KEGG   ORTHOLOGY: K01388
Entry
K01388                      KO                                     

Name
MMP1
Definition
matrix metalloproteinase-1 (interstitial collagenase) [EC:3.4.24.7]
Pathway
ko03320  PPAR signaling pathway
ko04657  IL-17 signaling pathway
ko04926  Relaxin signaling pathway
ko05171  Coronavirus disease - COVID-19
ko05200  Pathways in cancer
ko05219  Bladder cancer
ko05323  Rheumatoid arthritis
Disease
H00028  Choriocarcinoma
H01714  Chronic obstructive pulmonary disease (COPD)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04657 IL-17 signaling pathway
    K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase)
  09152 Endocrine system
   03320 PPAR signaling pathway
    K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase)
   04926 Relaxin signaling pathway
    K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase)
  09162 Cancer: specific types
   05219 Bladder cancer
    K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase)
  09163 Immune disease
   05323 Rheumatoid arthritis
    K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase)
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.7  interstitial collagenase
     K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase)
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M10
   K01388  MMP1; matrix metalloproteinase-1 (interstitial collagenase)
Genes
HSA: 4312(MMP1)
PTR: 451510(MMP1)
PPS: 100995251(MMP1)
GGO: 101131051(MMP1)
PON: 100459931(MMP1)
NLE: 100582292(MMP1)
MCC: 703653(MMP1)
MCF: 102142258(MMP1)
CSAB: 103248335(MMP1)
RRO: 104674665(MMP1)
RBB: 108514074(MMP1)
CJC: 100400727(MMP1)
SBQ: 101051246(MMP1)
MMU: 83995(Mmp1a) 83996(Mmp1b)
MPAH: 110327208
RNO: 300338(Mmp1b) 300339(Mmp1)
CGE: 100754854
HGL: 101697620(Mmp1)
CCAN: 109689286(Mmp1)
OCU: 100009110(MMP1)
TUP: 102489479(MMP1) 102490608
CFA: 489428(MMP1)
VVP: 112925907
AML: 100478167(MMP1) 100481181
UMR: 103662453(MMP1) 103662455
FCA: 101083957 101084217(MMP1)
PTG: 102951453 102970572(MMP1)
BTA: 112441463 281308(MMP1)
BOM: 102264402(MMP1)
CHX: 102170620(MMP1)
OAS: 101120355(MMP1)
SSC: 397320(MMP1)
CFR: 102517049(MMP1)
CDK: 105087169(MMP1)
BACU: 103009752(MMP1)
LVE: 103089047(MMP1)
OOR: 101270980(MMP1)
DLE: 111167568(MMP1)
PCAD: 102996438(MMP1)
ECB: 100033896(MMP1)
EPZ: 103552636(MMP1)
EAI: 106843117(MMP1)
MYB: 102253167(MMP1)
MYD: 102770236(MMP1)
MNA: 107532387(MMP1)
HAI: 109376363
DRO: 112317543(MMP1)
PALE: 102893881(MMP1)
RAY: 107504633(MMP1)
MJV: 108385449(MMP1)
LAV: 100656422(MMP1)
TMU: 101341516
MDO: 100012472(MMP1)
SHR: 100915062(MMP1)
PCW: 110215019
OAA: 100078975
GGA: 418982(MMP1)
MGP: 100543241
CJO: 107308399
NMEL: 110389878
APLA: 101798298
ACYG: 106034204
TGU: 100218575
LSR: 110470054
SCAN: 103827284
GFR: 102045551(MMP1)
FAB: 101811360(MMP1)
PHI: 102110938(MMP1)
PMAJ: 107213683
CCAE: 111924335
CCW: 104690063
ETL: 114067040
FPG: 101924590(MMP1)
FCH: 102051111
CLV: 102089808
EGZ: 104128912
NNI: 104023069
ACUN: 113477011
PADL: 103915454
AAM: 106495498
AMJ: 102563438(MMP8) 102563684(MMP1) 109281824
PSS: 102448178
ACS: 100552848
PVT: 110089072
TSR: 106552779
PMUA: 114595663
GJA: 107119159
XLA: 108708733(mmp1.L) 495287(mmp1.S)
XTR: 594916(mmp1)
NPR: 108795960
VEM: 105565628
 » show all
Reference
PMID:2167156
  Authors
Templeton NS, Brown PD, Levy AT, Margulies IM, Liotta LA, Stetler-Stevenson WG
  Title
Cloning and characterization of human tumor cell interstitial collagenase.
  Journal
Cancer Res 50:5431-7 (1990)
  Sequence
[hsa:4312]
Reference
  Authors
Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C
  Title
Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.
