KEGG   ORTHOLOGY: K01593
Entry
K01593                      KO                                     

Name
DDC, TDC
Definition
aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]
Pathway
ko00350  Tyrosine metabolism
ko00360  Phenylalanine metabolism
ko00380  Tryptophan metabolism
ko00901  Indole alkaloid biosynthesis
ko00950  Isoquinoline alkaloid biosynthesis
ko00965  Betalain biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko04361  Axon regeneration
ko04726  Serotonergic synapse
ko04728  Dopaminergic synapse
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
Module
M00037  Melatonin biosynthesis, tryptophan => serotonin => melatonin
M00042  Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Disease
H01161  Aromatic L-amino acid decarboxylase deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   00360 Phenylalanine metabolism
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   00380 Tryptophan metabolism
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
  09110 Biosynthesis of other secondary metabolites
   00901 Indole alkaloid biosynthesis
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   00950 Isoquinoline alkaloid biosynthesis
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   00965 Betalain biosynthesis
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
 09150 Organismal Systems
  09156 Nervous system
   04728 Dopaminergic synapse
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   04726 Serotonergic synapse
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
  09158 Development and regeneration
   04361 Axon regeneration
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
 09160 Human Diseases
  09165 Substance dependence
   05030 Cocaine addiction
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   05031 Amphetamine addiction
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
   05034 Alcoholism
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.1  Carboxy-lyases
    4.1.1.28  aromatic-L-amino-acid decarboxylase
     K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
    4.1.1.105  L-tryptophan decarboxylase
     K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase
Other DBs
RN: R00685 R00699 R00736 R02080 R02701 R04909
COG: COG0076
GO: 0004058 0036469
Genes
HSA: 1644(DDC)
PTR: 463409(DDC)
PPS: 100971531(DDC)
GGO: 101145222(DDC)
PON: 100435277(DDC)
NLE: 100597933(DDC)
MCC: 693677(DDC)
MCF: 102119567(DDC)
CSAB: 103226076(DDC)
RRO: 104657651(DDC)
RBB: 108527366(DDC)
CJC: 100402255(DDC)
SBQ: 101040684(DDC)
MMU: 13195(Ddc)
MCAL: 110305561(Ddc)
MPAH: 110330601(Ddc)
RNO: 24311(Ddc)
MUN: 110554532(Ddc)
CGE: 100761742(Ddc)
NGI: 103746991(Ddc)
HGL: 101697555(Ddc)
CCAN: 109689534(Ddc)
OCU: 100355492(DDC)
TUP: 102499553(DDC)
CFA: 606852(DDC)
VVP: 112925826(DDC)
AML: 100475392(DDC)
UMR: 103674553(DDC)
