KEGG   ORTHOLOGY: K01837Help
Entry
K01837                      KO                                     

Name
BPGM
Definition
bisphosphoglycerate/phosphoglycerate mutase [EC:5.4.2.4 5.4.2.11]
Pathway
ko00010  Glycolysis / Gluconeogenesis
ko00260  Glycine, serine and threonine metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
Disease
H00664  Anemia due to disorders of glycolytic enzymes
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K01837  BPGM; bisphosphoglycerate/phosphoglycerate mutase
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    K01837  BPGM; bisphosphoglycerate/phosphoglycerate mutase
Enzymes [BR:ko01000]
 5. Isomerases
  5.4  Intramolecular transferases
   5.4.2  Phosphotransferases (phosphomutases)
    5.4.2.4  bisphosphoglycerate mutase
     K01837  BPGM; bisphosphoglycerate/phosphoglycerate mutase
    5.4.2.11  phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)
     K01837  BPGM; bisphosphoglycerate/phosphoglycerate mutase
BRITE hierarchy
Other DBs
RN: R01516 R01518 R01662
GO: 0004082
Genes
HSA: 669(BPGM)
PTR: 463746(BPGM)
PPS: 100967755(BPGM)
GGO: 101148078(BPGM)
PON: 100445966(BPGM)
NLE: 100586238(BPGM)
MCC: 706741(BPGM)
MCF: 101925598(BPGM)
CSAB: 103226934(BPGM)
RRO: 104655279(BPGM) 104657786
RBB: 108522539(BPGM)
CJC: 100386672(BPGM)
SBQ: 101031409(BPGM)
MMU: 12183(Bpgm)
MCAL: 110296243(Bpgm)
MPAH: 110316482(Bpgm)
RNO: 296973(Bpgm)
MUN: 110561663(Bpgm)
CGE: 100757548(Bpgm)
NGI: 103726061(Bpgm)
HGL: 101706859(Bpgm)
CCAN: 109688796
OCU: 100009096(BPGM)
TUP: 102496494(BPGM)
CFA: 482704(BPGM)
VVP: 112908884(BPGM)
AML: 100479620(BPGM)
UMR: 103678255(BPGM)
UAH: 113264369(BPGM)
ORO: 101365932(BPGM)
ELK: 111151975
FCA: 101095644(BPGM)
PTG: 102952979(BPGM)
PPAD: 109269034(BPGM)
AJU: 106975708(BPGM)
BTA: 112447087 533785(BPGM)
BIU: 109557654(BPGM)
BBUB: 102402470(BPGM)
CHX: 102187916(BPGM)
OAS: 101121089(BPGM)
SSC: 106506774(BPGM)
CFR: 102514048(BPGM)
CDK: 105085404(BPGM)
BACU: 103009787(BPGM) 103015640
LVE: 103089210(BPGM)
OOR: 101286738 101287641(BPGM)
DLE: 111178164(BPGM) 111178314
PCAD: 102985972(BPGM)
ECB: 100065115(BPGM)
EPZ: 103551316(BPGM)
EAI: 106830008(BPGM)
MYB: 102254057(BPGM)
MYD: 102772643(BPGM)
MNA: 107544342(BPGM)
HAI: 109389371(BPGM)
DRO: 112299894(BPGM)
PALE: 102886645(BPGM)
RAY: 107510540(BPGM)
MJV: 108396501(BPGM)
LAV: 100673907(BPGM)
TMU: 101360256
MDO: 100021814(BPGM)
SHR: 100920227(BPGM)
PCW: 110219158(BPGM)
OAA: 100075920(BPGM)
GGA: 418172(BPGM)
MGP: 100546129(BPGM)
CJO: 107314945(BPGM)
NMEL: 110395716(BPGM)
APLA: 101803151(BPGM)
ACYG: 106030917(BPGM)
TGU: 100221163(BPGM)
LSR: 110482586(BPGM)
SCAN: 103820477(BPGM)
GFR: 102033451(BPGM)
FAB: 101817641(BPGM)
PHI: 102108959(BPGM)
PMAJ: 107204390(BPGM)
CCAE: 111928156(BPGM)
CCW: 104692259(BPGM)
ETL: 114066474(BPGM)
FPG: 101915204(BPGM)
FCH: 102046661(BPGM)
CLV: 102089457(BPGM)
