KEGG   ORTHOLOGY: K02216
Entry
K02216                      KO                                     

Name
CHEK1
Definition
serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
Pathway
ko04110  Cell cycle
ko04111  Cell cycle - yeast
ko04113  Meiosis - yeast
ko04115  p53 signaling pathway
ko04218  Cellular senescence
ko05166  Human T-cell leukemia virus 1 infection
ko05170  Human immunodeficiency virus 1 infection
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
   04111 Cell cycle - yeast
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
   04113 Meiosis - yeast
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
   04115 p53 signaling pathway
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
   04218 Cellular senescence
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
   05170 Human immunodeficiency virus 1 infection
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K02216  CHEK1; serine/threonine-protein kinase CHEK1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  CAMKL family
   K02216  CHEK1; serine/threonine-protein kinase CHEK1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K02216  CHEK1; serine/threonine-protein kinase CHEK1
Other DBs
COG: COG0515
Genes
HSA: 1111(CHEK1)
PTR: 739836(CHEK1)
PPS: 100982317(CHEK1)
GGO: 101131993(CHEK1)
PON: 100436550(CHEK1)
NLE: 100596673(CHEK1)
MCC: 713358(CHEK1)
MCF: 101926004(CHEK1)
CSAB: 103248769(CHEK1)
RRO: 104653937(CHEK1)
RBB: 108542336(CHEK1)
CJC: 100405400(CHEK1)
SBQ: 101044792(CHEK1)
MMU: 12649(Chek1)
MCAL: 110301495(Chek1)
MPAH: 110327308(Chek1)
RNO: 140583(Chek1)
MUN: 110549439(Chek1)
CGE: 100751099(Chek1)
NGI: 103735579(Chek1)
HGL: 101701035(Chek1)
CCAN: 109700303(Chek1)
OCU: 100345729(CHEK1)
TUP: 102480757(CHEK1)
CFA: 609767(CHEK1)
VVP: 112920276(CHEK1)
AML: 100467858(CHEK1)
UMR: 103660629(CHEK1)
UAH: 113259903(CHEK1)
ORO: 101362614(CHEK1)
ELK: 111153780
FCA: 101083365(CHEK1)
PTG: 102948766(CHEK1)
PPAD: 109257420(CHEK1)
AJU: 106976641(CHEK1)
BTA: 513678(CHEK1)
BOM: 102266500
BIU: 109554657(CHEK1)
BBUB: 102398478(CHEK1)
CHX: 102184881(CHEK1)
OAS: 101111403(CHEK1)
SSC: 100511709(CHEK1)
CFR: 102505566(CHEK1)
CDK: 105094454(CHEK1)
BACU: 103015970(CHEK1)
LVE: 103073805(CHEK1)
OOR: 101270160(CHEK1)
DLE: 111167465(CHEK1)
PCAD: 102989266(CHEK1)
ECB: 100064353(CHEK1)
EPZ: 103557005(CHEK1)
EAI: 106835962(CHEK1)
MYB: 102255905(CHEK1)
MYD: 102751668(CHEK1)
MNA: 107530590(CHEK1)
HAI: 109391372(CHEK1)
DRO: 112301845(CHEK1)
PALE: 102882405(CHEK1)
RAY: 107498938(CHEK1)
MJV: 108401047(CHEK1)
LAV: 100658513(CHEK1)
TMU: 101345463
MDO: 100016170(CHEK1)
SHR: 100933648(CHEK1)
PCW: 110218134(CHEK1)
OAA: 100090345(CHEK1)
GGA: 374260(CHEK1)
MGP: 100547861(CHEK1)
CJO: 107324224(CHEK1)
