KEGG   ORTHOLOGY: K02187
Entry
K02187                      KO                                     

Name
CASP3
Definition
caspase 3 [EC:3.4.22.56]
Pathway
ko01524  Platinum drug resistance
ko04010  MAPK signaling pathway
ko04115  p53 signaling pathway
ko04210  Apoptosis
ko04215  Apoptosis - multiple species
ko04650  Natural killer cell mediated cytotoxicity
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko04726  Serotonergic synapse
ko04932  Non-alcoholic fatty liver disease
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis
ko05016  Huntington disease
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05130  Pathogenic Escherichia coli infection
ko05132  Salmonella infection
ko05133  Pertussis
ko05134  Legionellosis
ko05145  Toxoplasmosis
ko05146  Amoebiasis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05222  Small cell lung cancer
ko05416  Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K02187  CASP3; caspase 3
   04668 TNF signaling pathway
    K02187  CASP3; caspase 3
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02187  CASP3; caspase 3
   04215 Apoptosis - multiple species
    K02187  CASP3; caspase 3
   04115 p53 signaling pathway
    K02187  CASP3; caspase 3
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K02187  CASP3; caspase 3
   04657 IL-17 signaling pathway
    K02187  CASP3; caspase 3
  09156 Nervous system
   04726 Serotonergic synapse
    K02187  CASP3; caspase 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02187  CASP3; caspase 3
   05206 MicroRNAs in cancer
    K02187  CASP3; caspase 3
   05205 Proteoglycans in cancer
    K02187  CASP3; caspase 3
   05203 Viral carcinogenesis
    K02187  CASP3; caspase 3
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02187  CASP3; caspase 3
   05222 Small cell lung cancer
    K02187  CASP3; caspase 3
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02187  CASP3; caspase 3
   05012 Parkinson disease
    K02187  CASP3; caspase 3
   05014 Amyotrophic lateral sclerosis
    K02187  CASP3; caspase 3
   05016 Huntington disease
    K02187  CASP3; caspase 3
   05020 Prion disease
    K02187  CASP3; caspase 3
   05022 Pathways of neurodegeneration - multiple diseases
    K02187  CASP3; caspase 3
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K02187  CASP3; caspase 3
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K02187  CASP3; caspase 3
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02187  CASP3; caspase 3
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K02187  CASP3; caspase 3
   05130 Pathogenic Escherichia coli infection
    K02187  CASP3; caspase 3
   05132 Salmonella infection
    K02187  CASP3; caspase 3
   05133 Pertussis
    K02187  CASP3; caspase 3
   05134 Legionellosis
    K02187  CASP3; caspase 3
   05152 Tuberculosis
    K02187  CASP3; caspase 3
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K02187  CASP3; caspase 3
   05161 Hepatitis B
    K02187  CASP3; caspase 3
   05160 Hepatitis C
    K02187  CASP3; caspase 3
   05164 Influenza A
    K02187  CASP3; caspase 3
   05162 Measles
    K02187  CASP3; caspase 3
   05168 Herpes simplex virus 1 infection
    K02187  CASP3; caspase 3
   05163 Human cytomegalovirus infection
    K02187  CASP3; caspase 3
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02187  CASP3; caspase 3
   05169 Epstein-Barr virus infection
    K02187  CASP3; caspase 3
   05165 Human papillomavirus infection
    K02187  CASP3; caspase 3
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K02187  CASP3; caspase 3
   05145 Toxoplasmosis
    K02187  CASP3; caspase 3
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K02187  CASP3; caspase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K02187  CASP3; caspase 3
