KEGG   ORTHOLOGY: K02580
Entry
K02580                      KO                                     

Name
NFKB1
Definition
nuclear factor NF-kappa-B p105 subunit
Pathway
map01523  Antifolate resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04066  HIF-1 signaling pathway
map04071  Sphingolipid signaling pathway
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04211  Longevity regulating pathway
map04218  Cellular senescence
map04380  Osteoclast differentiation
map04613  Neutrophil extracellular trap formation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04624  Toll and Imd signaling pathway
map04625  C-type lectin receptor signaling pathway
map04657  IL-17 signaling pathway
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04668  TNF signaling pathway
map04722  Neurotrophin signaling pathway
map04917  Prolactin signaling pathway
map04920  Adipocytokine signaling pathway
map04926  Relaxin signaling pathway
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04933  AGE-RAGE signaling pathway in diabetic complications
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05030  Cocaine addiction
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05134  Legionellosis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05145  Toxoplasmosis
map05146  Amoebiasis
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05203  Viral carcinogenesis
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05212  Pancreatic cancer
map05215  Prostate cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05222  Small cell lung cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05321  Inflammatory bowel disease
map05415  Diabetic cardiomyopathy
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H00088  Common variable immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04014 Ras signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04064 NF-kappa B signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04668 TNF signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04066 HIF-1 signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04071 Sphingolipid signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04024 cAMP signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04151 PI3K-Akt signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04218 Cellular senescence
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04620 Toll-like receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04624 Toll and Imd signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04621 NOD-like receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04622 RIG-I-like receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04623 Cytosolic DNA-sensing pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04625 C-type lectin receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04660 T cell receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04658 Th1 and Th2 cell differentiation
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04659 Th17 cell differentiation
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04657 IL-17 signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04662 B cell receptor signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04062 Chemokine signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04917 Prolactin signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04926 Relaxin signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09149 Aging
   04211 Longevity regulating pathway
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05202 Transcriptional misregulation in cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05206 MicroRNAs in cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05207 Chemical carcinogenesis - receptor activation
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05208 Chemical carcinogenesis - reactive oxygen species
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05203 Viral carcinogenesis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05221 Acute myeloid leukemia
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05220 Chronic myeloid leukemia
