KEGG   ORTHOLOGY: K02206
Entry
K02206                      KO                                     

Name
CDK2
Definition
cyclin-dependent kinase 2 [EC:2.7.11.22]
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04114  Oocyte meiosis
ko04115  p53 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04218  Cellular senescence
ko04914  Progesterone-mediated oocyte maturation
ko04934  Cushing syndrome
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05215  Prostate cancer
ko05222  Small cell lung cancer
ko05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K02206  CDK2; cyclin-dependent kinase 2
   04151 PI3K-Akt signaling pathway
    K02206  CDK2; cyclin-dependent kinase 2
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02206  CDK2; cyclin-dependent kinase 2
   04114 Oocyte meiosis
    K02206  CDK2; cyclin-dependent kinase 2
   04115 p53 signaling pathway
    K02206  CDK2; cyclin-dependent kinase 2
   04218 Cellular senescence
    K02206  CDK2; cyclin-dependent kinase 2
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K02206  CDK2; cyclin-dependent kinase 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02206  CDK2; cyclin-dependent kinase 2
   05203 Viral carcinogenesis
    K02206  CDK2; cyclin-dependent kinase 2
  09162 Cancer: specific types
   05226 Gastric cancer
    K02206  CDK2; cyclin-dependent kinase 2
   05215 Prostate cancer
    K02206  CDK2; cyclin-dependent kinase 2
   05222 Small cell lung cancer
    K02206  CDK2; cyclin-dependent kinase 2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K02206  CDK2; cyclin-dependent kinase 2
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02206  CDK2; cyclin-dependent kinase 2
   05162 Measles
    K02206  CDK2; cyclin-dependent kinase 2
   05161 Hepatitis B
    K02206  CDK2; cyclin-dependent kinase 2
   05160 Hepatitis C
    K02206  CDK2; cyclin-dependent kinase 2
   05169 Epstein-Barr virus infection
    K02206  CDK2; cyclin-dependent kinase 2
   05165 Human papillomavirus infection
    K02206  CDK2; cyclin-dependent kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02206  CDK2; cyclin-dependent kinase 2
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K02206  CDK2; cyclin-dependent kinase 2
   03036 Chromosome and associated proteins
    K02206  CDK2; cyclin-dependent kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02206  CDK2; cyclin-dependent kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  CDK family
   K02206  CDK2; cyclin-dependent kinase 2
DNA replication proteins [BR:ko03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   CDK (cyclin dependent kinase)
    K02206  CDK2; cyclin-dependent kinase 2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K02206  CDK2; cyclin-dependent kinase 2
Other DBs
COG: COG0515
