SHJG_2291
SVE: SVEN_6682
SALS: SLNWT_7151
SFI: SFUL_4907
SALU: DC74_6913
SALL: SAZ_35900
SLV: SLIV_03965(axeA)
SGU: SGLAU_03235(axeA)
STRE: GZL_01842
SLD: T261_1053
SAMB: SAM23877_1034(axeA)
SRW: TUE45_01052(axeA)
SLE: sle_63340(sle_63340)
SRN: A4G23_05285(axeA)
SNR: SNOUR_08235(axeA)
SMAL: SMALA_1210
SGE: DWG14_02113(axeA_1) DWG14_07762(axeA_2)
KSK: KSE_04670(axe1) KSE_10120(axe2)
CMI: CMM_0227
CMS: CMS0795
CMC: CMN_00165
MOO: BWL13_02328(axeA)
MLV: CVS47_02091(axeA)
MOY: CVS54_01193(axeA)
ART: Arth_3303
ARR: ARUE_c34390(cah)
ARM: ART_3104
AAU: AAur_3303
ACH: Achl_3101
XCE: Xcel_2723
IDO: I598_3177(axeA)
CFL: Cfla_0926
PACC: PAC1_01355
PACH: PAGK_0284
ACIJ: JS278_00650(axeA)
KFL: Kfla_0274
TFU: Tfu_1462
STRR: EKD16_07995(axeA)
SRO: Sros_2720
ACE: Acel_2045
AMYY: YIM_43875(cah2)
SESP: BN6_23910
ACTI: UA75_20520
ACAD: UA74_20020
AHG: AHOG_17940(axeA)
ALO: CRK56630
SAQ: Sare_3004
ASE: ACPL_5484(axe1)
ACTN: L083_3285(axe1)
ACTS: ACWT_5353
SNA: Snas_3115
TBI: Tbis_1965
RCA: Rcas_1231
HAU: Haur_0886
ATM: ANT_24920
PBF: CFX0092_B0571(axeA)
TTR: Tter_0201
OTE: Oter_2302
OBG: Verru16b_00600(axe7A)
PSL: Psta_3096
FMR: Fuma_05337(axe7A)
GMR: GmarT_49880(axe7A_1) GmarT_49890(axe7A_2)
PBAS: SMSP2_02919(axeA)
LBJ: LBJ_1652
LBL: LBL_1871
LBF: LBF_1671
LST: LSS_18918
BRM: Bmur_1237
BPW: WESB_0039
BIP: Bint_2614
ABAC: LuPra_03250(axe7A)
GBA: J421_6187
BOA: Bovatus_02937(axe7A_2) Bovatus_03857(axe7A_3)
BCEL: BcellWH2_02032(axe7A_1) BcellWH2_03177(axe7A_2)
PMUC: ING2E5A_2654(axe7A)
PSAC: PSM36_0087(axeA) PSM36_0328
POC: NCTC13071_01505(cah)
FLN: FLA_1343
STHA: NCTC11429_04415(cah)
MGOT: MgSA37_04241(axe7A_1) MgSA37_04242(axe7A_2)
DFE: Dfer_1236
SLI: Slin_2229
FAE: FAES_2723
ZGA: ZOBELLIA_2105(axeA)
NDO: DDD_0348
AALG: AREALGSMS7_03788(axe7A)
MARF: CJ739_1188
TMW: THMA_0073
TMQ: THMB_0073
TMX: THMC_0073
TPT: Tpet_0847
TNA: CTN_0615
TNP: Tnap_0707
TLE: Tlet_0356
DTU: Dtur_0265
 » show all
Reference
  Authors
Levisson M, Han GW, Deller MC, Xu Q, Biely P, Hendriks S, Ten Eyck LF, Flensburg C, Roversi P, Miller MD, McMullan D, von Delft F, Kreusch A, Deacon AM, van der Oost J, Lesley SA, Elsliger MA, Kengen SW, Wilson IA
  Title
Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima.
  Journal
Proteins 80:1545-59 (2012)
DOI:10.1002/prot.24041
  Sequence
[tma:TM0077]
LinkDB