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05215 Prostate cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05222 Small cell lung cancer
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05170 Human immunodeficiency virus 1 infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05161 Hepatitis B
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05160 Hepatitis C
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05171 Coronavirus disease - COVID-19
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05164 Influenza A
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05162 Measles
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05168 Herpes simplex virus 1 infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05163 Human cytomegalovirus infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05169 Epstein-Barr virus infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05165 Human papillomavirus infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05130 Pathogenic Escherichia coli infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05132 Salmonella infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05131 Shigellosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05135 Yersinia infection
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05133 Pertussis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05134 Legionellosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05152 Tuberculosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05145 Toxoplasmosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05140 Leishmaniasis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05142 Chagas disease
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09163 Immune disease
   05321 Inflammatory bowel disease
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05022 Pathways of neurodegeneration - multiple diseases
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09165 Substance dependence
   05030 Cocaine addiction
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05418 Fluid shear stress and atherosclerosis
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   05415 Diabetic cardiomyopathy
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04931 Insulin resistance
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Rel/Ankyrin
    K02580  NFKB1; nuclear factor NF-kappa-B p105 subunit
Genes
HSA: 4790(NFKB1)
PTR: 461406(NFKB1)
PPS: 100979341(NFKB1)
GGO: 101153465(NFKB1)
PON: 100461595(NFKB1)
NLE: 100581655(NFKB1)
MCC: 710324(NFKB1)
MCF: 102138273(NFKB1)
CSAB: 103236047(NFKB1)
CATY: 105571369(NFKB1)
PANU: 101026781(NFKB1)
RRO: 104662315(NFKB1)
RBB: 108532817(NFKB1)
TFN: 117085710(NFKB1)
PTEH: 111547971(NFKB1)
CJC: 100415321(NFKB1)
SBQ: 101035787(NFKB1)
MMUR: 105874819(NFKB1)
MMU: 18033(Nfkb1)
MCAL: 110291231(Nfkb1)
MPAH: 110319789(Nfkb1)
RNO: 81736(Nfkb1)
MCOC: 116093825(Nfkb1)
MUN: 110558602(Nfkb1)
CGE: 100770607(Nfkb1)
PLEU: 114683205(Nfkb1)
NGI: 103728077(Nfkb1)
HGL: 101696485(Nfkb1)
CCAN: 109682963(Nfkb1)
OCU: 100349426(NFKB1)
TUP: 102487413(NFKB1)
CFA: 442859(NFKB1)
VVP: 112908352(NFKB1)
VLG: 121492781(NFKB1)
AML: 100467906(NFKB1)
UMR: 103677947(NFKB1)
UAH: 113263101(NFKB1)
ORO: 101371488(NFKB1)
ELK: 111153611
MPUF: 101680542(NFKB1)
EJU: 114199341(NFKB1)
MLX: 118027047(NFKB1)
FCA: 100142683(NFKB1)
PTG: 102964232(NFKB1)
PPAD: 109247385(NFKB1)
AJU: 106984704(NFKB1)
HHV: 120222817(NFKB1)
BTA: 616115(NFKB1)
BOM: 102286969(NFKB1)
BIU: 109560296(NFKB1)
BBUB: 102403930(NFKB1)
CHX: 102175660(NFKB1)
OAS: 101108228(NFKB1)
ODA: 120861869(NFKB1)
SSC: 751869(NFKB1)
CFR: 102505905(NFKB1)
CDK: 105089560(NFKB1)
BACU: 102999230(NFKB1)
LVE: 103068644(NFKB1)
OOR: 101279857(NFKB1)
DLE: 111179110(NFKB1)
PCAD: 102981135(NFKB1)
ECB: 100067894(NFKB1)
EPZ: 103556719(NFKB1)
EAI: 106825951(NFKB1)
MYB: 102255251(NFKB1)
MYD: 102770715(NFKB1)
MMYO: 118671867(NFKB1)
MNA: 107545508(NFKB1)
HAI: 109372541(NFKB1)
DRO: 112317867(NFKB1)
SHON: 118979949(NFKB1)
AJM: 119057921(NFKB1)
MMF: 118624789(NFKB1)
PALE: 102880692(NFKB1)
RAY: 107517900(NFKB1)
MJV: 108391706(NFKB1)
TOD: 119243680(NFKB1)
LAV: 100662194(NFKB1)
TMU: 101351866
