KEGG   ORTHOLOGY: K02084
Entry
K02084                      KO                                     

Name
APAF1
Definition
apoptotic protease-activating factor
Pathway
ko01524  Platinum drug resistance
ko04115  p53 signaling pathway
ko04210  Apoptosis
ko04214  Apoptosis - fly
ko04215  Apoptosis - multiple species
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis
ko05016  Huntington disease
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05134  Legionellosis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05164  Influenza A
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02084  APAF1; apoptotic protease-activating factor
   04214 Apoptosis - fly
    K02084  APAF1; apoptotic protease-activating factor
   04215 Apoptosis - multiple species
    K02084  APAF1; apoptotic protease-activating factor
   04115 p53 signaling pathway
    K02084  APAF1; apoptotic protease-activating factor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02084  APAF1; apoptotic protease-activating factor
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K02084  APAF1; apoptotic protease-activating factor
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02084  APAF1; apoptotic protease-activating factor
   05012 Parkinson disease
    K02084  APAF1; apoptotic protease-activating factor
   05014 Amyotrophic lateral sclerosis
    K02084  APAF1; apoptotic protease-activating factor
   05016 Huntington disease
    K02084  APAF1; apoptotic protease-activating factor
   05020 Prion disease
    K02084  APAF1; apoptotic protease-activating factor
   05022 Pathways of neurodegeneration - multiple diseases
    K02084  APAF1; apoptotic protease-activating factor
  09171 Infectious disease: bacterial
   05134 Legionellosis
    K02084  APAF1; apoptotic protease-activating factor
   05152 Tuberculosis
    K02084  APAF1; apoptotic protease-activating factor
  09172 Infectious disease: viral
   05161 Hepatitis B
    K02084  APAF1; apoptotic protease-activating factor
   05160 Hepatitis C
    K02084  APAF1; apoptotic protease-activating factor
   05164 Influenza A
    K02084  APAF1; apoptotic protease-activating factor
   05162 Measles
    K02084  APAF1; apoptotic protease-activating factor
   05168 Herpes simplex virus 1 infection
    K02084  APAF1; apoptotic protease-activating factor
   05169 Epstein-Barr virus infection
    K02084  APAF1; apoptotic protease-activating factor
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K02084  APAF1; apoptotic protease-activating factor
Genes
HSA: 317(APAF1)
PTR: 452153(APAF1)
PPS: 100995524(APAF1)
GGO: 101135722(APAF1)
PON: 100459074(APAF1)
NLE: 100590369(APAF1)
MCC: 694164(APAF1)
MCF: 102137473(APAF1)
CSAB: 103238923(APAF1)
RRO: 104656342(APAF1)
RBB: 108543462(APAF1)
CJC: 100403825(APAF1)
SBQ: 101048222(APAF1)
MMU: 11783(Apaf1)
MCAL: 110302801(Apaf1)
MPAH: 110326877(Apaf1)
RNO: 78963(Apaf1)
CGE: 100758500
NGI: 103733246(Apaf1)
HGL: 101706721(Apaf1)
CCAN: 109690039(Apaf1)
OCU: 103348383(APAF1)
TUP: 102476798(APAF1)
CFA: 482620(APAF1)
VVP: 112930669(APAF1)
AML: 100464163(APAF1)
UMR: 103660136(APAF1)
UAH: 113256111(APAF1)
ORO: 101383104(APAF1)
ELK: 111142091
FCA: 768257(APAF1)
PTG: 102964536(APAF1)
PPAD: 109265383(APAF1)
AJU: 106973746(APAF1)
BTA: 537782(APAF1)
BOM: 102285660(APAF1)
BIU: 109559418(APAF1)
BBUB: 102396152(APAF1)
CHX: 102188830(APAF1)
OAS: 100135699(APAF1)
SSC: 100513283(APAF1)
CFR: 102516966(APAF1)
CDK: 105097442(APAF1)
BACU: 103006029(APAF1)
LVE: 103069785(APAF1)
OOR: 101280303(APAF1)
DLE: 111187821(APAF1)
PCAD: 102994125(APAF1)
ECB: 100052552(APAF1)
EPZ: 103550811(APAF1)
EAI: 106827252(APAF1)