KEGG   ENZYME: 3.1.1.41
Entry
EC 3.1.1.41                 Enzyme                                 

Name
cephalosporin-C deacetylase;
cephalosporin C acetyl-hydrolase;
cephalosporin C acetylase;
cephalosporin acetylesterase;
cephalosporin C acetylesterase;
cephalosporin C acetyl-esterase;
cephalosporin C deacetylase
Class
Hydrolases;
Acting on ester bonds;
Carboxylic-ester hydrolases
Sysname
cephalosporin-C acetylhydrolase
Reaction(IUBMB)
cephalosporin C + H2O = deacetylcephalosporin C + acetate [RN:R03062]
Reaction(KEGG)
R03062
Substrate
cephalosporin C [CPD:C00916];
H2O [CPD:C00001]
Product
deacetylcephalosporin C [CPD:C03112];
acetate [CPD:C00033]
Comment
Hydrolyses the acetyl ester bond on the 10-position of the antibiotic cephalosporin C.
History
EC 3.1.1.41 created 1976
Pathway
ec00311  Penicillin and cephalosporin biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K01060  cephalosporin-C deacetylase
Genes
VAS: GT360_16360
CATE: C2869_07180
METU: GNH96_13140
MMT: Metme_1885
MDN: JT25_021245
MDH: AYM39_10145
MKO: MKLM6_2137
METL: U737_14500
MPSY: CEK71_05805
MMAI: sS8_2978 sS8_3683
TEE: Tel_08835
MLO: mlr6993
ARA: Arad_9051
RLE: RL2908
RLG: Rleg_2440
MGM: Mmc1_2518
BSU: BSU03180(cah)
BSR: I33_0363
BSL: A7A1_1880
BSH: BSU6051_03180(cah)
BSUT: BSUB_00367(cah)
BSUL: BSUA_00367(cah)
BSUS: Q433_01915
BSS: BSUW23_01625(cah)
BST: GYO_0523
BSO: BSNT_06647(cah)
BSQ: B657_03180(cah)
BSX: C663_0308(cah)
BLI: BL01713(cah)
BLD: BLi00379(cah)
BLH: BaLi_c03950(cah)
BAQ: BACAU_0285(cah)
BYA: BANAU_0284(cah)
BAMP: B938_01465
BAML: BAM5036_0301(cah)
BAMA: RBAU_0315(cah)
BAMN: BASU_0300(cah)
BAMB: BAPNAU_0285(cah)
BAMT: AJ82_01875
BAMY: V529_03050(cah)
BMP: NG74_00324(cah)
BAO: BAMF_0291(cah)
BAZ: BAMTA208_01460(cah)
BQL: LL3_00299(cah)
BXH: BAXH7_00302(cah)
BQY: MUS_0300(cah)
BAMI: KSO_017950
BAMC: U471_03020
BAMF: U722_01760
BPU: BPUM_0297
BPUM: BW16_01880
BPUS: UP12_01885
BJS: MY9_0327
BACW: QR42_01840
BACP: SB24_08095
BACB: OY17_04375
BACY: QF06_00545
BACL: BS34A_03730(cah)
BALM: BsLM_0331
BGY: BGLY_0386(cah)
BBEV: BBEV_0471(cah)
BHA: BH3326
BCL: ABC1769(cah)
AXL: AXY_21800(axe) AXY_22340(axe)
BSE: Bsel_0980
PPM: PPSC2_18660(cah3) PPSC2_24180(cah5)
PPO: PPM_3754(cah3) PPM_4801(cah5)
PSWU: SY83_03310
PBK: Back11_05030(axe1_1) Back11_30500(axe1_2)
COHN: KCTCHS21_15190(cah) KCTCHS21_52180(axe1)
LLK: LLKF_1447(axe)
LLX: NCDO2118_1409(axe)
LLR: llh_7440
LLI: uc509_1372(axe)
LLW: kw2_1343
LLJ: LG36_1029(axe)
SPN: SP_1695
SPD: SPD_1506
SPR: spr1538(axe1)
SPW: SPCG_1668(axe1)
SJJ: SPJ_1589
SPX: SPG_1602(axe1)
SPV: SPH_1800
SPP: SPP_1712
SNP: SPAP_1703
SAG: SAG0041
SAN: gbs0040
SAK: SAK_0074
SGC: A964_0040
SAGM: BSA_740
SAGI: MSA_780
SAGR: SAIL_770
SAGE: EN72_00375
SAGG: EN73_00375
SAGN: W903_0076(axe1)
SSA: SSA_0070(axe1)
SEZ: Sez_0253
SEQ: SZO_17040
SEQU: Q426_07955
SUB: SUB1651
SGT: SGGB_0215(axe1)
SMB: smi_0600
SOR: SOR_0547
STB: SGPB_0158(axe1)
SCF: Spaf_1050
SMN: SMA_192(cah)
STRN: SNAG_0541(axeA)
EFA: EF1236
EFL: EF62_1680
EFS: EFS1_1059
EFQ: DR75_300
ENE: ENT_06680
CPE: CPE1596
CPF: CPF_1848(axe1)
CBV: U729_2266(axe1)
CTH: Cthe_3063
HSC: HVS_10845(cah)
CCE: Ccel_0210
CSS: Cst_c14440(cah)
CSD: Clst_1394
CCEL: CCDG5_2025
