KEGG   ORTHOLOGY: K01367
Entry
K01367                      KO                                     

Name
CAPN1
Definition
calpain-1 [EC:3.4.22.52]
Pathway
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04217  Necroptosis
ko04218  Cellular senescence
ko05010  Alzheimer disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05131  Shigellosis
Disease
H00266  Hereditary spastic paraplegia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K01367  CAPN1; calpain-1
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K01367  CAPN1; calpain-1
   04217 Necroptosis
    K01367  CAPN1; calpain-1
   04218 Cellular senescence
    K01367  CAPN1; calpain-1
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K01367  CAPN1; calpain-1
   05022 Pathways of neurodegeneration - multiple diseases
    K01367  CAPN1; calpain-1
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K01367  CAPN1; calpain-1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01367  CAPN1; calpain-1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.52  calpain-1
     K01367  CAPN1; calpain-1
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C2: calpain family
   K01367  CAPN1; calpain-1
Other DBs
GO: 0004198
Genes
HSA: 823(CAPN1)
PTR: 451317(CAPN1)
PPS: 100975624(CAPN1)
GGO: 101139860(CAPN1)
PON: 100174090(CAPN1)
NLE: 100605026(CAPN1)
MCC: 716618(CAPN1)
MCF: 101867512(CAPN1)
CSAB: 103230332(CAPN1)
RRO: 104662820(CAPN1)
RBB: 108543285(CAPN1)
CJC: 100411931(CAPN1)
SBQ: 101034774(CAPN1)
MMU: 12333(Capn1)
MCAL: 110285309(Capn1)
MPAH: 110316020(Capn1)
RNO: 29153(Capn1)
MUN: 110549350(Capn1)
CGE: 100758636(Capn1)
NGI: 103724977(Capn1)
HGL: 101696511(Capn1)
CCAN: 109687155(Capn1)
OCU: 100009089(CAPN1)
TUP: 102482492(CAPN1)
CFA: 483745(CAPN1)
VVP: 112924271(CAPN1)
AML: 100468407(CAPN1)
UMR: 103679450(CAPN1)
UAH: 113244126(CAPN1)
ORO: 101386731(CAPN1)
ELK: 111149415
FCA: 101096916(CAPN1)
PTG: 102955453(CAPN1)
PPAD: 109246719(CAPN1)
AJU: 106971147(CAPN1)
BTA: 281661(CAPN1)
BOM: 102283099(CAPN1)
BIU: 109554508(CAPN1)
BBUB: 102406040(CAPN1)
CHX: 100861313(CAPN1)
OAS: 443130(CAPN1)
SSC: 397027(CAPN1)
CFR: 102517688(CAPN1)
CDK: 105102612(CAPN1)
BACU: 103013016(CAPN1)
LVE: 103069107(CAPN1)
OOR: 101287191(CAPN1)
DLE: 111183768(CAPN1)
PCAD: 102984504(CAPN1)
ECB: 100051106(CAPN1)
EPZ: 103559156(CAPN1)
EAI: 106833590(CAPN1)
MYB: 102249013(CAPN1)
MYD: 102770312(CAPN1)
MNA: 107533638(CAPN1)
HAI: 109384300(CAPN1)
DRO: 112317121(CAPN1)
PALE: 102891365(CAPN1)
RAY: 107497519(CAPN1)
MJV: 108399216(CAPN1)
LAV: 100658150(CAPN1)
TMU: 101341766
MDO: 100030405(CAPN1)
SHR: 100927376(CAPN1)
PCW: 110195314(CAPN1) 110213557(CAPN11)
OAA: 100092537(CAPN11) 100680746(CAPN1)
GGA: 396240(CAPN11) 693249(CAPN1)
MGP: 100549763(CAPN11)
CJO: 107307079(CAPN1) 107311285(CAPN11)
NMEL: 110395367(CAPN11)
APLA: 101793085(CAPN11) 101794453
ACYG: 106048204(CAPN11) 106049805(CAPN1)
TGU: 100232236(CAPN11)
LSR: 110478839(CAPN1) 110481680(CAPN11)
SCAN: 103817882(CAPN11) 103824981(CAPN1)
GFR: 102035321(CAPN11) 102043510(CAPN1)
FAB: 101816358(CAPN11) 101818353
PHI: 102099356(CAPN11) 102102785(CAPN1)
