KEGG   ORTHOLOGY: K01074Help
Entry
K01074                      KO                                     

Name
PPT
Definition
palmitoyl-protein thioesterase [EC:3.1.2.22]
Pathway
ko00062  Fatty acid elongation
ko01100  Metabolic pathways
ko01212  Fatty acid metabolism
ko04142  Lysosome
Disease
H00149  Neuronal ceroid lipofuscinosis
H02277  Santavuori-Haltia disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K01074  PPT; palmitoyl-protein thioesterase
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K01074  PPT; palmitoyl-protein thioesterase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01004 Lipid biosynthesis proteins
    K01074  PPT; palmitoyl-protein thioesterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.22  palmitoyl[protein] hydrolase
     K01074  PPT; palmitoyl-protein thioesterase
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Component type
   K01074  PPT; palmitoyl-protein thioesterase
BRITE hierarchy
Other DBs
RN: R01274
GO: 0008474
Genes
HSA: 5538(PPT1) 9374(PPT2)
PTR: 456789(PPT1) 462580(PPT2)
PPS: 100969155(PPT1) 100989791(PPT2)
GGO: 101127127(PPT2) 101154001(PPT1)
PON: 100174770(PPT1) 100434271(PPT2)
NLE: 100599270(PPT2) 100604487(PPT1)
MCC: 693377(PPT1) 717212(PPT2)
MCF: 102124313(PPT2) 102126191(PPT1)
CSAB: 103221712(PPT2) 103225040(PPT1)
RRO: 104654886(PPT1) 104674001(PPT2)
RBB: 108519890(PPT2) 108530410(PPT1)
CJC: 100403808(PPT1) 100413646(PPT2)
SBQ: 101038156(PPT1) 101043430(PPT2)
MMU: 19063(Ppt1) 54397(Ppt2)
MCAL: 110293291(Ppt1) 110312604(Ppt2)
MPAH: 110315065 110322779(Ppt1) 110335365(Ppt2)
RNO: 29411(Ppt1) 54398(Ppt2)
MUN: 110549960(Ppt1) 110565387(Ppt2)
NGI: 103724411(Ppt2) 103735139(Ppt1)
HGL: 101713926(Ppt2) 101718692(Ppt1)
CCAN: 109690406(Ppt2) 109691574(Ppt1)
OCU: 100339827(PPT1) 100358167(PPT2)
TUP: 102484501(PPT2) 102490310(PPT1)
CFA: 474856(PPT2) 475316(PPT1)
VVP: 112908239(PPT1) 112913636(PPT2)
AML: 100475095(PPT1) 100476267(PPT2)
UMR: 103682279(PPT2) 103682394(PPT1)
UAH: 113243752(PPT2) 113268238(PPT1)
ORO: 101362292(PPT2) 101368745 101386758(PPT1)
FCA: 101095578(PPT2) 101097408(PPT1)
PTG: 102963070(PPT1) 102971153(PPT2)
PPAD: 109254853(PPT1) 109260524(PPT2)
AJU: 106983473(PPT2) 106988413(PPT1)
BTA: 281421(PPT1) 516797(PPT2)
BOM: 102264883(PPT2) 102280715(PPT1)
BIU: 109556456(PPT1) 109576851(PPT2)
BBUB: 102397627(PPT2) 102398714(PPT1)
CHX: 102173897(PPT2) 102188105(PPT1)
OAS: 101112855(PPT2) 101121049(PPT1)
SSC: 100144537(PPT2) 100517533(PPT1)
CFR: 102512385(PPT1) 102522115(PPT2)
CDK: 105090849(PPT2) 105103370(PPT1)
BACU: 103006799(PPT1) 103014067(PPT2)
LVE: 103084593(PPT1) 103091119(PPT2)
