KEGG   ORTHOLOGY: K01403Help
Entry
K01403                      KO                                     

Name
MMP9
Definition
matrix metalloproteinase-9 (gelatinase B) [EC:3.4.24.35]
Pathway
ko01522  Endocrine resistance
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko04670  Leukocyte transendothelial migration
ko04915  Estrogen signaling pathway
ko04926  Relaxin signaling pathway
ko05161  Hepatitis B
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05215  Prostate cancer
ko05219  Bladder cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00025  Penile cancer
H00479  Metaphyseal dysplasias
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
 09150 Organismal Systems
  09151 Immune system
   04657 IL-17 signaling pathway
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   04670 Leukocyte transendothelial migration
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   04926 Relaxin signaling pathway
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05202 Transcriptional misregulation in cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05206 MicroRNAs in cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05205 Proteoglycans in cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  09162 Cancer: specific types
   05219 Bladder cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
   05215 Prostate cancer
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  09172 Infectious disease: viral
   05161 Hepatitis B
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.35  gelatinase B
     K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
Peptidases and inhibitors [BR:ko01002]
 Metallo peptidases
  Family M10
   K01403  MMP9; matrix metalloproteinase-9 (gelatinase B)
BRITE hierarchy
Genes
HSA: 4318(MMP9)
PTR: 458294(MMP9)
PPS: 100974722(MMP9)
GGO: 101138361(MMP9)
PON: 100455867(MMP9)
NLE: 100587873(MMP9)
MCC: 708084(MMP9)
MCF: 102117693(MMP9)
CSAB: 103245064(MMP9)
RRO: 104678814(MMP9)
RBB: 108533326(MMP9)
CJC: 100415095(MMP9)
SBQ: 101036569(MMP9)
MMU: 17395(Mmp9)
MCAL: 110290048(Mmp9)
MPAH: 110318332(Mmp9)
RNO: 81687(Mmp9)
MUN: 110549307(Mmp9)
CGE: 100770707(Mmp9)
NGI: 103751232(Mmp9)
HGL: 101717243(Mmp9)
CCAN: 109689278(Mmp9)
OCU: 100008993(MMP9)
TUP: 102487885(MMP9)
CFA: 403885(MMP9)
VVP: 112931929(MMP9)
AML: 100475429(MMP9)
UMR: 103669705(MMP9)
UAH: 113258671(MMP9)
ORO: 101380511(MMP9)
FCA: 101084185(MMP9)
PTG: 102959269(MMP9)
PPAD: 109272345(MMP9)
AJU: 106969010(MMP9)
BTA: 282871(MMP9)
BOM: 102273141(MMP9)
BIU: 109567506(MMP9)
BBUB: 102414528(MMP9)
CHX: 102168469(MMP9)
OAS: 100192422(MMP9)
SSC: 654325(MMP9)
CFR: 102509767(MMP9)
CDK: 105087845(MMP9)
BACU: 103016628(MMP9)
LVE: 103086240(MMP9)
OOR: 101277919(MMP9)
DLE: 111170142(MMP9)
PCAD: 102977941(MMP9)
ECB: 100056599(MMP9)
EPZ: 103551921(MMP9)
EAI: 106843045(MMP9)
MYB: 102260281(MMP9)
MYD: 102765342(MMP9)
MNA: 107530893(MMP9)
HAI: 109379910(MMP9)
DRO: 112304108(MMP9)
PALE: 102889517(MMP9)
RAY: 107514536(MMP9)
MJV: 108392902(MMP9)
LAV: 100664260(MMP9)
TMU: 101347888
MDO: 100022144(MMP9)
SHR: 100934566(MMP9)
PCW: 110193756(MMP9)
GGA: 395387(MMP9)
MGP: 100540313(MMP9)
CJO: 107323128(MMP9)
NMEL: 110408379(MMP9)
APLA: 101793782(MMP9)
ACYG: 106047143(MMP9)
TGU: 100227728(MMP9)
SCAN: 103818645
GFR: 102042403(MMP9)
FAB: 101813444(MMP9)
PHI: 102112681(MMP9)
PMAJ: 107213224(MMP9)
CCAE: 111938166(MMP9)
CCW: 104687728(MMP9)
ETL: 114063050(MMP9)
FPG: 101912755(MMP9)
FCH: 102053895(MMP9)
CLV: 102094215(MMP9)
EGZ: 104127957(MMP9)
NNI: 104018301(MMP9)
ACUN: 113487708(MMP9)
PADL: 103923314
AAM: 106497585(MMP9)
ASN: 102368987(MMP9)
AMJ: 106736975(MMP9)
PSS: 106732917
CPIC: 101936391(MMP9)
PBI: 103064710(MMP9)
PMUR: 107298160
TSR: 106556466(MMP9)
GJA: 107114269 107114899(MMP9) 107125021(ELSPBP1)
XLA: 100037129(mmp9.L) 108702732 379663(mmp9.S)
XTR: 100494738(mmp9) 448591(mmp9)
NPR: 108789114(MMP9)
DRE: 406397(mmp9)
IPU: 100304980(mmp9) 108265954
PHYP: 113527001
AMEX: 103023931
EEE: 113567502(mmp9)
TRU: 653023(mmp9)
LCO: 104926671(mmp9)
NCC: 104964418(mmp9)
MZE: 101483885(mmp9)
ONL: 100701193(mmp9)
OLA: 100125420(mmp9)
XMA: 102229854(mmp9)
XCO: 114145245(mmp9)
CVG: 107087470(mmp9)
NFU: 107390812(mmp9)
KMR: 108236720(mmp9)
ALIM: 106525577(mmp9)
AOCE: 111583419(mmp9)
CSEM: 103384600(mmp9)
POV: 109630977(mmp9)
LCF: 108876510(mmp9)
SDU: 111219019(mmp9)
SLAL: 111670614(mmp9)
BPEC: 110164611(mmp9)
MALB: 109972052(mmp9)
SASA: 100195428(mmp9) 106566399
ELS: 105023758(mmp9)
SFM: 108931255(mmp9) 114910772
PKI: 111855870(mmp9)
LCM: 102358076(MMP9)
CMK: 103191321(mmp9)
RTP: 109913301
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2551898
  Authors
Wilhelm SM, Collier IE, Marmer BL, Eisen AZ, Grant GA, Goldberg GI
  Title
SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages.
  Journal
J Biol Chem 264:17213-21 (1989)
  Sequence
[hsa:4318]
Reference
  Authors
Fanjul-Fernandez M, Folgueras AR, Cabrera S, Lopez-Otin C
  Title
Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.
  Journal
Biochim Biophys Acta 1803:3-19 (2010)
DOI:10.1016/j.bbamcr.2009.07.004
Reference
  Authors
Amalinei C, Caruntu ID, Balan RA
  Title
Biology of metalloproteinases.
  Journal
Rom J Morphol Embryol 48:323-34 (2007)
Reference
  Authors
Hua H, Li M, Luo T, Yin Y, Jiang Y
  Title
Matrix metalloproteinases in tumorigenesis: an evolving paradigm.
  Journal
Cell Mol Life Sci 68:3853-68 (2011)
DOI:10.1007/s00018-011-0763-x
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