GO: 0004693
Genes
HSA: 1017(CDK2)
PTR: 467032(CDK2)
PPS: 100981695(CDK2)
GGO: 101134769(CDK2)
PON: 100446748(CDK2)
NLE: 100592796(CDK2)
MCC: 711002(CDK2)
MCF: 102139233(CDK2)
CSAB: 103238495(CDK2)
RRO: 104673700(CDK2)
RBB: 108516053(CDK2)
CJC: 100398703(CDK2)
SBQ: 101053477(CDK2)
MMU: 12566(Cdk2)
MCAL: 110303221(Cdk2)
MPAH: 110327130(Cdk2)
RNO: 362817(Cdk2)
MUN: 110559398(Cdk2)
CGE: 100689039(Cdk2)
NGI: 103746495(Cdk2)
HGL: 101725353(Cdk2)
CCAN: 109698572(Cdk2)
OCU: 100134865(CDK2)
TUP: 102500015(CDK2)
CFA: 100855704(CDK2)
VVP: 112922404(CDK2)
AML: 100468314(CDK2)
UMR: 103682503(CDK2)
UAH: 113256451(CDK2)
ORO: 101383299(CDK2)
ELK: 111160135
FCA: 101093368(CDK2)
PTG: 102959572(CDK2)
PPAD: 109270309(CDK2)
AJU: 106986916(CDK2)
BTA: 519217(CDK2)
BOM: 102277344(CDK2)
BIU: 109559386(CDK2)
BBUB: 102398457(CDK2)
CHX: 100860751(CDK2)
OAS: 100216433(CDK2)
SSC: 100154715(CDK2)
CFR: 102504649(CDK2)
CDK: 105086385(CDK2)
BACU: 103012976(CDK2)
LVE: 103089138(CDK2)
OOR: 101289729(CDK2)
DLE: 111173897(CDK2)
PCAD: 102995000(CDK2)
ECB: 100051790(CDK2)
EPZ: 103560212(CDK2)
EAI: 106841302(CDK2)
MYB: 102256122(CDK2)
MYD: 102756838(CDK2)
MNA: 107538223(CDK2)
HAI: 109396882(CDK2)
DRO: 112319068(CDK2)
PALE: 102893397(CDK2)
RAY: 107521282(CDK2)
MJV: 108395918(CDK2)
LAV: 100668134(CDK2)
TMU: 101355616
SHR: 100925631(CDK2)
PCW: 110210908(CDK2)
OAA: 114814505(CDK2)
GGA: 100529062(CDK2)
MGP: 100542044
CJO: 107325763(CDK2)
NMEL: 110389218(CDK2)
TGU: 115491439(CDK2)
LSR: 110482124(CDK2)
SCAN: 115485039
PHI: 102108666
ETL: 114070800(CDK2)
NNI: 104017516(CDK2)
AAM: 106482119(CDK2)
ASN: 102376317(CDK2)
AMJ: 102570724(CDK2)
PSS: 102459974(CDK2)
CMY: 102929928(CDK2)
CPIC: 101933939(CDK2)
ACS: 100555545(cdk2)
PVT: 110073535(CDK2)
PBI: 103054413(CDK2)
PMUR: 107287774(CDK2)
TSR: 106539726(CDK2)
GJA: 107105847(CDK2)
XLA: 399314(cdk2.S) 432036(cdk2.L)
XTR: 493498(cdk2)
NPR: 108790510(CDK2)
DRE: 406715(cdk2)
SRX: 107730883
CCAR: 109048648(cdk2) 109075792
IPU: 108255265(cdk2)
PHYP: 113537787(cdk2)
AMEX: 103028318(cdk2)
EEE: 113592247(cdk2)
TRU: 101062041(cdk2)
LCO: 104931999(cdk2)
NCC: 104956742(cdk2)
MZE: 101479025(cdk2) 112431130
ONL: 100706903(cdk2)
OLA: 101161880(cdk2)
XMA: 102233595(cdk2)
XCO: 114135983(cdk2)
PRET: 103465316(cdk2)
CVG: 107082114(cdk2)
NFU: 107385661(cdk2)
KMR: 108235601(cdk2)
ALIM: 106510759(cdk2)
AOCE: 111579731(cdk2)
CSEM: 103386039(cdk2)
POV: 109629344(cdk2)
LCF: 108886434 108898963(cdk2)
SDU: 111221516(cdk2)
SLAL: 111667739(cdk2)
HCQ: 109522438(cdk2)
BPEC: 110171255(cdk2)
SASA: 100196712(cdk2) 106565437
SALP: 111965495 111970205(cdk2)
ELS: 105016957(cdk2)
SFM: 108918171(cdk2)
PKI: 111854723(cdk2)
LCM: 102366560(CDK2) 102367189
CMK: 103182904 103189561(cdk2)
BFO: 118403845
CIN: 100182544
SPU: 585950
APLC: 110975774
SKO: 100367943