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.56  caspase-3
     K02187  CASP3; caspase 3
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C14: caspase family
   K02187  CASP3; caspase 3
Other DBs
GO: 0097200
Genes
HSA: 836(CASP3)
PTR: 461669(CASP3)
PPS: 100974934(CASP3)
GGO: 101126742(CASP3)
PON: 100435491(CASP3)
NLE: 100585064(CASP3)
MCC: 694473(CASP3)
MCF: 102144182(CASP3)
CSAB: 103236614(CASP3)
RRO: 104666783 104673791(CASP3)
RBB: 108512689
CJC: 100387570(CASP3)
SBQ: 101029697(CASP3)
MMU: 12367(Casp3)
MCAL: 110299851(Casp3)
MPAH: 110336608(Casp3)
RNO: 25402(Casp3)
CGE: 100689061(Casp3)
NGI: 103744668 103750475(Casp3)
OCU: 100008840(CASP3)
TUP: 102472926(CASP3) 102487119
CFA: 403567(CASP3)
VVP: 112934766(CASP3)
AML: 100469056(CASP3)
UMR: 103680991(CASP3)
UAH: 113262259(CASP3)
ORO: 101371336(CASP3)
ELK: 111144607
FCA: 493932(CASP3)
PTG: 102954729(CASP3)
PPAD: 109251018(CASP3)
AJU: 106979326(CASP3)
BTA: 408016(CASP3)
BOM: 102287348(CASP3)
BIU: 109553316(CASP3)
BBUB: 102415768(CASP3)
CHX: 102177031(CASP3)
OAS: 114116869 443031(CASP3)
SSC: 397244(CASP3)
CFR: 102520133(CASP3)
CDK: 105084433(CASP3)
BACU: 103019939(CASP3)
LVE: 103073819(CASP3)
OOR: 101289847(CASP3)
DLE: 111173401(CASP3)
PCAD: 102975528 102977692(CASP3)
ECB: 100034083(CASP3)
EPZ: 103549132(CASP3)
EAI: 106830081(CASP3)
MYB: 102258599(CASP3)
MYD: 102760961(CASP3)
MNA: 107535740(CASP3)
HAI: 109395706(CASP3)
DRO: 112306749(CASP3)
PALE: 102897289(CASP3)
RAY: 107510456(CASP3)
MJV: 108389793(CASP3)
LAV: 100672256(CASP3)
TMU: 101354307
MDO: 654273(CASP3) 654275
SHR: 100922500(CASP3) 100922757
PCW: 110222594(CASP3)
OAA: 100087105(CASP3)
GGA: 395476(CASP3)
MGP: 100548182(CASP3)
CJO: 107313280(CASP3)
NMEL: 110397291(CASP3)
APLA: 101805296(CASP3)
ACYG: 106035172(CASP3)
TGU: 100230799(CASP3)
LSR: 110477516(CASP3)
SCAN: 103825669(CASP3)
GFR: 102035830(CASP3)
FAB: 101808212(CASP3)
PHI: 102104322(CASP3)
PMAJ: 107203069(CASP3)
CCAE: 111945572(CASP3)
CCW: 104690575(CASP3)
ETL: 114055579(CASP3)
FPG: 101913355(CASP3) 101922533
FCH: 102050683 102056397(CASP3)
CLV: 102089427(CASP3)
EGZ: 104129473(CASP3)
NNI: 104021286(CASP3)
ACUN: 113479376(CASP3)
PADL: 103922530(CASP3) 103926227
AAM: 106484082(CASP3)
ASN: 102369935 102383553(CASP3)
AMJ: 102572621(CASP3) 102576234(CASP14)
PSS: 102463409
CMY: 102942062(CASP3)
CPIC: 101948246(CASP3)
ACS: 100563931(casp3)
PVT: 110083865(CASP3)
PBI: 103049711(CASP3)
PMUR: 107302670(CASP3)
TSR: 106539846(CASP3)
PMUA: 114585959 114604250(CASP3)
GJA: 107115654(CASP3)
XLA: 100036910(casp3.L) 397720(casp3.S)
XTR: 100151728(casp3.2) 100486222(casp3.1)
DRE: 140621(casp3a) 566604(casp3b)
IPU: 100528811(casp3) 108260860
EEE: 113581517(casp3) 113586537
TRU: 446083(casp3)
LCO: 104928227 104936945(caspase-3)
NCC: 104959742 104967108(casp3)
OLA: 100049215(casp3) 100049265
XCO: 114139499 114144355(casp3)
CVG: 107090480 107094160(casp3)
NFU: 107390752(casp3) 107397381
CSEM: 103383467 103391460(casp3)
MALB: 109957512(casp3) 109972113
SASA: 100194892(casp3) 106602722(CASP3) 106612018
ELS: 105006735(casp3) 105029385(casp3)
SFM: 108924572(casp3) 114912449
PKI: 111853593(casp3)
LCM: 106705928(CASP3)
CMK: 103187405(casp3) 103190313
APLC: 110975794
DPE: 113565090
DMN: 108158700
DHE: 111592184
MDE: 101899570
LCQ: 111676405
AAG: 5567300
PVM: 113829172
MYI: 110452312
LAK: 106173180
SHX: MS3_07622
EGL: EGR_04745
NVE: 5502486
EPA: 110247107
 » show all
Reference
PMID:7983002
  Authors
Fernandes-Alnemri T, Litwack G, Alnemri ES
  Title
CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.
  Journal
J Biol Chem 269:30761-4 (1994)
  Sequence
[hsa:836]
Reference
  Authors
Brentnall M, Rodriguez-Menocal L, De Guevara RL, Cepero E, Boise LH
  Title
Caspase-9, caspase-3 and caspase-7 have distinct roles during intrinsic apoptosis.
