KEGG   ORTHOLOGY: K02157
Entry
K02157                      KO                                     

Name
AXIN1
Definition
axin 1
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04934  Cushing syndrome
ko05010  Alzheimer disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05217  Basal cell carcinoma
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00048  Hepatocellular carcinoma
H00934  Caudal duplication anomaly
H01667  Medulloblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K02157  AXIN1; axin 1
   04390 Hippo signaling pathway
    K02157  AXIN1; axin 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K02157  AXIN1; axin 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02157  AXIN1; axin 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02157  AXIN1; axin 1
   05225 Hepatocellular carcinoma
    K02157  AXIN1; axin 1
   05226 Gastric cancer
    K02157  AXIN1; axin 1
   05217 Basal cell carcinoma
    K02157  AXIN1; axin 1
   05213 Endometrial cancer
    K02157  AXIN1; axin 1
   05224 Breast cancer
    K02157  AXIN1; axin 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02157  AXIN1; axin 1
   05022 Pathways of neurodegeneration - multiple diseases
    K02157  AXIN1; axin 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K02157  AXIN1; axin 1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K02157  AXIN1; axin 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K02157  AXIN1; axin 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02157  AXIN1; axin 1
Genes
HSA: 8312(AXIN1)
PTR: 453789(AXIN1)
PPS: 100986279(AXIN1)
GGO: 101150555(AXIN1)
PON: 100434225(AXIN1)
NLE: 101179424(AXIN1)
MCC: 100424087(AXIN1)
MCF: 102142970(AXIN1)
CSAB: 103225216(AXIN1)
RRO: 104676962(AXIN1)
RBB: 108521119(AXIN1)
CJC: 100392475(AXIN1)
SBQ: 101035780(AXIN1)
MMU: 12005(Axin1)
MCAL: 110284040(Axin1)
MPAH: 110338127(Axin1)
RNO: 79257(Axin1)
MUN: 110548696(Axin1)
CGE: 100758169(Axin1)
NGI: 103748223(Axin1)
HGL: 101700795(Axin1)
CCAN: 109694685(Axin1)
OCU: 100348127(AXIN1)
TUP: 102469399(AXIN1)
CFA: 490099(AXIN1)
VVP: 112909128(AXIN1)
AML: 100473018(AXIN1)
UMR: 103668450(AXIN1)
UAH: 113245367(AXIN1)
ORO: 101375084(AXIN1)
ELK: 111156118
FCA: 101088804(AXIN1)
PTG: 102951323(AXIN1)
PPAD: 109259643(AXIN1)
AJU: 106977359(AXIN1)
BTA: 504357(AXIN1)
BOM: 102267637(AXIN1)
BIU: 109578518(AXIN1)
BBUB: 102394098(AXIN1)
CHX: 102170375(AXIN1)
OAS: 101122656(AXIN1)
SSC: 100523725(AXIN1)
CFR: 102508916(AXIN1)
CDK: 105098424(AXIN1)
BACU: 103006014(AXIN1)
LVE: 103085333(AXIN1)
OOR: 101272348(AXIN1)
DLE: 111185093(AXIN1)
PCAD: 102986270(AXIN1)
ECB: 100065116(AXIN1)
EPZ: 103564115(AXIN1)
EAI: 106836161(AXIN1)
MYB: 102248340(AXIN1)
MYD: 102759594(AXIN1)
MNA: 107539654(AXIN1)
HAI: 109385980(AXIN1)
DRO: 112298256(AXIN1)
PALE: 102878657(AXIN1)
RAY: 107506131(AXIN1)
MJV: 108408106(AXIN1)
LAV: 100655765(AXIN1)
TMU: 101346985
MDO: 100016298(AXIN1)
SHR: 100923576(AXIN1)
PCW: 110221974(AXIN1)
OAA: 100093450(AXIN1)
GGA: 395786(AXIN1)
MGP: 100539162(AXIN1)
CJO: 107320950(AXIN1)
NMEL: 110405669(AXIN1)
APLA: 101800899(AXIN1)
ACYG: 106033419(AXIN1)
