KEGG   ORTHOLOGY: K02089Help
Entry
K02089                      KO                                     

Name
CDK4
Definition
cyclin-dependent kinase 4 [EC:2.7.11.22]
Pathway
ko01522  Endocrine resistance
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04218  Cellular senescence
ko04530  Tight junction
ko04660  T cell receptor signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04934  Cushing syndrome
ko05160  Hepatitis C
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05212  Pancreatic cancer
ko05214  Glioma
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
Disease
H00030  Cervical cancer
H00038  Melanoma
H00042  Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02089  CDK4; cyclin-dependent kinase 4
   04115 p53 signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
   04218 Cellular senescence
    K02089  CDK4; cyclin-dependent kinase 4
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K02089  CDK4; cyclin-dependent kinase 4
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05203 Viral carcinogenesis
    K02089  CDK4; cyclin-dependent kinase 4
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05225 Hepatocellular carcinoma
    K02089  CDK4; cyclin-dependent kinase 4
   05214 Glioma
    K02089  CDK4; cyclin-dependent kinase 4
   05220 Chronic myeloid leukemia
    K02089  CDK4; cyclin-dependent kinase 4
   05218 Melanoma
    K02089  CDK4; cyclin-dependent kinase 4
   05219 Bladder cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05224 Breast cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05222 Small cell lung cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05223 Non-small cell lung cancer
    K02089  CDK4; cyclin-dependent kinase 4
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02089  CDK4; cyclin-dependent kinase 4
   04934 Cushing syndrome
    K02089  CDK4; cyclin-dependent kinase 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02089  CDK4; cyclin-dependent kinase 4
   05162 Measles
    K02089  CDK4; cyclin-dependent kinase 4
   05164 Influenza A
    K02089  CDK4; cyclin-dependent kinase 4
   05160 Hepatitis C
    K02089  CDK4; cyclin-dependent kinase 4
   05163 Human cytomegalovirus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05169 Epstein-Barr virus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05165 Human papillomavirus infection
    K02089  CDK4; cyclin-dependent kinase 4
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K02089  CDK4; cyclin-dependent kinase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02089  CDK4; cyclin-dependent kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02089  CDK4; cyclin-dependent kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  CDK family
   K02089  CDK4; cyclin-dependent kinase 4
BRITE hierarchy
Other DBs
GO: 0004693
Genes
HSA: 1019(CDK4)
PTR: 452025(CDK4)
PPS: 100976294(CDK4)
GGO: 101147065(CDK4)
PON: 100443314(CDK4)
NLE: 100594967(CDK4)
MCC: 715650(CDK4)
MCF: 101925733(CDK4)
CSAB: 103238589(CDK4)
RRO: 104682344(CDK4)
