KEGG   ORTHOLOGY: K01332
Entry
K01332                      KO                                     

Name
C2
Definition
complement component 2 [EC:3.4.21.43]
Pathway
ko04610  Complement and coagulation cascades
ko05133  Pertussis
ko05150  Staphylococcus aureus infection
ko05171  Coronavirus disease - COVID-19
ko05322  Systemic lupus erythematosus
Disease
H00080  Systemic lupus erythematosus
H00102  Classic complement pathway component defects
H00821  Age-related macular degeneration
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K01332  C2; complement component 2
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K01332  C2; complement component 2
  09171 Infectious disease: bacterial
   05133 Pertussis
    K01332  C2; complement component 2
   05150 Staphylococcus aureus infection
    K01332  C2; complement component 2
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K01332  C2; complement component 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01332  C2; complement component 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.43  classical-complement-pathway C3/C5 convertase
     K01332  C2; complement component 2
Peptidases and inhibitors [BR:ko01002]
 Serine peptidases
  Family S1: chymotrypsin family
   K01332  C2; complement component 2
Genes
HSA: 717(C2)
PTR: 100608992(C2)
PPS: 103783827(C2)
GGO: 101145799(C2)
PON: 100173033(C2)
NLE: 100606928(C2)
MCC: 106997899(C2)
MCF: 102137096(C2)
CSAB: 103221735(C2)
RRO: 104678122(C2)
RBB: 108520263(C2)
CJC: 103792363(C2)
SBQ: 104650316(C2)
MMU: 12263(C2)
MCAL: 110312387(C2)
MPAH: 110336126(C2)
RNO: 24231(C2)
MUN: 110560138(C2)
CGE: 100759069(C2)
NGI: 103724419(C2)
HGL: 101723809(C2)
CCAN: 109689592(C2)
OCU: 100355553(C2)
TUP: 102480144(C2)
CFA: 474853(C2)
VVP: 112913623(C2)
AML: 100474163(C2)
UMR: 103682287(C2)
UAH: 113243740(C2)
ORO: 101377842(C2)
ELK: 111152312
FCA: 101092434(C2)
PTG: 102969252(C2)
PPAD: 109260505(C2)
AJU: 106983482(C2)
BTA: 515440(C2)
BOM: 102269155(C2)
BIU: 109576932(C2)
BBUB: 102406076(C2)
CHX: 102176085(C2)
OAS: 101115321(C2)
SSC: 448981(C2)
CFR: 102518989(C2)
CDK: 105087440(C2)
BACU: 103018276(C2)
LVE: 103071578(C2)
OOR: 101281566(C2)
DLE: 111170704(C2)
PCAD: 102992128(C2)
ECB: 100059162(C2)
EPZ: 103563291(C2)
EAI: 106831000(C2)
MYB: 102263362(C2)
MYD: 102766284(C2)
MNA: 107538982(C2)
PALE: 102889530(C2)
RAY: 107498438(C2)
MJV: 108393991(C2)
LAV: 100668309(C2)
TMU: 101350027
MDO: 100025443(C2)
SHR: 105750443(CFB)
PCW: 110199442(C2)
OAA: 100089242
GGA: 419574(C2)
MGP: 104914277
CJO: 107323905
NMEL: 110387356
ASN: 102381270(CFB)
AMJ: 102574290(C2)
CMY: 102937942(C2)
CPIC: 101947880(C2)
ACS: 100556178(c2)
PVT: 110088698(C2)
PBI: 103049015
PMUR: 107295035
GJA: 107105482
XLA: 734198(c2.L)
XTR: 100491079(c2)
NPR: 108786508
DRE: 563828(si:ch1073-280e3.1)
SRX: 107720441
SANH: 107662575
SGH: 107567682
CCAR: 109055343
IPU: 100862743(cfb)
PHYP: 113539139
AMEX: 103046310
EEE: 113574701
TRU: 101064033
LCO: 104930441
NCC: 104962863
MZE: 101480328
ONL: 100697699
OLA: 101167637
XCO: 114161640
PRET: 103474842
CVG: 107102499
NFU: 107397014
KMR: 108244431
ALIM: 106530408
AOCE: 111574507
POV: 109642964
LCF: 108890635
BPEC: 110162865
SASA: 106580826
OTW: 112265208
SALP: 111982534
ELS: 105011227
SFM: 108928780
PKI: 111854971
RTP: 109921429
BFO: 118420754
CIN: 497243(bf-1) 619241(bf-2)
APLC: 110983861
SKO: 100368814
PTEP: 107450490
 » show all
Reference
  Authors
Sim RB, Tsiftsoglou SA
  Title
Proteases of the complement system.
  Journal
Biochem Soc Trans 32:21-7 (2004)
DOI:10.1042/bst0320021
Reference
PMID:2949737
  Authors
Bentley DR
  Title
Primary structure of human complement component C2. Homology to two unrelated protein families.
  Journal
Biochem J 239:339-45 (1986)
DOI:10.1042/bj2390339
  Sequence
[hsa:717]
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