UAH: 113257543(DDC)
ORO: 101364177(DDC)
ELK: 111157035
FCA: 101082989(DDC)
PTG: 102955370(DDC)
PPAD: 109267969(DDC)
AJU: 106968187(DDC)
BTA: 280762(DDC)
BOM: 102287020(DDC)
BIU: 109558177(DDC)
BBUB: 102405051(DDC)
CHX: 102169726(DDC)
OAS: 101106765(DDC)
SSC: 396857(DDC)
CFR: 102513068(DDC)
CDK: 105105292(DDC)
BACU: 102999539(DDC)
LVE: 103080634(DDC)
OOR: 101290071(DDC)
DLE: 111184555(DDC)
PCAD: 102988654(DDC)
ECB: 100052557(DDC)
EPZ: 103558736 103563419(DDC)
EAI: 106822940(DDC)
MYB: 102254659(DDC)
MYD: 102774614(DDC)
MNA: 107526019(DDC)
HAI: 109388356(DDC)
DRO: 112307000(DDC)
PALE: 102893985(DDC)
RAY: 107512420(DDC)
MJV: 108409738(DDC)
LAV: 100677538(DDC)
TMU: 101348227
MDO: 100030001(DDC)
SHR: 100917570(DDC)
PCW: 110205002(DDC)
OAA: 100074589(DDC)
GGA: 420947(DDC)
MGP: 100542576(DDC)
CJO: 107309491(DDC)
NMEL: 110393205(DDC)
APLA: 101796508(DDC)
ACYG: 106036562(DDC)
TGU: 100226623(DDC)
LSR: 110479536(DDC)
SCAN: 103824172(DDC)
GFR: 102032520(DDC)
FAB: 101811896(DDC)
PHI: 102104958(DDC)
PMAJ: 107216322(DDC)
CCAE: 111925383(DDC)
CCW: 104685862(DDC)
ETL: 114055148(DDC)
FPG: 101922826(DDC)
FCH: 102059671(DDC)
EGZ: 104126196(DDC)
NNI: 104017967 104018896(DDC)
ACUN: 113476218(DDC)
PADL: 103922341(DDC)
AAM: 106492855(DDC)
ASN: 102375703(DDC)
AMJ: 106736839(DDC)
PSS: 102452351(DDC)
CMY: 102937578(DDC)
CPIC: 101939746(DDC)
ACS: 100564794(ddc)
PVT: 110085760(DDC)
PBI: 103055744(DDC)
PMUR: 107287642(DDC)
TSR: 106538958(DDC)
PMUA: 114582385(DDC)
GJA: 107121867(DDC)
XLA: 100126640(ddc.L)
XTR: 496742(ddc)
NPR: 108788303(DDC)
DRE: 406651(ddc)
SANH: 107657571(ddc) 107704081
CCAR: 109066248 109071918(ddc)
IPU: 108275746(ddc)
PHYP: 113533710(ddc)
AMEX: 103039119(ddc)
EEE: 113586562(ddc)
TRU: 101070663(ddc)
LCO: 104939491(ddc)
MZE: 101472888(ddc)
ONL: 100703971(ddc)
OLA: 100301599(ddc)
XMA: 102226428(ddc)
XCO: 114142376(ddc)
PRET: 103478360(ddc)
CVG: 107094111(ddc)
NFU: 107378764(ddc)
KMR: 108232186(ddc)
ALIM: 106514240(ddc)
AOCE: 111573425(ddc)
CSEM: 103388766(ddc)
POV: 109632088(ddc)
LCF: 108888820(ddc)
SDU: 111227826(ddc)
SLAL: 111655924(ddc)
HCQ: 109531054(ddc)
BPEC: 110171777(ddc)
MALB: 109958276(ddc)
ELS: 105025918(ddc)
SFM: 108940501(ddc)
PKI: 111840945(ddc)
CMK: 103181195(ddc)
RTP: 109911430
CIN: 100101815(hdcl) 100182530
APLC: 110989624
DME: Dmel_CG10697(Ddc)
DER: 6549499
DSE: 6614650
DSI: Dsimw501_GD21778(Dsim_Ddc)
DAN: 6498023
DSR: 110181456
DPO: Dpse_GA10503(Dpse_Ddc)
DPE: 6598065
DMN: 108163291
DWI: 6644461
DAZ: 108611630
DNV: 108658877
DHE: 111600378
DVI: 6634251
LCQ: 111686140
AAG: 5563940
CCAL: 108628644
PVM: 113822883
DPTE: 113795103
PTEP: 107451419
CEL: CELE_C05D2.3(basl-1) CELE_C05D2.4(bas-1)
CBR: CBG08967(Cbr-bas-1)
BMY: Bm1_24405
TSP: Tsp_00610
PCAN: 112576021
EGL: EGR_09525
ATH: AT2G20340(AAS)
ALY: 9322341