MDO: 100014446(NFKB1)
SHR: 100917619(NFKB1)
PCW: 110209686(NFKB1)
OAA: 100083819(NFKB1)
GGA: 396033(NFKB1)
PCOC: 116238905(NFKB1)
MGP: 100547165(NFKB1)
CJO: 107313652(NFKB1)
NMEL: 110398425(NFKB1)
APLA: 101803431(NFKB1)
ACYG: 106045319(NFKB1)
TGU: 100221542(NFKB1)
LSR: 110471151(NFKB1)
SCAN: 103826026(NFKB1)
PMOA: 120498829(NFKB1)
GFR: 102038208(NFKB1)
FAB: 101815528(NFKB1)
PHI: 102106412(NFKB1)
PMAJ: 107202925(NFKB1)
CCAE: 111927739(NFKB1)
CCW: 104697095(NFKB1)
ETL: 114068171(NFKB1)
FPG: 101920008(NFKB1)
FCH: 102049462(NFKB1)
CLV: 102086078(NFKB1)
EGZ: 104122596
NNI: 104021184(NFKB1)
ACUN: 113479867(NFKB1)
PADL: 103919520(NFKB1)
AAM: 106491979(NFKB1)
ASN: 102369946(NFKB1)
AMJ: 102558052(NFKB1)
CPOO: 109322137(NFKB1)
GGN: 109303876(NFKB1)
PSS: 102457132(NFKB1)
CMY: 102944582(NFKB1)
CPIC: 101935476(NFKB1)
TST: 117878027(NFKB1)
CABI: 116826296(NFKB1)
PVT: 110085341(NFKB1)
PBI: 103049819(NFKB1)
PMUR: 107299002(NFKB1)
PGUT: 117679890(NFKB1)
PMUA: 114603990(NFKB1)
ZVI: 118083370(NFKB1)
GJA: 107105754(NFKB1)
XLA: 108706736(nfkb1.S) 447632(nfkb1.L)
XTR: 100486083(nfkb1)
NPR: 108789059(NFKB1)
DRE: 565756(nfkb1)
IPU: 108277163(nfkb1)
PHYP: 113546951(nfkb1)
AMEX: 103038869(nfkb1)
EEE: 113588037(nfkb1)
TRU: 101072751(nfkb1)
ELY: 117260994
SLUC: 116058049(nfkb1)
PFLV: 114563320
GAT: 120817215(nfkb1)
MSAM: 119888973(nfkb1)
CUD: 121516478(nfkb1)
MZE: 101479063(nfkb1)
ONL: 100702187(nfkb1)
OAU: 116329661(nfkb1)
OLA: 101167764(nfkb1)
OML: 112137892(nfkb1)
XMA: 102218233(nfkb1)
XCO: 114139461(nfkb1)
XHE: 116714586(nfkb1)
PRET: 103471905
CVG: 107083804(nfkb1)
CTUL: 119784550(nfkb1)
NFU: 107380900(nfkb1)
KMR: 108228584(nfkb1)
ALIM: 106536450
AOCE: 111583748(nfkb1)
CSEM: 103391096(nfkb1)
POV: 109644052
LCF: 108873754
SDU: 111233505(nfkb1)
SLAL: 111665614
XGL: 120785165
HCQ: 109516575(nfkb1)
BPEC: 110165498(nfkb1)
MALB: 109956744(nfkb1)
OTW: 112220841
ELS: 105029910(nfkb1)
SFM: 108920826(nfkb1) 108930913
PKI: 111833172(nfkb1) 111853948
LOC: 102693746(nfkb1)
LCM: 102356725(NFKB1)
CMK: 103177625(nfkb1)
RTP: 109918515(nfkb1)
BFO: 118411445
CIN: 778692(nfkbp105)
SPU: 373533(NFkB)
APLC: 110977565
SKO: 100303565(NFkB)
DME: Dmel_CG11992(Rel)
DER: 6552452
DSE: 6607161
DSI: Dsimw501_GD20822(Dsim_Rel)
DYA: Dyak_GE24800(Dyak_Rel)
DAN: 6501204
DSR: 110186937
DPE: 6594689
DMN: 108155718
DWI: 6650773
DAZ: 108608608
DNV: 108653026
DHE: 111604788
DVI: 6629859
MDE: 101893515
LCQ: 111688371
AGA: AgaP_AGAP006747(REL2)
ACOZ: 120947282
AARA: 120898646
AAG: 5569427
CPII: 120418477
AME: 552247
ACER: 107995490
BIM: 100745113
BTER: 100631072
CCAL: 108629959
MGEN: 117225658
NMEA: 116424535
CGIG: 122395523
SOC: 105195705
MPHA: 105832445
AEC: 105144460
ACEP: 105622536
PBAR: 105431788
VEM: 105561638
HST: 105192416
DQU: 106741078
CFO: 105257468
FEX: 115235108
LHU: 105668729
PGC: 109852148
OBO: 105282066
PCF: 106785644
NVI: 100118169
CSOL: 105360447
MDL: 103573915
TCA: 659499(ird)
ATD: 109595648
AGB: 108906876
NVL: 108566978
APLN: 108741595
PPYR: 116163095
OTU: 111413329
BMOR: 100124425(Rel)
BMAN: 114239802
MSEX: 115446883
BANY: 112053564
PMAC: 106720577
PPOT: 106103489
PXU: 106115910
PRAP: 110999469
ZCE: 119840577
HAW: 110373764
TNL: 113500911
CLEC: 106667016
NLU: 111053267
ZNE: 110838042
CSEC: 111870192
FCD: 110842715
PVM: 113806131
HAME: 121870678
EAF: 111697016
RMP: 119160771
CSCU: 111625397
PCAN: 112576253
BGT: 106058661
GAE: 121378614
CRG: 105325572
MYI: 110456751
PMAX: 117339378
OBI: 106873263
LAK: 106170138
EPA: 110254138
ATEN: 116300424
ADF: 107345201
AMIL: 114954524
PDAM: 113666425
SPIS: 111328927
AQU: 100616089(Nfkb)
 » show all
Reference
PMID:2203531
  Authors
Kieran M, Blank V, Logeat F, Vandekerckhove J, Lottspeich F, Le Bail O, Urban MB, Kourilsky P, Baeuerle PA, Israel A
  Title
The DNA binding subunit of NF-kappa B is identical to factor KBF1 and homologous to the rel oncogene product.
  Journal
Cell 62:1007-18 (1990)
DOI:10.1016/0092-8674(90)90275-J
  Sequence
[hsa:4790]
Reference
  Authors
Beinke S, Robinson MJ, Hugunin M, Ley SC
  Title
Lipopolysaccharide activation of the TPL-2/MEK/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IkappaB kinase-induced proteolysis of NF-kappaB1 p105.