NMEL: 110387692(CHEK1)
APLA: 101790669(CHEK1)
ACYG: 106040556(CHEK1)
TGU: 100219597(CHEK1)
LSR: 110468180(CHEK1)
SCAN: 103822842(CHEK1)
GFR: 102039036(CHEK1)
FAB: 101815748(CHEK1)
PHI: 102103508(CHEK1)
PMAJ: 107214301(CHEK1)
CCAE: 111939252(CHEK1)
CCW: 104692217(CHEK1)
ETL: 114064599(CHEK1)
FPG: 101911598(CHEK1)
FCH: 102048652(CHEK1)
CLV: 102094428(CHEK1)
EGZ: 104129228(CHEK1)
NNI: 104016679(CHEK1)
ACUN: 113488427(CHEK1)
ASN: 102385348(CHEK1)
AMJ: 102574519(CHEK1)
PSS: 102451245(CHEK1)
CMY: 102945662(CHEK1)
CPIC: 101933610(CHEK1)
ACS: 100564808(chek1)
PVT: 110070287(CHEK1)
PBI: 103064116(CHEK1)
TSR: 106545333(CHEK1)
PMUA: 114585208(CHEK1)
GJA: 107117803(CHEK1)
XLA: 108696394(chek1.L) 398191(chek1.S)
XTR: 100038224(chek1)
NPR: 108783681(CHEK1) 108792688
DRE: 393162(chek1)
CCAR: 109069289 109099921(chek1)
IPU: 108278491(chek1)
PHYP: 113541633(chek1)
AMEX: 103021956(chek1)
EEE: 113573544(chek1)
TRU: 101069769(chek1)
LCO: 104929933(chek1)
NCC: 104964655(chek1)
MZE: 101487018(chek1)
ONL: 100707719(chek1)
OLA: 101170780(chek1)
XMA: 102238315(chek1)
XCO: 114152470(chek1)
PRET: 103475471(chek1)
CVG: 107098496(chek1)
NFU: 107386371(chek1)
KMR: 108236904(chek1)
ALIM: 106514075(chek1)
AOCE: 111580652(chek1)
CSEM: 103395155(chek1)
POV: 109628292(chek1)
LCF: 108893136(chek1)
SDU: 111234478(chek1)
SLAL: 111666155(chek1)
HCQ: 109517900(chek1)
BPEC: 110158508(chek1)
MALB: 109959175(chek1)
SASA: 106563964(chek1)
OTW: 112236999(chek1)
SALP: 112078987(chek1)
ELS: 105009476(chek1)
SFM: 108924764(chek1)
PKI: 111837953(chek1)
LCM: 102357495(CHEK1)
CMK: 103180289(chek1)
RTP: 109921452(chek1)
BFO: 118416821
CIN: 100185343
SPU: 115921093 592974(Chk1)
APLC: 110985006
SKO: 100367549
DME: Dmel_CG17161(grp)
DER: 6547505
DSE: 6614402
DSI: Dsimw501_GD24070(Dsim_GD24070)
DAN: 6496833
DSR: 110181142
DPE: 6589812
DMN: 108162008
DAZ: 108610244
DNV: 108658305
DHE: 111596373
DVI: 6627442
LCQ: 111687874
AAG: 23687802
AALB: 109421007
AME: 413964
BIM: 100745568
BTER: 100651141
CCAL: 108628718
OBB: 114873109
SOC: 105194877
MPHA: 105835436
AEC: 105150077
ACEP: 105621342
PBAR: 105428835
VEM: 105570083
HST: 105190670
DQU: 106743820
CFO: 105249949
LHU: 105679793
PGC: 109856525
OBO: 105277573
PCF: 106791186
NVI: 116415964
CSOL: 105360491
MDL: 103575699
DPA: 109543242
ATD: 109597186
NVL: 108569681
BMOR: 101739025
BMAN: 114252094
PMAC: 106712696
PRAP: 111003679
TNL: 113506314
BTAB: 109034678
CLEC: 106667684
ZNE: 110828242
FCD: 110845196
DPTE: 113792438
CSCU: 111620828
PTEP: 107445423
CEL: CELE_Y39H10A.7(chk-1)
BMY: Bm1_30470
TSP: Tsp_05158
PCAN: 112568434
CRG: 105344353
MYI: 110465676
OBI: 106874761
LAK: 106166281
SHX: MS3_00407
EPA: 110232258
AMIL: 114969891
PDAM: 113678678
SPIS: 111328711
DGT: 114531963