LJA: Lj0g3v0211149.1(Lj0g3v0211149.1) Lj1g3v4528440.1(Lj1g3v4528440.1) Lj6g3v1679480.1(Lj6g3v1679480.1)
CSV: 101205061
CMO: 103489832
MCHA: 111022679
RCU: 8266698
CANN: 107842494(TDC2) 107877290(TDC1) 107878308
DOSA: Os07t0437500-01(Os07g0437500) Os08t0140300-01(Os08g0140300) Os08t0140500-00(Os08g0140500) Os10t0400500-00(Os10g0400500)
ATS: 109734067(LOC109734067) 109739063(LOC109739063) 109748394(LOC109748394) 109749033(LOC109749033) 109749204(LOC109749204) 109751651(LOC109751651) 109754049(LOC109754049) 109756139(LOC109756139) 109759289(LOC109759289) 109759294(LOC109759294) 109782055(LOC109782055) 109783548(LOC109783548) 109783549(LOC109783549)
SMO: SELMODRAFT_169665(TYDC5-2) SELMODRAFT_84876(TYDC5-1)
CRE: CHLREDRAFT_116869(DDC1)
APRO: F751_5176
NCR: NCU08275
NTE: NEUTE1DRAFT128600(NEUTE1DRAFT_128600)
SSCK: SPSK_03252
MAW: MAC_06737
MAJ: MAA_01165
CMT: CCM_04742
MBE: MBM_06276
ANI: AN2357.2
ANG: ANI_1_2316014(An01g02000)
ABE: ARB_03722
TVE: TRV_07554
PTE: PTT_10253
CNE: CND00950
CNB: CNBD5350
TASA: A1Q1_07845
ABP: AGABI1DRAFT119334(AGABI1DRAFT_119334)
ABV: AGABI2DRAFT185212(AGABI2DRAFT_185212)
MGL: MGL_3372
MRT: MRET_2673
SMIN: v1.2.008729.t1(symbB.v1.2.008729.t1)
SPAR: SPRG_03246
YPE: YPO1193
YPK: y2996(dcd)
YPH: YPC_3018
YPA: YPA_0905
YPN: YPN_2783
YPM: YP_0943(dcd1)
YPZ: YPZ3_1100
YPD: YPD4_1061
YPX: YPD8_1086
YPW: CH59_650
YPJ: CH55_1355
YPV: BZ15_2363
YPL: CH46_3938
YPS: YPTB1234
YPO: BZ17_1292
YPY: YPK_2867
YPB: YPTS_1322
YPQ: DJ40_1004
YPU: BZ21_503
YPR: BZ20_754
YPC: BZ23_833
YPF: BZ19_633
YRU: BD65_352
SRL: SOD_c40120(ddc)
PLU: plu4269
PPU: PP_2552
PPF: Pput_3163
PPT: PPS_2093
PPI: YSA_00462
PPX: T1E_3359
PPUH: B479_10915
PPUT: L483_10035
PPUN: PP4_33460
PPUD: DW66_2355
PMON: X969_08790
PMOT: X970_08450
PFC: PflA506_1055(ddc)
PFB: VO64_4209
PEN: PSEEN2370
PSEC: CCOS191_3137(ELI5)
CYQ: Q91_1616
NOC: Noc_2983
NHL: Nhal_0369
NWA: Nwat_3038
NTT: TAO_0198
WMA: WM2015_41
GAI: IMCC3135_01190(ddc_1)
BSTG: WT74_21605
VEI: Veis_4529
MPT: Mpe_A3338
JAG: GJA_5140
GCA: Galf_1039
SLAC: SKTS_17560
CBLA: CBLAS_1661
DVU: DVU0867
DVL: Dvul_2115
DVM: DvMF_2916
DDE: Dde_1124
SCL: sce2299
SHZ: shn_28130
BJA: bll5848
BRA: BRADO5059
BBT: BBta_5531
BRS: S23_24000
AOL: S58_26260
RPA: RPA4452
RPB: RPB_4283
RPC: RPC_4871
RPD: RPD_4177
RPE: RPE_4837
RPT: Rpal_4944
NWI: Nwi_1102
NHA: Nham_1334
XAU: Xaut_0071
AZC: AZC_4111
MET: M446_1957
MNO: Mnod_1238
MAQU: Maq22A_c11740(gadB)
RVA: Rvan_3231
MSC: BN69_2416
PLEO: OHA_1_02537(ddc)
RBM: TEF_10700
TSV: DSM104635_00811(ddc_1)
SIL: SPO3687
RUT: FIU92_20810(ddc)
JAN: Jann_3501
PGD: Gal_00109
OTM: OSB_14810(ddc_1)
MALG: MALG_00130
RHC: RGUI_0736
LABT: FIU93_03720(ddc1) FIU93_12310(ddc2)
SPSE: SULPSESMR1_00270(ddc)
RID: RIdsm_05196(ddc)
HNE: HNE_0613
GOX: GOX0052
GOH: B932_2473
ACR: Acry_2647
GDI: GDI1891
GDJ: Gdia_0114
GXY: GLX_05560
GXL: H845_1669
KSC: CD178_02401(ddc)
ASZ: ASN_3751