  Journal
BMC Cell Biol 14:32 (2013)
DOI:10.1186/1471-2121-14-32
  Sequence
[mmu:12367]
LinkDB

KEGG   ORTHOLOGY: K04398
Entry
K04398                      KO                                     

Name
CASP8
Definition
caspase 8 [EC:3.4.22.61]
Pathway
ko01524  Platinum drug resistance
ko04115  p53 signaling pathway
ko04210  Apoptosis
ko04214  Apoptosis - fly
ko04215  Apoptosis - multiple species
ko04217  Necroptosis
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04624  Toll and Imd signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko04932  Non-alcoholic fatty liver disease
ko05010  Alzheimer disease
ko05016  Huntington disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05130  Pathogenic Escherichia coli infection
ko05132  Salmonella infection
ko05134  Legionellosis
ko05142  Chagas disease
ko05145  Toxoplasmosis
ko05152  Tuberculosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05416  Viral myocarditis
Disease
H00108  Autoimmune lymphoproliferative syndromes
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K04398  CASP8; caspase 8
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K04398  CASP8; caspase 8
   04214 Apoptosis - fly
    K04398  CASP8; caspase 8
   04215 Apoptosis - multiple species
    K04398  CASP8; caspase 8
   04217 Necroptosis
    K04398  CASP8; caspase 8
   04115 p53 signaling pathway
    K04398  CASP8; caspase 8
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04624 Toll and Imd signaling pathway
    K04398  CASP8; caspase 8
   04621 NOD-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04622 RIG-I-like receptor signaling pathway
    K04398  CASP8; caspase 8
   04625 C-type lectin receptor signaling pathway
    K04398  CASP8; caspase 8
   04657 IL-17 signaling pathway
    K04398  CASP8; caspase 8
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04398  CASP8; caspase 8
   05203 Viral carcinogenesis
    K04398  CASP8; caspase 8
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04398  CASP8; caspase 8
   05016 Huntington disease
    K04398  CASP8; caspase 8
   05022 Pathways of neurodegeneration - multiple diseases
    K04398  CASP8; caspase 8
  09166 Cardiovascular disease
   05416 Viral myocarditis
    K04398  CASP8; caspase 8
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04398  CASP8; caspase 8
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04398  CASP8; caspase 8
   05132 Salmonella infection
    K04398  CASP8; caspase 8
   05134 Legionellosis
    K04398  CASP8; caspase 8
   05152 Tuberculosis
    K04398  CASP8; caspase 8
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04398  CASP8; caspase 8
   05161 Hepatitis B
    K04398  CASP8; caspase 8
   05160 Hepatitis C
    K04398  CASP8; caspase 8
   05164 Influenza A
    K04398  CASP8; caspase 8
   05162 Measles
    K04398  CASP8; caspase 8
   05168 Herpes simplex virus 1 infection
    K04398  CASP8; caspase 8
   05163 Human cytomegalovirus infection
    K04398  CASP8; caspase 8
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04398  CASP8; caspase 8
   05169 Epstein-Barr virus infection
    K04398  CASP8; caspase 8
   05165 Human papillomavirus infection
    K04398  CASP8; caspase 8
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04398  CASP8; caspase 8
   05142 Chagas disease
    K04398  CASP8; caspase 8
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K04398  CASP8; caspase 8
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K04398  CASP8; caspase 8
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.22  Cysteine endopeptidases
    3.4.22.61  caspase-8
     K04398  CASP8; caspase 8