RBB: 108524397(CDK4)
CJC: 100408304(CDK4)
SBQ: 101040767(CDK4)
MMU: 12567(Cdk4)
MCAL: 110303132(Cdk4)
MPAH: 110326196(Cdk4)
RNO: 94201(Cdk4)
MUN: 110561245(Cdk4)
CGE: 100760122(Cdk4)
NGI: 103742900(Cdk4) 108491251
HGL: 101702608(Cdk4)
CCAN: 109686224(Cdk4)
OCU: 100009039(CDK4)
TUP: 102493291(CDK4)
CFA: 481131(CDK4)
VVP: 112922331(CDK4)
AML: 100481236(CDK4)
UMR: 103656694(CDK4)
UAH: 113256363(CDK4)
ORO: 101362330(CDK4)
FCA: 101097903(CDK4)
PTG: 102970281(CDK4)
AJU: 106975871(CDK4)
BTA: 510618(CDK4)
BOM: 102278545(CDK4)
BIU: 109559308(CDK4)
BBUB: 102412787(CDK4)
PHD: 102344246(CDK4)
CHX: 102171306(CDK4)
OAS: 100144756(CDK4)
SSC: 100144492(CDK4)
CFR: 102522300(CDK4)
CDK: 105100330(CDK4)
BACU: 103000540(CDK4) 103010593
LVE: 103084826(CDK4)
OOR: 101283760(CDK4)
DLE: 111173824(CDK4)
PCAD: 102985179(CDK4)
ECB: 100051005(CDK4)
EPZ: 103553644(CDK4)
EAI: 106833016(CDK4)
MYB: 102261527(CDK4)
MYD: 102758995(CDK4)
MNA: 107546223(CDK4)
HAI: 109390747(CDK4)
RSS: 109452989(CDK4)
DRO: 112319119(CDK4)
PALE: 102894222(CDK4)
RAY: 107501504(CDK4)
LAV: 104847103(CDK4)
TMU: 101355276
SHR: 100932899(CDK4)
PCW: 110210989(CDK4)
CJO: 107325825(CDK4)
PHI: 102103942(CDK4)
PMAJ: 107199280
AAM: 106492770
ASN: 102387479(CDK4)
AMJ: 102572556(CDK4)
CMY: 102945436(CDK4)
CPIC: 101943854(CDK4)
ACS: 100559515(cdk4)
PVT: 110074435(CDK4)
PBI: 103058869(CDK4)
PMUR: 107291540(CDK4)
GJA: 107119665(CDK4)
XLA: 108705492 379406(cdk4.L) 496334(cdk6.L)
XTR: 549496(cdk4)
NPR: 108795357(CDK4)
DRE: 777730(cdk4)
SGH: 107567936
IPU: 108255186(cdk4)
PHYP: 113525662
AMEX: 103034254(cdk4)
EEE: 113572459(cdk4)
TRU: 101063081(cdk4)
LCO: 104929049(cdk4)
NCC: 104954858 104955917(cdk4)
MZE: 101475315
OLA: 101172808(cdk4)
XMA: 102220323(cdk4)
XCO: 114135419(cdk4)
PRET: 103465328(cdk4)
NFU: 107385649(cdk4)
KMR: 108235797(cdk4)
AOCE: 111587634(cdk4)
CSEM: 103386052(cdk4)
POV: 109629352(cdk4)
LCF: 108898964(cdk4)
SDU: 111221753(cdk4)
HCQ: 109522590(cdk4)
BPEC: 110171259(cdk4)
MALB: 109956190(cdk4)
OTW: 112216345
ELS: 105016970(cdk4)
SFM: 108918175(cdk4)
PKI: 111854375(cdk4) 111856032
LCM: 102363370(CDK4)
CMK: 103191316(cdk4)
DME: Dmel_CG5072(Cdk4)
DER: 6548425
DSI: Dsimw501_GD11207(Dsim_GD11207)
DPE: 6591061
DWI: 6639792
DAZ: 108615638
DNV: 108653601
DHE: 111593550
MDE: 101892496
LCQ: 111675356
AAG: 5570506
SOC: 105196992
MPHA: 105838129
PBAR: 105433444
VEM: 105561026
HST: 105187057
DQU: 106744310
CFO: 105249672
LHU: 105675373
PGC: 109855281
PCF: 106790376
NVI: 100122192(Cdk4)
MDL: 103574306
TCA: 663975
NVL: 108558807
BMOR: 100316860
PMAC: 106709519
PRAP: 110993439
HAW: 110381856
TNL: 113499972
TSP: Tsp_00762
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Blain SW
  Title
Switching cyclin D-Cdk4 kinase activity on and off.
  Journal
Cell Cycle 7:892-8 (2008)
DOI:10.4161/cc.7.7.5637
Reference
PMID:7652577
  Authors
Wolfel T, Hauer M, Schneider J, Serrano M, Wolfel C, Klehmann-Hieb E, De Plaen E, Hankeln T, Meyer zum Buschenfelde KH, Beach D
  Title
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.