MAG: amb2852
MAGX: XM1_3709
MAGN: WV31_09565
SAUU: SA957_0062
SAMS: NI36_00320
SEP: SE0112
SEPP: SEB_00062
SEPS: DP17_1345
SHA: SH0069
SCA: SCA_2446
SDP: NCTC12225_00163(ddc)
EAC: EAL2_c17260(ddc)
RFA: A3L23_05009(ddc)
SBH: SBI_08556
SMAL: SMALA_8139
SLAU: SLA_6971
KSK: KSE_08450
AUW: AURUGA1_00257(ddc_1)
MPH: MLP_41930(ddc)
KFL: Kfla_4019
GOB: Gobs_3209
BSD: BLASA_2287(tdcA)
MMAR: MODMU_3399(ELI)
SEN: SACE_2888
SACC: EYD13_18150(ddc)
AMYY: YIM_07890(ddc1)
PDX: Psed_3994
PSEA: WY02_04890
AMI: Amir_5685
SESP: BN6_68200
KAL: KALB_5849
ACTI: UA75_21780
ACAD: UA74_21300
AHG: AHOG_18795(ddc2)
RXY: Rxyl_1038
GLJ: GKIL_2961
CAU: Caur_2842
CAG: Cagg_1126
MRB: Mrub_1738
GES: VT84_23180(ddc)
AGV: OJF2_33820(ddc)
ACA: ACP_3028(ddc)
ABAS: ACPOL_3015
ABAC: LuPra_00260(ddc_1) LuPra_06070(ddc_2)
DORI: FH5T_14760
SRU: SRU_1258
SRM: SRM_01447(gadB)
SGN: SGRA_2370
MUC: MuYL_2297
MGOT: MgSA37_02060(ddc)
ZGA: ZOBELLIA_3227(tyrDC)
TMAR: MARIT_1331
IAL: IALB_2412
MRO: MROS_1175
CABY: Cabys_2336
MCJ: MCON_0966
HME: HFX_2597
AG: AAB39708(TDC1) AAB39709(TDC2) CAA47898(TDC)
 » show all
Reference
PMID:2192610
  Authors
Siow YL, Dakshinamurti K
  Title
Neuronal dopa decarboxylase.
  Journal
Ann N Y Acad Sci 585:173-88 (1990)
DOI:10.1111/j.1749-6632.1990.tb28052.x
Reference
  Authors
Koyanagi T, Nakagawa A, Sakurama H, Yamamoto K, Sakurai N, Takagi Y, Minami H, Katayama T, Kumagai H
  Title
Eukaryotic-type aromatic amino acid decarboxylase from the root colonizer Pseudomonas putida is highly specific for 3,4-dihydroxyphenyl-L-alanine, an allelochemical in the rhizosphere.
  Journal
Microbiology 158:2965-74 (2012)
DOI:10.1099/mic.0.062463-0
  Sequence
[ppu:PP_2552]
Reference
PMID:8159173
  Authors
Goddijn OJ, Lohman FP, de Kam RJ, Schilperoort RA, Hoge JH
  Title
Nucleotide sequence of the tryptophan decarboxylase gene of Catharanthus roseus and expression of tdc-gusA gene fusions in Nicotiana tabacum.
  Journal
Mol Gen Genet 242:217-25 (1994)
DOI:10.1007/BF00391016
  Sequence
LinkDB

KEGG   ENZYME: 4.1.1.28
Entry
EC 4.1.1.28                 Enzyme                                 

Name
aromatic-L-amino-acid decarboxylase;
DOPA decarboxylase;
tryptophan decarboxylase;
hydroxytryptophan decarboxylase;
L-DOPA decarboxylase;
aromatic amino acid decarboxylase;
5-hydroxytryptophan decarboxylase;
aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)
Class
Lyases;
Carbon-carbon lyases;
Carboxy-lyases
Sysname
aromatic-L-amino-acid carboxy-lyase
Reaction(IUBMB)
(1) L-dopa = dopamine + CO2 [RN:R02080];
(2) 5-hydroxy-L-tryptophan = 5-hydroxytryptamine + CO2 [RN:R02701]
Reaction(KEGG)
Substrate
L-dopa [CPD:C00355];
5-hydroxy-L-tryptophan [CPD:C00643]
Product
dopamine [CPD:C03758];
CO2 [CPD:C00011];
5-hydroxytryptamine [CPD:C00780]
Comment
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine.
