KEGG   ORTHOLOGY: K02159Help
Entry
K02159                      KO                                     

Name
BAX
Definition
apoptosis regulator BAX
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04071  Sphingolipid signaling pathway
ko04115  p53 signaling pathway
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04215  Apoptosis - multiple species
ko04217  Necroptosis
ko04722  Neurotrophin signaling pathway
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05014  Amyotrophic lateral sclerosis (ALS)
ko05016  Huntington disease
ko05020  Prion diseases
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05203  Viral carcinogenesis
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00020  Colorectal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K02159  BAX; apoptosis regulator BAX
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    K02159  BAX; apoptosis regulator BAX
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02159  BAX; apoptosis regulator BAX
   04215 Apoptosis - multiple species
    K02159  BAX; apoptosis regulator BAX
   04217 Necroptosis
    K02159  BAX; apoptosis regulator BAX
   04115 p53 signaling pathway
    K02159  BAX; apoptosis regulator BAX
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K02159  BAX; apoptosis regulator BAX
  09149 Aging
   04211 Longevity regulating pathway
    K02159  BAX; apoptosis regulator BAX
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02159  BAX; apoptosis regulator BAX
   05202 Transcriptional misregulation in cancer
    K02159  BAX; apoptosis regulator BAX
   05203 Viral carcinogenesis
    K02159  BAX; apoptosis regulator BAX
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02159  BAX; apoptosis regulator BAX
   05212 Pancreatic cancer
    K02159  BAX; apoptosis regulator BAX
   05225 Hepatocellular carcinoma
    K02159  BAX; apoptosis regulator BAX
   05226 Gastric cancer
    K02159  BAX; apoptosis regulator BAX
   05214 Glioma
    K02159  BAX; apoptosis regulator BAX
   05216 Thyroid cancer
    K02159  BAX; apoptosis regulator BAX
   05220 Chronic myeloid leukemia
    K02159  BAX; apoptosis regulator BAX
   05217 Basal cell carcinoma
    K02159  BAX; apoptosis regulator BAX
   05218 Melanoma
    K02159  BAX; apoptosis regulator BAX
   05213 Endometrial cancer
    K02159  BAX; apoptosis regulator BAX
   05224 Breast cancer
    K02159  BAX; apoptosis regulator BAX
   05222 Small cell lung cancer
    K02159  BAX; apoptosis regulator BAX
   05223 Non-small cell lung cancer
    K02159  BAX; apoptosis regulator BAX
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis (ALS)
    K02159  BAX; apoptosis regulator BAX
   05016 Huntington disease
    K02159  BAX; apoptosis regulator BAX
   05020 Prion diseases
    K02159  BAX; apoptosis regulator BAX
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K02159  BAX; apoptosis regulator BAX
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02159  BAX; apoptosis regulator BAX
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K02159  BAX; apoptosis regulator BAX
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02159  BAX; apoptosis regulator BAX
   05170 Human immunodeficiency virus 1 infection
    K02159  BAX; apoptosis regulator BAX
   05162 Measles
    K02159  BAX; apoptosis regulator BAX
   05164 Influenza A
    K02159  BAX; apoptosis regulator BAX
   05161 Hepatitis B
    K02159  BAX; apoptosis regulator BAX
   05160 Hepatitis C
    K02159  BAX; apoptosis regulator BAX
   05168 Herpes simplex virus 1 infection
    K02159  BAX; apoptosis regulator BAX