  Journal
Science 269:1281-4 (1995)
DOI:10.1126/science.7652577
  Sequence
[hsa:1019]
LinkDB All DBs

KEGG   ORTHOLOGY: K02091Help
Entry
K02091                      KO                                     

Name
CDK6
Definition
cyclin-dependent kinase 6 [EC:2.7.11.22]
Pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04218  Cellular senescence
ko04934  Cushing syndrome
ko05160  Hepatitis C
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05206  MicroRNAs in cancer
ko05212  Pancreatic cancer
ko05214  Glioma
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
Disease
H00269  Primary microcephaly
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K02091  CDK6; cyclin-dependent kinase 6
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02091  CDK6; cyclin-dependent kinase 6
   04115 p53 signaling pathway
    K02091  CDK6; cyclin-dependent kinase 6
   04218 Cellular senescence
    K02091  CDK6; cyclin-dependent kinase 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05206 MicroRNAs in cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05203 Viral carcinogenesis
    K02091  CDK6; cyclin-dependent kinase 6
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05225 Hepatocellular carcinoma
    K02091  CDK6; cyclin-dependent kinase 6
   05214 Glioma
    K02091  CDK6; cyclin-dependent kinase 6
   05220 Chronic myeloid leukemia
    K02091  CDK6; cyclin-dependent kinase 6
   05218 Melanoma
    K02091  CDK6; cyclin-dependent kinase 6
   05224 Breast cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05222 Small cell lung cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05223 Non-small cell lung cancer
    K02091  CDK6; cyclin-dependent kinase 6
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K02091  CDK6; cyclin-dependent kinase 6
  09172 Infectious disease: viral
   05162 Measles
    K02091  CDK6; cyclin-dependent kinase 6
   05164 Influenza A
    K02091  CDK6; cyclin-dependent kinase 6
   05160 Hepatitis C
    K02091  CDK6; cyclin-dependent kinase 6
   05163 Human cytomegalovirus infection
    K02091  CDK6; cyclin-dependent kinase 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02091  CDK6; cyclin-dependent kinase 6
   05169 Epstein-Barr virus infection
    K02091  CDK6; cyclin-dependent kinase 6
   05165 Human papillomavirus infection
    K02091  CDK6; cyclin-dependent kinase 6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02091  CDK6; cyclin-dependent kinase 6
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02091  CDK6; cyclin-dependent kinase 6
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  CDK family
   K02091  CDK6; cyclin-dependent kinase 6
BRITE hierarchy
Genes
HSA: 1021(CDK6)
PTR: 746968(CDK6)
PPS: 100981258(CDK6)
GGO: 109023121(CDK6)
PON: 100454924(CDK6)
NLE: 100602542(CDK6)
MCC: 701822(CDK6)
MCF: 102140874(CDK6)
CSAB: 103226555(CDK6)
RRO: 104682750(CDK6)
RBB: 108528490(CDK6)
CJC: 100385604(CDK6)
SBQ: 101040507(CDK6)
MMU: 12571(Cdk6)
MCAL: 110294345(Cdk6)
MPAH: 110316496(Cdk6)
RNO: 114483(Cdk6)
MUN: 110558380(Cdk6)
CGE: 100764515(Cdk6)
NGI: 103725210(Cdk6)
HGL: 101719908(Cdk6)
OCU: 100009040(CDK6)
TUP: 102488432(CDK6)