PMAJ: 107202038(CAPN11)
CCAE: 111927556(CAPN11)
CCW: 104684409(CAPN11)
ETL: 114059349(CAPN11)
FPG: 101911941(CAPN1) 101913440(CAPN11)
FCH: 102045859(CAPN11) 102058565(CAPN1)
CLV: 102090692
EGZ: 104132723(CAPN11)
NNI: 104008776 104021518(CAPN11)
ACUN: 113478451(CAPN11)
PADL: 103922858(CAPN11)
AAM: 106485511(CAPN11) 106494368(CAPN1)
ASN: 102368421(CAPN11) 102375021(CAPN1)
AMJ: 102557663(CAPN11) 102561469(CAPN1)
PSS: 102448184(CAPN11) 102458417(CAPN1)
CMY: 102940343(CAPN1)
CPIC: 101935497(CAPN1) 101953330(CAPN11)
PVT: 110070204(CAPN1) 110074688(CAPN11)
PBI: 103061442 103062813(CAPN1)
PMUR: 107294378(CAPN1) 107294458
TSR: 106543129(CAPN11) 106553714
PMUA: 114586334(CAPN1) 114594533(CAPN11)
GJA: 107111051(CAPN1) 107115263(CAPN11)
XLA: 380177(capn1) 398288 398772 447208
XTR: 541454(capn11) 541455(capn1)
NPR: 108785269(CAPN1) 108802349
DRE: 393417(capn1a) 406768(capn1) 553353(si:ch211-202f3.3) 565106(capn1b) 565825(si:dkeyp-50d11.2)
LCM: 102347136(CAPN1) 102363773(CAPN11)
CMK: 103177926(capn1)
RTP: 109926169
 » show all
Reference
PMID:3017764
  Authors
Aoki K, Imajoh S, Ohno S, Emori Y, Koike M, Kosaki G, Suzuki K
  Title
Complete amino acid sequence of the large subunit of the low-Ca2+-requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence.
  Journal
FEBS Lett 205:313-7 (1986)
DOI:10.1016/0014-5793(86)80919-x
  Sequence
[hsa:823]
Reference
  Authors
Arnandis T, Ferrer-Vicens I, Torres L, Garcia C, Garcia-Trevijano ER, Zaragoza R, Vina JR
  Title
Differential functions of calpain 1 during epithelial cell death and adipocyte differentiation in mammary gland involution.
  Journal
Biochem J 459:355-68 (2014)
DOI:10.1042/BJ20130847
  Sequence
[mmu:12333]
LinkDB

KEGG   ORTHOLOGY: K03853
Entry
K03853                      KO                                     

Name
CAPN2
Definition
calpain-2 [EC:3.4.22.53]
Pathway
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04217  Necroptosis
ko04218  Cellular senescence
ko04510  Focal adhesion
ko05010  Alzheimer disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05131  Shigellosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03853  CAPN2; calpain-2
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03853  CAPN2; calpain-2
   04217 Necroptosis
    K03853  CAPN2; calpain-2
   04218 Cellular senescence
    K03853  CAPN2; calpain-2
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K03853  CAPN2; calpain-2
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03853  CAPN2; calpain-2
   05022 Pathways of neurodegeneration - multiple diseases
    K03853  CAPN2; calpain-2
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K03853  CAPN2; calpain-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03853  CAPN2; calpain-2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.53  calpain-2
     K03853  CAPN2; calpain-2
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C2: calpain family
   K03853  CAPN2; calpain-2
Other DBs
GO: 0004198
Genes
HSA: 824(CAPN2)
PTR: 457765(CAPN2)
PPS: 100988890(CAPN2)
GGO: 101149206(CAPN2)
PON: 100445754(CAPN2)
