KEGG   ORTHOLOGY: K02212
Entry
K02212                      KO                                     

Name
MCM4, CDC54
Definition
DNA replication licensing factor MCM4 [EC:3.6.4.12]
Pathway
ko03030  DNA replication
ko04110  Cell cycle
ko04111  Cell cycle - yeast
ko04113  Meiosis - yeast
Disease
H00094  Immunodeficiency associated with DNA repair defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    K02212  MCM4, CDC54; DNA replication licensing factor MCM4
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02212  MCM4, CDC54; DNA replication licensing factor MCM4
   04111 Cell cycle - yeast
    K02212  MCM4, CDC54; DNA replication licensing factor MCM4
   04113 Meiosis - yeast
    K02212  MCM4, CDC54; DNA replication licensing factor MCM4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K02212  MCM4, CDC54; DNA replication licensing factor MCM4
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.4  Acting on acid anhydrides to facilitate cellular and subcellular movement
    3.6.4.12  DNA helicase
     K02212  MCM4, CDC54; DNA replication licensing factor MCM4
DNA replication proteins [BR:ko03032]
 Eukaryotic type
  DNA Replication Initiation Factors
   pre-RC (pre-replication complex)
    K02212  MCM4, CDC54; DNA replication licensing factor MCM4
Other DBs
COG: COG1241
GO: 0042555
Genes
HSA: 4173(MCM4)
PTR: 472757(MCM4)
PPS: 100978179(MCM4)
GGO: 101128616(MCM4)
PON: 100460767(MCM4)
NLE: 100587695(MCM4)
MCC: 714686(MCM4)
MCF: 102120551(MCM4)
CSAB: 103236759(MCM4)
RRO: 104657633(MCM4)
RBB: 108535349(MCM4)
CJC: 100399985(MCM4)
SBQ: 101030175(MCM4)
MMU: 17217(Mcm4)
MCAL: 110311400(Mcm4)
MPAH: 110329521(Mcm4)
RNO: 29728(Mcm4)
MUN: 110561337(Mcm4)
CGE: 100770466(Mcm4)
HGL: 101721409(Mcm4)
CCAN: 109688673(Mcm4)
OCU: 100349822(MCM4)
TUP: 102496583(MCM4)
CFA: 477871(MCM4)
VVP: 112929172(MCM4)
AML: 100483038(MCM4)
UMR: 103677406(MCM4)
UAH: 113268118(MCM4)
ORO: 101379869(MCM4)
ELK: 111155446
FCA: 101089576(MCM4)
PTG: 102959870(MCM4)
PPAD: 109254737(MCM4)
AJU: 106982123(MCM4)
BTA: 504367(MCM4)
BOM: 102279151(MCM4)
BIU: 109568210(MCM4)
BBUB: 102392228(MCM4)
CHX: 102175140(MCM4)
OAS: 101105420(MCM4)
SSC: 100156398(MCM4)
CFR: 102520800(MCM4)
CDK: 105095922(MCM4)
BACU: 103019338(MCM4)
LVE: 103091041(MCM4)
OOR: 101286037(MCM4)
DLE: 111165805(MCM4)
PCAD: 102984273(MCM4)
ECB: 100051303(MCM4)
EPZ: 103567518(MCM4)
EAI: 106833582(MCM4)
MYB: 102245047(MCM4)
MYD: 102774510(MCM4)
MNA: 107526458(MCM4)
HAI: 109392681(MCM4)
DRO: 112320825(MCM4)
PALE: 102894958(MCM4)
RAY: 107505080(MCM4)