History
EC 4.1.1.28 created 1961 (EC 4.1.1.26 and EC 4.1.1.27 both created 1961 and incorporated 1972)
Pathway
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00380  Tryptophan metabolism
ec00950  Isoquinoline alkaloid biosynthesis
ec00965  Betalain biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K01593  aromatic-L-amino-acid/L-tryptophan decarboxylase
Genes
HSA: 1644(DDC)
PTR: 463409(DDC)
PPS: 100971531(DDC)
GGO: 101145222(DDC)
PON: 100435277(DDC)
NLE: 100597933(DDC)
MCC: 693677(DDC)
MCF: 102119567(DDC)
CSAB: 103226076(DDC)
RRO: 104657651(DDC)
RBB: 108527366(DDC)
CJC: 100402255(DDC)
SBQ: 101040684(DDC)
MMU: 13195(Ddc)
MCAL: 110305561(Ddc)
MPAH: 110330601(Ddc)
RNO: 24311(Ddc)
MUN: 110554532(Ddc)
CGE: 100761742(Ddc)
NGI: 103746991(Ddc)
HGL: 101697555(Ddc)
CCAN: 109689534(Ddc)
OCU: 100355492(DDC)
TUP: 102499553(DDC)
CFA: 606852(DDC)
VVP: 112925826(DDC)
AML: 100475392(DDC)
UMR: 103674553(DDC)
UAH: 113257543(DDC)
ORO: 101364177(DDC)
ELK: 111157035
FCA: 101082989(DDC)
PTG: 102955370(DDC)
PPAD: 109267969(DDC)
AJU: 106968187(DDC)
BTA: 280762(DDC)
BOM: 102287020(DDC)
BIU: 109558177(DDC)
BBUB: 102405051(DDC)
CHX: 102169726(DDC)
OAS: 101106765(DDC)
SSC: 396857(DDC)
CFR: 102513068(DDC)
CDK: 105105292(DDC)
BACU: 102999539(DDC)
LVE: 103080634(DDC)
OOR: 101290071(DDC)
DLE: 111184555(DDC)
PCAD: 102988654(DDC)
ECB: 100052557(DDC)
EPZ: 103558736 103563419(DDC)
EAI: 106822940(DDC)
MYB: 102254659(DDC)
MYD: 102774614(DDC)
MNA: 107526019(DDC)
HAI: 109388356(DDC)
DRO: 112307000(DDC)
PALE: 102893985(DDC)
RAY: 107512420(DDC)
MJV: 108409738(DDC)
LAV: 100677538(DDC)
TMU: 101348227
MDO: 100030001(DDC)
SHR: 100917570(DDC)
PCW: 110205002(DDC)
OAA: 100074589(DDC)
GGA: 420947(DDC)
MGP: 100542576(DDC)
CJO: 107309491(DDC)
NMEL: 110393205(DDC)
APLA: 101796508(DDC)
ACYG: 106036562(DDC)
TGU: 100226623(DDC)
LSR: 110479536(DDC)
SCAN: 103824172(DDC)
GFR: 102032520(DDC)
FAB: 101811896(DDC)
PHI: 102104958(DDC)
PMAJ: 107216322(DDC)
CCAE: 111925383(DDC)
CCW: 104685862(DDC)
ETL: 114055148(DDC)
FPG: 101922826(DDC)
FCH: 102059671(DDC)
EGZ: 104126196(DDC)
NNI: 104017967 104018896(DDC)
ACUN: 113476218(DDC)
PADL: 103922341(DDC)
AAM: 106492855(DDC)
ASN: 102375703(DDC)
AMJ: 106736839(DDC)
PSS: 102452351(DDC)
CMY: 102937578(DDC)
CPIC: 101939746(DDC)
ACS: 100564794(ddc)
PVT: 110085760(DDC)
PBI: 103055744(DDC)
PMUR: 107287642(DDC)
TSR: 106538958(DDC)
PMUA: 114582385(DDC)
GJA: 107121867(DDC)
