KEGG   ORTHOLOGY: K01833
Entry
K01833                      KO                                     

Name
TRYS
Definition
trypanothione synthetase/amidase [EC:6.3.1.9 3.5.1.-]
Pathway
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K01833  TRYS; trypanothione synthetase/amidase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.1  In linear amides
    3.5.1.-  
     K01833  TRYS; trypanothione synthetase/amidase
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.1  Acid-D-ammonia (or amine) ligases (amide synthases)
    6.3.1.9  trypanothione synthase
     K01833  TRYS; trypanothione synthetase/amidase
Other DBs
RN: R01917 R01918 R03822 R08350 R08351 R08352 R08353 R08354 R08355
GO: 0047479
Genes
TBR: Tb927.2.4370
TBG: TbgDal_II2440
TCR: 509099.50 509319.90
LMA: LMJF_27_1870(TRYS)
LIF: LINJ_27_1770(TRYS)
LDO: LDBPK_271770
LMI: LMXM_27_1870
LBZ: LBRM_27_2010
LPAN: LPMP_271850(TRYS)
AG: AAC39132(TRS)
Reference
PMID:9677355
  Authors
Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH.
  Title
Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata.
  Journal
J Biol Chem 273:19383-90 (1998)
DOI:10.1074/jbc.273.31.19383
  Sequence
Reference
  Authors
Oza SL, Tetaud E, Ariyanayagam MR, Warnon SS, Fairlamb AH.
  Title
A single enzyme catalyses formation of Trypanothione from glutathione and spermidine in Trypanosoma cruzi.
  Journal
J Biol Chem 277:35853-61 (2002)
DOI:10.1074/jbc.M204403200
  Sequence
[tcr:509099.50]
Reference
  Authors
Oza SL, Ariyanayagam MR, Aitcheson N, Fairlamb AH.
  Title
Properties of trypanothione synthetase from Trypanosoma brucei.
  Journal
Mol Biochem Parasitol 131:25-33 (2003)
DOI:10.1016/S0166-6851(03)00176-2
  Sequence
Reference
  Authors
Oza SL, Shaw MP, Wyllie S, Fairlamb AH.
  Title
Trypanothione biosynthesis in Leishmania major.
  Journal
Mol Biochem Parasitol 139:107-16 (2005)
DOI:10.1016/j.molbiopara.2004.10.004
  Sequence
LinkDB

KEGG   REACTION: R01918
Entry
R01918                      Reaction                               

Name
gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase
Definition
Glutathionylspermidine + H2O <=> Glutathione + Spermidine
Equation
Reaction class
RC00090  C00051_C05730
RC00096  C00315_C05730
Enzyme
3.5.1.78        3.5.1.-
Pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Orthology
K01460  glutathionylspermidine amidase/synthetase [EC:3.5.1.78 6.3.1.8]
K01833  trypanothione synthetase/amidase [EC:6.3.1.9 3.5.1.-]
Other DBs
RHEA: 17176
LinkDB

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