KEGG ORTHOLOGY: K01389

ORTHOLOGY: K01389

Entry

K01389                      KO

Symbol

MME, CD10

Name

neprilysin [EC:3.4.24.11]

Pathway

map04614

Renin-angiotensin system

map04640

Hematopoietic cell lineage

map04974

Protein digestion and absorption

map05010

Alzheimer disease

Disease

H00063

Spinocerebellar ataxia (SCA)

H00264

Charcot-Marie-Tooth disease

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K01389  MME, CD10; neprilysin
  09152 Endocrine system
   04614 Renin-angiotensin system
    K01389  MME, CD10; neprilysin
  09154 Digestive system
   04974 Protein digestion and absorption
    K01389  MME, CD10; neprilysin
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K01389  MME, CD10; neprilysin
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01389  MME, CD10; neprilysin
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01389  MME, CD10; neprilysin
   04090 CD molecules
    K01389  MME, CD10; neprilysin
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.11  neprilysin
     K01389  MME, CD10; neprilysin
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M13: neprilysin family
   K01389  MME, CD10; neprilysin
Exosome [BR:ko04147]
Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K01389  MME, CD10; neprilysin
CD molecules [BR:ko04090]
Proteins
  K01389  CD10, MME; membrane metallo-endopeptidase

Genes

HSA:

4311(MME)

PTR:	460792(MME)

PPS:	100985469(MME)

GGO:	101130840(MME)

PON:	100173750(MME)

NLE:	100587997(MME)

HMH:	116481179(MME)

MCC:	707667(MME)

MCF:	101925772(MME)

MTHB:

126947517

MNI:	105499001(MME)

CSAB:

103241443(MME)

CATY:

105597789(MME)

PANU:

101009712(MME)

TGE:	112618680(MME)

MLEU:

105552397(MME)

RRO:	104668763(MME)

RBB:	108512221(MME)

TFN:	117079579(MME)

PTEH:

111526510(MME)

CANG:

105523937(MME)

CJC:	100387438(MME)

SBQ:	101046081(MME)

CIMI:

108300216(MME)

CSYR:

103261931(MME)

MMUR:

105876660(MME)

LCAT:

123630199(MME)

PCOQ:

105809118(MME)

OGA:	100943156(MME)

MMU:	17380(Mme)

MCAL:

110290750(Mme)

MPAH:

110319726(Mme)

RNO:	24590(Mme)

MCOC:

116092944(Mme)

ANU:	117701816 117707711(Mme)

MUN:	110553985(Mme)

CGE:	100756999(Mme)

MAUA:

101841281(Mme)

PROB:

127232562(Mme)

PLEU:

114710383(Mme)

MORG:

121452919(Mme)

MFOT:

126504862

AAMP:

119826806(Mme)

NGI:	103726236 103740089(Mme)

HGL:	101715828(Mme)

CPOC:

100724320(Mme)

CCAN:

109693062(Mme)

DORD:

105985621(Mme)

DSP:	122112611(Mme)

PLOP:

125352044(Mme) 125367570

NCAR:

124993153

MMMA:

107143294(Mme)

OCU:	100009251(MME)

OPI:	101535249(MME)

TUP:	102478575(MME)

GVR:	103596113(MME)

CFA:	477120(MME)

CLUD:

112652529(MME)

VVP:	112911327(MME)

VLG:	121478714(MME)

NPO:	129507127(MME)

AML:	100474251(MME)

UMR:	103677644(MME)

UAH:	113254091(MME)

UAR:	123801890(MME)

ELK:

111148232

MPUF:

101672244(MME)

MNP:	132012112(MME)

MLK:	131824962(MME)

NVS:	122908622(MME)

ORO:	101369234(MME)

EJU:	114209088(MME)

ZCA:	113917167(MME)

MLX:	118005521(MME)

NSU:	110581591(MME)

LWW:	102745000(MME)

FCA:	101087516(MME)

PYU:	121033874(MME)

PCOO:

112849307(MME)

PBG:	122491827(MME)

PVIV:

125175714(MME)

LRUF:

124526753

PTG:	102956005(MME)

PPAD:

109261526(MME)

PUC:

125921231

AJU:

106974867

HHV:	120234280(MME)

BTA:	536741(MME)

BOM:	102276645(MME)

BIU:	109559100(MME)

BBUB:

102389157(MME)

BBIS:

104992028(MME)

CHX:	102184949(MME)

OAS:	101112618(MME)

BTAX:

128046541(MME)

ODA:	120868534(MME)

CCAD:

122445014(MME)

MBEZ:

129551925(MME)

SSC:	100511536(MME)

CFR:	102510634(MME)

CBAI:

105066623(MME)

CDK:	105094476(MME)

VPC:	102542450(MME)

BACU:

103006902(MME)

BMUS:

118894752(MME)

LVE:

103088815

OOR:	101279513(MME)

DLE:	111179330(MME)

PCAD:

102991612(MME)

PSIU:

116753358(MME)

NASI:

112415923(MME)

ECB:	100053541(MME)