  Journal
Mol Cell Biol 24:9658-67 (2004)
DOI:10.1128/MCB.24.21.9658-9667.2004
LinkDB

KEGG   ORTHOLOGY: K04735
Entry
K04735                      KO                                     

Name
RELA
Definition
transcription factor p65
Pathway
map01523  Antifolate resistance
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04064  NF-kappa B signaling pathway
map04066  HIF-1 signaling pathway
map04071  Sphingolipid signaling pathway
map04137  Mitophagy - animal
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04211  Longevity regulating pathway
map04218  Cellular senescence
map04380  Osteoclast differentiation
map04613  Neutrophil extracellular trap formation
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04622  RIG-I-like receptor signaling pathway
map04623  Cytosolic DNA-sensing pathway
map04625  C-type lectin receptor signaling pathway
map04657  IL-17 signaling pathway
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04668  TNF signaling pathway
map04722  Neurotrophin signaling pathway
map04917  Prolactin signaling pathway
map04920  Adipocytokine signaling pathway
map04926  Relaxin signaling pathway
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04933  AGE-RAGE signaling pathway in diabetic complications
map05010  Alzheimer disease
map05022  Pathways of neurodegeneration - multiple diseases
map05030  Cocaine addiction
map05120  Epithelial cell signaling in Helicobacter pylori infection
map05130  Pathogenic Escherichia coli infection
map05131  Shigellosis
map05132  Salmonella infection
map05133  Pertussis
map05134  Legionellosis
map05135  Yersinia infection
map05140  Leishmaniasis
map05142  Chagas disease
map05145  Toxoplasmosis
map05146  Amoebiasis
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05203  Viral carcinogenesis
map05207  Chemical carcinogenesis - receptor activation
map05208  Chemical carcinogenesis - reactive oxygen species
map05212  Pancreatic cancer
map05215  Prostate cancer
map05220  Chronic myeloid leukemia
map05221  Acute myeloid leukemia
map05222  Small cell lung cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05321  Inflammatory bowel disease
map05415  Diabetic cardiomyopathy
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04735  RELA; transcription factor p65
   04014 Ras signaling pathway
    K04735  RELA; transcription factor p65
   04064 NF-kappa B signaling pathway
    K04735  RELA; transcription factor p65
   04668 TNF signaling pathway
    K04735  RELA; transcription factor p65
   04066 HIF-1 signaling pathway
    K04735  RELA; transcription factor p65
   04071 Sphingolipid signaling pathway
    K04735  RELA; transcription factor p65
   04024 cAMP signaling pathway
    K04735  RELA; transcription factor p65
   04151 PI3K-Akt signaling pathway
    K04735  RELA; transcription factor p65
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K04735  RELA; transcription factor p65
  09143 Cell growth and death
   04210 Apoptosis
    K04735  RELA; transcription factor p65
   04218 Cellular senescence
    K04735  RELA; transcription factor p65
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K04735  RELA; transcription factor p65
   04620 Toll-like receptor signaling pathway
    K04735  RELA; transcription factor p65
   04621 NOD-like receptor signaling pathway
    K04735  RELA; transcription factor p65
   04622 RIG-I-like receptor signaling pathway
    K04735  RELA; transcription factor p65
   04623 Cytosolic DNA-sensing pathway
    K04735  RELA; transcription factor p65
   04625 C-type lectin receptor signaling pathway
    K04735  RELA; transcription factor p65
   04660 T cell receptor signaling pathway
    K04735  RELA; transcription factor p65
   04658 Th1 and Th2 cell differentiation
    K04735  RELA; transcription factor p65
   04659 Th17 cell differentiation
    K04735  RELA; transcription factor p65
   04657 IL-17 signaling pathway
    K04735  RELA; transcription factor p65
   04662 B cell receptor signaling pathway
    K04735  RELA; transcription factor p65
   04062 Chemokine signaling pathway