  Journal
Biochim Biophys Acta 1803:3-19 (2010)
DOI:10.1016/j.bbamcr.2009.07.004
Reference
  Authors
Amalinei C, Caruntu ID, Balan RA
  Title
Biology of metalloproteinases.
  Journal
Rom J Morphol Embryol 48:323-34 (2007)
LinkDB

KEGG   ORTHOLOGY: K01398
Entry
K01398                      KO                                     

Name
MMP2
Definition
matrix metalloproteinase-2 (gelatinase A) [EC:3.4.24.24]
Pathway
ko01522  Endocrine resistance
ko04670  Leukocyte transendothelial migration
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05219  Bladder cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00025  Penile cancer
H00028  Choriocarcinoma
H00472  Torg syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09152 Endocrine system
   04912 GnRH signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   04915 Estrogen signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   04926 Relaxin signaling pathway
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
   05205 Proteoglycans in cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09162 Cancer: specific types
   05219 Bladder cancer
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.24  gelatinase A
     K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M10
   K01398  MMP2; matrix metalloproteinase-2 (gelatinase A)
Genes
HSA: 4313(MMP2)
PTR: 454094(MMP2)
PPS: 100970966(MMP2)
GGO: 101147102(MMP2)
PON: 100451667(MMP2)
NLE: 100597186(MMP2)
MCC: 698478(MMP2)
MCF: 101865544(MMP2)
CSAB: 103233007(MMP2)
RRO: 104671481(MMP2)
RBB: 108531264(MMP2)
CJC: 100387448(MMP2)
SBQ: 101042210(MMP2)
MMU: 17390(Mmp2)
MCAL: 110299708(Mmp2)
MPAH: 110337240(Mmp2)
RNO: 81686(Mmp2)
MUN: 110545189(Mmp2)
CGE: 100774744(Mmp2)
NGI: 103731682(Mmp2)
HGL: 101696977(Mmp2)
CCAN: 109690723(Mmp2)
OCU: 100009000(MMP2)
TUP: 102483061(MMP2)
CFA: 403733(MMP2)
VVP: 112929621(MMP2)
AML: 100476183(MMP2)
UMR: 103673901(MMP2)
UAH: 113252249(MMP2)
ORO: 101378425(MMP2)
ELK: 111157340
FCA: 101098838(MMP2)
PTG: 102956398(MMP2)
PPAD: 109270907(MMP2)
AJU: 106973291(MMP2)
BTA: 282872(MMP2)
BOM: 102269336(MMP2)
BIU: 109572595(MMP2)
BBUB: 102401701(MMP2)
CHX: 102184364(MMP2)
OAS: 443115(MMP2)
SSC: 397391(MMP2)
CFR: 102521167(MMP2)
CDK: 105097506(MMP2)
BACU: 103016736(MMP2)
LVE: 103071760(MMP2)
OOR: 101275485(MMP2)
DLE: 111164984(MMP2)
PCAD: 102973920(MMP2)
ECB: 100033948(MMP2)
EPZ: 103553197(MMP2)
EAI: 106822484(MMP2)
MYB: 102260608(MMP2)
MYD: 102767174(MMP2)
MNA: 107543503(MMP2)
HAI: 109383663(MMP2)
DRO: 112296673(MMP2)
PALE: 102883808(MMP2)
RAY: 107499669(MMP2)
MJV: 108387896(MMP2)
LAV: 100659450(MMP2)
TMU: 101358817
MDO: 100020585(MMP2)
SHR: 100935012(MMP2)
PCW: 110207503(MMP2)
OAA: 100077120(MMP2) 103166153
GGA: 386583(MMP2)
MGP: 100125331(MMP2)
CJO: 107319190(MMP2)
NMEL: 110404299(MMP2)
APLA: 101802059(MMP2)
ACYG: 106043076(MMP2)
TGU: 100228546(MMP2)
LSR: 110484414(MMP2)
SCAN: 103816631(MMP2)
GFR: 102040497(MMP2)
FAB: 101815345(MMP2)
PHI: 102107059(MMP2)
PMAJ: 107209744(MMP2)
CCAE: 111934584(MMP2)
CCW: 104687474(MMP2)
ETL: 114060386(MMP2)
FPG: 101924896(MMP2)
FCH: 102056005(MMP2)
CLV: 102092170(MMP2)
EGZ: 104125198(MMP2)
NNI: 104016354(MMP2)
ACUN: 113484433(MMP2)
PADL: 103914183(MMP2)
AAM: 106483196(MMP2)
ASN: 102372370(MMP2)
AMJ: 102562302(MMP2)
PSS: 102463152(MMP2)
CMY: 102946066(MMP2)
CPIC: 101941088(MMP2)
ACS: 100557569(mmp2)
PVT: 110082478(MMP2)
PBI: 103055844(MMP2)
PMUR: 107295718(MMP2)
PMUA: 114602200(MMP2)