HMG: 100206960
AQU: 100640078
QSU: 112019642
SCE: YBR274W(CHK1)
ERC: Ecym_6307
KMX: KLMA_50053(CHK1)
NCS: NCAS_0B07380(NCAS0B07380)
NDI: NDAI_0B04700(NDAI0B04700)
TPF: TPHA_0O01400(TPHA0O01400)
TDL: TDEL_0D02040(TDEL0D02040)
KAF: KAFR_0C04280(KAFR0C04280)
PIC: PICST_33177(CHK1)
SLB: AWJ20_2911(CHK1)
NCR: NCU08346(un-1)
NTE: NEUTE1DRAFT114358(NEUTE1DRAFT_114358)
MGR: MGG_03729
SSCK: SPSK_04135
MAW: MAC_07613
MAJ: MAA_00521
CMT: CCM_05529
BFU: BCIN_05g06110(Bcchk1)
MBE: MBM_03411
ANI: AN5494.2
ANG: ANI_1_2436074(An08g10320)
ABE: ARB_07449
TVE: TRV_03991
PTE: PTT_09831
SPO: SPCC1259.13(chk1)
CNE: CNG04000
CNB: CNBG0730
TASA: A1Q1_03668
ABP: AGABI1DRAFT122426(AGABI1DRAFT_122426) AGABI1DRAFT132921(AGABI1DRAFT_132921)
ABV: AGABI2DRAFT120023(AGABI2DRAFT_120023) AGABI2DRAFT122240(AGABI2DRAFT_122240)
MGL: MGL_0494
MRT: MRET_2319
 » show all
Reference
  Authors
Yang XH, Shiotani B, Classon M, Zou L
  Title
Chk1 and Claspin potentiate PCNA ubiquitination.
  Journal
Genes Dev 22:1147-52 (2008)
DOI:10.1101/gad.1632808
  Sequence
[hsa:1111]
Reference
  Authors
Huang M, Miao ZH, Zhu H, Cai YJ, Lu W, Ding J
  Title
Chk1 and Chk2 are differentially involved in homologous recombination repair and cell cycle arrest in response to DNA double-strand breaks induced by camptothecins.
  Journal
Mol Cancer Ther 7:1440-9 (2008)
DOI:10.1158/1535-7163.MCT-07-2116
  Sequence
[hsa:1111]
Reference
PMID:9278511
  Authors
Sanchez Y, Wong C, Thoma RS, Richman R, Wu Z, Piwnica-Worms H, Elledge SJ
  Title
Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25.
  Journal
Science 277:1497-501 (1997)
DOI:10.1126/science.277.5331.1497
  Sequence
[hsa:1111]
LinkDB

KEGG   ORTHOLOGY: K06641
Entry
K06641                      KO                                     

Name
CHEK2
Definition
serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
Pathway
ko04110  Cell cycle
ko04111  Cell cycle - yeast
ko04115  p53 signaling pathway
ko04218  Cellular senescence
ko05166  Human T-cell leukemia virus 1 infection
Disease
H00881  Li-Fraumeni syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
   04111 Cell cycle - yeast
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
   04115 p53 signaling pathway
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
   04218 Cellular senescence
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06641  CHEK2; serine/threonine-protein kinase CHEK2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  RAD53 family
   K06641  CHEK2; serine/threonine-protein kinase CHEK2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
Other DBs
COG: COG0515
Genes
HSA: 11200(CHEK2)
PTR: 458733(CHEK2)
PPS: 100987687(CHEK2)
GGO: 101124618(CHEK2)
PON: 100461345(CHEK2)
NLE: 100594542(CHEK2)