EGZ: 104134376(BPGM)
NNI: 104017943(BPGM)
ACUN: 113491488(BPGM)
PADL: 103924352(BPGM)
AAM: 106488955(BPGM)
ASN: 102373803(BPGM)
AMJ: 102568684(BPGM)
PSS: 102447629(BPGM)
CMY: 102946921(BPGM)
CPIC: 101941911(BPGM)
ACS: 100564984(bpgm)
PVT: 110088825(BPGM)
PBI: 103062795(BPGM)
PMUR: 107294354(BPGM)
TSR: 106545025(BPGM)
PMUA: 114605263(BPGM)
GJA: 107125358(BPGM)
XLA: 444102(bpgm.L) 444279(bpgm.S)
XTR: 549353(bpgm)
NPR: 108792024(BPGM)
DRE: 436903(bpgm)
SANH: 107661509
IPU: 108269072(bpgm)
PHYP: 113529410(bpgm)
AMEX: 103029505(bpgm)
EEE: 113579716(bpgm)
TRU: 101074347(bpgm)
LCO: 104940663(bpgm)
NCC: 104946798(bpgm)
MZE: 101473870(bpgm)
ONL: 100708072(bpgm)
OLA: 101172407(bpgm)
XMA: 102233730(bpgm)
XCO: 114133815(bpgm)
PRET: 103465823(bpgm)
CVG: 107095033(bpgm)
NFU: 107388481(bpgm)
KMR: 108229885(bpgm)
ALIM: 106525486(bpgm)
AOCE: 111567052(bpgm)
CSEM: 103380563(bpgm)
POV: 109623942(bpgm)
LCF: 108888560(bpgm)
SDU: 111229658(bpgm)
SLAL: 111651502(bpgm)
HCQ: 109530859(bpgm)
BPEC: 110169450(bpgm)
MALB: 109951197(bpgm)
SASA: 100196266(pmge) 106561646
ELS: 105021856(bpgm)
LCM: 102350982(BPGM)
CMK: 103185559(bpgm)
RTP: 109927982(bpgm)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wang Y, Wei Z, Bian Q, Cheng Z, Wan M, Liu L, Gong W
  Title
Crystal structure of human bisphosphoglycerate mutase.
  Journal
J Biol Chem 279:39132-8 (2004)
DOI:10.1074/jbc.M405982200
  Sequence
[hsa:669]
LinkDB All DBs

KEGG   ENZYME: 5.4.2.4Help
Entry
EC 5.4.2.4                  Enzyme                                 

Name
bisphosphoglycerate mutase;
diphosphoglycerate mutase;
glycerate phosphomutase;
bisphosphoglycerate synthase;
bisphosphoglyceromutase;
biphosphoglycerate synthase;
diphosphoglyceric mutase;
2,3-diphosphoglycerate mutase;
phosphoglyceromutase;
2,3-diphosphoglycerate synthase;
DPGM;
2,3-bisphosphoglycerate mutase;
BPGM;
diphosphoglyceromutase;
2,3-diphosphoglyceromutase
Class
Isomerases;
Intramolecular transferases;
Phosphotransferases (phosphomutases)
BRITE hierarchy
Sysname
3-phospho-D-glycerate 1,2-phosphomutase
Reaction(IUBMB)
3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate [RN:R01662]
Reaction(KEGG)
Substrate
3-phospho-D-glyceroyl phosphate [CPD:C00236]
Product
2,3-bisphospho-D-glycerate [CPD:C01159]
Comment
In the direction shown, this enzyme is phosphorylated by 3-phosphoglyceroyl phosphate, to give phosphoenzyme and 3-phosphoglycerate. The latter is rephosphorylated by the enzyme to yield 2,3-bisphosphoglycerate, but this reaction is slowed by dissociation of 3-phosphoglycerate from the enzyme, which is therefore more active in the presence of added 3-phosphoglycerate. This enzyme also catalyses, slowly, the reaction of EC 5.4.2.11 [phosphoglycerate mutase (2,3-diphosphoglycerate-dependent)] and EC 5.4.2.12 [phosphoglycerate mutase (2,3-diphosphoglycerate-independent)].