OOR: 101277496(PPT2) 101283893(PPT1)
DLE: 111170952(PPT2) 111175643(PPT1)
PCAD: 102977386(PPT2) 102990562(PPT1)
ECB: 100051483 100068301(PPT1)
EPZ: 103553563(PPT1) 103566642(PPT2)
EAI: 106823113(PPT1) 106831016(PPT2)
MYB: 102242959(PPT1) 102253546(PPT2)
MYD: 102768095(PPT2) 102770643(PPT1)
MNA: 107531194(PPT1)
HAI: 109373111(PPT2) 109383389(PPT1)
DRO: 112299191(PPT1) 112302223(PPT2)
PALE: 102897388(PPT2) 102898049(PPT1)
RAY: 107498454(PPT2) 107508325(PPT1)
MJV: 108384552(PPT1) 108393796(PPT2)
LAV: 100665656 100671106(PPT1)
MDO: 100024015(PPT2) 100032080(PPT1)
SHR: 100917850(PPT1) 100933490(PPT2)
PCW: 110199428(PPT2) 110206304(PPT1)
OAA: 100077897(PPT1) 100078347(PPT2)
GGA: 419681(PPT1)
MGP: 100540149(PPT1) 104915837(PPT2)
CJO: 107307852(PPT2) 107323936(PPT1)
NMEL: 110387306(PPT1)
ACYG: 106037878(PPT1)
TGU: 100190233(PPT1)
LSR: 110475001(PPT2) 110475332(PPT1)
SCAN: 103823503(PPT1)
GFR: 102042422(PPT1)
FAB: 101810323(PPT1)
PHI: 102113700(PPT1) 102114091(PPT2)
PMAJ: 107214159(PPT1)
CCAE: 111939127(PPT1)
CCW: 104694666(PPT1)
ETL: 114067769(PPT1)
FPG: 101924773(PPT1)
FCH: 102053964(PPT1)
CLV: 102085710(PPT1) 102094639(PPT2)
EGZ: 104134971(PPT1)
NNI: 104017862(PPT1)
ACUN: 113488227(PPT1)
PADL: 103923769(PPT1)
AAM: 106493355(PPT1)
ASN: 102377936(PPT2) 102384268(PPT1)
AMJ: 102566224(PPT1) 102570797(PPT2)
PSS: 102450927(PPT1)
CMY: 102945976(PPT1)
CPIC: 101942757(PPT1) 101949778(PPT2)
ACS: 100556763(ppt2) 100563048(ppt1)
PBI: 103048105(PPT2) 103065485(PPT1)
PMUR: 107294851(PPT2) 107300276 107301587(PPT1)
TSR: 106544227(PPT1)
PMUA: 114592076(PPT2) 114601601(PPT1)
GJA: 107112540(PPT1) 107118454(PPT2)
XLA: 100036952(ppt1.S) 100037210(ppt1.L) 379689(ppt2.L) 444228(ppt2l.L)
XTR: 100101696(ppt2) 448650(ppt1)
NPR: 108786546(PPT2) 108793538(PPT1)
DRE: 100126133(ppt2) 393135(zgc:55621) 393657 405845(zgc:77118) 406648(ppt1)
IPU: 108257031(ppt1) 108274839(ppt2) 108277463
EEE: 113578429(ppt1) 113586395 113589076(ppt2)
LCO: 104921533(ppt1) 104922538(ppt2) 104935034
MZE: 101472327 101475534(ppt2) 101479416(ppt1)
ONL: 100694706 100703641(ppt2) 100710936(ppt1)
XMA: 102235654 102236538(ppt1) 102238371(ppt2)
XCO: 114141548 114156111(ppt1) 114156141(ppt2)
PRET: 103472910(ppt2) 103473078(ppt1) 103477738
KMR: 108237780(ppt2) 108249591(ppt1) 108249862
ALIM: 106510754(ppt1) 106520838(ppt2) 106532611
CSEM: 103394015(ppt1) 103394071(ppt2)
SDU: 111222602 111223008(ppt1) 111223511(ppt2)
SLAL: 111651732(ppt2) 111655676 111671854(ppt1)
BPEC: 110155804 110159233(ppt1) 110173282(ppt2)
SASA: 100196302(ppt2a) 106570032(PPT1) 106570067 106588210 106588481(PPT1)
SFM: 108927395 108931813(ppt1) 108935599(ppt2)