CFA: 609920(CDK6)
VVP: 112923889(CDK6)
AML: 100476389(CDK6)
UMR: 103658796(CDK6)
UAH: 113259981(CDK6)
ORO: 101378405(CDK6)
FCA: 100037415(CDK6)
PTG: 102967948(CDK6)
AJU: 106969949(CDK6)
BTA: 511754(CDK6)
BOM: 102264992(CDK6)
BIU: 109558203(CDK6)
BBUB: 102407325(CDK6)
PHD: 102321501(CDK6)
CHX: 102180182(CDK6)
OAS: 100144761(CDK6)
CFR: 102520456(CDK6)
CDK: 105088747(CDK6)
BACU: 103011327(CDK6)
LVE: 103081338(CDK6)
OOR: 101271733(CDK6)
DLE: 111180943(CDK6)
PCAD: 102992532(CDK6)
ECB: 100061625(CDK6)
EPZ: 103549196(CDK6)
EAI: 106832259(CDK6)
MYB: 102258140(CDK6)
MYD: 102760528(CDK6)
MNA: 107541691(CDK6)
HAI: 109373596(CDK6)
RSS: 109446377(CDK6)
DRO: 112319896(CDK6)
PALE: 102896272(CDK6)
RAY: 107519055(CDK6)
LAV: 100655429(CDK6)
MDO: 100021675(CDK6)
SHR: 100924154(CDK6)
PCW: 110209152(CDK6)
OAA: 100091822(CDK6)
GGA: 420558(CDK6)
MGP: 100539044(CDK6)
CJO: 107309074(CDK6)
NMEL: 110393133(CDK6)
APLA: 101793324(CDK6)
ACYG: 106039673(CDK6)
TGU: 100229620(CDK6)
LSR: 110482460(CDK6)
SCAN: 103812819(CDK6)
GFR: 102034159(CDK6)
FAB: 101815768(CDK6)
PHI: 102114646(CDK6)
PMAJ: 107200146(CDK6)
CCAE: 111924218(CDK6)
CCW: 104689173(CDK6)
ETL: 114062117(CDK6)
FPG: 101921135(CDK6)
FCH: 102047555(CDK6)
CLV: 102091430(CDK6)
EGZ: 104128955(CDK6)
NNI: 104014021(CDK6)
ACUN: 113476723(CDK6)
PADL: 103922381(CDK6)
AAM: 106483627(CDK6)
ASN: 102387975(CDK6)
AMJ: 102561028(CDK6)
PSS: 102454031(CDK6)
CMY: 102944070(CDK6)
CPIC: 101938073(CDK6)
ACS: 100558412(cdk6)
PVT: 110074720(CDK6)
PBI: 103059655(CDK6)
PMUR: 107283642(CDK6)
GJA: 107108272(CDK6)
XTR: 100489734(cdk6)
NPR: 108787899(CDK6)
DRE: 100034507(cdk6) 569515(cdk21)
IPU: 108257114(cdk6) 108274791
PHYP: 113528439 113536004(cdk6)
AMEX: 103047757(cdk6)
EEE: 113578681(cdk6) 113588899
TRU: 101070296(cdk6) 101078305
LCO: 104926452 104927455(cdk6)
NCC: 104944671
MZE: 101464773(cdk6) 101478399
OLA: 101165981 101168879(cdk6)
XMA: 102235700(cdk6) 102237928
XCO: 114156288(cdk6) 114159833
PRET: 103469340 103472249(cdk6)
NFU: 107378559 107383310(cdk6)
KMR: 108237737 108241821(cdk6)
AOCE: 111573355(cdk6) 111574249
CSEM: 103392753 103394142(cdk6)
POV: 109631907(cdk6) 109634060
LCF: 108872758 108877644(cdk6)
SDU: 111217648 111223044(cdk6)
HCQ: 109527671(cdk6) 109532677
BPEC: 110159294
MALB: 109963185 109968183(cdk6)
ELS: 105007255 105022797(cdk6)
PKI: 111843897(cdk6)
LCM: 102353660(CDK6) 102366718
CMK: 103183765 103185269(cdk6)
CIN: 100175205
SPU: 373289(cdk4)
APLC: 110984198
SKO: 100371039
FCD: 110852991
TUT: 107365344
CEL: CELE_F18H3.5(cdk-4)
PCAN: 112556231
MYI: 110452126
OBI: 106881146
LAK: 106162008
SHX: MS3_06893
EGL: EGR_00718
EPA: 110244942
PDAM: 113669926
SPIS: 111332639
HMG: 100206502
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lucas JJ, Domenico J, Gelfand EW
  Title
Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells.
  Journal
Mol Cancer Res 2:105-14 (2004)
  Sequence
[hsa:1021]
Reference
PMID:1639063
  Authors
Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH
  Title
A family of human cdc2-related protein kinases.
  Journal
EMBO J 11:2909-17 (1992)
  Sequence
[hsa:1021]
LinkDB All DBs

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