KEGG   ORTHOLOGY: K01568Help
Entry
K01568                      KO                                     

Name
PDC, pdc
Definition
pyruvate decarboxylase [EC:4.1.1.1]
Pathway
ko00010  Glycolysis / Gluconeogenesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K01568  PDC, pdc; pyruvate decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.1  pyruvate decarboxylase
     K01568  PDC, pdc; pyruvate decarboxylase
BRITE hierarchy
Other DBs
RN: R00014 R00755
COG: COG3961
GO: 0004737
Genes
ATH: AT4G33070 AT5G01320 AT5G01330(PDC3) AT5G54960(PDC2)
ALY: 9302143 9303277 9307000 9307001
CRB: 17875390 17880643 17882212
CSAT: 104708983 104716857 104721511 104726025 104729954 104731233 104734170 104761513
EUS: EUTSA_v10013008mg EUTSA_v10013010mg
BRP: 103844946 103848377 103850424
BNA: 106371229 106411347 106423972 106423973 106427901 106435877
BOE: 106313582 106318780 106324500 106325144
RSZ: 108814219 108818099 108827930
THJ: 104805986 104816205 104823375 104827046
LJA: Lj0g3v0332289.1(Lj0g3v0332289.1) Lj1g3v2372300.1(Lj1g3v2372300.1) Lj6g3v1995950.1(Lj6g3v1995950.1)
DOSA: Os01t0160100-01(Os01g0160100) Os03t0293500-01(Os03g0293500) Os05t0469600-01(Os05g0469600) Os05t0469800-00(Os05g0469800) Os07t0693100-01(Os07g0693100)
ATS: 109733433(LOC109733433) 109756002(LOC109756002) 109773867(LOC109773867) 109777039(LOC109777039) 109785840(LOC109785840) 109785842(LOC109785842)
ZMA: 103634444 103642047 541919(pdc3) 542376(pdc1) 542651(pdc2)
AOF: 109843566
ATR: 18433507
CRE: CHLREDRAFT_127786(PDC3)
APRO: F751_5081
SCE: YDL080C(THI3) YGR087C(PDC6) YLR044C(PDC1) YLR134W(PDC5)
KMX: KLMA_40053(THI3) KLMA_60075(PDC1)
NCS: NCAS_0A04000(NCAS0A04000) NCAS_0A14240(NCAS0A14240) NCAS_0A14630(NCAS0A14630) NCAS_0D01660(NCAS0D01660)
NDI: NDAI_0A01400(NDAI0A01400) NDAI_0A02510(NDAI0A02510) NDAI_0C03110(NDAI0C03110) NDAI_0D03270(NDAI0D03270) NDAI_0E01700(NDAI0E01700)
TPF: TPHA_0G02620(TPHA0G02620) TPHA_0H00950(TPHA0H00950)
TBL: TBLA_0B07520(TBLA0B07520) TBLA_0B08820(TBLA0B08820) TBLA_0B10060(TBLA0B10060) TBLA_0D02840(TBLA0D02840) TBLA_0E03070(TBLA0E03070)
TDL: TDEL_0C07020(TDEL0C07020) TDEL_0E05080(TDEL0E05080) TDEL_0F00150(TDEL0F00150) TDEL_0G03210(TDEL0G03210)
KAF: KAFR_0E01520(KAFR0E01520) KAFR_0E02020(KAFR0E02020) KAFR_0F02990(KAFR0F02990)
PIC: PICST_64926(PDC1) PICST_86443(PDC2)
CDU: CD36_41740 CD36_46050(CaPDC11)
SLB: AWJ20_1628(PDC1) AWJ20_4040(PDC1)
NCR: NCU02193(cfp) NCU02397(ilv-5)
NTE: NEUTE1DRAFT117898(NEUTE1DRAFT_117898) NEUTE1DRAFT123952(NEUTE1DRAFT_123952)
MGR: MGG_01892
SSCK: SPSK_00477
ANG: ANI_1_1024084(An09g01030) ANI_1_2276014(An01g01590) ANI_1_796114(An13g03320) ANI_1_936024(An02g06820)
ZTR: MYCGRDRAFT_40465(PDC1)
CNE: CNJ00950
CNB: CNBJ2540
ABP: AGABI1DRAFT113984(AGABI1DRAFT_113984)
ABV: AGABI2DRAFT193820(AGABI2DRAFT_193820)
MRT: MRET_2230
NGD: NGA_0377300(PDC)
EKF: KO11_18225(pdc-1) KO11_18265(pdc-2) KO11_18305(pdc-3) KO11_18345(pdc-4) KO11_18385(pdc-5) KO11_18425(pdc-6) KO11_18465(pdc-7) KO11_18505(pdc-8) KO11_18545(pdc-9) KO11_18585(pdc-10) KO11_18625(pdc-11) KO11_18665(pdc-12) KO11_18705(pdc-13) KO11_18745(pdc-14) KO11_18785(pdc-15) KO11_18825(pdc-16) KO11_18865(pdc-17) KO11_18905(pdc-18) KO11_18945(pdc-19) KO11_18985(pdc-20)
MICT: FIU95_19035(pdc)
LPN: lpg1155
LPH: LPV_1308
LPO: LPO_1168
LPM: LP6_1136
LPF: lpl1162
LPP: lpp1157
LPC: LPC_0618
LPA: lpa_01798
LPE: lp12_1135
LCJ: NCTC11976_00923(pdc)
BID: Bind_3389
ZMO: ZMO1360
ZMN: Za10_1819
ZMM: Zmob_1740
ZMB: ZZ6_1712
ZMI: ZCP4_1765
ZMC: A265_01761(pdc)
ZMR: A254_01762(pdc)
GOX: GOX1081
GOH: B932_1857
GOY: GLS_c11500(pdc)
GDI: GDI0172(pdc)
GDJ: Gdia_2242
GXY: GLX_13670
GXL: H845_2636
KSC: CD178_01418(pdc)
APK: APA386B_1186(pdc)
ASZ: ASN_888(pdc)
GMR: GmarT_51680(pdc)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3029726
  Authors
Neale AD, Scopes RK, Wettenhall RE, Hoogenraad NJ
  Title
Nucleotide sequence of the pyruvate decarboxylase gene from Zymomonas mobilis.
  Journal
Nucleic Acids Res 15:1753-61 (1987)
DOI:10.1093/nar/15.4.1753
  Sequence
[zmo:ZMO1360]
LinkDB All DBs