XLA: 100126640(ddc.L)
XTR: 496742(ddc)
NPR: 108788303(DDC)
DRE: 406651(ddc)
SANH: 107657571(ddc) 107704081
CCAR: 109066248 109071918(ddc)
IPU: 108275746(ddc)
PHYP: 113533710(ddc)
AMEX: 103039119(ddc)
EEE: 113586562(ddc)
TRU: 101070663(ddc)
LCO: 104939491(ddc)
MZE: 101472888(ddc)
ONL: 100703971(ddc)
OLA: 100301599(ddc)
XMA: 102226428(ddc)
XCO: 114142376(ddc)
PRET: 103478360(ddc)
CVG: 107094111(ddc)
NFU: 107378764(ddc)
KMR: 108232186(ddc)
ALIM: 106514240(ddc)
AOCE: 111573425(ddc)
CSEM: 103388766(ddc)
POV: 109632088(ddc)
LCF: 108888820(ddc)
SDU: 111227826(ddc)
SLAL: 111655924(ddc)
HCQ: 109531054(ddc)
BPEC: 110171777(ddc)
MALB: 109958276(ddc)
ELS: 105025918(ddc)
SFM: 108940501(ddc)
PKI: 111840945(ddc)
CMK: 103181195(ddc)
RTP: 109911430
CIN: 100101815(hdcl) 100182530
APLC: 110989624
DME: Dmel_CG10697(Ddc)
DER: 6549499
DSE: 6614650
DSI: Dsimw501_GD21778(Dsim_Ddc)
DAN: 6498023
DSR: 110181456
DPO: Dpse_GA10503(Dpse_Ddc)
DPE: 6598065
DMN: 108163291
DWI: 6644461
DAZ: 108611630
DNV: 108658877
DHE: 111600378
DVI: 6634251
LCQ: 111686140
AAG: 5563940
CCAL: 108628644
PVM: 113822883
DPTE: 113795103
PTEP: 107451419
CEL: CELE_C05D2.3(basl-1) CELE_C05D2.4(bas-1)
CBR: CBG08967(Cbr-bas-1)
BMY: Bm1_24405
TSP: Tsp_00610
PCAN: 112576021
EGL: EGR_09525
ATH: AT2G20340(AAS)
ALY: 9322341
LJA: Lj0g3v0211149.1(Lj0g3v0211149.1) Lj1g3v4528440.1(Lj1g3v4528440.1) Lj6g3v1679480.1(Lj6g3v1679480.1)
CSV: 101205061
CMO: 103489832
MCHA: 111022679
RCU: 8266698
CANN: 107842494(TDC2) 107877290(TDC1) 107878308
DOSA: Os07t0437500-01(Os07g0437500) Os08t0140300-01(Os08g0140300) Os08t0140500-00(Os08g0140500) Os10t0400500-00(Os10g0400500)
ATS: 109734067(LOC109734067) 109739063(LOC109739063) 109748394(LOC109748394) 109749033(LOC109749033) 109749204(LOC109749204) 109751651(LOC109751651) 109754049(LOC109754049) 109756139(LOC109756139) 109759289(LOC109759289) 109759294(LOC109759294) 109782055(LOC109782055) 109783548(LOC109783548) 109783549(LOC109783549)
SMO: SELMODRAFT_169665(TYDC5-2) SELMODRAFT_84876(TYDC5-1)
CRE: CHLREDRAFT_116869(DDC1)
APRO: F751_5176
NCR: NCU08275
NTE: NEUTE1DRAFT128600(NEUTE1DRAFT_128600)
SSCK: SPSK_03252
MAW: MAC_06737
MAJ: MAA_01165
CMT: CCM_04742
MBE: MBM_06276
ANI: AN2357.2
ANG: ANI_1_2316014(An01g02000)
ABE: ARB_03722
TVE: TRV_07554
PTE: PTT_10253
CNE: CND00950
CNB: CNBD5350
TASA: A1Q1_07845
ABP: AGABI1DRAFT119334(AGABI1DRAFT_119334)
ABV: AGABI2DRAFT185212(AGABI2DRAFT_185212)
