KEGG   ORTHOLOGY: K01655Help
Entry
K01655                      KO                                     

Name
LYS21, LYS20
Definition
homocitrate synthase [EC:2.3.3.14]
Pathway
ko00300  Lysine biosynthesis
ko00620  Pyruvate metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K01655  LYS21, LYS20; homocitrate synthase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K01655  LYS21, LYS20; homocitrate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.14  homocitrate synthase
     K01655  LYS21, LYS20; homocitrate synthase
BRITE hierarchy
Other DBs
RN: R00271
COG: COG0119
GO: 0004410
Genes
QSU: 112011564 112029854
SCE: YDL131W(LYS21) YDL182W(LYS20)
AGO: AGOS_ADR107W
ERC: Ecym_8045
KLA: KLLA0_E23695g KLLA0_F05489g
KMX: KLMA_10771(LYS21) KLMA_60493(LYS21)
LTH: KLTH0E12848g KLTH0H02486g
VPO: Kpol_2000p11
ZRO: ZYRO0A13222g ZYRO0C09416g
CGR: CAGL0J06402g CAGL0J09240g
NCS: NCAS_0A13800(NCAS0A13800) NCAS_0E03640(NCAS0E03640)
NDI: NDAI_0A02240(NDAI0A02240) NDAI_0A02990(NDAI0A02990)
TPF: TPHA_0P00840(TPHA0P00840)
TBL: TBLA_0A05940(TBLA0A05940)
TDL: TDEL_0B02910(TDEL0B02910) TDEL_0H01490(TDEL0H01490)
KAF: KAFR_0B01160(KAFR0B01160)
PIC: PICST_28701(LYS21) PICST_89386(LYS22)
SLB: AWJ20_418(LYS21)
NCR: NCU05526(lys-5)
NTE: NEUTE1DRAFT68872(NEUTE1DRAFT_68872)
MGR: MGG_01092
SSCK: SPSK_02501
CMT: CCM_06007
MBE: MBM_09052
ANI: AN1990.2
ANG: ANI_1_1952184(An04g06210)
PCS: Pc22g13190(lys1)
ABE: ARB_01923
TVE: TRV_02108
PTE: PTT_15621
SPO: SPBC1105.02c(lys4)
CNE: CND01200
CNB: CNBD5100
ABP: AGABI1DRAFT114278(AGABI1DRAFT_114278)
ABV: AGABI2DRAFT191298(AGABI2DRAFT_191298)
MGL: MGL_3987
MRT: MRET_4216
ADE: Adeh_1436
CAU: Caur_0328
CAG: Cagg_3603
HAU: Haur_3301
DRA: DR_1238
DGE: Dgeo_1257
DEZ: DKM44_08475(lysS)
DWU: DVJ83_05005(lysS)
DFC: DFI_09345
TRA: Trad_1388
TTH: TT_C1550
TTJ: TTHA1914
TSC: TSC_c01850(lysS1)
TAQ: TO73_0091
MRB: Mrub_2729
TTR: Tter_2761
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Quezada H, Marin-Hernandez A, Aguilar D, Lopez G, Gallardo-Perez JC, Jasso-Chavez R, Gonzalez A, Saavedra E, Moreno-Sanchez R
  Title
The Lys20 homocitrate synthase isoform exerts most of the flux control over the lysine synthesis pathway in Saccharomyces cerevisiae.
  Journal
Mol Microbiol 82:578-90 (2011)
DOI:10.1111/j.1365-2958.2011.07832.x
Reference
  Authors
Quezada H, Aranda C, DeLuna A, Hernandez H, Calcagno ML, Marin-Hernandez A, Gonzalez A
  Title
Specialization of the paralogue LYS21 determines lysine biosynthesis under respiratory metabolism in Saccharomyces cerevisiae.
  Journal
Microbiology 154:1656-67 (2008)
DOI:10.1099/mic.0.2008/017103-0
LinkDB All DBs