KEGG   ENZYME: 4.1.1.1Help
Entry
EC 4.1.1.1                  Enzyme                                 

Name
pyruvate decarboxylase;
alpha-carboxylase (ambiguous);
pyruvic decarboxylase;
alpha-ketoacid carboxylase;
2-oxo-acid carboxy-lyase
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
BRITE hierarchy
Sysname
2-oxo-acid carboxy-lyase (aldehyde-forming)
Reaction(IUBMB)
a 2-oxo carboxylate = an aldehyde + CO2 [RN:R00636]
Reaction(KEGG)
Substrate
2-oxo carboxylate [CPD:C00161]
Product
aldehyde [CPD:C00071];
CO2 [CPD:C00011]
Comment
A thiamine-diphosphate protein. Also catalyses acyloin formation.
History
EC 4.1.1.1 created 1961
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01568  pyruvate decarboxylase
Genes
ATH: AT4G33070 AT5G01320 AT5G01330(PDC3) AT5G54960(PDC2)
ALY: 9302143 9303277 9307000 9307001
CRB: 17875390 17880643 17882212
CSAT: 104708983 104716857 104721511 104726025 104729954 104731233 104734170 104761513
EUS: EUTSA_v10013008mg EUTSA_v10013010mg
BRP: 103844946 103848377 103850424
BNA: 106371229 106411347 106423972 106423973 106427901 106435877
BOE: 106313582 106318780 106324500 106325144
RSZ: 108814219 108818099 108827930
THJ: 104805986 104816205 104823375 104827046
LJA: Lj0g3v0332289.1(Lj0g3v0332289.1) Lj1g3v2372300.1(Lj1g3v2372300.1) Lj6g3v1995950.1(Lj6g3v1995950.1)
DOSA: Os01t0160100-01(Os01g0160100) Os03t0293500-01(Os03g0293500) Os05t0469600-01(Os05g0469600) Os05t0469800-00(Os05g0469800) Os07t0693100-01(Os07g0693100)
ATS: 109733433(LOC109733433) 109756002(LOC109756002) 109773867(LOC109773867) 109777039(LOC109777039) 109785840(LOC109785840) 109785842(LOC109785842)
ZMA: 103634444 103642047 541919(pdc3) 542376(pdc1) 542651(pdc2)
AOF: 109843566
ATR: 18433507
CRE: CHLREDRAFT_127786(PDC3)
APRO: F751_5081
SCE: YDL080C(THI3) YGR087C(PDC6) YLR044C(PDC1) YLR134W(PDC5)
KMX: KLMA_40053(THI3) KLMA_60075(PDC1)
NCS: NCAS_0A04000(NCAS0A04000) NCAS_0A14240(NCAS0A14240) NCAS_0A14630(NCAS0A14630) NCAS_0D01660(NCAS0D01660)
NDI: NDAI_0A01400(NDAI0A01400) NDAI_0A02510(NDAI0A02510) NDAI_0C03110(NDAI0C03110) NDAI_0D03270(NDAI0D03270) NDAI_0E01700(NDAI0E01700)
TPF: TPHA_0G02620(TPHA0G02620) TPHA_0H00950(TPHA0H00950)
TBL: TBLA_0B07520(TBLA0B07520) TBLA_0B08820(TBLA0B08820) TBLA_0B10060(TBLA0B10060) TBLA_0D02840(TBLA0D02840) TBLA_0E03070(TBLA0E03070)
TDL: TDEL_0C07020(TDEL0C07020) TDEL_0E05080(TDEL0E05080) TDEL_0F00150(TDEL0F00150) TDEL_0G03210(TDEL0G03210)
KAF: KAFR_0E01520(KAFR0E01520) KAFR_0E02020(KAFR0E02020) KAFR_0F02990(KAFR0F02990)
PIC: PICST_64926(PDC1) PICST_86443(PDC2)
CDU: CD36_41740 CD36_46050(CaPDC11)
SLB: AWJ20_1628(PDC1) AWJ20_4040(PDC1)
NCR: NCU02193(cfp) NCU02397(ilv-5)
NTE: NEUTE1DRAFT117898(NEUTE1DRAFT_117898) NEUTE1DRAFT123952(NEUTE1DRAFT_123952)
MGR: MGG_01892
SSCK: SPSK_00477
ANG: ANI_1_1024084(An09g01030) ANI_1_2276014(An01g01590) ANI_1_796114(An13g03320) ANI_1_936024(An02g06820)