History
EC 5.4.2.4 created 1961 as EC 2.7.5.4, transferred 1984 to EC 5.4.2.4
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
Orthology
K01837  bisphosphoglycerate/phosphoglycerate mutase
Genes
HSA: 669(BPGM)
PTR: 463746(BPGM)
PPS: 100967755(BPGM)
GGO: 101148078(BPGM)
PON: 100445966(BPGM)
NLE: 100586238(BPGM)
MCC: 706741(BPGM)
MCF: 101925598(BPGM)
CSAB: 103226934(BPGM)
RRO: 104655279(BPGM) 104657786
RBB: 108522539(BPGM)
CJC: 100386672(BPGM)
SBQ: 101031409(BPGM)
MMU: 12183(Bpgm)
MCAL: 110296243(Bpgm)
MPAH: 110316482(Bpgm)
RNO: 296973(Bpgm)
MUN: 110561663(Bpgm)
CGE: 100757548(Bpgm)
NGI: 103726061(Bpgm)
HGL: 101706859(Bpgm)
CCAN: 109688796
OCU: 100009096(BPGM)
TUP: 102496494(BPGM)
CFA: 482704(BPGM)
VVP: 112908884(BPGM)
AML: 100479620(BPGM)
UMR: 103678255(BPGM)
UAH: 113264369(BPGM)
ORO: 101365932(BPGM)
ELK: 111151975
FCA: 101095644(BPGM)
PTG: 102952979(BPGM)
PPAD: 109269034(BPGM)
AJU: 106975708(BPGM)
BTA: 112447087 533785(BPGM)
BIU: 109557654(BPGM)
BBUB: 102402470(BPGM)
CHX: 102187916(BPGM)
OAS: 101121089(BPGM)
SSC: 106506774(BPGM)
CFR: 102514048(BPGM)
CDK: 105085404(BPGM)
BACU: 103009787(BPGM) 103015640
LVE: 103089210(BPGM)
OOR: 101286738 101287641(BPGM)
DLE: 111178164(BPGM) 111178314
PCAD: 102985972(BPGM)
ECB: 100065115(BPGM)
EPZ: 103551316(BPGM)
EAI: 106830008(BPGM)
MYB: 102254057(BPGM)
MYD: 102772643(BPGM)
MNA: 107544342(BPGM)
HAI: 109389371(BPGM)
DRO: 112299894(BPGM)
PALE: 102886645(BPGM)
RAY: 107510540(BPGM)
MJV: 108396501(BPGM)
LAV: 100673907(BPGM)
TMU: 101360256
MDO: 100021814(BPGM)
SHR: 100920227(BPGM)
PCW: 110219158(BPGM)
OAA: 100075920(BPGM)
GGA: 418172(BPGM)
MGP: 100546129(BPGM)
CJO: 107314945(BPGM)
NMEL: 110395716(BPGM)
APLA: 101803151(BPGM)
ACYG: 106030917(BPGM)
TGU: 100221163(BPGM)
LSR: 110482586(BPGM)
SCAN: 103820477(BPGM)
GFR: 102033451(BPGM)
FAB: 101817641(BPGM)
PHI: 102108959(BPGM)
PMAJ: 107204390(BPGM)
CCAE: 111928156(BPGM)
CCW: 104692259(BPGM)
ETL: 114066474(BPGM)
FPG: 101915204(BPGM)
FCH: 102046661(BPGM)
CLV: 102089457(BPGM)
EGZ: 104134376(BPGM)
NNI: 104017943(BPGM)
ACUN: 113491488(BPGM)
PADL: 103924352(BPGM)
AAM: 106488955(BPGM)
ASN: 102373803(BPGM)
AMJ: 102568684(BPGM)
PSS: 102447629(BPGM)
CMY: 102946921(BPGM)
CPIC: 101941911(BPGM)
ACS: 100564984(bpgm)