   05163 Human cytomegalovirus infection
    K02159  BAX; apoptosis regulator BAX
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02159  BAX; apoptosis regulator BAX
   05169 Epstein-Barr virus infection
    K02159  BAX; apoptosis regulator BAX
   05165 Human papillomavirus infection
    K02159  BAX; apoptosis regulator BAX
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K02159  BAX; apoptosis regulator BAX
   01524 Platinum drug resistance
    K02159  BAX; apoptosis regulator BAX
   01522 Endocrine resistance
    K02159  BAX; apoptosis regulator BAX
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K02159  BAX; apoptosis regulator BAX
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K02159  BAX; apoptosis regulator BAX
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Fission and Fusion factors
    K02159  BAX; apoptosis regulator BAX
Transporters [BR:ko02000]
 Other Transporters
  Pores ion channels
   K02159  BAX; apoptosis regulator BAX
BRITE hierarchy
Other DBs
TC: 1.A.21.1.2
Genes
HSA: 581(BAX)
PTR: 747093(BAX)
PPS: 100991820(BAX)
GGO: 101152769(BAX)
PON: 100450682(BAX)
NLE: 100593013(BAX)
MCC: 718948(BAX)
MCF: 102132255(BAX)
CSAB: 103235004(BAX)
RRO: 104666540(BAX)
RBB: 108523624(BAX)
CJC: 100391322(BAX)
SBQ: 101050177(BAX)
MMU: 12028(Bax)
MCAL: 110297919(Bax)
MPAH: 110320030(Bax)
RNO: 24887(Bax)
CGE: 100689032(Bax)
NGI: 103743639(Bax)
HGL: 101713575(Bax)
CCAN: 109682703(Bax)
OCU: 100355675(BAX)
TUP: 102471776(BAX)
CFA: 403523(BAX)
VVP: 112931372(BAX)
AML: 100471095(BAX)
UMR: 103657107(BAX)
UAH: 113243322(BAX)
ORO: 101371652(BAX)
FCA: 493837(BAX)
PTG: 102949153(BAX)
AJU: 106988699(BAX)
BTA: 280730(BAX)
BOM: 102279740(BAX)
BIU: 109571778(BAX) 109571977
BBUB: 102400076(BAX)
PHD: 102323618(BAX)
CHX: 100846984(BAX)
OAS: 443059(BAX)
SSC: 396633(BAX)
CFR: 102512073(BAX)
CDK: 105102890(BAX)
BACU: 103019528(BAX)
LVE: 103084066(BAX)
OOR: 101285349(BAX)
DLE: 111180640(BAX)
ECB: 100054674(BAX)
EPZ: 103553312(BAX)
EAI: 106838268(BAX)
MYB: 106723573(BAX)
MYD: 102761803(BAX)
MNA: 107531901(BAX)
HAI: 109391068(BAX)
RSS: 109452567(BAX)
DRO: 112310132(BAX)
PALE: 102885135(BAX)
LAV: 100673560(BAX)
TMU: 101356564
MDO: 100030412(BAX)
PCW: 110219776(BAX)
OAA: 114814649(BAX)
TGU: 100227148(BAX)
LSR: 110481417(BAX)
SCAN: 103825597(BAX)
PHI: 102106020(BAX)
PMAJ: 107199046(BAX)
CCAE: 111943854(BAX)
FPG: 101920283(BAX)
ASN: 102384471(BAX)
AMJ: 102568113(BAX) 106737548
PSS: 102446385
CMY: 102942796(BAX)
CPIC: 101948093(BAX)
ACS: 100561911 100562834(bax)
XLA: 108696744 373637(bax.L)
XTR: 394793(bax)
NPR: 108796054(BAX)
DRE: 100004321 58081(baxa) 767645(zgc:153993)
SFM: 108923902 108941669(bax)
LCM: 102352490(BAX) 102359041
CIN: 100179864
SPU: 586236
APLC: 110974870
SKO: 102808194
CRG: 105326257
MYI: 110461955
OBI: 106869728
LAK: 106168833
EPA: 110245059
ADF: 107346175
PDAM: 113669589
SPIS: 111326054
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8358790
  Authors
Oltvai ZN, Milliman CL, Korsmeyer SJ
  Title
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
  Journal
Cell 74:609-19 (1993)
DOI:10.1016/0092-8674(93)90509-O
  Sequence
[hsa:581]
Reference
  Authors
Ruiz-Vela A, Opferman JT, Cheng EH, Korsmeyer SJ
  Title
Proapoptotic BAX and BAK control multiple initiator caspases.
  Journal
EMBO Rep 6:379-85 (2005)
DOI:10.1038/sj.embor.7400375
Reference
  Authors
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD
  Title
BAX activation is initiated at a novel interaction site.
  Journal
Nature 455:1076-81 (2008)
DOI:10.1038/nature07396
  Sequence
[hsa:581]
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