KEGG   ORTHOLOGY: K01655
Entry
K01655                      KO                                     
Symbol
LYS21, LYS20
Name
homocitrate synthase [EC:2.3.3.14]
Pathway
map00300  Lysine biosynthesis
map00620  Pyruvate metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map01120  Microbial metabolism in diverse environments
map01210  2-Oxocarboxylic acid metabolism
map01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K01655  LYS21, LYS20; homocitrate synthase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K01655  LYS21, LYS20; homocitrate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.14  homocitrate synthase
     K01655  LYS21, LYS20; homocitrate synthase
Enzymes of 2-oxocarboxylic acid metabolism [br01601.html]
 2-Oxoacid chain elongation
  K01655
Other DBs
RN: R00271
COG: COG0119
GO: 0004410
Genes
QSU: 112011564 112029854
SCE: YDL131W(LYS21) YDL182W(LYS20)
SEUB: DI49_0897
SPAO: SPAR_D00610 SPAR_D01060
AGO: AGOS_ADR107W
ERC: Ecym_8045
KLA: KLLA0_E23695g KLLA0_F05489g
KMX: KLMA_10771(LYS21) KLMA_60493(LYS21)
LTH: KLTH0E12848g KLTH0H02486g
VPO: Kpol_2000p11
NCS: NCAS_0A13800(NCAS0A13800) NCAS_0E03640(NCAS0E03640)
NDI: NDAI_0A02240(NDAI0A02240) NDAI_0A02990(NDAI0A02990)
TPF: TPHA_0P00840(TPHA0P00840)
TBL: TBLA_0A05940(TBLA0A05940)
TDL: TDEL_0B02910(TDEL0B02910) TDEL_0H01490(TDEL0H01490)
KAF: KAFR_0B01160(KAFR0B01160)
KNG: KNAG_0B02880(KNAG0B02880) KNAG_0C04080(KNAG0C04080)
PIC: PICST_28701(LYS21) PICST_89386(LYS22)
SLB: AWJ20_418(LYS21)
BNN: FOA43_003157(LYS21)
BBRX: BRETT_000905(LYS21_1) BRETT_003395(LYS21_2)
NCR: NCU05526(lys-5)
NTE: NEUTE1DRAFT68872(NEUTE1DRAFT_68872)
MGR: MGG_01092
SSCK: SPSK_02501
CMT: CCM_06007
MBE: MBM_09052
ANI: AN1990.2
ANG: ANI_1_1952184(An04g06210)
ALUC: AKAW2_51586A(LYS1_2)
ACHE: ACHE_10778S(LYS1_1)
APUU: APUU_21064S(LYS1_1)
PCS: Pc22g13190(lys1)
ABE: ARB_01923
TVE: TRV_02108
PTE: PTT_15621
SPO: SPBC1105.02c(lys4)
CNE: CND01200
CNB: CNBD5100
TASA: A1Q1_00939
ABP: AGABI1DRAFT114278(AGABI1DRAFT_114278)
ABV: AGABI2DRAFT191298(AGABI2DRAFT_191298)
MORE: E1B28_011484(LYS4_1)
SCM: SCHCO_02503178(SCHCODRAFT_02503178)
MGL: MGL_3987
MRT: MRET_4216
ADE: Adeh_1436
AORY: AMOR_52870
APAU: AMPC_18610
NED: HUN01_23180(lysS)
CAU: Caur_0328
CAG: Cagg_3603
HAU: Haur_3301
THUG: KNN16_06535(lysS)
TTR: Tter_2761
PMET: G4Y79_18420(lysS)
DRA: DR_1238
DGE: Dgeo_1257
DEZ: DKM44_08475(lysS)
DWU: DVJ83_05005(lysS)
DFC: DFI_09345
DEIN: DAAJ005_07905(lysS)
DPH: EHF33_05040(lysS)
DRB: N0D28_09395(lysS)
TRA: Trad_1388
TTH: TT_C1550
TTJ: TTHA1914(TTHA1914)
TSC: TSC_c01850(lysS1)
TAQ: TO73_0091
TANT: KNN15_05095(lysS)
MRB: Mrub_2729
SCOR: J3U87_19125(lysS)
 » show all
Reference
  Authors
Quezada H, Marin-Hernandez A, Aguilar D, Lopez G, Gallardo-Perez JC, Jasso-Chavez R, Gonzalez A, Saavedra E, Moreno-Sanchez R
  Title
The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae.
  Journal
Mol Microbiol 82:578-90 (2011)
DOI:10.1111/j.1365-2958.2011.07832.x
Reference
  Authors
Quezada H, Aranda C, DeLuna A, Hernandez H, Calcagno ML, Marin-Hernandez A, Gonzalez A
  Title
Specialization of the paralogue LYS21 determines lysine biosynthesis under respiratory metabolism in Saccharomyces cerevisiae.
  Journal
Microbiology 154:1656-67 (2008)
DOI:10.1099/mic.0.2008/017103-0
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