NLE: 100589114(CAPN2)
MCC: 703047(CAPN2)
MCF: 102122692(CAPN2)
CSAB: 103230023(CAPN2)
RRO: 104677285(CAPN2)
RBB: 108528248(CAPN2)
CJC: 100405215(CAPN2)
SBQ: 101035587(CAPN2)
MMU: 12334(Capn2)
MCAL: 110296563(Capn2)
MPAH: 110321506(Capn2)
RNO: 29154(Capn2)
MUN: 110546658(Capn2)
CGE: 100771239(Capn2)
NGI: 103726266(Capn2)
HGL: 101720177(Capn2)
CCAN: 109677038(Capn2)
OCU: 100009092(CAPN2)
TUP: 102481316(CAPN2)
CFA: 480118(CAPN2)
VVP: 112923580(CAPN2)
AML: 100476150(CAPN2)
UMR: 103669131(CAPN2)
UAH: 113262899(CAPN2)
ORO: 101364547(CAPN2)
ELK: 111150685
FCA: 101083231(CAPN2)
PPAD: 109258888(CAPN2)
AJU: 106983173(CAPN2)
BTA: 281662(CAPN2)
BOM: 102276298(CAPN2)
BIU: 109570370(CAPN2)
BBUB: 102415122(CAPN2)
CHX: 102181227(CAPN2)
OAS: 100127211(CAPN2)
SSC: 397393(CAPN2)
CFR: 102512386(CAPN2)
CDK: 105099835(CAPN2)
BACU: 103007207(CAPN2) 103019749
LVE: 103080579(CAPN2)
OOR: 101270285(CAPN2)
DLE: 111177507(CAPN2)
PCAD: 102976041(CAPN2)
ECB: 100055184(CAPN2)
EPZ: 103563904(CAPN2)
EAI: 106829535(CAPN2)
MYB: 102240228(CAPN2)
MYD: 102769788(CAPN2)
MNA: 107543584(CAPN2)
HAI: 109381194(CAPN2)
DRO: 112318759
PALE: 102897695(CAPN2)
RAY: 107498969
MJV: 108400832(CAPN2)
LAV: 100663804(CAPN2)
TMU: 101341399
MDO: 100018672(CAPN2)
SHR: 100922649(CAPN2)
PCW: 110205536(CAPN2)
OAA: 100081577(CAPN2)
GGA: 395963(CAPN2)
MGP: 100546180(CAPN2)
CJO: 107311033(CAPN2)
NMEL: 110395702
APLA: 101799042
ACYG: 106031621(CAPN2)
TGU: 100225408
LSR: 110483833
SCAN: 103819275(CAPN2)
GFR: 102045030(CAPN2)
FAB: 101809391(CAPN2)
PHI: 102111446(CAPN2)
PMAJ: 107202529(CAPN2)
CCAE: 111926249(CAPN2)
CCW: 104685555(CAPN2)
ETL: 114073709(CAPN2)
FPG: 101919959(CAPN2)
FCH: 102048431(CAPN2)
CLV: 102084552
EGZ: 104124542(CAPN2)
NNI: 104019299(CAPN2)
ACUN: 113477955(CAPN2)
PADL: 103925056(CAPN2)
AAM: 106482724(CAPN2)
ASN: 102373508(CAPN2)
AMJ: 102560432(CAPN2)
PSS: 102458713(CAPN2)
CMY: 102937008(CAPN2)
CPIC: 101940996(CAPN2)
ACS: 100561808(capn2)
PVT: 110075406(CAPN2)
PBI: 103056946
PMUR: 107288074(CAPN2)
TSR: 106549641(CAPN2)
PMUA: 114594632(CAPN2)
GJA: 107121636(CAPN2)
XLA: 100127267 108716477 108717697(capn2.2.S) 399075(capn2.2.L)
XTR: 100379861(capn8.5) 100494922 100495980 448035(capn2)
NPR: 108786661 108787073(CAPN2)
DRE: 337730(capn8) 445091(capn2l) 541374(capn2a) 563053(capn2b)
PHYP: 113547581
ALIM: 106515918(capn11) 106536239
LCM: 102347065(CAPN2)
CMK: 103177931
RTP: 109927474
 » show all
Reference
PMID:2852952
  Authors
Imajoh S, Aoki K, Ohno S, Emori Y, Kawasaki H, Sugihara H, Suzuki K
  Title
Molecular cloning of the cDNA for the large subunit of the high-Ca2+-requiring form of human Ca2+-activated neutral protease.
  Journal
Biochemistry 27:8122-8 (1988)
DOI:10.1021/bi00421a022
  Sequence
[hsa:824]
Reference
  Authors
Santos DM, Xavier JM, Morgado AL, Sola S, Rodrigues CM
  Title
Distinct regulatory functions of calpain 1 and 2 during neural stem cell self-renewal and differentiation.
  Journal
PLoS One 7:e33468 (2012)
DOI:10.1371/journal.pone.0033468
  Sequence
[mmu:12334]
LinkDB

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