KEGG   ORTHOLOGY: K02159
Entry
K02159                      KO                                     

Name
BAX
Definition
apoptosis regulator BAX
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map01524  Platinum drug resistance
map04071  Sphingolipid signaling pathway
map04115  p53 signaling pathway
map04141  Protein processing in endoplasmic reticulum
map04210  Apoptosis
map04211  Longevity regulating pathway
map04215  Apoptosis - multiple species
map04217  Necroptosis
map04722  Neurotrophin signaling pathway
map04932  Non-alcoholic fatty liver disease
map04933  AGE-RAGE signaling pathway in diabetic complications
map05012  Parkinson disease
map05014  Amyotrophic lateral sclerosis
map05016  Huntington disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05203  Viral carcinogenesis
map05210  Colorectal cancer
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05218  Melanoma
map05220  Chronic myeloid leukemia
map05222  Small cell lung cancer
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05417  Lipid and atherosclerosis
Disease
H00020  Colorectal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K02159  BAX; apoptosis regulator BAX
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    K02159  BAX; apoptosis regulator BAX
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02159  BAX; apoptosis regulator BAX
   04215 Apoptosis - multiple species
    K02159  BAX; apoptosis regulator BAX
   04217 Necroptosis
    K02159  BAX; apoptosis regulator BAX
   04115 p53 signaling pathway
    K02159  BAX; apoptosis regulator BAX
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K02159  BAX; apoptosis regulator BAX
  09149 Aging
   04211 Longevity regulating pathway
    K02159  BAX; apoptosis regulator BAX
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02159  BAX; apoptosis regulator BAX
   05202 Transcriptional misregulation in cancer
    K02159  BAX; apoptosis regulator BAX
   05203 Viral carcinogenesis
    K02159  BAX; apoptosis regulator BAX
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02159  BAX; apoptosis regulator BAX
   05212 Pancreatic cancer
    K02159  BAX; apoptosis regulator BAX
   05225 Hepatocellular carcinoma
    K02159  BAX; apoptosis regulator BAX
   05226 Gastric cancer
    K02159  BAX; apoptosis regulator BAX
   05214 Glioma
    K02159  BAX; apoptosis regulator BAX
   05216 Thyroid cancer
    K02159  BAX; apoptosis regulator BAX
   05220 Chronic myeloid leukemia
    K02159  BAX; apoptosis regulator BAX
   05217 Basal cell carcinoma
    K02159  BAX; apoptosis regulator BAX
   05218 Melanoma
    K02159  BAX; apoptosis regulator BAX
   05213 Endometrial cancer
    K02159  BAX; apoptosis regulator BAX
   05224 Breast cancer
    K02159  BAX; apoptosis regulator BAX
   05222 Small cell lung cancer
    K02159  BAX; apoptosis regulator BAX
   05223 Non-small cell lung cancer
    K02159  BAX; apoptosis regulator BAX
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02159  BAX; apoptosis regulator BAX
   05170 Human immunodeficiency virus 1 infection
    K02159  BAX; apoptosis regulator BAX
   05161 Hepatitis B
    K02159  BAX; apoptosis regulator BAX
   05160 Hepatitis C
    K02159  BAX; apoptosis regulator BAX
   05164 Influenza A
    K02159  BAX; apoptosis regulator BAX
   05162 Measles
    K02159  BAX; apoptosis regulator BAX
   05168 Herpes simplex virus 1 infection
    K02159  BAX; apoptosis regulator BAX
   05163 Human cytomegalovirus infection
    K02159  BAX; apoptosis regulator BAX
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02159  BAX; apoptosis regulator BAX
   05169 Epstein-Barr virus infection
    K02159  BAX; apoptosis regulator BAX
   05165 Human papillomavirus infection
    K02159  BAX; apoptosis regulator BAX
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K02159  BAX; apoptosis regulator BAX
   05132 Salmonella infection
    K02159  BAX; apoptosis regulator BAX
   05131 Shigellosis
    K02159  BAX; apoptosis regulator BAX
   05152 Tuberculosis
    K02159  BAX; apoptosis regulator BAX
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K02159  BAX; apoptosis regulator BAX
   05014 Amyotrophic lateral sclerosis
    K02159  BAX; apoptosis regulator BAX
   05016 Huntington disease
    K02159  BAX; apoptosis regulator BAX
   05020 Prion disease
    K02159  BAX; apoptosis regulator BAX
   05022 Pathways of neurodegeneration - multiple diseases
    K02159  BAX; apoptosis regulator BAX
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K02159  BAX; apoptosis regulator BAX
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K02159  BAX; apoptosis regulator BAX