BPRO: PMF13cell1_02357(cah)
ACEL: acsn021_44380(axeA)
DSY: DSY0351
DHD: Dhaf_0284
SGY: Sgly_0270
TIT: Thit_0191
CSC: Csac_2436
ATE: Athe_0152
SCO: SCO7057(SC4G1.23c)
SALB: XNR_3892
SMA: SAVERM_1302(axe1) SAVERM_1457(axe2)
SGB: WQO_23395
SHY: SHJG_2291
SVE: SVEN_6682
SALS: SLNWT_7151
SFI: SFUL_4907
SALU: DC74_6913
SALL: SAZ_35900
SLV: SLIV_03965(axeA)
SGU: SGLAU_03235(axeA)
STRE: GZL_01842
SLD: T261_1053
SAMB: SAM23877_1034(axeA)
SRW: TUE45_01052(axeA)
SLE: sle_63340(sle_63340)
SRN: A4G23_05285(axeA)
SNR: SNOUR_08235(axeA)
SMAL: SMALA_1210
SGE: DWG14_02113(axeA_1) DWG14_07762(axeA_2)
KSK: KSE_04670(axe1) KSE_10120(axe2)
CMI: CMM_0227
CMS: CMS0795
CMC: CMN_00165
MOO: BWL13_02328(axeA)
MLV: CVS47_02091(axeA)
MOY: CVS54_01193(axeA)
ART: Arth_3303
ARR: ARUE_c34390(cah)
ARM: ART_3104
AAU: AAur_3303
ACH: Achl_3101
XCE: Xcel_2723
IDO: I598_3177(axeA)
CFL: Cfla_0926
PACC: PAC1_01355
PACH: PAGK_0284
ACIJ: JS278_00650(axeA)
KFL: Kfla_0274
TFU: Tfu_1462
STRR: EKD16_07995(axeA)
SRO: Sros_2720
ACE: Acel_2045
AMYY: YIM_43875(cah2)
SESP: BN6_23910
ACTI: UA75_20520
ACAD: UA74_20020
AHG: AHOG_17940(axeA)
ALO: CRK56630
SAQ: Sare_3004
ASE: ACPL_5484(axe1)
ACTN: L083_3285(axe1)
ACTS: ACWT_5353
SNA: Snas_3115
TBI: Tbis_1965
RCA: Rcas_1231
HAU: Haur_0886
ATM: ANT_24920
PBF: CFX0092_B0571(axeA)
TTR: Tter_0201
OTE: Oter_2302
OBG: Verru16b_00600(axe7A)
PSL: Psta_3096
FMR: Fuma_05337(axe7A)
GMR: GmarT_49880(axe7A_1) GmarT_49890(axe7A_2)
PBAS: SMSP2_02919(axeA)
LBJ: LBJ_1652
LBL: LBL_1871
LBF: LBF_1671
LST: LSS_18918
BRM: Bmur_1237
BPW: WESB_0039
BIP: Bint_2614
ABAC: LuPra_03250(axe7A)
GBA: J421_6187
BOA: Bovatus_02937(axe7A_2) Bovatus_03857(axe7A_3)
BCEL: BcellWH2_02032(axe7A_1) BcellWH2_03177(axe7A_2)
PMUC: ING2E5A_2654(axe7A)
PSAC: PSM36_0087(axeA) PSM36_0328
POC: NCTC13071_01505(cah)
FLN: FLA_1343
STHA: NCTC11429_04415(cah)
MGOT: MgSA37_04241(axe7A_1) MgSA37_04242(axe7A_2)
DFE: Dfer_1236
SLI: Slin_2229
FAE: FAES_2723
ZGA: ZOBELLIA_2105(axeA)
NDO: DDD_0348
AALG: AREALGSMS7_03788(axe7A)
MARF: CJ739_1188
TMW: THMA_0073
TMQ: THMB_0073
TMX: THMC_0073
TPT: Tpet_0847
TNA: CTN_0615
TNP: Tnap_0707
TLE: Tlet_0356
DTU: Dtur_0265
 » show all
Reference
1  [PMID:4519146]
  Authors
Fujisawa Y, Shirafugi H, Kida M, Nara K, Yoneda M, Kanzaki T.
  Title
New findings on cephalosporin C biosynthesis.
  Journal
Nat New Biol 246:154-5 (1973)
DOI:10.1038/newbio246154a0
Other DBs
ExplorEnz - The Enzyme Database: 3.1.1.41
IUBMB Enzyme Nomenclature: 3.1.1.41
ExPASy - ENZYME nomenclature database: 3.1.1.41
BRENDA, the Enzyme Database: 3.1.1.41
CAS: 52227-71-1
LinkDB

KEGG   REACTION: R03062
Entry
R03062                      Reaction                               

Name
Cephalosporin-C acetylhdrolase
Definition
Cephalosporin C + H2O <=> Deacetylcephalosporin C + Acetate
Equation
Comment
Ref.1 : Appl. Environ. Microbiol. June 1995, Vol61, No6, p2224-2229
Reaction class
RC00020  C00033_C00916
RC00041  C00916_C03112
Enzyme
Pathway
rn00311  Penicillin and cephalosporin biosynthesis
rn01110  Biosynthesis of secondary metabolites
Orthology
K01060  cephalosporin-C deacetylase [EC:3.1.1.41]
Other DBs
RHEA: 22599
LinkDB

DBGET integrated database retrieval system