MCC: 713668(CHEK2)
MCF: 102122988(CHEK2)
CSAB: 103223122(CHEK2)
RRO: 104658998(CHEK2)
RBB: 108517558(CHEK2)
CJC: 100404949(CHEK2)
SBQ: 101051768(CHEK2)
MMU: 50883(Chek2)
MCAL: 110294527(Chek2)
MPAH: 110312870(Chek2)
RNO: 114212(Chek2)
MUN: 110553166(Chek2)
CGE: 100769280(Chek2)
NGI: 103750875(Chek2)
HGL: 101721212(Chek2)
CCAN: 109690250(Chek2)
OCU: 100339430(CHEK2)
TUP: 102484993(CHEK2)
CFA: 486338(CHEK2)
VVP: 112906959(CHEK2)
AML: 100467146(CHEK2)
UMR: 103659236(CHEK2)
UAH: 113244997(CHEK2)
ORO: 101386368(CHEK2)
ELK: 111160086
FCA: 101085665(CHEK2)
PTG: 102960814(CHEK2)
PPAD: 109253543(CHEK2)
AJU: 106985461(CHEK2)
BTA: 518897(CHEK2)
BOM: 102283552(CHEK2)
BIU: 109571019(CHEK2)
BBUB: 102409445(CHEK2)
CHX: 102184180(CHEK2)
OAS: 101105532(CHEK2)
SSC: 100192447(CHEK2)
CFR: 102508820(CHEK2)
CDK: 105099476(CHEK2)
BACU: 103014798(CHEK2)
LVE: 103076926(CHEK2)
OOR: 101289528(CHEK2)
DLE: 111162720(CHEK2)
PCAD: 102986126(CHEK2)
ECB: 100059288(CHEK2)
EPZ: 103554111(CHEK2)
EAI: 106827624(CHEK2)
MYB: 102250232(CHEK2)
MYD: 102766522(CHEK2)
MNA: 107526210(CHEK2)
HAI: 109383036(CHEK2)
DRO: 112310842(CHEK2)
PALE: 102882358(CHEK2)
RAY: 107520494(CHEK2)
MJV: 108408453(CHEK2)
LAV: 100666208(CHEK2)
TMU: 101359759
MDO: 100030584(CHEK2)
SHR: 100932330(CHEK2)
PCW: 110215254(CHEK2)
OAA: 100077482(CHEK2)
GGA: 768913(CHEK2)
MGP: 100543068(CHEK2)
CJO: 107321227(CHEK2)
NMEL: 110406189(CHEK2)
ACYG: 106043894(CHEK2)
TGU: 100228558(CHEK2)
LSR: 110478117(CHEK2)
SCAN: 103818108(CHEK2)
GFR: 102038788(CHEK2)
FAB: 101811158(CHEK2)
PHI: 102110514(CHEK2)
PMAJ: 107211857(CHEK2)
CCAE: 111936476(CHEK2)
CCW: 104688640(CHEK2)
ETL: 114061540(CHEK2)
FPG: 101911493(CHEK2)
FCH: 102057640(CHEK2)
CLV: 102090751(CHEK2)
EGZ: 104122580(CHEK2)
NNI: 104015770(CHEK2)
ACUN: 113486115(CHEK2)
PADL: 103922582(CHEK2)
AAM: 106492744(CHEK2)
ASN: 102386466(CHEK2)
AMJ: 102574431(CHEK2)
PSS: 102461937(CHEK2)
CMY: 102947582(CHEK2)
CPIC: 101952469(CHEK2)
PVT: 110083425(CHEK2)
PBI: 103066019(CHEK2)
PMUR: 107287280(CHEK2)
TSR: 106550569(CHEK2)
PMUA: 114587126(CHEK2)
GJA: 107123921(CHEK2)
XLA: 398179(chek2.L)
XTR: 100144952(chek2)
NPR: 108788045(CHEK2)
DRE: 336998(chek2)
SRX: 107723314(chek2) 107751420
IPU: 108255821(chek2)
PHYP: 113525110(chek2)
AMEX: 103034962(chek2)
EEE: 113572926(chek2)
TRU: 101063164(chek2)
MZE: 101485707(chek2)
ONL: 100708289(chek2)
OLA: 101170645(chek2)
XMA: 102224037
XCO: 114154787
PRET: 103460387(chek2)
CVG: 107105136
NFU: 107386179(chek2)
KMR: 108248076
ALIM: 106536288(chek2)
AOCE: 111573057(chek2)
CSEM: 103397943(chek2)
POV: 109645723
LCF: 108894515(chek2)
SDU: 111237444(chek2)
SLAL: 111649055(chek2)
HCQ: 109525295(chek2)
BPEC: 110169250(chek2)
MALB: 109957388
ELS: 105014423(chek2)