MYB: 102242936(APAF1)
MYD: 102773861(APAF1)
MNA: 107545129(APAF1)
HAI: 109382336(APAF1)
DRO: 112321814(APAF1)
PALE: 102897687(APAF1)
RAY: 107517482(APAF1)
MJV: 108406748(APAF1)
LAV: 100665091(APAF1)
TMU: 101349393
MDO: 100013051(APAF1)
SHR: 100932636(APAF1)
PCW: 110221734(APAF1)
OAA: 100073402(APAF1)
GGA: 417926(APAF1)
MGP: 100549497(APAF1)
CJO: 107311930(APAF1)
NMEL: 110403055(APAF1)
APLA: 101799443(APAF1)
ACYG: 106036949(APAF1)
TGU: 100222477(APAF1)
LSR: 110469328(APAF1)
SCAN: 103813383(APAF1)
GFR: 102039129(APAF1)
FAB: 101817511(APAF1)
PHI: 102103178(APAF1)
PMAJ: 107204470(APAF1)
CCAE: 111933973(APAF1)
CCW: 104696424(APAF1)
ETL: 114065277(APAF1)
FPG: 101911538(APAF1)
FCH: 102046505(APAF1)
CLV: 102095228(APAF1)
EGZ: 104132316(APAF1)
NNI: 104011661(APAF1)
ACUN: 113491382(APAF1)
PADL: 103914625(APAF1)
AAM: 106488625(APAF1)
ASN: 102371819(APAF1)
AMJ: 102560580(APAF1)
PSS: 102451576(APAF1)
CMY: 102940699(APAF1)
CPIC: 101942057(APAF1)
ACS: 100556318(apaf1)
PVT: 110084192(APAF1)
PBI: 103057709(APAF1)
PMUR: 107290550(APAF1)
TSR: 106547253
PMUA: 114605383(APAF1)
GJA: 107118861(APAF1)
XLA: 444261(apaf1.L)
XTR: 100127738(apaf1)
NPR: 108798110(APAF1)
DRE: 58131(apaf1)
SRX: 107725574(apaf1) 107744928
SANH: 107664840 107695885(apaf1)
SGH: 107576429 107593638(apaf1)
IPU: 108274767(apaf1)
PHYP: 113529624(apaf1)
AMEX: 103032437(apaf1)
TRU: 101076369(apaf1)
LCO: 104925081(apaf1)
NCC: 104967722(apaf1)
MZE: 101470098(apaf1)
ONL: 100701636(apaf1)
OLA: 101158654(apaf1)
XMA: 102220895(apaf1)
XCO: 114160921(apaf1)
PRET: 103459197(apaf1)
CVG: 107101831(apaf1)
NFU: 107373731 107385893(apaf1)
KMR: 108233243(apaf1)
ALIM: 106514788(apaf1)
AOCE: 111578144(apaf1)
CSEM: 103382677(apaf1)
POV: 109632693(apaf1)
LCF: 108889265(apaf1)
SDU: 111224851(apaf1)
SLAL: 111656499(apaf1)
HCQ: 109523695(apaf1)
BPEC: 110161643(apaf1)
MALB: 109959862(apaf1)
ELS: 105020401(apaf1)
SFM: 108931524(apaf1)
PKI: 111846556(apaf1)
LCM: 102354670(APAF1)
CMK: 103187971(apaf1)
RTP: 109932240
BFO: 118419621
APLC: 110975466
SKO: 102804745
DME: Dmel_CG6829(Dark)
DER: 6548165
DSE: 6609536
DSI: Dsimw501_GD11239(Dsim_GD11239)
DSR: 110176079
DPE: 6590833
DMN: 108159879
DWI: 6640154
DAZ: 108615603
DNV: 108653831
DHE: 111599658
MDE: 101889170
LCQ: 111684219
AAG: 5567237
AME: 100578356
BIM: 100748962
BTER: 100651239
CCAL: 108627465
OBB: 114882933
SOC: 105193154
MPHA: 105830371
AEC: 105154033
ACEP: 105617990
PBAR: 105432976
VEM: 105566676
HST: 105183168
DQU: 106744477
CFO: 105257852
LHU: 105672289
PGC: 109852961
OBO: 105282532
PCF: 106788106
NVI: 100679184
CSOL: 105362014
MDL: 106693462
TCA: 662893
ATD: 109599977
NVL: 108557857
BMOR: 100529085(Apaf-1)
BMAN: 114247650
PMAC: 106711546
PRAP: 110999308
HAW: 110370241
TNL: 113498317
PXY: 105383941
API: 100571592
DNX: 107164576
AGS: 114127840
RMD: 113560550
CLEC: 106668095
ZNE: 110839034
FCD: 110858562
DPTE: 113796506
CSCU: 111640868
TSP: Tsp_01495
NVE: 5519825
ADF: 107354394
AMIL: 114953128
PDAM: 113670324
SPIS: 111330240
DGT: 114518196
HMG: 100210403(APAF-1)
AQU: 105313814
 » show all
Reference
PMID:9267021
  Authors
Zou H, Henzel WJ, Liu X, Lutschg A, Wang X
  Title
Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3.
  Journal
Cell 90:405-13 (1997)
DOI:10.1016/S0092-8674(00)80501-2
  Sequence
[hsa:317]
Reference
  Authors
Hara H, Takeda A, Takeuchi M, Wakeham AC, Itie A, Sasaki M, Mak TW, Yoshimura A, Nomoto K, Yoshida H
  Title
The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes.
  Journal
J Immunol 168:2288-95 (2002)
DOI:10.4049/jimmunol.168.5.2288
  Sequence
[mmu:11783]
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