MGL: MGL_3372
MRT: MRET_2673
SMIN: v1.2.008729.t1(symbB.v1.2.008729.t1)
SPAR: SPRG_03246
YPE: YPO1193
YPK: y2996(dcd)
YPH: YPC_3018
YPA: YPA_0905
YPN: YPN_2783
YPM: YP_0943(dcd1)
YPZ: YPZ3_1100
YPD: YPD4_1061
YPX: YPD8_1086
YPW: CH59_650
YPJ: CH55_1355
YPV: BZ15_2363
YPL: CH46_3938
YPS: YPTB1234
YPO: BZ17_1292
YPY: YPK_2867
YPB: YPTS_1322
YPQ: DJ40_1004
YPU: BZ21_503
YPR: BZ20_754
YPC: BZ23_833
YPF: BZ19_633
YRU: BD65_352
SRL: SOD_c40120(ddc)
PLU: plu4269
PPU: PP_2552
PPF: Pput_3163
PPT: PPS_2093
PPI: YSA_00462
PPX: T1E_3359
PPUH: B479_10915
PPUT: L483_10035
PPUN: PP4_33460
PPUD: DW66_2355
PMON: X969_08790
PMOT: X970_08450
PFC: PflA506_1055(ddc)
PFB: VO64_4209
PEN: PSEEN2370
PSEC: CCOS191_3137(ELI5)
CYQ: Q91_1616
NOC: Noc_2983
NHL: Nhal_0369
NWA: Nwat_3038
NTT: TAO_0198
WMA: WM2015_41
GAI: IMCC3135_01190(ddc_1)
BSTG: WT74_21605
VEI: Veis_4529
MPT: Mpe_A3338
JAG: GJA_5140
GCA: Galf_1039
SLAC: SKTS_17560
CBLA: CBLAS_1661
DVU: DVU0867
DVL: Dvul_2115
DVM: DvMF_2916
DDE: Dde_1124
SCL: sce2299
SHZ: shn_28130
BJA: bll5848
BRA: BRADO5059
BBT: BBta_5531
BRS: S23_24000
AOL: S58_26260
RPA: RPA4452
RPB: RPB_4283
RPC: RPC_4871
RPD: RPD_4177
RPE: RPE_4837
RPT: Rpal_4944
NWI: Nwi_1102
NHA: Nham_1334
XAU: Xaut_0071
AZC: AZC_4111
MET: M446_1957
MNO: Mnod_1238
MAQU: Maq22A_c11740(gadB)
RVA: Rvan_3231
MSC: BN69_2416
PLEO: OHA_1_02537(ddc)
RBM: TEF_10700
TSV: DSM104635_00811(ddc_1)
SIL: SPO3687
RUT: FIU92_20810(ddc)
JAN: Jann_3501
PGD: Gal_00109
OTM: OSB_14810(ddc_1)
MALG: MALG_00130
RHC: RGUI_0736
LABT: FIU93_03720(ddc1) FIU93_12310(ddc2)
SPSE: SULPSESMR1_00270(ddc)
RID: RIdsm_05196(ddc)
HNE: HNE_0613
GOX: GOX0052
GOH: B932_2473
ACR: Acry_2647
GDI: GDI1891
GDJ: Gdia_0114
GXY: GLX_05560
GXL: H845_1669
KSC: CD178_02401(ddc)
ASZ: ASN_3751
MAG: amb2852
MAGX: XM1_3709
MAGN: WV31_09565
SAUU: SA957_0062
SAMS: NI36_00320
SEP: SE0112
SEPP: SEB_00062
SEPS: DP17_1345
SHA: SH0069
SCA: SCA_2446
SDP: NCTC12225_00163(ddc)
EAC: EAL2_c17260(ddc)
RFA: A3L23_05009(ddc)
SBH: SBI_08556
SMAL: SMALA_8139
SLAU: SLA_6971
KSK: KSE_08450
AUW: AURUGA1_00257(ddc_1)
MPH: MLP_41930(ddc)
KFL: Kfla_4019
GOB: Gobs_3209
BSD: BLASA_2287(tdcA)
MMAR: MODMU_3399(ELI)
SEN: SACE_2888
SACC: EYD13_18150(ddc)
AMYY: YIM_07890(ddc1)
PDX: Psed_3994
PSEA: WY02_04890
AMI: Amir_5685
SESP: BN6_68200
KAL: KALB_5849
ACTI: UA75_21780
ACAD: UA74_21300
AHG: AHOG_18795(ddc2)
RXY: Rxyl_1038
GLJ: GKIL_2961
CAU: Caur_2842
CAG: Cagg_1126