SFM: 108927301(chek2)
PKI: 111852734(chek2)
LCM: 102362683(CHEK2)
CMK: 103184008(chek2)
RTP: 109911275(chek2)
BFO: 118426647
CIN: 100175326
APLC: 110976646
SKO: 100372241
DME: Dmel_CG10895(lok)
DER: 6549116
DSE: 6614767
DSI: Dsimw501_GD24241(Dsim_GD24241)
DAN: 6497269
DPE: 6596561
DMN: 108162747
DWI: 6646756
DAZ: 108609925
DNV: 108650024
DHE: 111600369
DVI: 6634353
MDE: 101896859
LCQ: 111686974
AAG: 5569344
AME: 551949
BIM: 100745014
BTER: 100649762
CCAL: 108628555
OBB: 114871747
MPHA: 105833500
AEC: 105151042
ACEP: 105619804
PBAR: 105422193
VEM: 105566545
HST: 105181538
DQU: 106746783
CFO: 105258386
LHU: 105668387
PGC: 109861563
OBO: 105285139
PCF: 106793397
NVI: 100117742
CSOL: 105366519
MDL: 103568664
TCA: 661264
DPA: 109538347
ATD: 109608704
NVL: 108558766
BMOR: 692482(Chk2)
BMAN: 114252597
PMAC: 106717857
PRAP: 111003433
HAW: 110374774
TNL: 113498960
PXY: 105381643
API: 100163511
DNX: 107174043
AGS: 114123755
RMD: 113547984
BTAB: 109031651
CLEC: 106664898
PVM: 113829798
CSCU: 111617872
CEL: CELE_T08D2.7(T08D2.7) CELE_Y60A3A.12(chk-2)
CBR: CBG20512(Cbr-chk-2)
PCAN: 112561834
CRG: 105318723
MYI: 110445255
OBI: 106878443
LAK: 106155701
SHX: MS3_02323
EGL: EGR_00376
NVE: 5516550
EPA: 110232754
ADF: 107341547
AMIL: 114959893
PDAM: 113686167
SPIS: 111336580
DGT: 114520644
HMG: 100207948
SCE: YDL101C(DUN1)
ERC: Ecym_5624
KMX: KLMA_20647(DUN1)
NCS: NCAS_0B05910(NCAS0B05910)
NDI: NDAI_0B03190(NDAI0B03190)
TPF: TPHA_0C04570(TPHA0C04570)
TBL: TBLA_0B07330(TBLA0B07330)
TDL: TDEL_0G02820(TDEL0G02820)
KAF: KAFR_0K02450(KAFR0K02450)
CAL: CAALFM_C505100CA(DUN1)
NCR: NCU02814(prd-4)
NTE: NEUTE1DRAFT133979(NEUTE1DRAFT_133979)
MGR: MGG_01596
SSCK: SPSK_05999
MAW: MAC_01056
MAJ: MAA_05678
CMT: CCM_01421
MBE: MBM_06218
ANI: AN4279.2
ANG: ANI_1_520114(An13g00100)
ABE: ARB_00949
TVE: TRV_00735
PNO: SNOG_03701(SNOG_03700)
PTE: PTT_12246
MBR: MONBRDRAFT_15828(Cds1)
DDI: DDB_G0281567(fhkC)
DFA: DFA_05550(fhkA)
EHI: EHI_011510(90.t00001)
 » show all
Reference
  Authors
Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H
  Title
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.
  Journal
Mol Cell Biol 28:5874-85 (2008)
DOI:10.1128/MCB.00821-08
  Sequence
[hsa:11200]
Reference
  Authors
Bahassi EM, Ovesen JL, Riesenberg AL, Bernstein WZ, Hasty PE, Stambrook PJ
  Title
The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.
  Journal
Oncogene 27:3977-85 (2008)
DOI:10.1038/onc.2008.17
  Sequence
[hsa:11200]
Reference
PMID:9836640
  Authors
Matsuoka S, Huang M, Elledge SJ
  Title
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
  Journal
Science 282:1893-7 (1998)
DOI:10.1126/science.282.5395.1893
  Sequence
[hsa:11200]
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