KEGG   ORTHOLOGY: K10977Help
Entry
K10977                      KO                                     

Name
aksA
Definition
methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
Pathway
ko00300  Lysine biosynthesis
ko00620  Pyruvate metabolism
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01130  Biosynthesis of antibiotics
ko01210  2-Oxocarboxylic acid metabolism
ko01230  Biosynthesis of amino acids
Module
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K10977  aksA; methanogen homocitrate synthase
  09102 Energy metabolism
   00680 Methane metabolism
    K10977  aksA; methanogen homocitrate synthase
  09105 Amino acid metabolism
   00300 Lysine biosynthesis
    K10977  aksA; methanogen homocitrate synthase
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.3  Acyl groups converted into alkyl groups on transfer
    2.3.3.14  homocitrate synthase
     K10977  aksA; methanogen homocitrate synthase
    2.3.3.-  
     K10977  aksA; methanogen homocitrate synthase
BRITE hierarchy
Other DBs
RN: R00271 R08213 R08331 R08332
COG: COG0119
GO: 0004410
Genes
OTM: OSB_07940(leuA_1)
HAT: RC74_12750
MJA: MJ_0503
MFE: Mefer_0710
MVU: Metvu_1576
MFS: MFS40622_1791
MIF: Metin_1354
MJH: JH146_1425
MIG: Metig_0696
MMP: MMP0153(aksA)
MMD: GYY_00785(aksA)
MAE: Maeo_0994
MVO: Mvol_1568
MTH: MTH_1630
MMG: MTBMA_c02150(leuA2)
METC: MTCT_1489
MWO: MWSIV6_0176(aksA)
METE: tca_01580(leuA_3)
MST: Msp_1099(leuA2)
METB: AW729_10320(aksA)
MSI: Msm_0722
MRU: mru_0385(aksA)
MEB: Abm4_0181(aksA)
MMIL: sm9_2160(aksA)
MEYE: TL18_01070(aksA)
MOL: YLM1_0056
METH: MBMB1_0290(aksA)
MFC: BRM9_1985(aksA)
MFI: DSM1535_0177(aksA)
MCUB: MCBB_0566(aksA)
MSUB: BK009_11615(aksA)
METN: BK008_07190(aksA)
METT: CIT01_06835(aksA)
METO: CIT02_05435(aksA)
MFV: Mfer_0964
MKA: MK1209(leuA)
MAC: MA_3342(leuA)
MBAR: MSBR2_0170
MBAK: MSBR3_1047
MMA: MM_2785
MMAC: MSMAC_1183
METM: MSMTP_1363
MTHE: MSTHC_0289
MTHR: MSTHT_0432
MHOR: MSHOH_1618
MFZ: AOB57_000055(aksA)
MBU: Mbur_0854(cimA)
MMET: MCMEM_0986
MMH: Mmah_1162
MHAZ: BHR79_07725(aksA)
MPY: Mpsy_2899
MTP: Mthe_1533
MCJ: MCON_2596(leuA)
MHI: Mhar_1932
MHU: Mhun_1801
MLA: Mlab_0232
MBG: BN140_1718(aksA)
MEMA: MMAB1_2210(aksA)
MPI: Mpet_2488
MBN: Mboo_0598
MPL: Mpal_2142
MPD: MCP_1960(aksA)
MEZ: Mtc_1560(aksA)
RCI: RCIX2647(leuA-4)
BARB: AOA66_0016(aksA)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9665716
  Authors
Howell DM, Harich K, Xu H, White RH
  Title
Alpha-keto acid chain elongation reactions involved in the biosynthesis of coenzyme B (7-mercaptoheptanoyl threonine phosphate) in methanogenic Archaea.
  Journal
Biochemistry 37:10108-17 (1998)
DOI:10.1021/bi980662p
LinkDB All DBs

KEGG   REACTION: R00271Help
Entry
R00271                      Reaction                               

Name
acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)
Definition
Acetyl-CoA + H2O + 2-Oxoglutarate <=> (R)-2-Hydroxybutane-1,2,4-tricarboxylate + CoA
Equation
Reaction class
RC00004  C00010_C00024
RC00067  C00026_C01251
RC02754  C00024_C01251
Enzyme
Pathway
rn00300  Lysine biosynthesis
rn00620  Pyruvate metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01130  Biosynthesis of antibiotics
rn01210  2-Oxocarboxylic acid metabolism
rn01230  Biosynthesis of amino acids
Module
M00030  Lysine biosynthesis, AAA pathway, 2-oxoglutarate => 2-aminoadipate => lysine
M00433  Lysine biosynthesis, 2-oxoglutarate => 2-oxoadipate
M00608  2-Oxocarboxylic acid chain extension, 2-oxoglutarate => 2-oxoadipate => 2-oxopimelate => 2-oxosuberate
Orthology
K01655  homocitrate synthase [EC:2.3.3.14]
K02594  homocitrate synthase NifV [EC:2.3.3.14]
K10977  methanogen homocitrate synthase [EC:2.3.3.14 2.3.3.-]
Other DBs
RHEA: 12932
LinkDB All DBs

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