MJV: 108403582(MCM4)
LAV: 100667013(MCM4)
TMU: 101346478
MDO: 100030676(MCM4)
SHR: 100925406(MCM4)
PCW: 110212577(MCM4)
OAA: 100084454(MCM4)
GGA: 426764(MCM4)
MGP: 100547780(MCM4)
CJO: 107310154(MCM4)
NMEL: 110394405(MCM4)
APLA: 101804977(MCM4)
ACYG: 106038436(MCM4)
TGU: 100222050(MCM4)
LSR: 110473760(MCM4)
SCAN: 103816121(MCM4)
GFR: 102044176(MCM4)
FAB: 101807243(MCM4)
PHI: 102108308(MCM4)
PMAJ: 107200968(MCM4)
CCAE: 111924875(MCM4)
CCW: 104690432(MCM4)
ETL: 114060613(MCM4)
FPG: 101914710(MCM4)
FCH: 102045846(MCM4)
CLV: 102098866
EGZ: 104127678(MCM4)
NNI: 104019797(MCM4)
ACUN: 113476128(MCM4)
PADL: 103923189(MCM4)
AAM: 106494391(MCM4)
ASN: 102385755(MCM4)
AMJ: 102575077(MCM4)
PSS: 102462305 102462549
CMY: 102937106 102937336
CPIC: 101954116(MCM4)
ACS: 100562294(mcm4)
PVT: 110077636(MCM4)
PBI: 103061138(MCM4)
PMUR: 107289323(MCM4)
TSR: 106554043(MCM4)
PMUA: 114600633(MCM4)
GJA: 107122362(MCM4)
XLA: 373601(mcm4.L) 397843(mcm4.S)
XTR: 448137(mcm4)
NPR: 108798152(MCM4)
DRE: 337598(mcm4)
SRX: 107717354 107732126
SANH: 107667215(mcm4) 107677264
SGH: 107554683 107599677
CCAR: 109095030(mcm4)
IPU: 108264004(mcm4)
PHYP: 113533801(mcm4)
AMEX: 103034183(mcm4)
EEE: 113581635(mcm4)
TRU: 101064276(mcm4)
TNG: GSTEN00016183G001
LCO: 104917667(mcm4)
NCC: 104955969(mcm4)
MZE: 101463880(mcm4)
ONL: 100697842(mcm4)
OLA: 101173977(mcm4)
XMA: 102236930(mcm4)
XCO: 114146649(mcm4)
PRET: 103479683(mcm4)
CVG: 107102860(mcm4)
NFU: 107383877(mcm4)
KMR: 108241641(mcm4)
ALIM: 106533671(mcm4)
AOCE: 111577414(mcm4)
CSEM: 103396298(mcm4)
POV: 109646138(mcm4)
LCF: 108883375(mcm4)
SDU: 111231045(mcm4)
SLAL: 111653294(mcm4)
HCQ: 109521226(mcm4)
BPEC: 110158075(mcm4)
MALB: 109957794(mcm4)
SASA: 100380456(mcm4) 106569128
OTW: 112226810 112260610
SALP: 111956537 111979598 112080119
ELS: 105019516(mcm4)
SFM: 108933769(mcm4)
PKI: 111860058(mcm4)
LCM: 102352679(MCM4)
CMK: 103175166(mcm4)
RTP: 109913874(mcm4)
BFO: 118417713
CIN: 100176589
SPU: 582341
APLC: 110980119
SKO: 100367050
DME: Dmel_CG1616(dpa)
DER: 6543061
DSE: 6608006
DSI: Dsimw501_GD29100(Dsim_GD29100)
DYA: Dyak_GE23926
DAN: 6496512
DSR: 110180038
DPO: Dpse_GA14047
DPE: 6602056
DMN: 108158096 117188335
DWI: 6637900
DGR: Dgri_GH19815 Dgri_GH23696
DMO: Dmoj_GI20404
DAZ: 108616580
DNV: 108653847
DHE: 111594025
DVI: 6624816
MDE: 101894499
LCQ: 111675885
AGA: AgaP_AGAP004956
AAG: 5564603
AALB: 109430667 115270238
CQU: CpipJ_CPIJ010887
AME: 552291
BIM: 100744910
BTER: 100649788
CCAL: 108632143
OBB: 114873398
SOC: 105198551
MPHA: 105834226