DME: Dmel_CG10498(Cdk2)
DER: 6553444
DSE: 6619226
DSI: Dsimw501_GD19371(Dsim_GD19371)
DYA: Dyak_GE25682(Dyak_cdc2c)
DAN: 6499484
DSR: 110177210
DPE: 6598840
DMN: 108154199
DWI: 6649527
DAZ: 108615142
DNV: 108655175
DHE: 111600669
DVI: 26530763
MDE: 101895014
LCQ: 111680789
AME: 409959
BIM: 100744168
BTER: 100643829
CCAL: 108631904
OBB: 114883093
SOC: 105201449
MPHA: 105835905
AEC: 105145907
ACEP: 105622080
PBAR: 105429084
VEM: 105565286
HST: 105182056
CFO: 105253817
LHU: 105671693
PGC: 109863842
OBO: 105284368
PCF: 106785463
NVI: 100117828(Cdk2)
CSOL: 105362512
MDL: 103570423
TCA: 103313355 103314472(cdc2)
DPA: 109538506
ATD: 109608543
BMOR: 101738936(CDK2)
BMAN: 114246697
PMAC: 106709693
PRAP: 110999496
HAW: 110381543
API: 100162479
DNX: 107166377
AGS: 114127444
RMD: 113548928
CLEC: 106672288
ZNE: 110831693
FCD: 110856503
DPX: DAPPUDRAFT_299469(Cdk2)
PVM: 113822976
TUT: 107361131
DPTE: 113799438
CSCU: 111640752
PTEP: 107443618
BMY: Bm1_31455
PCAN: 112556656
CRG: 105325500
MYI: 110446820
OBI: 106876684
LAK: 106173442
NVE: 5513160
EPA: 110238330
ADF: 107351566
AMIL: 114966721
PDAM: 113685713
SPIS: 111320806
DGT: 114538481
HMG: 100212745
AQU: 100641341
ATH: AT3G48750(CDC2)
ALY: 9313699
CRB: 17886903
CPAP: 110815056
TCC: 18587577
LJA: Lj0g3v0192439.1(Lj0g3v0192439.1) Lj4g3v0334720.1(Lj4g3v0334720.1) Lj6g3v1589780.1(Lj6g3v1589780.1)
AIP: 107638937
FVE: 101303270
PPER: 18787950
PAVI: 110764980
ZJU: 107416239
CMO: 103489404
MCHA: 111018643
JCU: 105628962
VVI: 100262312
SLY: 101248452 544139(SICDKA1) 544140(cdc2A-2)
HAN: 110921605
SOE: 110795436
DOSA: Os02t0123100-01(Os02g0123100) Os03t0118400-01(Os03g0118400)
ATS: 109738027(LOC109738027) 109755114(LOC109755114)
ZMA: 100273306(gpm167a) 100284730(pco133105a) 103627970 103628436 542270(cdc2)
DCT: 110103529
PEQ: 110020414
APRO: F751_4573
MIS: MICPUN_55646(CDKA)
MPP: MICPUCDRAFT_69828(CDKA)
DDI: DDB_G0272813(cdk1)
DFA: DFA_00840(cdk1)
EHI: EHI_065280(119.t00008) EHI_152430(6.t00087) EHI_153140(13.t00001)
PCB: PCHAS_135550(PC000342.01.0)
TPV: TP04_0446
BBO: BBOV_III001400(17.m07143)
SMIN: v1.2.004367.t1(symbB.v1.2.004367.t1) v1.2.011577.t1(symbB.v1.2.011577.t1) v1.2.024101.t1(symbB.v1.2.024101.t1) v1.2.029202.t1(symbB.v1.2.029202.t1)
AAF: AURANDRAFT_37561(CDK1)
 » show all
Reference
PMID:1714386
  Authors
Elledge SJ, Spottswood MR
  Title
A new human p34 protein kinase, CDK2, identified by complementation of a cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1.
  Journal
EMBO J 10:2653-9 (1991)
DOI:10.1002/j.1460-2075.1991.tb07808.x
  Sequence
[hsa:1017]
Reference
  Authors
Zhao H, Chen X, Gurian-West M, Roberts JM
  Title
Loss of cyclin-dependent kinase 2 (CDK2) inhibitory phosphorylation in a CDK2AF knock-in mouse causes misregulation of DNA replication and centrosome duplication.
