Entry
Symbol
hya
Name
Pathway
Module
M00076 Dermatan sulfate degradation
M00077 Chondroitin sulfate degradation
Disease
H00133 Mucopolysaccharidosis type IX
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09107 Glycan biosynthesis and metabolism
00531 Glycosaminoglycan degradation
K01197 hya; hyaluronoglucosaminidase
09140 Cellular Processes
09141 Transport and catabolism
04142 Lysosome
K01197 hya; hyaluronoglucosaminidase
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
02042 Bacterial toxins
K01197 hya; hyaluronoglucosaminidase
00536 Glycosaminoglycan binding proteins
K01197 hya; hyaluronoglucosaminidase
00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
K01197 hya; hyaluronoglucosaminidase
Enzymes [BR:ko01000 ]
3. Hydrolases
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.1.35 hyaluronoglucosaminidase
K01197 hya; hyaluronoglucosaminidase
Bacterial toxins [BR:ko02042 ]
Toxins that damage the extracellular matrix
Hyaluronidases/Collagenases
K01197 hya; hyaluronoglucosaminidase
Glycosaminoglycan binding proteins [BR:ko00536 ]
Heparan sulfate / Heparin
Enzymes
K01197 hya; hyaluronoglucosaminidase
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537 ]
Enzymes
K01197 hya; hyaluronoglucosaminidase
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Genes
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Taxonomy Virus taxonomy UniProt
Reference
Authors
Lepperdinger G, Strobl B, Kreil G
Title
HYAL2, a human gene expressed in many cells, encodes a lysosomal hyaluronidase with a novel type of specificity.
Journal
Sequence
Reference
Authors
Lokeshwar VB, Schroeder GL, Carey RI, Soloway MS, Iida N
Title
Regulation of hyaluronidase activity by alternative mRNA splicing.
Journal
Sequence
Reference
Authors
Kaneiwa T, Mizumoto S, Sugahara K, Yamada S
Title
Identification of human hyaluronidase-4 as a novel chondroitin sulfate hydrolase that preferentially cleaves the galactosaminidic linkage in the trisulfated tetrasaccharide sequence.
Journal
Sequence
Reference
Authors
Gmachl M, Sagan S, Ketter S, Kreil G
Title
The human sperm protein PH-20 has hyaluronidase activity.
Journal
Sequence
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