AEC: 105152171
ACEP: 105625900
PBAR: 105431343
VEM: 105560480
HST: 105188757
DQU: 106748774
CFO: 105249834
LHU: 105677750
PGC: 109855488
OBO: 105277458
PCF: 106785796
NVI: 100124268
CSOL: 105362220
MDL: 103573056
TCA: 662486
DPA: 109534123
ATD: 109598153
NVL: 108563465
BMOR: 101746848
BMAN: 114239491
DPL: KGM_210471A
PMAC: 106716487
PRAP: 111002701
HAW: 110369901
TNL: 113503128
PXY: 105391993
API: 100163482
DNX: 107166048
AGS: 114131847
RMD: 113554923
BTAB: 109038359
CLEC: 106664319
PHU: Phum_PHUM177450
ZNE: 110832585
FCD: 110860840
DPX: DAPPUDRAFT_329431
PVM: 113814059
ISC: IscW_ISCW019440
TUT: 107365297
DPTE: 113788375 113795295 113799463
CSCU: 111634387
PTEP: 107441637
CEL: CELE_Y39G10AR.14(mcm-4)
CBR: CBG03890(Cbr-mcm-4)
BMY: Bm1_48490
LOA: LOAG_10273
NAI: NECAME_07211
TSP: Tsp_06355
HRO: HELRODRAFT_67429
LGI: LOTGIDRAFT_206222
PCAN: 112576739
CRG: 105346597
MYI: 110441928
OBI: 106874208
LAK: 106156400 106179387
SMM: Smp_172530
SHX: MS3_06328
OVI: T265_07572
EGL: EGR_08992
NVE: 116613718
EPA: 110240936
ADF: 107355687
AMIL: 114957768
PDAM: 113665928
SPIS: 111337706
DGT: 114532617
HMG: 100202591
TAD: TRIADDRAFT_35366
AQU: 100631974
ATH: AT2G16440(MCM4)
ALY: 9320238
CRB: 17891827
CSAT: 104748747 104766943 104792288
EUS: EUTSA_v10022552mg
BRP: 103860462
BNA: 106429437 106439842
BOE: 106328279
RSZ: 108805243 108862143
THJ: 104819624
CPAP: 110808203
CIT: 102619925
CIC: CICLE_v10027807mg
TCC: 18607717
GRA: 105783654
GHI: 107913539 107920789
GAB: 108464517
DZI: 111308252
EGR: 104453362
GMX: 100782586 100805788
GSJ: 114373093 114378362
PVU: PHAVU_011G041300g
VRA: 106756632
VAR: 108338907
VUN: 114168395
CCAJ: 109798646
MTR: MTR_4g071090
CAM: 101490846
LJA: Lj0g3v0085309.1(Lj0g3v0085309.1) Lj0g3v0085309.2(Lj0g3v0085309.2)
ADU: 107477032
AIP: 107632280
LANG: 109351480 109355478
FVE: 101293449
RCN: 112173086
PPER: 18766282
PMUM: 103335718
PAVI: 110768538
MDM: 103445117 114827546
PXB: 103942716 103962069
ZJU: 107426697
CSV: 101211850
CMO: 103490357
MCHA: 111007934
CMAX: 111468442 111496758
CMOS: 111432387 111455061
CPEP: 111776473 111792253
RCU: 8284343
JCU: 105630109
HBR: 110657018
MESC: 110608263
POP: 7456349
PEU: 105141966
JRE: 109005731
QSU: 111993728 112014572 112027052
VVI: 100262415(MCM4)
SLY: 101264867
SPEN: 107007820
SOT: 102584896
CANN: 107840463
NTA: 107795484 107799705
NSY: 104234170
NTO: 104097381
NAU: 109224478
INI: 109160133
SIND: 105172915
OEU: 111412103
HAN: 110897923 110928430
LSV: 111912453
CCAV: 112517283
DCR: 108204533
BVG: 104904296
SOE: 110789558