  Journal
Mol Cell Biol 32:1421-32 (2012)
DOI:10.1128/MCB.06721-11
LinkDB

KEGG   ORTHOLOGY: K02089
Entry
K02089                      KO                                     

Name
CDK4
Definition
cyclin-dependent kinase 4 [EC:2.7.11.22]
Pathway
ko01522  Endocrine resistance
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04218  Cellular senescence
ko04530  Tight junction
ko04660  T cell receptor signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko04934  Cushing syndrome
ko05160  Hepatitis C
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05212  Pancreatic cancer
ko05214  Glioma
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
Disease
H00030  Cervical cancer
H00038  Melanoma
H00042  Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02089  CDK4; cyclin-dependent kinase 4
   04115 p53 signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
   04218 Cellular senescence
    K02089  CDK4; cyclin-dependent kinase 4
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K02089  CDK4; cyclin-dependent kinase 4
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K02089  CDK4; cyclin-dependent kinase 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05203 Viral carcinogenesis
    K02089  CDK4; cyclin-dependent kinase 4
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05225 Hepatocellular carcinoma
    K02089  CDK4; cyclin-dependent kinase 4
   05214 Glioma
    K02089  CDK4; cyclin-dependent kinase 4
   05220 Chronic myeloid leukemia
    K02089  CDK4; cyclin-dependent kinase 4
   05218 Melanoma
    K02089  CDK4; cyclin-dependent kinase 4
   05219 Bladder cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05224 Breast cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05222 Small cell lung cancer
    K02089  CDK4; cyclin-dependent kinase 4
   05223 Non-small cell lung cancer
    K02089  CDK4; cyclin-dependent kinase 4
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02089  CDK4; cyclin-dependent kinase 4
   04934 Cushing syndrome
    K02089  CDK4; cyclin-dependent kinase 4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02089  CDK4; cyclin-dependent kinase 4
   05162 Measles
    K02089  CDK4; cyclin-dependent kinase 4
   05164 Influenza A
    K02089  CDK4; cyclin-dependent kinase 4
   05160 Hepatitis C
    K02089  CDK4; cyclin-dependent kinase 4
   05163 Human cytomegalovirus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05169 Epstein-Barr virus infection
    K02089  CDK4; cyclin-dependent kinase 4
   05165 Human papillomavirus infection
    K02089  CDK4; cyclin-dependent kinase 4
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K02089  CDK4; cyclin-dependent kinase 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02089  CDK4; cyclin-dependent kinase 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02089  CDK4; cyclin-dependent kinase 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  CDK family
   K02089  CDK4; cyclin-dependent kinase 4
Other DBs
GO: 0004693
Genes
HSA: 1019(CDK4)
PTR: 452025(CDK4)
PPS: 100976294(CDK4)
GGO: 101147065(CDK4)
PON: 100443314(CDK4)
NLE: 100594967(CDK4)
MCC: 715650(CDK4)
MCF: 101925733(CDK4)
CSAB: 103238589(CDK4)
RRO: 104682344(CDK4)
RBB: 108524397(CDK4)
CJC: 100408304(CDK4)
SBQ: 101040767(CDK4)