TGU: 100226467(AXIN1)
LSR: 110480560(AXIN1)
SCAN: 103817752(AXIN1)
GFR: 102034015(AXIN1)
FAB: 101812314(AXIN1)
PHI: 102108019(AXIN1)
PMAJ: 107211202(AXIN1)
CCAE: 111935875(AXIN1)
CCW: 104684681(AXIN1)
ETL: 114057037(AXIN1)
FPG: 101924311(AXIN1)
FCH: 102054847(AXIN1)
CLV: 102091034(AXIN1)
EGZ: 104135741(AXIN1)
NNI: 104023427(AXIN1)
ACUN: 113485942(AXIN1)
PADL: 103917539(AXIN1)
AAM: 106482339(AXIN1)
ASN: 102383198(AXIN1)
AMJ: 102566966(AXIN1)
PSS: 102453080(AXIN1)
CMY: 102945350(AXIN1)
CPIC: 101932057(AXIN1)
ACS: 100561864(axin1)
PVT: 110089118
PBI: 103053070(AXIN1)
PMUR: 107283957
TSR: 106551582(AXIN1)
PMUA: 114583932(AXIN1)
GJA: 107109315(AXIN1)
XLA: 398097(axin1.L) 734298(axin1.S)
XTR: 100498631(axin1)
NPR: 108796271(AXIN1)
DRE: 57931(axin1)
IPU: 108257243(axin1)
PHYP: 113536021(axin1)
AMEX: 103030717 103045152(axin1)
EEE: 113570287(axin1) 113591421
TRU: 101065196(axin1) 101075840
LCO: 104918719(axin1) 104921153
NCC: 104952093
MZE: 101472703 101487168(axin1)
OLA: 101155494 101155852(axin1)
XMA: 102228925 102232266(axin1)
XCO: 114144827 114160292(axin1)
PRET: 103456513 103468679(axin1)
CVG: 107092806(axin1) 107097051
NFU: 107378411(axin1) 107395828
KMR: 108241749 108243734(axin1)
ALIM: 106522717 106528550(axin1)
AOCE: 111576703(axin1) 111587652
CSEM: 103383461 103392632(axin1)
POV: 109634337(axin1) 109639592
LCF: 108901170 108903015(axin1)
SDU: 111216635 111217642(axin1)
SLAL: 111651284 111660637(axin1)
HCQ: 109511398 109513801(axin1)
MALB: 109965916(axin1) 109973291
ELS: 105013228(axin1) 105030252
LCM: 102351869(AXIN1)
CMK: 103188268(axin1)
RTP: 109935789
BFO: 118429299
CIN: 778548(axin)
SPU: 576611
APLC: 110976115
SKO: 100303567(axin1)
DME: Dmel_CG7926(Axn)
DER: 6554369
DSE: 6612800
DSI: Dsimw501_GD21494(Dsim_Axn)
DAN: 6505639
DSR: 110186964
DPE: 6594969
DMN: 108156381
DWI: 6651128
DAZ: 108610356
DNV: 108654142
DHE: 111594530
DVI: 6633016
MDE: 101894228
LCQ: 111676782
AAG: 5577995
AME: 724501
BIM: 100745962
BTER: 100642412
CCAL: 108624328
OBB: 114881966
SOC: 105204827
MPHA: 105833647
AEC: 105150595
ACEP: 105620205
PBAR: 105423342
HST: 105190922
DQU: 106743662
CFO: 105259438
LHU: 105674899
PGC: 109856767
OBO: 105275558
PCF: 106787463
NVI: 100120010
CSOL: 105361110
MDL: 103574084
TCA: 655873(Axn)
DPA: 109538975
ATD: 109599437
NVL: 108558537
BMOR: 101739893
BMAN: 114245438
PMAC: 106713369
PRAP: 111000147
HAW: 110372041
TNL: 113494741
API: 100167569
DNX: 107166081
AGS: 114128484
RMD: 113549693
BTAB: 109031478
CLEC: 106670580
ZNE: 110835724
FCD: 110848502
DPTE: 113794778
CSCU: 111630953
PTEP: 107454244
CEL: CELE_C37A5.9(pry-1)
CBR: CBG18802(Cbr-pry-1)
TSP: Tsp_05616
PCAN: 112567648
CRG: 105334024
MYI: 110455658
OBI: 106867786
LAK: 106168343
NVE: 5516880
ADF: 107345943
AMIL: 114966965
PDAM: 113671162
SPIS: 111333300
DGT: 114519489
HMG: 100206389
 » show all
Reference
PMID:9230313
  Authors
Zeng L, Fagotto F, Zhang T, Hsu W, Vasicek TJ, Perry WL 3rd, Lee JJ, Tilghman SM, Gumbiner BM, Costantini F
  Title
The mouse Fused locus encodes Axin, an inhibitor of the Wnt signaling pathway that regulates embryonic axis formation.