PVT: 110088825(BPGM)
PBI: 103062795(BPGM)
PMUR: 107294354(BPGM)
TSR: 106545025(BPGM)
PMUA: 114605263(BPGM)
GJA: 107125358(BPGM)
XLA: 444102(bpgm.L) 444279(bpgm.S)
XTR: 549353(bpgm)
NPR: 108792024(BPGM)
DRE: 436903(bpgm)
SANH: 107661509
IPU: 108269072(bpgm)
PHYP: 113529410(bpgm)
AMEX: 103029505(bpgm)
EEE: 113579716(bpgm)
TRU: 101074347(bpgm)
LCO: 104940663(bpgm)
NCC: 104946798(bpgm)
MZE: 101473870(bpgm)
ONL: 100708072(bpgm)
OLA: 101172407(bpgm)
XMA: 102233730(bpgm)
XCO: 114133815(bpgm)
PRET: 103465823(bpgm)
CVG: 107095033(bpgm)
NFU: 107388481(bpgm)
KMR: 108229885(bpgm)
ALIM: 106525486(bpgm)
AOCE: 111567052(bpgm)
CSEM: 103380563(bpgm)
POV: 109623942(bpgm)
LCF: 108888560(bpgm)
SDU: 111229658(bpgm)
SLAL: 111651502(bpgm)
HCQ: 109530859(bpgm)
BPEC: 110169450(bpgm)
MALB: 109951197(bpgm)
SASA: 100196266(pmge) 106561646
ELS: 105021856(bpgm)
LCM: 102350982(BPGM)
CMK: 103185559(bpgm)
RTP: 109927982(bpgm)
 » show all
Taxonomy
Reference
1
  Authors
Ray, W.J., Jr. and Peck, E.J., Jr.
  Title
Phosphomutases.
  Journal
In: Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 6, 1972, p. 407-477.
Reference
2  [PMID:5687724]
  Authors
Rose ZB.
  Title
The purification and properties of diphosphoglycerate mutase from human erythrocytes.
  Journal
J Biol Chem 243:4810-20 (1968)
Reference
3  [PMID:6255773]
  Authors
Rose ZB.
  Title
The enzymology of 2,3-bisphosphoglycerate.
  Journal
Adv Enzymol Relat Areas Mol Biol 51:211-53 (1980)
DOI:10.1002/9780470122969.ch5
Other DBs
ExplorEnz - The Enzyme Database: 5.4.2.4
IUBMB Enzyme Nomenclature: 5.4.2.4
ExPASy - ENZYME nomenclature database: 5.4.2.4
BRENDA, the Enzyme Database: 5.4.2.4
CAS: 37211-69-1
LinkDB All DBs

KEGG   REACTION: R01662Help
Entry
R01662                      Reaction                               

Name
3-phospho-D-glycerate 1,2-phosphomutase
Definition
3-Phospho-D-glyceroyl phosphate <=> 2,3-Bisphospho-D-glycerate
Equation
Reaction class
RC00579  C00236_C01159
Enzyme
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn01100  Metabolic pathways
Orthology
K01837  bisphosphoglycerate/phosphoglycerate mutase [EC:5.4.2.4 5.4.2.11]
Other DBs
RHEA: 17768
LinkDB All DBs

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