MMU: 12567(Cdk4)
MCAL: 110303132(Cdk4)
MPAH: 110326196(Cdk4)
RNO: 94201(Cdk4)
MUN: 110561245(Cdk4)
CGE: 100760122(Cdk4)
NGI: 103742900(Cdk4)
HGL: 101702608(Cdk4)
CCAN: 109686224(Cdk4)
OCU: 100009039(CDK4)
TUP: 102493291(CDK4)
CFA: 481131(CDK4)
VVP: 112922331(CDK4)
AML: 100481236(CDK4)
UMR: 103656694(CDK4)
UAH: 113256363(CDK4)
ORO: 101362330(CDK4)
ELK: 111160230
FCA: 101097903(CDK4)
PTG: 102970281(CDK4)
PPAD: 109270390(CDK4)
AJU: 106975871(CDK4)
BTA: 510618(CDK4)
BOM: 102278545(CDK4)
BIU: 109559308(CDK4)
BBUB: 102412787(CDK4)
CHX: 102171306(CDK4)
OAS: 100144756(CDK4)
SSC: 100144492(CDK4)
CFR: 102522300(CDK4)
CDK: 105100330(CDK4)
BACU: 103000540(CDK4) 103010593
LVE: 103084826(CDK4)
OOR: 101283760(CDK4)
DLE: 111173824(CDK4)
PCAD: 102985179(CDK4)
ECB: 100051005(CDK4)
EPZ: 103553644(CDK4)
EAI: 106833016(CDK4)
MYB: 102261527(CDK4)
MYD: 102758995(CDK4)
MNA: 107546223(CDK4)
HAI: 109390747(CDK4)
DRO: 112319119(CDK4)
PALE: 102894222(CDK4)
RAY: 107501504(CDK4)
MJV: 108387631(CDK4)
LAV: 104847103(CDK4)
TMU: 101355276
SHR: 100932899(CDK4)
PCW: 110210989(CDK4)
CJO: 107325825(CDK4)
PHI: 102103942(CDK4)
PMAJ: 107199280
AAM: 106492770
ASN: 102387479(CDK4)
AMJ: 102572556(CDK4)
CMY: 102945436(CDK4)
CPIC: 101943854(CDK4)
ACS: 100559515(cdk4)
PVT: 110074435(CDK4)
PBI: 103058869(CDK4)
PMUR: 107291540(CDK4)
TSR: 106540822(CDK4)
PMUA: 114593035(CDK4)
GJA: 107119665(CDK4)
XLA: 108705492 379406(cdk4.L) 496334(cdk6.L)
XTR: 549496(cdk4)
NPR: 108795357(CDK4)
DRE: 777730(cdk4)
SGH: 107567936
IPU: 108255186(cdk4)
PHYP: 113525662
AMEX: 103034254(cdk4)
EEE: 113572459(cdk4)
TRU: 101063081(cdk4)
LCO: 104929049(cdk4)
NCC: 104955917(cdk4)
MZE: 101475315
ONL: 100710125(cdk4)
OLA: 101172808(cdk4)
XMA: 102220323(cdk4)
XCO: 114135419(cdk4)
PRET: 103465328(cdk4)
CVG: 107082148(cdk4)
NFU: 107385649(cdk4)
KMR: 108235797(cdk4)
ALIM: 106518078
AOCE: 111587634(cdk4)
CSEM: 103386052(cdk4)
POV: 109629352(cdk4)
LCF: 108898964(cdk4)
SDU: 111221753(cdk4)
SLAL: 111667889(cdk4)
HCQ: 109522590(cdk4)
BPEC: 110171259(cdk4)
MALB: 109956190(cdk4)
OTW: 112216345
ELS: 105016970(cdk4)
SFM: 108918175(cdk4)
PKI: 111854375(cdk4) 111856032
LCM: 102363370(CDK4)
CMK: 103191316(cdk4)
RTP: 109925336(cdk4)
DME: Dmel_CG5072(Cdk4)
DER: 6548425
DSE: 6609465
DSI: Dsimw501_GD11207(Dsim_GD11207)
DAN: 6494260
DSR: 110187091
DPE: 6591061
DWI: 6639792
DAZ: 108615638
DNV: 108653601
DHE: 111593550
DVI: 6625181
MDE: 101892496
LCQ: 111675356
AAG: 5570506
AALB: 109406441
BIM: 100740274
CCAL: 108633063
SOC: 105196992
MPHA: 105838129
AEC: 105153633
PBAR: 105433444
VEM: 105561026
HST: 105187057
DQU: 106744310
CFO: 105249672
LHU: 105675373
PGC: 109855281
PCF: 106790376
NVI: 100122192(Cdk4)
CSOL: 105361031
MDL: 103574306
TCA: 663975
NVL: 108558807
BMOR: 100316860
BMAN: 114250235
PMAC: 106709519
PRAP: 110993439
HAW: 110381856
TNL: 113499972
PXY: 105389917
BMY: Bm1_33670
TSP: Tsp_00762
 » show all
Reference
  Authors
Blain SW
  Title
Switching cyclin D-Cdk4 kinase activity on and off.
  Journal
Cell Cycle 7:892-8 (2008)
DOI:10.4161/cc.7.7.5637
Reference
PMID:7652577
  Authors
Wolfel T, Hauer M, Schneider J, Serrano M, Wolfel C, Klehmann-Hieb E, De Plaen E, Hankeln T, Meyer zum Buschenfelde KH, Beach D
  Title
A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma.
