KEGG   ORTHOLOGY: K01668
Entry
K01668                      KO                                     

Name
E4.1.99.2
Definition
tyrosine phenol-lyase [EC:4.1.99.2]
Pathway
ko00350  Tyrosine metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00350 Tyrosine metabolism
    K01668  E4.1.99.2; tyrosine phenol-lyase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.99  Other carbon-carbon lyases
    4.1.99.2  tyrosine phenol-lyase
     K01668  E4.1.99.2; tyrosine phenol-lyase
Other DBs
RN: R00728
GO: 0050371
Genes
KQV: B8P98_13910
CKO: CKO_03467
CFD: CFNIH1_09255
CBRA: A6J81_13920
CWE: CO701_18800
CYO: CD187_21020
CPOT: FOB25_08080
CFQ: C2U38_02820
CIF: AL515_04345
CIE: AN232_00695
METY: MRY16398_33370(tpl)
PAM: PANA_3984(tpl)
PLF: PANA5342_p10091(tpl)
PAJ: PAJ_p0025(tpl)
PAQ: PAGR_p073
MMK: MU9_2951
LRI: NCTC12151_02412(tpl)
PMU: PM0811
PMV: PMCN06_0880(tpl)
PMP: Pmu_08910(tpl)
PMUL: DR93_1650
AAT: D11S_1940
AAN: D7S_01988
AACN: AANUM_2335
RPNE: NCTC8284_00313(tpl)
MVS: MVIS_2967(tnaA)
MYA: MORIYA_1533(tnaA)
DNO: DNO_0442
CHJ: NCTC10426_00445(tpl)
OFO: BRW83_0351(tpl)
RGE: RGE_20590(tnaA)
RBN: RBXJA2T_17611(tnaA)
EBA: ebA605(tnaA)
TCL: Tchl_2494
CBLA: CBLAS_0788
ATP: ATR_1949(tnaA)
APOC: APORC_2028(tnaA)
SAT: SYN_01455
RPB: RPB_1966
RPC: RPC_2787
RPD: RPD_3423
RPE: RPE_2915
RPT: Rpal_4083
RVA: Rvan_2623
BVR: BVIR_1448
BLAG: BLTE_20100(tpl)
MSC: BN69_2860
RCP: RCAP_rcc00516(tpl) RCAP_rcc02309(tnaA)
PSF: PSE_0962(tnaA)
RSU: NHU_02389(tnaA)
HNE: HNE_0810
MAGX: XM1_0733(tpl)
MAGN: WV31_12030
CTC: CTC_00818
CCOH: SAMEA4530647_0763(tpl_2)
HSC: HVS_04190(tpl)
STH: STH2842
DSY: DSY3653
DHD: Dhaf_1723
TAE: TepiRe1_2021(tpl)
PUF: UFO1_1418
PFT: JBW_03623
LPIL: LIP_0995
CMD: B841_11865(tnaA)
CHM: B842_02140(tnaA)
SALU: DC74_716
SALL: SAZ_04135(tnaA)
NCA: Noca_1624
AOI: AORI_5366
AJA: AJAP_22805(tpl)
AMYY: YIM_16040(tpl)
AORI: SD37_23450
RCA: Rcas_0866
CAU: Caur_0573
CAG: Cagg_3438
PBF: CFX0092_A2268(tnaA)
DFC: DFI_10615
OTE: Oter_0376
AMU: Amuc_1995
SACI: Sinac_1688
TDE: TDE1118(tpl)
TPED: TPE_1499(tpl)
SUS: Acid_6369
ABAC: LuPra_04134(tpl)
EMI: Emin_0932
FNU: FN1988
TAI: Taci_0642
PCRE: NCTC12858_00848(tpl_1)
PCAG: NCTC12856_00106(tpl_1)
PMUC: ING2E5A_1495(tpl)
DORI: FH5T_08715
SRU: SRU_1708(tnaA)
SRM: SRM_01915(tnaA)
RMR: Rmar_1948
SMIZ: 4412673_01210(tpl_2)
CHZ: CHSO_0681(tnaA)
CTAK: 4412677_01735(tpl_2)
IAL: IALB_2618(tnaA)
DTN: DTL3_0081(tpl)
CABY: Cabys_2412
NMV: NITMOv2_0067(tnaA)
NJA: NSJP_0536(tnaA)
BANA: BARAN1_0718(tpl)
PSYT: DSAG12_02524(tpl)
 » show all
LinkDB