MRB: Mrub_1738
GES: VT84_23180(ddc)
AGV: OJF2_33820(ddc)
ACA: ACP_3028(ddc)
ABAS: ACPOL_3015
ABAC: LuPra_00260(ddc_1) LuPra_06070(ddc_2)
DORI: FH5T_14760
SRU: SRU_1258
SRM: SRM_01447(gadB)
SGN: SGRA_2370
MUC: MuYL_2297
MGOT: MgSA37_02060(ddc)
ZGA: ZOBELLIA_3227(tyrDC)
TMAR: MARIT_1331
IAL: IALB_2412
MRO: MROS_1175
CABY: Cabys_2336
MCJ: MCON_0966
HME: HFX_2597
 » show all
Reference
1  [PMID:4536745]
  Authors
Christenson JG, Dairman W, Udenfriend S.
  Title
On the identity of DOPA decarboxylase and 5-hydroxytryptophan decarboxylase (immunological titration-aromatic L-amino acid decarboxylase-serotonin-dopamine-norepinephrine).
  Journal
Proc Natl Acad Sci U S A 69:343-7 (1972)
DOI:10.1073/pnas.69.2.343
Reference
2  [PMID:14466899]
  Authors
LOVENBERG W, WEISSBACH H, UDENFRIEND S.
  Title
Aromatic L-amino acid decarboxylase.
  Journal
J Biol Chem 237:89-93 (1962)
Reference
3  [PMID:18871240]
  Authors
McGILVERY RW, COHEN PP
  Title
The decarboxylation of L-phenylalanine by Streptococcus faecalis R.
  Journal
J Biol Chem 174:813-6 (1948)
Reference
4  [PMID:14054806]
  Authors
SEKERIS CE
  Title
[ON TYROSINE METABOLISM IN INSECTS. XII. PURIFICATION, PROPERTIES AND SUBSTRATE SPECIFICITY OF DOPA-DECARBOXYLASE].
  Journal
Hoppe Seylers Z Physiol Chem 332:70-8 (1963)
DOI:10.1515/bchm2.1963.332.1.70
Reference
5  [PMID:13462983]
  Authors
WEISSBACH H, BOGDANSKI DF, REDFIELD BG, UDENFRIEND S.
  Title
Studies on the effect of vitamin B6 on 5-hydroxytryptamine (serotonin) formation.
  Journal
J Biol Chem 227:617-24 (1957)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.1.28
IUBMB Enzyme Nomenclature: 4.1.1.28
ExPASy - ENZYME nomenclature database: 4.1.1.28
BRENDA, the Enzyme Database: 4.1.1.28
CAS: 9042-64-2
LinkDB

KEGG   REACTION: R00736
Entry
R00736                      Reaction                               

Name
L-tyrosine carboxy-lyase (tyramine-forming)
Definition
L-Tyrosine <=> Tyramine + CO2
Equation
Reaction class
RC00299  C00082_C00483
Enzyme
4.1.1.25        4.1.1.28
Pathway
rn00350  Tyrosine metabolism
rn00680  Methane metabolism
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K01592  tyrosine decarboxylase [EC:4.1.1.25]
K01593  aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]
K18933  tyrosine decarboxylase / aspartate 1-decarboxylase [EC:4.1.1.25 4.1.1.11]
Other DBs
RHEA: 14348
LinkDB

DBGET integrated database retrieval system