  Journal
Science 269:1281-4 (1995)
DOI:10.1126/science.7652577
  Sequence
[hsa:1019]
LinkDB

KEGG   ORTHOLOGY: K02091
Entry
K02091                      KO                                     

Name
CDK6
Definition
cyclin-dependent kinase 6 [EC:2.7.11.22]
Pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04218  Cellular senescence
ko04934  Cushing syndrome
ko05160  Hepatitis C
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05206  MicroRNAs in cancer
ko05212  Pancreatic cancer
ko05214  Glioma
ko05218  Melanoma
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
Disease
H00269  Primary microcephaly
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K02091  CDK6; cyclin-dependent kinase 6
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02091  CDK6; cyclin-dependent kinase 6
   04115 p53 signaling pathway
    K02091  CDK6; cyclin-dependent kinase 6
   04218 Cellular senescence
    K02091  CDK6; cyclin-dependent kinase 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05206 MicroRNAs in cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05203 Viral carcinogenesis
    K02091  CDK6; cyclin-dependent kinase 6
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05225 Hepatocellular carcinoma
    K02091  CDK6; cyclin-dependent kinase 6
   05214 Glioma
    K02091  CDK6; cyclin-dependent kinase 6
   05220 Chronic myeloid leukemia
    K02091  CDK6; cyclin-dependent kinase 6
   05218 Melanoma
    K02091  CDK6; cyclin-dependent kinase 6
   05224 Breast cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05222 Small cell lung cancer
    K02091  CDK6; cyclin-dependent kinase 6
   05223 Non-small cell lung cancer
    K02091  CDK6; cyclin-dependent kinase 6
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K02091  CDK6; cyclin-dependent kinase 6
  09172 Infectious disease: viral
   05162 Measles
    K02091  CDK6; cyclin-dependent kinase 6
   05164 Influenza A
    K02091  CDK6; cyclin-dependent kinase 6
   05160 Hepatitis C
    K02091  CDK6; cyclin-dependent kinase 6
   05163 Human cytomegalovirus infection
    K02091  CDK6; cyclin-dependent kinase 6
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02091  CDK6; cyclin-dependent kinase 6
   05169 Epstein-Barr virus infection
    K02091  CDK6; cyclin-dependent kinase 6
   05165 Human papillomavirus infection
    K02091  CDK6; cyclin-dependent kinase 6
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02091  CDK6; cyclin-dependent kinase 6
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.22  cyclin-dependent kinase
     K02091  CDK6; cyclin-dependent kinase 6
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  CDK family
   K02091  CDK6; cyclin-dependent kinase 6
Genes
HSA: 1021(CDK6)
PTR: 746968(CDK6)
PPS: 100981258(CDK6)
GGO: 109023121(CDK6)
PON: 100454924(CDK6)
NLE: 100602542(CDK6)
MCC: 701822(CDK6)
MCF: 102140874(CDK6)
CSAB: 103226555(CDK6)
RRO: 104682750(CDK6)
RBB: 108528490(CDK6)
CJC: 100385604(CDK6)
SBQ: 101040507(CDK6)
MMU: 12571(Cdk6)
MCAL: 110294345(Cdk6)
MPAH: 110316496(Cdk6)
RNO: 114483(Cdk6)
MUN: 110558380(Cdk6)
CGE: 100764515(Cdk6)
NGI: 103725210(Cdk6)
HGL: 101719908(Cdk6)
OCU: 100009040(CDK6)
TUP: 102488432(CDK6)
CFA: 609920(CDK6)
VVP: 112923889(CDK6)
AML: 100476389(CDK6)
UMR: 103658796(CDK6)
UAH: 113259981(CDK6)