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02159  BAX; apoptosis regulator BAX
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K02159  BAX; apoptosis regulator BAX
   01524 Platinum drug resistance
    K02159  BAX; apoptosis regulator BAX
   01522 Endocrine resistance
    K02159  BAX; apoptosis regulator BAX
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K02159  BAX; apoptosis regulator BAX
  09183 Protein families: signaling and cellular processes
   02000 Transporters
    K02159  BAX; apoptosis regulator BAX
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Fission and Fusion factors
    K02159  BAX; apoptosis regulator BAX
Transporters [BR:ko02000]
 Other transporters
  Pores ion channels
   K02159  BAX; apoptosis regulator BAX
Other DBs
TC: 1.A.21.1.2
Genes
HSA: 581(BAX)
PTR: 747093(BAX)
PPS: 100991820(BAX)
GGO: 101152769(BAX)
PON: 100450682(BAX)
NLE: 100593013(BAX)
MCC: 718948(BAX)
MCF: 102132255(BAX)
CSAB: 103235004(BAX)
CATY: 105595265(BAX)
RRO: 104666540(BAX)
RBB: 108523624(BAX)
TFN: 117091541(BAX)
PTEH: 111520083(BAX)
CJC: 100391322(BAX)
SBQ: 101050177(BAX)
MMUR: 105865602(BAX)
MMU: 12028(Bax)
MCAL: 110297919(Bax)
MPAH: 110320030(Bax)
RNO: 24887(Bax)
MCOC: 116102201(Bax)
CGE: 100689032(Bax)
PLEU: 114684640(Bax)
NGI: 103743639(Bax)
HGL: 101713575(Bax)
CCAN: 109682703(Bax)
OCU: 100355675(BAX)
TUP: 102471776(BAX)
CFA: 403523(BAX)
VVP: 112931372(BAX)
VLG: 121484229(BAX)
AML: 100471095(BAX)
UMR: 103657107(BAX)
UAH: 113243322(BAX)
ORO: 101371652(BAX)
ELK: 111160657
MPUF: 101686802(BAX)
EJU: 114199627(BAX)
MLX: 117998245(BAX)
FCA: 493837(BAX)
PTG: 102949153(BAX)
AJU: 106988699(BAX)
HHV: 120243716(BAX)
BTA: 280730(BAX)
BOM: 102279740(BAX)
BIU: 109571778(BAX) 109571977
BBUB: 102400076(BAX)
CHX: 100846984(BAX)
OAS: 443059(BAX)
ODA: 120872170(BAX)
SSC: 396633(BAX)
CFR: 102512073
CDK: 105102890(BAX)
BACU: 103019528(BAX)
LVE: 103084066(BAX)
OOR: 101285349(BAX)
DLE: 111180640(BAX)
ECB: 100054674(BAX)
EPZ: 103553312(BAX)
EAI: 106838268(BAX)
MYB: 106723573(BAX)
MYD: 102761803(BAX)
MMYO: 118655437(BAX)
MNA: 107531901(BAX)
HAI: 109391068(BAX)
DRO: 112310132(BAX)
AJM: 119037607(BAX)
MMF: 118638701(BAX)
PALE: 102885135(BAX)
RAY: 107498831(BAX)
MJV: 108400315(BAX)
LAV: 100673560(BAX)
TMU: 101356564
MDO: 100030412(BAX)
PCW: 110219776(BAX)
OAA: 114814649(BAX)
LSR: 110481417(BAX)
PMOA: 120510409(BAX)
PHI: 102106020(BAX)
PMAJ: 107199046(BAX)
CCAE: 111943854(BAX)
FPG: 101920283(BAX)
ASN: 102384471(BAX)
AMJ: 102568113(BAX) 106737548
CPOO: 109320825(BAX) 109320834
PSS: 102446385
CMY: 102942796(BAX)
CPIC: 101948093(BAX) 101948354
ACS: 100561911 100562834(bax)
PMUA: 114581596(BAX)
ZVI: 118095300(BAX)
XLA: 108696744(bax.L) 373637(bax.S)
XTR: 394793(bax)
NPR: 108796054(BAX)
DRE: 100004321 58081(baxa) 767645(zgc:153993)
NCC: 104944891
PLEP: 121943319(zgc:153993) 121943733 121956673
SLUC: 116059287 116062819 116067388(zgc:153993)
ECRA: 117942138(zgc:153993) 117958554
PFLV: 114560203 114569518(bax)
GAT: 120810188(zgc:153993) 120828108
MSAM: 119890589(zgc:153993) 119892082(baxa)
CUD: 121509517(zgc:153993) 121529111
OAU: 116312494 116323706(zgc:153993) 116335600
XHE: 116719101 116735411(bax)
CTUL: 119777841(zgc:153993) 119778850 119778851
KMR: 108237852(zgc:153993) 108246126 108246134
SLAL: 111660532(bax) 111669314
XGL: 120788025 120788415 120795111(zgc:153993)
SFM: 108923902 108941669(bax)
LOC: 102689963(bax)
ARUT: 117432031(zgc:153993) 117434851
LCM: 102352490(BAX) 102359041
RTP: 109918844
CIN: 100179864
SCLV: 120346045
SPU: 586236
APLC: 110974870
SKO: 102808194
ATD: 109602366
AGB: 111691333
DCI: 103508495
CSEC: 111865768
EAF: 111706477
DSV: 119461275
VDE: 111246470
VJA: 111267914
CRG: 105326257
MYI: 110461955
OBI: 106869728
NVE: 5514629
EPA: 110245059
ATEN: 116286506
ADF: 107346175
AMIL: 114958535
PDAM: 113669589
SPIS: 111326054
AQU: 100631893
 » show all
Reference
PMID:8358790
  Authors
Oltvai ZN, Milliman CL, Korsmeyer SJ
  Title
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.
  Journal
Cell 74:609-19 (1993)
DOI:10.1016/0092-8674(93)90509-O
  Sequence
[hsa:581]
Reference
  Authors
Ruiz-Vela A, Opferman JT, Cheng EH, Korsmeyer SJ
  Title
Proapoptotic BAX and BAK control multiple initiator caspases.
  Journal
EMBO Rep 6:379-85 (2005)
DOI:10.1038/sj.embor.7400375
Reference
  Authors
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD
  Title
BAX activation is initiated at a novel interaction site.
  Journal
Nature 455:1076-81 (2008)
DOI:10.1038/nature07396
  Sequence
[hsa:581]
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