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C14: caspase family
   K04398  CASP8; caspase 8
Other DBs
GO: 0097199
Genes
HSA: 841(CASP8)
PTR: 746477(CASP8)
PPS: 100978497(CASP8)
GGO: 101138898(CASP8)
PON: 100172115(CASP8)
NLE: 100586183(CASP8)
MCC: 702781(CASP8)
MCF: 101865354(CASP8)
CSAB: 103217637(CASP8)
RRO: 104671864(CASP8)
RBB: 108532002(CASP8)
CJC: 100395220(CASP8)
SBQ: 101053601(CASP8)
MMU: 12370(Casp8)
MCAL: 110291975(Casp8)
MPAH: 110321675(Casp8)
RNO: 64044(Casp8)
MUN: 110557662(Casp8)
CGE: 100689369(Casp8)
NGI: 103738672(Casp8)
HGL: 101702773(Casp8)
CCAN: 109689613(Casp8)
OCU: 100348477(CASP8)
TUP: 102498355(CASP8)
CFA: 488473(CASP8)
VVP: 112922873(CASP8)
AML: 100472842(CASP8)
UMR: 103659742(CASP8)
UAH: 113250592(CASP8)
ORO: 101365855(CASP8)
ELK: 111141026
FCA: 100142684(CASP8)
PTG: 102962460(CASP8)
PPAD: 109260762(CASP8)
AJU: 106987995(CASP8)
BTA: 507481(CASP8)
BOM: 102272602(CASP8)
BIU: 109569521(CASP8)
BBUB: 102412929(CASP8)
CHX: 102169919(CASP8)
OAS: 101107334(CASP8)
SSC: 595105(CASP8)
CFR: 102508224(CASP8)
CDK: 105099181(CASP8)
BACU: 103004642(CASP8)
LVE: 103077054(CASP8)
OOR: 101281780(CASP8)
DLE: 111171726(CASP8)
PCAD: 102988082(CASP8)
ECB: 100066502(CASP8)
EPZ: 103565685(CASP8)
EAI: 106823493(CASP8)
MYB: 102246377(CASP8)
MYD: 102761550(CASP8)
MNA: 107533931(CASP8)
HAI: 109379228(CASP8)
DRO: 112307787(CASP8)
PALE: 102878181(CASP8)
RAY: 107503155(CASP8)
MJV: 108398898(CASP8)
LAV: 100660542(CASP8) 100663575
TMU: 101344302
MDO: 100017025(CASP18) 100617599(CASP8)
SHR: 100931580(CASP8)
PCW: 110197193(CASP8)
GGA: 395284(CASP8) 693266(CASP18)
APLA: 101803161(CASP8) 106014283
LSR: 110484576(CASP8) 110484625
SCAN: 103814506 103814507(CASP8)
PHI: 102110759
CCAE: 111931990
CCW: 104693779
FPG: 101916968(CASP8) 106113022
FCH: 106630990(CASP8)
EGZ: 104130511(CASP8)
NNI: 104010196(CASP8)
PADL: 103923440 103924262(CASP8)
AAM: 106492412 106492473(CASP8)
AMJ: 102573591(CASP8) 102575862(CASP18)
CPIC: 101934006(CASP8) 101934828
XLA: 373559(casp8.L)
XTR: 100495471(casp8)
NPR: 108795080
DRE: 100049706(casp8l1) 557302(casp8l2) 561021(casp22) 58022(casp8)
OLA: 100049400(casp8) 100125536
SDU: 111218362 111229030(casp8)
SLAL: 111648895 111666542(casp8)
HCQ: 109520533
MALB: 109958094
CMK: 103171902(casp8)
CIN: 100183123
DME: Dmel_CG7486(Dredd)
DER: 6555550
DSE: 6615883
DSI: Dsimw501_GD16467(Dsim_Dredd)
DYA: Dyak_GE16575(Dyak_Dredd)
DAN: 6504896
DSR: 110182574
DPE: 6599948
DMN: 108153528
DWI: 6644580
DAZ: 108619540
DNV: 108656798
DHE: 111592986
DVI: 6633308
MDE: 101900122
AGA: AgaP_AGAP011693(CASPL1)
AAG: 5563818
AALB: 115262725
AME: 724930
BIM: 100741190
BTER: 100652115
CCAL: 108627268
OBB: 114878450
SOC: 105205440
MPHA: 105828235
AEC: 105147270
ACEP: 105625685
PBAR: 105429159
VEM: 105558011
HST: 105190451
DQU: 106743797
CFO: 105248277
LHU: 105678455
PGC: 109856665
OBO: 105280305
PCF: 106791240
NVI: 100680000
CSOL: 105360146
MDL: 103579887
TCA: 661095(Dredd)
DPA: 109534720
ATD: 109598530
NVL: 108556913
BMOR: 100141428(Dredd)
BMAN: 114248879
PMAC: 106720189
PRAP: 110996855
HAW: 110369675
TNL: 113491750
PXY: 105390324
CLEC: 106661122
ZNE: 110835030
PVM: 113822604
CSCU: 111615099
PCAN: 112560982
MYI: 110449259
SHX: MS3_10084
NVE: 5505811
EPA: 110231936
ADF: 107335805
AMIL: 114961919
PDAM: 113682606
SPIS: 111335203
 » show all
Reference
PMID:9931493
  Authors
Grenet J, Teitz T, Wei T, Valentine V, Kidd VJ
  Title
Structure and chromosome localization of the human CASP8 gene.
  Journal
Gene 226:225-32 (1999)
DOI:10.1016/S0378-1119(98)00565-4
  Sequence
[hsa:841]
LinkDB

DBGET integrated database retrieval system