ORO: 101378405(CDK6)
ELK: 111147246
FCA: 100037415(CDK6)
PTG: 102967948(CDK6)
PPAD: 109263689(CDK6)
AJU: 106969949(CDK6)
BTA: 511754(CDK6)
BOM: 102264992(CDK6)
BIU: 109558203(CDK6)
BBUB: 102407325(CDK6)
CHX: 102180182(CDK6)
OAS: 100144761(CDK6)
CFR: 102520456(CDK6)
CDK: 105088747(CDK6)
BACU: 103011327(CDK6)
LVE: 103081338(CDK6)
OOR: 101271733(CDK6)
DLE: 111180943(CDK6)
PCAD: 102992532(CDK6)
ECB: 100061625(CDK6)
EPZ: 103549196(CDK6)
EAI: 106832259(CDK6)
MYB: 102258140(CDK6)
MYD: 102760528(CDK6)
MNA: 107541691(CDK6)
HAI: 109373596(CDK6)
DRO: 112319896(CDK6)
PALE: 102896272(CDK6)
RAY: 107519055(CDK6)
MJV: 108392535(CDK6)
LAV: 100655429(CDK6)
MDO: 100021675(CDK6)
SHR: 100924154(CDK6)
PCW: 110209152(CDK6)
OAA: 100091822(CDK6)
GGA: 420558(CDK6)
MGP: 100539044(CDK6)
CJO: 107309074(CDK6)
NMEL: 110393133(CDK6)
APLA: 101793324(CDK6)
ACYG: 106039673(CDK6)
TGU: 100229620(CDK6)
LSR: 110482460(CDK6)
SCAN: 103812819(CDK6)
GFR: 102034159(CDK6)
FAB: 101815768(CDK6)
PHI: 102114646(CDK6)
PMAJ: 107200146(CDK6)
CCAE: 111924218(CDK6)
CCW: 104689173(CDK6)
ETL: 114062117(CDK6)
FPG: 101921135(CDK6)
FCH: 102047555(CDK6)
CLV: 102091430(CDK6)
EGZ: 104128955(CDK6)
NNI: 104014021(CDK6)
ACUN: 113476723(CDK6)
PADL: 103922381(CDK6)
AAM: 106483627(CDK6)
ASN: 102387975(CDK6)
AMJ: 102561028(CDK6)
PSS: 102454031(CDK6)
CMY: 102944070(CDK6)
CPIC: 101938073(CDK6)
ACS: 100558412(cdk6)
PVT: 110074720(CDK6)
PBI: 103059655(CDK6)
PMUR: 107283642(CDK6)
TSR: 106548960(CDK6)
PMUA: 114607812(CDK6)
GJA: 107108272(CDK6)
XTR: 100489734(cdk6)
NPR: 108787899(CDK6)
DRE: 100034507(cdk6) 569515(cdk21)
IPU: 108257114(cdk6) 108274791
PHYP: 113528439 113536004(cdk6)
AMEX: 103047757(cdk6)
EEE: 113578681(cdk6) 113588899
TRU: 101070296(cdk6) 101078305
LCO: 104926452 104927455(cdk6)
NCC: 104944671
MZE: 101464773(cdk6) 101478399
ONL: 100695113 100711614(cdk6)
OLA: 101165981 101168879(cdk6)
XMA: 102235700(cdk6) 102237928
XCO: 114156288(cdk6) 114159833
PRET: 103469340 103472249(cdk6)
CVG: 107084790 107085881(cdk6)
NFU: 107378559 107383310(cdk6)
KMR: 108237737 108241821(cdk6)
AOCE: 111573355(cdk6) 111574249
CSEM: 103392753 103394142(cdk6)
POV: 109631907(cdk6) 109634060
LCF: 108872758 108877644(cdk6)
SDU: 111217648 111223044(cdk6)
SLAL: 111656924(cdk6) 111658435
HCQ: 109527671(cdk6) 109532677
BPEC: 110159294
MALB: 109963185 109968183(cdk6)
ELS: 105007255 105022797(cdk6)
PKI: 111843897(cdk6)
LCM: 102353660(CDK6) 102366718
CMK: 103183765 103185269(cdk6)
BFO: 118403661
CIN: 100175205
SPU: 373289(cdk4)
APLC: 110984198
SKO: 100371039
FCD: 110852991
TUT: 107365344
CEL: CELE_F18H3.5(cdk-4)
CBR: CBG07433(Cbr-cdk-4)
PCAN: 112556231
MYI: 110452126
OBI: 106881146
LAK: 106162008
NVE: 5509062
EPA: 110244942
AMIL: 114965766
PDAM: 113669926
SPIS: 111332639
DGT: 114527048
HMG: 100206502
 » show all
Reference
  Authors
Lucas JJ, Domenico J, Gelfand EW
  Title
Cyclin-dependent kinase 6 inhibits proliferation of human mammary epithelial cells.
  Journal
Mol Cancer Res 2:105-14 (2004)
  Sequence
[hsa:1021]
Reference
PMID:1639063
  Authors
Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH
  Title
A family of human cdc2-related protein kinases.
  Journal
EMBO J 11:2909-17 (1992)
DOI:10.1002/j.1460-2075.1992.tb05360.x
  Sequence
[hsa:1021]
LinkDB

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