ZTR: MYCGRDRAFT_40465(PDC1)
CNE: CNJ00950
CNB: CNBJ2540
ABP: AGABI1DRAFT113984(AGABI1DRAFT_113984)
ABV: AGABI2DRAFT193820(AGABI2DRAFT_193820)
MRT: MRET_2230
NGD: NGA_0377300(PDC)
EKF: KO11_18225(pdc-1) KO11_18265(pdc-2) KO11_18305(pdc-3) KO11_18345(pdc-4) KO11_18385(pdc-5) KO11_18425(pdc-6) KO11_18465(pdc-7) KO11_18505(pdc-8) KO11_18545(pdc-9) KO11_18585(pdc-10) KO11_18625(pdc-11) KO11_18665(pdc-12) KO11_18705(pdc-13) KO11_18745(pdc-14) KO11_18785(pdc-15) KO11_18825(pdc-16) KO11_18865(pdc-17) KO11_18905(pdc-18) KO11_18945(pdc-19) KO11_18985(pdc-20)
MICT: FIU95_19035(pdc)
LPN: lpg1155
LPH: LPV_1308
LPO: LPO_1168
LPM: LP6_1136
LPF: lpl1162
LPP: lpp1157
LPC: LPC_0618
LPA: lpa_01798
LPE: lp12_1135
LCJ: NCTC11976_00923(pdc)
BID: Bind_3389
ZMO: ZMO1360
ZMN: Za10_1819
ZMM: Zmob_1740
ZMB: ZZ6_1712
ZMI: ZCP4_1765
ZMC: A265_01761(pdc)
ZMR: A254_01762(pdc)
GOX: GOX1081
GOH: B932_1857
GOY: GLS_c11500(pdc)
GDI: GDI0172(pdc)
GDJ: Gdia_2242
GXY: GLX_13670
GXL: H845_2636
KSC: CD178_01418(pdc)
APK: APA386B_1186(pdc)
ASZ: ASN_888(pdc)
GMR: GmarT_51680(pdc)
 » show all
Taxonomy
Reference
1  [PMID:12980978]
  Authors
SINGER TP, PENSKY J.
  Title
Isolation and properties of the carboxylase of wheat germ.
  Journal
J Biol Chem 196:375-88 (1952)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.1
IUBMB Enzyme Nomenclature: 4.1.1.1
ExPASy - ENZYME nomenclature database: 4.1.1.1
BRENDA, the Enzyme Database: 4.1.1.1
CAS: 9001-04-1
LinkDB All DBs

KEGG   REACTION: R00014Help
Entry
R00014                      Reaction                               

Name
pyruvate:thiamin diphosphate acetaldehydetransferase (decarboxylating)
Definition
Pyruvate + Thiamin diphosphate <=> 2-(alpha-Hydroxyethyl)thiamine diphosphate + CO2
Equation
Comment
2-oxoglutarate dehydrogenase complex: pyruvate dehydrogenase (see R01699), subsequently R03270
TPP-dependent enzymatic reaction (see R00006), subsequently R03050
TPP-dependent enzymatic reaction (see R00226), subsequently R04672
TPP-dependent enzymatic reaction (see R00224), subsequently R00755
TPP-dependent enzymatic reaction (see R08648), subsequently R04673
Reaction class
RC00027  C00068_C05125
RC02744  C00022_C05125
Enzyme
1.2.4.1         2.2.1.6         4.1.1.1
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn00020  Citrate cycle (TCA cycle)
rn00620  Pyruvate metabolism
Orthology
K00161  pyruvate dehydrogenase E1 component alpha subunit [EC:1.2.4.1]
K00162  pyruvate dehydrogenase E1 component beta subunit [EC:1.2.4.1]
K00163  pyruvate dehydrogenase E1 component [EC:1.2.4.1]
K01568  pyruvate decarboxylase [EC:4.1.1.1]
K01652  acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
K01653  acetolactate synthase I/III small subunit [EC:2.2.1.6]
K11258  acetolactate synthase II small subunit [EC:2.2.1.6]
LinkDB All DBs

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