CQI: 110705144 110718908
NNU: 104605513
PSOM: 113288745 113289226
OSA: 107275673
DOSA: Os01t0544450-01(Os01g0544450)
OBR: 102718231
BDI: 100821405
ATS: 109740006(LOC109740006)
SBI: 8075459
ZMA: 100281587 100383139
SITA: 101760715
PDA: 103709301
EGU: 105047127
MUS: 103997545
DCT: 110113591
PEQ: 110035757
AOF: 109840691
ATR: 18424154
SMO: SELMODRAFT_439569 SELMODRAFT_445155
PPP: 112272748
CRE: CHLREDRAFT_113236(MCM4)
VCN: VOLCADRAFT_106331(mcm4)
CSL: COCSUDRAFT_46876
CVR: CHLNCDRAFT_142932
APRO: F751_5909
OLU: OSTLU_51954
OTA: OT_ostta11g01760 OT_ostta14g01050
BPG: Bathy12g03400
MIS: MICPUN_95766
MPP: MICPUCDRAFT_36602
CME: CYME_CMP356C
GSL: Gasu_07680
CCP: CHC_T00008506001
SCE: YPR019W(MCM4)
AGO: AGOS_ADL026W
ERC: Ecym_8360
KLA: KLLA0_C17512g
KMX: KLMA_30303(MCM4)
LTH: KLTH0H08690g
VPO: Kpol_274p5
ZRO: ZYRO0E02574g
CGR: CAGL0K02431g
NCS: NCAS_0C04200(NCAS0C04200)
NDI: NDAI_0G03550(NDAI0G03550)
TPF: TPHA_0D00920(TPHA0D00920)
TBL: TBLA_0E03960(TBLA0E03960)
TDL: TDEL_0F01110(TDEL0F01110)
KAF: KAFR_0C03110(KAFR0C03110)
ZMK: HG535_0B03430
PPA: PAS_chr1-4_0142
DHA: DEHA2E16764g
PIC: PICST_75184(MCM4)
PGU: PGUG_03230
SPAA: SPAPADRAFT_139742(CDC54)
LEL: LELG_03524
CAL: CAALFM_C112550CA(CDC54)
CTP: CTRG_03541
COT: CORT_0D01940
CDU: CD36_11730
CTEN: CANTEDRAFT_118077
YLI: YALI0F04818g
CLU: CLUG_03029
CLUS: A9F13_12g00352
CAUR: CJI97_003541
SLB: AWJ20_4769(MCM4)
PKZ: C5L36_0B08010
BNN: FOA43_000937(MCM4)
NCR: NCU02539
NTE: NEUTE1DRAFT73454(NEUTE1DRAFT_73454)
SMP: SMAC_05830
PAN: PODANSg10147
TTT: THITE_2114040
MTM: MYCTH_2295747
CTHR: CTHT_0057150
MGR: MGG_09293
TMN: UCRPA7_1228
SSCK: SPSK_04882
FGR: FGSG_00504
FPU: FPSE_04409
FVR: FVEG_00961
FOX: FOXG_00552
NHE: NECHADRAFT_31306
TRE: TRIREDRAFT_73646
TRR: M419DRAFT_93873
MAW: MAC_02978
MAJ: MAA_04206
CMT: CCM_06218
PLJ: VFPFJ_05053
VAL: VDBG_04551
VDA: VDAG_04096
CFJ: CFIO01_10241
SAPO: SAPIO_CDS3341
ELA: UCREL1_6155
PFY: PFICI_01120
SSL: SS1G_01278
BFU: BCIN_11g05760(Bcmcm4)
MBE: MBM_09900
PSCO: LY89DRAFT_780734
GLZ: GLAREA_02235
ANI: AN6070.2
AFM: AFUA_2G09060
ACT: ACLA_080870
NFI: NFIA_084590
AOR: AO090011000793
ANG: ANI_1_1790104(An12g04720)
AFV: AFLA_045950
PCS: Pc16g10450
PDP: PDIP_19720
TMF: PMAA_029020
TRG: TRUGW13939_06034
CIM: CIMG_12809(CIMG01018)
CPW: CPC735_053410
PBL: PAAG_01035
PBN: PADG_11664(PADG_03794)
URE: UREG_00964
ABE: ARB_05050
TVE: TRV_01449
AJE: HCAG_03677
BGH: BDBG_05443
PNO: SNOG_03266
PTE: PTT_16497
BZE: COCCADRAFT_1226
BSC: COCSADRAFT_35216
BOR: COCMIDRAFT_33016
AALT: CC77DRAFT_970937
ZTR: MYCGRDRAFT_43403