KEGG   ENZYME: 4.1.99.2
Entry
EC 4.1.99.2                 Enzyme                                 

Name
tyrosine phenol-lyase;
beta-tyrosinase;
L-tyrosine phenol-lyase (deaminating)
Class
Lyases;
Carbon-carbon lyases;
Other carbon-carbon lyases
Sysname
L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
Reaction(IUBMB)
L-tyrosine + H2O = phenol + pyruvate + NH3 (overall reaction) [RN:R00728];
(1a) L-tyrosine = phenol + 2-aminoprop-2-enoate;
(1b) 2-aminoprop-2-enoate = 2-iminopropanoate (spontaneous);
(1c) 2-iminopropanoate + H2O = pyruvate + NH3 (spontaneous)
Reaction(KEGG)
R00728
Substrate
L-tyrosine [CPD:C00082];
H2O [CPD:C00001];
2-aminoprop-2-enoate [CPD:C02218];
2-iminopropanoate [CPD:C20904]
Product
phenol [CPD:C00146];
pyruvate [CPD:C00022];
NH3 [CPD:C00014];
2-aminoprop-2-enoate [CPD:C02218];
2-iminopropanoate [CPD:C20904]
Comment
A pyridoxal-phosphate protein. The enzyme cleaves a carbon-carbon bond, releasing phenol and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia. The latter reaction, which can occur spontaneously, can also be catalysed by EC 3.5.99.10, 2-iminobutanoate/2-iminopropanoate deaminase. The enzyme also slowly catalyses similar reactions with D-tyrosine, S-methyl-L-cysteine, L-cysteine, L-serine and D-serine.
History
EC 4.1.99.2 created 1972
Pathway
ec00350  Tyrosine metabolism
Orthology
K01668  tyrosine phenol-lyase
Genes
KQV: B8P98_13910
CKO: CKO_03467
CFD: CFNIH1_09255
CBRA: A6J81_13920
CWE: CO701_18800
CYO: CD187_21020
CPOT: FOB25_08080
CFQ: C2U38_02820
CIF: AL515_04345
CIE: AN232_00695
METY: MRY16398_33370(tpl)
PAM: PANA_3984(tpl)
PLF: PANA5342_p10091(tpl)
PAJ: PAJ_p0025(tpl)
PAQ: PAGR_p073
MMK: MU9_2951
LRI: NCTC12151_02412(tpl)
PMU: PM0811
PMV: PMCN06_0880(tpl)
PMP: Pmu_08910(tpl)
PMUL: DR93_1650
AAT: D11S_1940
AAN: D7S_01988
AACN: AANUM_2335
RPNE: NCTC8284_00313(tpl)
MVS: MVIS_2967(tnaA)
MYA: MORIYA_1533(tnaA)
DNO: DNO_0442
CHJ: NCTC10426_00445(tpl)
OFO: BRW83_0351(tpl)
RGE: RGE_20590(tnaA)
RBN: RBXJA2T_17611(tnaA)
EBA: ebA605(tnaA)
TCL: Tchl_2494
CBLA: CBLAS_0788
ATP: ATR_1949(tnaA)
APOC: APORC_2028(tnaA)
SAT: SYN_01455
RPB: RPB_1966
RPC: RPC_2787
RPD: RPD_3423
RPE: RPE_2915
RPT: Rpal_4083
RVA: Rvan_2623
BVR: BVIR_1448
BLAG: BLTE_20100(tpl)
MSC: BN69_2860
RCP: RCAP_rcc00516(tpl) RCAP_rcc02309(tnaA)
PSF: PSE_0962(tnaA)
RSU: NHU_02389(tnaA)
HNE: HNE_0810
MAGX: XM1_0733(tpl)
MAGN: WV31_12030
CTC: CTC_00818
CCOH: SAMEA4530647_0763(tpl_2)
HSC: HVS_04190(tpl)
STH: STH2842
DSY: DSY3653
DHD: Dhaf_1723
TAE: TepiRe1_2021(tpl)
PUF: UFO1_1418
PFT: JBW_03623
LPIL: LIP_0995
CMD: B841_11865(tnaA)
CHM: B842_02140(tnaA)
SALU: DC74_716
SALL: SAZ_04135(tnaA)
NCA: Noca_1624
AOI: AORI_5366
AJA: AJAP_22805(tpl)
AMYY: YIM_16040(tpl)
AORI: SD37_23450
RCA: Rcas_0866
CAU: Caur_0573
CAG: Cagg_3438
PBF: CFX0092_A2268(tnaA)
DFC: DFI_10615
OTE: Oter_0376
AMU: Amuc_1995
SACI: Sinac_1688
TDE: TDE1118(tpl)
TPED: TPE_1499(tpl)
SUS: Acid_6369
ABAC: LuPra_04134(tpl)
EMI: Emin_0932
FNU: FN1988
TAI: Taci_0642
PCRE: NCTC12858_00848(tpl_1)
PCAG: NCTC12856_00106(tpl_1)
PMUC: ING2E5A_1495(tpl)
DORI: FH5T_08715
SRU: SRU_1708(tnaA)
SRM: SRM_01915(tnaA)
RMR: Rmar_1948
SMIZ: 4412673_01210(tpl_2)
CHZ: CHSO_0681(tnaA)
CTAK: 4412677_01735(tpl_2)
IAL: IALB_2618(tnaA)
DTN: DTL3_0081(tpl)
CABY: Cabys_2412
NMV: NITMOv2_0067(tnaA)
NJA: NSJP_0536(tnaA)
BANA: BARAN1_0718(tpl)
PSYT: DSAG12_02524(tpl)
 » show all
Reference
1  [PMID:4908868]
  Authors
Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K.
  Title
Tyrosine phenol lyase. I. Purification, crystallization, and properties.
  Journal
J Biol Chem 245:1767-72 (1970)
Reference
2  [PMID:4908869]
  Authors
Kumagai H, Yamada H, Matsui H, Ohkishi H, Ogata K.
  Title
Tyrosine phenol lyase. II. Cofactor requrements.
  Journal
J Biol Chem 245:1773-7 (1970)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.99.2
IUBMB Enzyme Nomenclature: 4.1.99.2
ExPASy - ENZYME nomenclature database: 4.1.99.2
BRENDA, the Enzyme Database: 4.1.99.2
CAS: 9059-31-8
LinkDB

KEGG   REACTION: R00728
Entry
R00728                      Reaction                               

Name
L-tyrosine phenol-lyase (deaminating; pyruvate-forming)
Definition
L-Tyrosine + H2O <=> Phenol + Pyruvate + Ammonia
Equation
Reaction class
RC00355  C00022_C00082
RC00364  C00082_C00146
Enzyme
Pathway
rn00350  Tyrosine metabolism
Orthology
K01668  tyrosine phenol-lyase [EC:4.1.99.2]
Other DBs
RHEA: 21707
LinkDB

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