LCM: 102353105(PPT1) 102355870(PPT2)
CMK: 103188689(ppt1)
RTP: 109913990(ppt1) 109913995 109923505(ppt2)
DME: Dmel_CG12108(Ppt1) Dmel_CG4851(Ppt2)
DSI: Dsimw501_GD16099(Dsim_GD16099) Dsimw501_GD23774(Dsim_GD23774)
DNV: 108657092
NVI: 100119223(Ppt2) 100119614
DPTE: 113795664
PTEP: 107448095
CEL: CELE_F44C4.5(ppt-1)
CBR: CBG18981(Cbr-ppt-1)
BMY: Bm1_51565
TSP: Tsp_00608
OBI: 106871646
EGL: EGR_01013
VRA: 106778007
VAR: 108335114
VUN: 114173446
LJA: Lj2g3v1989240.1(Lj2g3v1989240.1)
MESC: 110629331
SOE: 110795412
DOSA: Os03t0101100-01(Os03g0101100) Os10t0563000-01(Os10g0563000)
ATS: 109758352(LOC109758352) 109772768(LOC109772768) 109786319(LOC109786319)
PDA: 103713625
EGU: 105043725
ATR: 18428257
MNG: MNEG_5752
APRO: F751_3938
CAL: CAALFM_CR04490CA(CaO19.540)
NCR: NCU06530
NTE: NEUTE1DRAFT145000(NEUTE1DRAFT_145000)
MGR: MGG_04920
SSCK: SPSK_03444
MAW: MAC_00241
MAJ: MAA_08177
CMT: CCM_08776
MBE: MBM_01578
ANI: AN2497.2
ANG: ANI_1_1416084(An09g04580)
PBL: PAAG_12104(PAAG_05837)
ABE: ARB_05715
TVE: TRV_03000
PTE: PTT_08509
SPO: SPBC530.12c(pdf1)
CNE: CNA00890
CNB: CNBA0860
ABP: AGABI1DRAFT112549(AGABI1DRAFT_112549)
ABV: AGABI2DRAFT192516(AGABI2DRAFT_192516)
MGL: MGL_1417
MRT: MRET_3942
DDI: DDB_G0285533(ppt1) DDB_G0288807(ppt2) DDB_G0292862(ppt3)
DFA: DFA_01175(ppt3) DFA_01247(ppt1) DFA_08205(ppt2)
SMIN: v1.2.004002.t1(symbB.v1.2.004002.t1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8786130
  Authors
Schriner JE, Yi W, Hofmann SL
  Title
cDNA and genomic cloning of human palmitoyl-protein thioesterase (PPT), the enzyme defective in infantile neuronal ceroid lipofuscinosis.
  Journal
Genomics 34:317-22 (1996)
DOI:10.1006/geno.1996.0292
  Sequence
[hsa:5538]
LinkDB All DBs

KEGG   REACTION: R01274Help
Entry
R01274                      Reaction                               

Name
palmitoyl-CoA hydrolase
Definition
Palmitoyl-CoA + H2O <=> CoA + Hexadecanoic acid
Equation
Reaction class
RC00004  C00010_C00154
RC00014  C00154_C00249
Enzyme
3.1.2.2         3.1.2.22        3.1.2.-
Pathway
rn00062  Fatty acid elongation
rn01040  Biosynthesis of unsaturated fatty acids
rn01100  Metabolic pathways
rn01212  Fatty acid metabolism
Orthology
K01068  acyl-coenzyme A thioesterase 1/2/4 [EC:3.1.2.2]
K01074  palmitoyl-protein thioesterase [EC:3.1.2.22]
K10804  acyl-CoA thioesterase I [EC:3.1.2.- 3.1.2.2 3.1.1.2 3.1.1.5]
K10805  acyl-CoA thioesterase II [EC:3.1.2.-]
K10806  acyl-CoA thioesterase YciA [EC:3.1.2.-]
K17360  acyl-coenzyme A thioesterase 7 [EC:3.1.2.2]
Other DBs
RHEA: 16648
LinkDB All DBs

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