PFJ: MYCFIDRAFT_26292
BCOM: BAUCODRAFT_148939
NPA: UCRNP2_4254
TML: GSTUM_00006910001
SPO: SPCC16A11.17(mcm4)
CNE: CNM01820
CNB: CNBM1700
CGI: CGB_M2450C
TMS: TREMEDRAFT_30971
TASA: A1Q1_02791
PPL: POSPLDRAFT_89221 POSPLDRAFT_89301
TVS: TRAVEDRAFT_174295
DSQ: DICSQDRAFT_180513
PCO: PHACADRAFT_118591
SHS: STEHIDRAFT_146881
HIR: HETIRDRAFT_156569
PSQ: PUNSTDRAFT_140833
ADL: AURDEDRAFT_145617
FME: FOMMEDRAFT_103281
GTR: GLOTRDRAFT_65399
LBC: LACBIDRAFT_248146
MPR: MPER_11154
MRR: Moror_14213
CCI: CC1G_11443
SCM: SCHCODRAFT_82494
ABP: AGABI1DRAFT60705(AGABI1DRAFT_60705)
CPUT: CONPUDRAFT_58823
SLA: SERLADRAFT_360946
WSE: WALSEDRAFT_61403
WIC: J056_001930
UMA: UMAG_01646
PFP: PFL1_03683
MGL: MGL_2638
MRT: MRET_0448
MSYM: MSY001_0202
PGR: PGTG_11989
MLR: MELLADRAFT_48743
ECU: ECU02_1150
EIN: Eint_021110
EHE: EHEL_021080
ERO: EROM_021060
NCE: NCER_101839
MBR: MONBRDRAFT_25497
SRE: PTSG_12543
DDI: DDB_G0275623(mcm4)
DPP: DICPUDRAFT_152308
DFA: DFA_09090(mcm4)
EHI: EHI_187720(345.t00011)
EDI: EDI_143670
EIV: EIN_378520
ACAN: ACA1_106010
PFA: PF3D7_1317100
PFH: PFHG_04657
PYO: PY17X_1417300
PCB: PCHAS_141740(PC000724.03.0)
PBE: PBANKA_1415600
PKN: PKH_141630
PVX: PVX_122675
PCY: PCYB_142640
TAN: TA17345
TPV: TP04_0057
BEQ: BEWA_000720
BBO: BBOV_II005160(18.m06427)
BMIC: BMR1_01G03255
CPV: cgd2_1250
CHO: Chro.20137
TGO: TGME49_219700
TET: TTHERM_00277550
PTM: GSPATT00012268001 GSPATT00015677001
SMIN: v1.2.032060.t1(symbB.v1.2.032060.t1)
PTI: PHATRDRAFT_51412(MCM4)
FCY: FRACYDRAFT_146869
TPS: THAPSDRAFT_269123
AAF: AURANDRAFT_33815
PIF: PITG_04527
PSOJ: PHYSODRAFT_344892
SPAR: SPRG_11368
EHX: EMIHUDRAFT_40909
GTT: GUITHDRAFT_99903
TBR: Tb11.01.4070
TBG: TbgDal_XI13690
TCR: 509023.130 511127.140
LMA: LMJF_09_0250
LIF: LINJ_09_0400
LDO: LDBPK_090400
LMI: LMXM_09_0250
LBZ: LBRM_09_0250
LPAN: LPMP_090240(MCM4)
NGR: NAEGRDRAFT_415
TVA: TVAG_250220
GLA: GL50803_009194
 » show all
Reference
PMID:9305914
  Authors
Ishimi Y
  Title
A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex.
  Journal
J Biol Chem 272:24508-13 (1997)
DOI:10.1074/jbc.272.39.24508
  Sequence
[hsa:4173]
Reference
  Authors
Masai H, Taniyama C, Ogino K, Matsui E, Kakusho N, Matsumoto S, Kim JM, Ishii A, Tanaka T, Kobayashi T, Tamai K, Ohtani K, Arai K
  Title
Phosphorylation of MCM4 by Cdc7 kinase facilitates its interaction with Cdc45 on the chromatin.
  Journal
J Biol Chem 281:39249-61 (2006)
DOI:10.1074/jbc.M608935200
  Sequence
[hsa:4173] [mmu:17217]
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