GJA: 107108344(MMP2)
XLA: 380389(mmp2.S)
XTR: 548506(mmp2)
NPR: 108797889(MMP2)
DRE: 337179(mmp2)
SANH: 107657110(mmp2) 107696695
IPU: 108259638(mmp2)
PHYP: 113540866(mmp2)
EEE: 113590945(mmp2)
TRU: 653022(mmp2)
LCO: 104926945(mmp2)
NCC: 104964801(mmp2)
MZE: 101472680(mmp2)
ONL: 100700606(mmp2)
OLA: 100125419(mmp2)
XMA: 102226344(mmp2)
XCO: 114142975(mmp2)
PRET: 103462668(mmp2)
CVG: 107095465(mmp2)
NFU: 107381256(mmp2)
KMR: 108240277(mmp2)
ALIM: 106517245(mmp2)
AOCE: 111577723(mmp2)
CSEM: 103378988(mmp2)
POV: 109625153(mmp2)
LCF: 108876984(mmp2)
SDU: 111218486(mmp2)
SLAL: 111649502(mmp2)
HCQ: 109513920(mmp2)
BPEC: 110175240(mmp2)
MALB: 109955873(mmp2)
SASA: 100194903(mmp2) 106562416(MMP2)
ELS: 105023458(mmp2)
PKI: 111832721(mmp2) 111858175
LCM: 102350008(MMP2)
CMK: 103176101(mmp2)
RTP: 109921647(mmp2)
CIN: 100181993
 » show all
Reference
PMID:2834383
  Authors
Collier IE, Wilhelm SM, Eisen AZ, Marmer BL, Grant GA, Seltzer JL, Kronberger A, He CS, Bauer EA, Goldberg GI
  Title
H-ras oncogene-transformed human bronchial epithelial cells (TBE-1) secrete a single metalloprotease capable of degrading basement membrane collagen.
  Journal
J Biol Chem 263:6579-87 (1988)
  Sequence
[hsa:4313]
Reference
  Authors
Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C
  Title
Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.
  Journal
Biochim Biophys Acta 1803:3-19 (2010)
DOI:10.1016/j.bbamcr.2009.07.004
Reference
  Authors
Amalinei C, Caruntu ID, Balan RA
  Title
Biology of metalloproteinases.
  Journal
Rom J Morphol Embryol 48:323-34 (2007)
LinkDB

KEGG   ORTHOLOGY: K01403
Entry
K01403                      KO                                     

Name
MMP9
Definition
matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
Pathway
ko01522  Endocrine resistance
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko04670  Leukocyte transendothelial migration
ko04915  Estrogen signaling pathway
ko04926  Relaxin signaling pathway
ko05161  Hepatitis B
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05215  Prostate cancer
ko05219  Bladder cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00025  Penile cancer
H00479  Metaphyseal dysplasias
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
 09150 Organismal Systems
  09151 Immune system
   04657 IL-17 signaling pathway
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   04670 Leukocyte transendothelial migration
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   04926 Relaxin signaling pathway
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05202 Transcriptional misregulation in cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05206 MicroRNAs in cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05205 Proteoglycans in cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  09162 Cancer: specific types
   05219 Bladder cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05215 Prostate cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  09172 Infectious disease: viral
   05161 Hepatitis B
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.35  gelatinase B
     K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M10
   K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
Genes
HSA: 4318(MMP9)
PTR: 458294(MMP9)
PPS: 100974722(MMP9)
GGO: 101138361(MMP9)
PON: 100455867(MMP9)
NLE: 100587873(MMP9)
MCC: 708084(MMP9)
MCF: 102117693(MMP9)
CSAB: 103245064(MMP9)
RBB: 108533326(MMP9)