  Journal
Cell 90:181-92 (1997)
DOI:10.1016/S0092-8674(00)80324-4
  Sequence
[hsa:8312]
Reference
  Authors
Luo W, Lin SC
  Title
Axin: a master scaffold for multiple signaling pathways.
  Journal
Neurosignals 13:99-113 (2004)
DOI:10.1159/000076563
Reference
  Authors
Willert K, Logan CY, Arora A, Fish M, Nusse R
  Title
A Drosophila Axin homolog, Daxin, inhibits Wnt signaling.
  Journal
Development 126:4165-73 (1999)
  Sequence
LinkDB

KEGG   ORTHOLOGY: K04385
Entry
K04385                      KO                                     

Name
AXIN2
Definition
axin 2
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04934  Cushing syndrome
ko05010  Alzheimer disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05217  Basal cell carcinoma
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00857  Oligodontia-colorectal cancer syndrome
H01667  Medulloblastoma
H02302  Hepatoblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04385  AXIN2; axin 2
   04390 Hippo signaling pathway
    K04385  AXIN2; axin 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04385  AXIN2; axin 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04385  AXIN2; axin 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04385  AXIN2; axin 2
   05225 Hepatocellular carcinoma
    K04385  AXIN2; axin 2
   05226 Gastric cancer
    K04385  AXIN2; axin 2
   05217 Basal cell carcinoma
    K04385  AXIN2; axin 2
   05213 Endometrial cancer
    K04385  AXIN2; axin 2
   05224 Breast cancer
    K04385  AXIN2; axin 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04385  AXIN2; axin 2
   05022 Pathways of neurodegeneration - multiple diseases
    K04385  AXIN2; axin 2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04385  AXIN2; axin 2
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K04385  AXIN2; axin 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K04385  AXIN2; axin 2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Other centriole associated proteins
    K04385  AXIN2; axin 2
Genes
HSA: 8313(AXIN2)
PTR: 468301(AXIN2)
PPS: 100990800(AXIN2)
GGO: 101154299(AXIN2)
PON: 100431721(AXIN2)
NLE: 100589482(AXIN2)
MCC: 718566(AXIN2)
MCF: 102129656(AXIN2)
CSAB: 103243176(AXIN2)
RRO: 104675432(AXIN2)
RBB: 108517751(AXIN2)
CJC: 100400518(AXIN2)
SBQ: 101036328(AXIN2)
MMU: 12006(Axin2)
MCAL: 110304669(Axin2)
MPAH: 110331423(Axin2)
RNO: 29134(Axin2)
MUN: 110563522(Axin2)
CGE: 100750382(Axin2)
NGI: 103742203(Axin2)
HGL: 101716964(Axin2)
CCAN: 109681311(Axin2)
OCU: 100339765(AXIN2)
TUP: 102493766(AXIN2)
CFA: 490903(AXIN2)
VVP: 112920730(AXIN2)
AML: 100477069(AXIN2)
UMR: 103665908(AXIN2)
UAH: 113265246(AXIN2)
ORO: 101362548(AXIN2)
ELK: 111158088
FCA: 101093061(AXIN2)