EPZ:	103551466(MME)

EAI:	106836570(MME)

MYB:	102259140(MME)

MYD:	102757655(MME)

MMYO:

118676435(MME)

MLF:	102439754(MME)

PKL:	118723619(MME)

EFUS:

103286671(MME)

MNA:	107544695(MME)

DRO:	112306866(MME)

SHON:

118987483(MME)

AJM:	119041213(MME)

PDIC:

114490570(MME)

PHAS:

123827041(MME)

MMF:	118617160(MME)

PPAM:

129075711(MME)

HAI:	109373662(MME)

RFQ:	117033273(MME)

PALE:

102892831(MME)

PGIG:

120598567(MME)

PVP:	105305828(MME)

RAY:	107507593(MME)

MJV:	108409423(MME)

TOD:	119257895(MME)

SARA:

101554636(MME)

LAV:	100676161(MME)

TMU:

101359371

ETF:	101662978(MME)

DNM:	101427480(MME)

MDO:	100012497(MME)

GAS:	123242813(MME)

SHR:	100920293(MME)

AFZ:

127552807

PCW:	110210116(MME)

OAA:	100092983(MME)

GGA:	425031(MME)

PCOC:

116235458(MME)

MGP:	100544190(MME)

CJO:	107318419(MME)

TPAI:

128081956(MME)

LMUT:

125697761(MME)

NMEL:

110397630(MME)

APLA:

101804711(MME)

ACYG:

106043555(MME)

CATA:

118258019(MME)

AFUL:

116492720(MME)

TGU:	100224600(MME)

LSR:	110476117(MME)

SCAN:

103815257(MME)

PMOA:

120504358(MME)

OTC:	121336656(MME)

PRUF:

121353796(MME)

GFR:	102042553(MME)

FAB:	101806893(MME)

OMA:	130256867(MME)

PHI:	102110334(MME)

PMAJ:

107208825(MME)

CCAE:

111933263(MME)

CCW:	104688087(MME)

CBRC:

103615681(MME)

ETL:	114062920(MME)

ZAB:	102066040(MME)

ACHL:

103807960(MME)

SVG:	106859138(MME)

MMEA:

130583821(MME)

HRT:	120757054(MME)

FPG:	101924415(MME)

FCH:	102059406(MME)

CLV:	102083559(MME)

EGZ:	104122315(MME)

NNI:	104011554(MME)

PCRI:

104030850(MME)

PLET:

104620726(MME)

EHS:	104511035(MME)

PCAO:

104045688(MME)

ACUN:

113483299(MME)

TALA:

104366802(MME)

PADL:

103925256(MME)

AFOR:

103898851(MME)

ACHC:

115347479(MME)

HALD:

104322812(MME)

HLE:	104842528(MME)

AGEN:

126039728

GCL:

127020288

CCRI:

104165924(MME)

CSTI:

104563473(MME)

CMAC:

104484246(MME)

MUI:	104533198(MME)

BREG:

104632707(MME)

FGA:	104076838(MME)

GSTE:

104250971

LDI:	104342956(MME)

MNB:	103768574(MME)

OHA:	104336540(MME)

NNT:	104399031(MME)

SHAB:

115611789(MME)

DPUB:

104305702(MME)

PGUU:

104458014(MME)

ACAR:

104531237(MME)

CPEA:

104395044(MME)

AVIT:

104277784(MME)

CVF:	104285890(MME)

RTD:	128911654(MME)

CUCA:

104065231(MME)

TEO:	104376350(MME)

BRHI:

104499547(MME)

AAM:	106497060(MME)

AROW:

112961970(MME)

NPD:	112952461(MME)

TGT:	104568265(MME)

DNE:	112981326(MME)

SCAM:

104139995(MME)

ASN:	102381364(MME)

AMJ:	102564695(MME)

CPOO:

109308359(MME)

GGN:	109287903(MME)

PSS:	102443820(MME)

CMY:	102942442(MME)

CCAY:

125642848(MME)

DCC:	119861279(MME)

CPIC:

101932856(MME)

TST:	117882606(MME)

CABI:

116828877(MME)

MRV:	120371495(MME)

ACS:	100558527(mme)

ASAO:

132770574(MME)

PVT:	110073080(MME)

SUND:

121926204(MME)

PBI:	103057528(MME)

PMUR:

107288042(MME)

CTIG:

120302375(MME)

TSR:	106538527(MME)

PGUT:

117678261(MME)

APRI:

131200692(MME)

PTEX:

113436917(MME)

NSS:	113410704(MME)

VKO:	123024760(MME)

PMUA:

114597903(MME)

PRAF:

128414684(MME)

ZVI:	118093570(MME)

HCG:	128350829 128350835(MME)

GJA:	107114156(MME)

STOW:

125437874(MME)

EMC:	129332290(MME)

XLA:	108716217(mme.L)

XTR:	101734885(mme)

MUO:	115478631(MME)

GSH:	117366539(MME)

SRX:	107714225 107740972(mme)

SANH:

107670267(mme) 107695447

SGH:	107548962 107550127(mme)

CCAR:

109102924 109109415(mme)

CAUA:

113118535(mme)

CGIB:

PTET:

LROH:

OMC:

PPRM:

RKG:

MAMB:

CIDE:

MASI:

TROS:

TDW:

MANU:

IPU:

IFU:

PHYP:

113534432(mme)

SMEO:

124396008

TFD:

113652724

TVC:

132851452

AMEX:

103041883(mme)

CMAO:

118817870

EEE:	113589488(mme)

CHAR:

105904823

TRU:	101067932(mme)

TFS:

130535116

TNG:	GSTEN00014711G001

LCO:	104927644(mme)

NCC:

TBEN:

CGOB:

PGEO:

GACU:

EMAC:

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116684009(mme)

PFLV:

114550948(mme)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

MSAM:

SCHU:

CUD:

ALAT:

MZE:	101488070(mme)

ONL:	100691568(mme)

OAU:

116323654

OLA:	101170860(mme)

OML:

112149225

CSAI:

133441826

XMA:	102217091(mme) 102217344

XCO:	114161465(mme) 114161469

XHE:	116737452(mme) 116737453

PRET:

103474711(mme) 103474713

PFOR:

103148056 103148057

PLAI:

106959740 106959747

PMEI:

106904215 106904216

GAF:	122832470 122832471 122832560

PPRL:

129370015 129370018 129370019

CVG:	107081874(mme)

CTUL:

119788825

GMU:

124884666

NFU:	107380056(mme)

KMR:

108240951

ALIM:

106519429(mme)

NWH:

119411285

AOCE:

111589102(mme)

MCEP:

125013269

CSEM:

103378377(mme)

POV:	109630371(mme)

SSEN:

HHIP:

HSP:

SMAU:

LCF:

SDU:	111239768(mme)

SLAL:

111652234(mme)

XGL:

120792438

HCQ:	109518499(mme)

SSCV:

SBIA:

PEE:

PTAO:

BPEC:

110163663(mme)

BSPL:

114868344

SJO:

128360530

SASA:

106581480 106613305

STRU:

115163780(mme) 115206649

OTW:	112265738 112267493

OMY:	110503425 110508054

OGO:	123992502 124017736 124027598

ONE:

115137733

OKI:	109887876 109904928(mme)

OKE:	118382731 118396904

SALP:

112072527

SNH:

120018333

CCLU:

121566838 121568479

ELS:	105029340(mme)

SFM:	108932122(mme)

PKI:	111849128(mme)

AANG:

118210400

LOC:	102690021(mme)

PSPA:

121322649 121327203

ARUT:

117417256 117423106

PSEX:

120531795

LCM:	102360975(MME)

CMK:

RTP:

CPLA:

HOC:

LERI:

BBEL:

CIN:

LPIC:

DWI:

DMO:	Dmoj_GI23283

DNV:

DHE:

AGA:

ACOZ:

AAG:	110681070 5570781 5571713

AALB:

109418396 109418398 109418400 109427327 115262953 115263969

CQU:	CpipJ_CPIJ014903 CpipJ_CPIJ014904

CPII:

BCOO:

FVI:

FEX:

NVI:

LBD:	127283718 127290514

MDL:

FAS:

ATD:

BMOR:

BMAN:

ZCE:

HAW:

TNL:

PXY:	105386901 105396533

RMD:

113549318

HVI:	124360849 124372385

MQU:

FCD:

DMK:

PPOI:

RSAN:

119381735 119382111 119385770 119387001 119388765 119389238 119389572 119389575 119391280 119394910 119395848 119398867 119398909 119399701 119402584

VJA:

TUT:

LPOL:

PMEO:

PVUL:

PCAN:

BGT:	106053821 106079514

HRF:

124116915

HRJ:	124280947 124287254

CRG:

105345294

CVN:

111132942

CANU:

128190401 128190585

OED:	125663588 125681313

MYI:

110456504

PMAX:

117344892

DPOL:

127832439

OSN:	115215068 115215167 115215224

» show all

Reference

PMID:2971756

Authors

Letarte M, Vera S, Tran R, Addis JB, Onizuka RJ, Quackenbush EJ, Jongeneel CV, McInnes RR

Title

Common acute lymphocytic leukemia antigen is identical to neutral endopeptidase.

Journal

J Exp Med 168:1247-53 (1988)
DOI:10.1084/jem.168.4.1247

Sequence

[hsa:4311]

Reference

PMID:18363935

Authors

Miners JS, Baig S, Palmer J, Palmer LE, Kehoe PG, Love S

Title

Abeta-degrading enzymes in Alzheimer's disease.

Journal

Brain Pathol 18:240-52 (2008)
DOI:10.1111/j.1750-3639.2008.00132.x

Reference

PMID:7937532

Authors

Bai JP

Title

Distribution of brush-border membrane peptidases along the rat intestine.

Journal

Pharm Res 11:897-900 (1994)
DOI:10.1023/a:1018946228432

LinkDB

DBGET integrated database retrieval system