CJC: 100415095(MMP9)
SBQ: 101036569(MMP9)
MMU: 17395(Mmp9)
MCAL: 110290048(Mmp9)
MPAH: 110318332(Mmp9)
RNO: 81687(Mmp9)
MUN: 110549307(Mmp9)
CGE: 100770707(Mmp9)
NGI: 103751232(Mmp9)
HGL: 101717243(Mmp9)
CCAN: 109689278(Mmp9)
OCU: 100008993(MMP9)
TUP: 102487885(MMP9)
CFA: 403885(MMP9)
VVP: 112931929(MMP9)
AML: 100475429(MMP9)
UMR: 103669705(MMP9)
UAH: 113258671(MMP9)
ORO: 101380511(MMP9)
ELK: 111141396
FCA: 101084185(MMP9)
PTG: 102959269(MMP9)
PPAD: 109272345(MMP9)
AJU: 106969010(MMP9)
BTA: 282871(MMP9)
BOM: 102273141(MMP9)
BIU: 109567506(MMP9)
BBUB: 102414528(MMP9)
CHX: 102168469(MMP9)
OAS: 100192422(MMP9)
SSC: 654325(MMP9)
CFR: 102509767(MMP9)
CDK: 105087845(MMP9)
BACU: 103016628(MMP9)
LVE: 103086240(MMP9)
OOR: 101277919(MMP9)
DLE: 111170142(MMP9)
PCAD: 102977941(MMP9)
ECB: 100056599(MMP9)
EPZ: 103551921(MMP9)
EAI: 106843045(MMP9)
MYB: 102260281(MMP9)
MYD: 102765342(MMP9)
MNA: 107530893(MMP9)
HAI: 109379910(MMP9)
DRO: 112304108(MMP9)
PALE: 102889517(MMP9)
RAY: 107514536(MMP9)
MJV: 108392902(MMP9)
LAV: 100664260(MMP9)
TMU: 101347888
MDO: 100022144(MMP9)
SHR: 100934566(MMP9)
PCW: 110193756(MMP9)
GGA: 395387(MMP9)
MGP: 100540313(MMP9)
CJO: 107323128(MMP9)
NMEL: 110408379(MMP9)
APLA: 101793782(MMP9)
ACYG: 106047143(MMP9)
TGU: 100227728(MMP9)
SCAN: 103818645
GFR: 102042403(MMP9)
FAB: 101813444(MMP9)
PHI: 102112681(MMP9)
PMAJ: 107213224(MMP9)
CCAE: 111938166(MMP9)
CCW: 104687728(MMP9)
ETL: 114063050(MMP9)
FPG: 101912755(MMP9)
FCH: 102053895(MMP9)
CLV: 102094215(MMP9)
EGZ: 104127957(MMP9)
NNI: 104018301(MMP9)
AAM: 106497585(MMP9)
ASN: 102368987(MMP9)
AMJ: 106736975(MMP9)
CMY: 102942105(MMP9)
PVT: 110086226(MMP9) 110089938
PBI: 103064710(MMP9)
PMUR: 107298160
TSR: 106556466(MMP9)
PMUA: 114599897(MMP9)
GJA: 107114899(MMP9)
XLA: 100037129(mmp9.L) 108702732 379663(mmp9.S)
XTR: 100494738(mmp9.2) 448591(mmp9.1)
NPR: 108789114(MMP9)
DRE: 406397(mmp9)
SRX: 107712005(mmp9) 107731127
IPU: 100304980(mmp9) 108265954
PHYP: 113527001
AMEX: 103023931
EEE: 113567502(mmp9)
TRU: 653023(mmp9)
LCO: 104926671(mmp9)
NCC: 104964418(mmp9)
MZE: 101483885(mmp9)
ONL: 100701193(mmp9)
OLA: 100125420(mmp9)
XMA: 102229854(mmp9)
XCO: 114145245(mmp9)
CVG: 107087470(mmp9)
NFU: 107390812(mmp9)
KMR: 108236720(mmp9)
ALIM: 106525577(mmp9)
AOCE: 111583419(mmp9)
CSEM: 103384600(mmp9)
POV: 109630977(mmp9)
LCF: 108876510(mmp9)
SDU: 111219019(mmp9)
SLAL: 111670614(mmp9)
BPEC: 110164611(mmp9)
MALB: 109972052(mmp9)
SASA: 100195428(mmp9) 106566399
ELS: 105023758(mmp9)
SFM: 108931255(mmp9)
PKI: 111855870(mmp9)
LCM: 102358076(MMP9)
CMK: 103191321(mmp9)
RTP: 109913301
 » show all
Reference
PMID:2551898
  Authors
Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI
  Title
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
  Journal
J Biol Chem 264:17213-21 (1989)
  Sequence
[hsa:4318]
Reference
  Authors
Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C
  Title
Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.
  Journal
Biochim Biophys Acta 1803:3-19 (2010)
DOI:10.1016/j.bbamcr.2009.07.004
Reference
  Authors
Amalinei C, Caruntu ID, Balan RA
  Title
Biology of metalloproteinases.
  Journal
Rom J Morphol Embryol 48:323-34 (2007)
Reference
  Authors
Hua H, Li M, Luo T, Yin Y, Jiang Y
  Title
Matrix metalloproteinases in tumorigenesis: an evolving paradigm.
  Journal
Cell Mol Life Sci 68:3853-68 (2011)
DOI:10.1007/s00018-011-0763-x
LinkDB

DBGET integrated database retrieval system