PTG: 102967280(AXIN2)
PPAD: 109277160(AXIN2)
AJU: 106975307(AXIN2)
BTA: 511619(AXIN2)
BOM: 102278168(AXIN2)
BBUB: 102388903(AXIN2)
CHX: 102180348(AXIN2)
OAS: 101109815(AXIN2)
SSC: 100739604(AXIN2)
CFR: 102508329(AXIN2)
CDK: 105085712(AXIN2)
BACU: 103006133(AXIN2)
LVE: 103072027(AXIN2)
OOR: 101277024(AXIN2)
DLE: 111182912(AXIN2)
PCAD: 102990422
ECB: 100630049(AXIN2)
EPZ: 103553492(AXIN2)
EAI: 106835348(AXIN2)
MYB: 102260435(AXIN2)
MYD: 102760211(AXIN2)
MNA: 107538303(AXIN2)
HAI: 109380327(AXIN2)
DRO: 112316324(AXIN2)
PALE: 102885831(AXIN2)
RAY: 107510301(AXIN2)
MJV: 108392410(AXIN2)
LAV: 100663921(AXIN2)
TMU: 101347495
MDO: 100024610(AXIN2)
SHR: 100933740(AXIN2)
PCW: 110218322(AXIN2)
OAA: 100077932(AXIN2)
GGA: 395152(AXIN2)
MGP: 100541268(AXIN2)
CJO: 107322239(AXIN2)
NMEL: 110407312(AXIN2)
APLA: 101799849(AXIN2)
ACYG: 106034604(AXIN2)
TGU: 100230658(AXIN2)
LSR: 110473992(AXIN2)
SCAN: 103819763(AXIN2)
GFR: 102040633(AXIN2)
FAB: 101818199(AXIN2)
PHI: 102099770(AXIN2)
PMAJ: 107212583(AXIN2)
CCAE: 111937572(AXIN2)
CCW: 104696031(AXIN2)
ETL: 114060683(AXIN2)
FPG: 101923006(AXIN2)
FCH: 102052896(AXIN2)
CLV: 102087539(AXIN2)
EGZ: 104129411(AXIN2)
NNI: 104014358(AXIN2)
ACUN: 113486959(AXIN2)
PADL: 103916718(AXIN2)
AAM: 106493090(AXIN2)
ASN: 102376921(AXIN2)
AMJ: 102568792(AXIN2)
PSS: 102451218(AXIN2)
CMY: 102940811(AXIN2)
CPIC: 101951915(AXIN2)
ACS: 100553926(axin2)
PVT: 110085879(AXIN2)
PBI: 103049867(AXIN2)
PMUR: 107288332(AXIN2)
TSR: 106555043(AXIN2)
PMUA: 114588192(AXIN2)
GJA: 107105953(AXIN2)
XLA: 108701205 108702158 373619(axin2.L) 447702(axin2.S)
XTR: 100380149(axin2) 116406464
NPR: 108801719(AXIN2) 108804668
DRE: 58080(axin2)
SANH: 107664537(axin2) 107701905
IPU: 108255292 108273124(axin2)
PHYP: 113528011 113538481(axin2)
AMEX: 103042974 103044632(axin2)
EEE: 113575334 113583264(axin2)
TRU: 101071501 105419692(axin2)
NCC: 104951344(axin2) 104959715
OLA: 101156143(axin2) 101159441
XMA: 102216583(axin2)
NFU: 107376523 107390091(axin2)
MALB: 109957969(axin2) 109971522
SALP: 111949326(axin2)
ELS: 105021564(axin2) 105026129
SFM: 108936851 108940092(axin2)
PKI: 111843302 111848373(axin2)
LCM: 102346005 102365123(AXIN2)
CMK: 103175739(axin2)
RTP: 109929544(axin2)
AQU: 100616092
 » show all
Reference
  Authors
Mai M, Qian C, Yokomizo A, Smith DI, Liu W
  Title
Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24.
  Journal
Genomics 55:341-4 (1999)
DOI:10.1006/geno.1998.5650
  Sequence
[hsa:8313]
Reference
  Authors
Hadjihannas MV, Bruckner M, Behrens J
  Title
Conductin/axin2 and Wnt signalling regulates centrosome cohesion.
  Journal
EMBO Rep 11:317-24 (2010)
DOI:10.1038/embor.2010.23
LinkDB

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