    K04735  RELA; transcription factor p65
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K04735  RELA; transcription factor p65
   04917 Prolactin signaling pathway
    K04735  RELA; transcription factor p65
   04926 Relaxin signaling pathway
    K04735  RELA; transcription factor p65
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K04735  RELA; transcription factor p65
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K04735  RELA; transcription factor p65
  09149 Aging
   04211 Longevity regulating pathway
    K04735  RELA; transcription factor p65
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04735  RELA; transcription factor p65
   05202 Transcriptional misregulation in cancer
    K04735  RELA; transcription factor p65
   05207 Chemical carcinogenesis - receptor activation
    K04735  RELA; transcription factor p65
   05208 Chemical carcinogenesis - reactive oxygen species
    K04735  RELA; transcription factor p65
   05203 Viral carcinogenesis
    K04735  RELA; transcription factor p65
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K04735  RELA; transcription factor p65
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K04735  RELA; transcription factor p65
   05221 Acute myeloid leukemia
    K04735  RELA; transcription factor p65
   05220 Chronic myeloid leukemia
    K04735  RELA; transcription factor p65
   05215 Prostate cancer
    K04735  RELA; transcription factor p65
   05222 Small cell lung cancer
    K04735  RELA; transcription factor p65
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K04735  RELA; transcription factor p65
   05170 Human immunodeficiency virus 1 infection
    K04735  RELA; transcription factor p65
   05161 Hepatitis B
    K04735  RELA; transcription factor p65
   05160 Hepatitis C
    K04735  RELA; transcription factor p65
   05171 Coronavirus disease - COVID-19
    K04735  RELA; transcription factor p65
   05164 Influenza A
    K04735  RELA; transcription factor p65
   05162 Measles
    K04735  RELA; transcription factor p65
   05168 Herpes simplex virus 1 infection
    K04735  RELA; transcription factor p65
   05163 Human cytomegalovirus infection
    K04735  RELA; transcription factor p65
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04735  RELA; transcription factor p65
   05169 Epstein-Barr virus infection
    K04735  RELA; transcription factor p65
   05165 Human papillomavirus infection
    K04735  RELA; transcription factor p65
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K04735  RELA; transcription factor p65
   05130 Pathogenic Escherichia coli infection
    K04735  RELA; transcription factor p65
   05132 Salmonella infection
    K04735  RELA; transcription factor p65
   05131 Shigellosis
    K04735  RELA; transcription factor p65
   05135 Yersinia infection
    K04735  RELA; transcription factor p65
   05133 Pertussis
    K04735  RELA; transcription factor p65
   05134 Legionellosis
    K04735  RELA; transcription factor p65
   05152 Tuberculosis
    K04735  RELA; transcription factor p65
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04735  RELA; transcription factor p65
   05145 Toxoplasmosis
    K04735  RELA; transcription factor p65
   05140 Leishmaniasis
    K04735  RELA; transcription factor p65
   05142 Chagas disease
    K04735  RELA; transcription factor p65
  09163 Immune disease
   05321 Inflammatory bowel disease
    K04735  RELA; transcription factor p65
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04735  RELA; transcription factor p65
   05022 Pathways of neurodegeneration - multiple diseases
    K04735  RELA; transcription factor p65
  09165 Substance dependence
   05030 Cocaine addiction
    K04735  RELA; transcription factor p65
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K04735  RELA; transcription factor p65
   05418 Fluid shear stress and atherosclerosis
    K04735  RELA; transcription factor p65
   05415 Diabetic cardiomyopathy
    K04735  RELA; transcription factor p65
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K04735  RELA; transcription factor p65
   04931 Insulin resistance
    K04735  RELA; transcription factor p65
   04933 AGE-RAGE signaling pathway in diabetic complications
    K04735  RELA; transcription factor p65
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K04735  RELA; transcription factor p65
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04735  RELA; transcription factor p65
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   RHR (Rel homology region) Rel/Ankyrin
    K04735  RELA; transcription factor p65
Genes
HSA: 5970(RELA)
PTR: 466665(RELA)
PPS: 100988429(RELA)
GGO: 101150285(RELA)
PON: 100456049(RELA)
NLE: 100588439(RELA)
MCC: 715919(RELA)
MCF: 101867324(RELA)
CSAB: 103227364(RELA)
CATY: 105577432(RELA)
PANU: 101017078(RELA)
RRO: 104664815(RELA)
RBB: 108543519(RELA)
TFN: 117081405(RELA)
PTEH: 111522422(RELA)
CJC: 100388493(RELA)
SBQ: 101035406(RELA)
MMUR: 105878531(RELA)
MMU: 19697(Rela)
MCAL: 110285703(Rela)
MPAH: 110317041(Rela)
RNO: 309165(Rela)
MCOC: 116103403(Rela)
MUN: 110549347(Rela)
CGE: 100763542(Rela)
PLEU: 114682099(Rela)
NGI: 103724994(Rela)
HGL: 101716738(Rela)
CCAN: 109687142(Rela)
TUP: 102490451(RELA)
CFA: 483729(RELA)
VVP: 112924254(RELA)
VLG: 121471268(RELA)
AML: 100480158(RELA)
UMR: 103679584(RELA)
UAH: 113244102(RELA)
ORO: 101381225(RELA)
ELK: 111149956
MPUF: 101680239(RELA)
EJU: 114220346(RELA)
MLX: 118016059(RELA)
FCA: 101096604(RELA)
PTG: 102951132(RELA)
PPAD: 109246747(RELA)
AJU: 106971136(RELA)
HHV: 120240185(RELA)
BTA: 508233(RELA)
BOM: 102268417(RELA)
BIU: 109554392(RELA)
BBUB: 102397938(RELA)
CHX: 102174096(RELA)
OAS: 101102191(RELA)
ODA: 120874649(RELA)
SSC: 100135665(RELA)
CFR: 102506204(RELA)
CDK: 105102595(RELA)
BACU: 103019614(RELA)
LVE: 103087304(RELA)
OOR: 101270342(RELA)
DLE: 111183745(RELA)
PCAD: 102974198(RELA)
ECB: 100057483(RELA)
EPZ: 103543692(RELA)
EAI: 106833569(RELA)
MYB: 102263790(RELA)
MYD: 102770704(RELA)
MMYO: 118665292(RELA)
MNA: 107533544(RELA)
HAI: 109384322(RELA)
DRO: 112317202(RELA)
SHON: 118991736(RELA)
AJM: 119050282(RELA)
MMF: 118628367(RELA)
PALE: 102878395(RELA)
RAY: 107497522(RELA)
MJV: 108397005(RELA)
TOD: 119248814(RELA)
LAV: 100654730(RELA)
TMU: 101361706
MDO: 100030053(RELA)
SHR: 100932473(RELA)
PCW: 110195563(RELA)
OAA: 100074633(RELA)
GGA: 396027(RELA)
CJO: 107307430
TGU: 115492066(RELA)
LSR: 110478845(RELA)
PMOA: 120507316(RELA)
PHI: 102105891(RELA)
CCW: 120412318
ASN: 102377458(RELA)
AMJ: 102573364(RELA)
PSS: 102457804(RELA)
CMY: 102947354(RELA)
CPIC: 101933001(RELA)
TST: 117880425(RELA)
CABI: 116838783(RELA)
ACS: 100556163(rela)
PVT: 110069799(RELA)
PBI: 103050942(RELA)
PMUR: 107297118(RELA)
TSR: 106556843(RELA)
PGUT: 117669743(RELA)
PMUA: 114587106(RELA)
ZVI: 118075687(RELA)
GJA: 107115220(RELA)
XLA: 108715128(rela.S) 394353(rela.L)
XTR: 407869(rela)
NPR: 108784114(RELA)
DRE: 415099(rela)
SGH: 107573921 107574010(rela)
IPU: 108260779
PHYP: 113545743
AMEX: 103032041
EEE: 113584194
TRU: 101073743
LCO: 109141199
NCC: 104965780(rela)
ELY: 117246128(rela)
PLEP: 121961933(rela)
SLUC: 116036053(rela)
ECRA: 117934772(rela)
PFLV: 114545913
GAT: 120821327(rela)
MSAM: 119911844(rela)
CUD: 121504461(rela)
MZE: 101487989(rela)
ONL: 100707676(rela)
OAU: 116335817(rela)
OLA: 101158728
OML: 112155860(rela)
XMA: 102219636
XCO: 114157395
XHE: 116732698
PRET: 103480184
CVG: 107082800(rela)
CTUL: 119772111(rela)
NFU: 107376749
KMR: 108239405(rela)
ALIM: 106523725
AOCE: 111582710
CSEM: 103385629
POV: 109637639
LCF: 108882042
SDU: 111226894(rela)
SLAL: 111670446(rela)
XGL: 120797026(rela)
HCQ: 109508419
BPEC: 110168801
MALB: 109969432(rela)
ELS: 105020694
SFM: 108934391
PSPA: 121310074(rela)
BFO: 118423605
AGB: 108916217
 » show all
Reference
PMID:2006423
  Authors
Ruben SM, Dillon PJ, Schreck R, Henkel T, Chen CH, Maher M, Baeuerle PA, Rosen CA
  Title
Isolation of a rel-related human cDNA that potentially encodes the 65-kD subunit of NF-kappa B.
  Journal
Science 251:1490-3 (1991)
DOI:10.1126/science.2006423
  Sequence
[hsa:5970]
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