KEGG   ORTHOLOGY: K02620
Entry
K02620                      KO                                     

Name
TCF7, TCF-1
Definition
transcription factor 7
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04916  Melanogenesis
ko04934  Cushing syndrome
ko05132  Salmonella infection
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05412  Arrhythmogenic right ventricular cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K02620  TCF7, TCF-1; transcription factor 7
   04390 Hippo signaling pathway
    K02620  TCF7, TCF-1; transcription factor 7
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K02620  TCF7, TCF-1; transcription factor 7
   04550 Signaling pathways regulating pluripotency of stem cells
    K02620  TCF7, TCF-1; transcription factor 7
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K02620  TCF7, TCF-1; transcription factor 7
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02620  TCF7, TCF-1; transcription factor 7
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05225 Hepatocellular carcinoma
    K02620  TCF7, TCF-1; transcription factor 7
   05226 Gastric cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05216 Thyroid cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05221 Acute myeloid leukemia
    K02620  TCF7, TCF-1; transcription factor 7
   05217 Basal cell carcinoma
    K02620  TCF7, TCF-1; transcription factor 7
   05215 Prostate cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05213 Endometrial cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05224 Breast cancer
    K02620  TCF7, TCF-1; transcription factor 7
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K02620  TCF7, TCF-1; transcription factor 7
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K02620  TCF7, TCF-1; transcription factor 7
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K02620  TCF7, TCF-1; transcription factor 7
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02620  TCF7, TCF-1; transcription factor 7
   05165 Human papillomavirus infection
    K02620  TCF7, TCF-1; transcription factor 7
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K02620  TCF7, TCF-1; transcription factor 7
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K02620  TCF7, TCF-1; transcription factor 7
Genes
HSA: 6932(TCF7)
PTR: 745839(TCF7)
PPS: 100980839(TCF7)
GGO: 101149731(TCF7)
PON: 100461234(TCF7)
NLE: 100595737(TCF7)
MCC: 710234(TCF7)
MCF: 102142248(TCF7)
CSAB: 103244543(TCF7)
RRO: 104659811(TCF7)
RBB: 108529562(TCF7)
CJC: 100399154(TCF7)
SBQ: 101029076(TCF7)
MMU: 21414(Tcf7)
MCAL: 110304948(Tcf7)
MPAH: 110332085(Tcf7)
RNO: 363595(Tcf7)
MUN: 110549622(Tcf7)
CGE: 100757390(Tcf7)
NGI: 103729786(Tcf7)
HGL: 101707882(Tcf7)
CCAN: 109689465(Tcf7)
OCU: 100339216(TCF7)
TUP: 102484318(TCF7)
CFA: 481506(TCF7)
VVP: 112917059(TCF7)
AML: 100476528(TCF7)
UMR: 103663815(TCF7)
UAH: 113261735(TCF7)
ORO: 101376237(TCF7)
ELK: 111141244
FCA: 101098768(TCF7)
PTG: 102957988(TCF7)
PPAD: 109250863(TCF7)
AJU: 106984911(TCF7)
BTA: 782690(TCF7)
BOM: 102266633(TCF7)
BIU: 109562015(TCF7)
BBUB: 102408996(TCF7)
CHX: 102173736(TCF7)
OAS: 101101980(TCF7)
SSC: 100512951(TCF7)
CFR: 102519063(TCF7)
CDK: 105090254(TCF7)
BACU: 103018264(TCF7)
LVE: 103074150(TCF7)
OOR: 101289599(TCF7)
DLE: 111182442(TCF7)
PCAD: 102992878(TCF7)
ECB: 100072786(TCF7)
EPZ: 103543120(TCF7)
EAI: 106834657(TCF7)
MYB: 102250528(TCF7)
MYD: 102757003(TCF7)
MNA: 107525397(TCF7)
HAI: 109382635(TCF7)
DRO: 112318180(TCF7)
PALE: 102885788(TCF7)
RAY: 107506797(TCF7)
MJV: 108406081(TCF7)
LAV: 100663559(TCF7)
TMU: 101350837
MDO: 100017589(TCF7)
SHR: 100930141(TCF7)
PCW: 110211723(TCF7)
OAA: 100082332(TCF7)
GGA: 395229(TCF7)
MGP: 100544924(TCF7)
CJO: 107320225(TCF7)
NMEL: 110405287(TCF7)
APLA: 101803610(TCF7)
ACYG: 106032766(TCF7)
TGU: 100221008(TCF7)
LSR: 110481074(TCF7)
SCAN: 103817470(TCF7)
GFR: 102036749(TCF7)
FAB: 101820491(TCF7)
PHI: 102110510(TCF7)
PMAJ: 107210639(TCF7)
CCAE: 111935599(TCF7)
CCW: 104683724(TCF7)
ETL: 114063910(TCF7)
FPG: 101919678(TCF7)
FCH: 102058554(TCF7)
CLV: 102094656(TCF7)
EGZ: 104133478(TCF7)
NNI: 104012004(TCF7)
ACUN: 113485114(TCF7)
PADL: 103915850(TCF7)
AAM: 106487174(TCF7)
ASN: 102383175(TCF7)
AMJ: 102576120(TCF7)
PSS: 102446665(TCF7)
CMY: 102943166
CPIC: 101937399(TCF7)
ACS: 100554608(tcf7)
PVT: 110079405(TCF7)
PBI: 103067042(TCF7)
PMUR: 107294908(TCF7)
TSR: 106542632(TCF7)
PMUA: 114591268(TCF7)
GJA: 107125983(TCF7)
XLA: 398658(tcf7.S)
XTR: 395061(tcf7)
NPR: 108792126(TCF7)
DRE: 497649(tcf7)
SRX: 107728269 107742437(tcf7)
SANH: 107661683(tcf7) 107692971
CCAR: 109048020
IPU: 108278866(tcf7)
PHYP: 113535749
AMEX: 103045826
EEE: 113578029(tcf7)
TRU: 101076516(tcf7)
LCO: 104924428
NCC: 104960861(tcf7)
MZE: 101469770(tcf7)
ONL: 100710520(tcf7)
XMA: 102221228(tcf7) 111610761
XCO: 114152465(tcf7) 114157642
PRET: 103460015(tcf7) 103480959
CVG: 107085909(tcf7)
NFU: 107378492 107386837(tcf7)
KMR: 108238102(tcf7)
ALIM: 106524564(tcf7) 106532889
AOCE: 111566135
CSEM: 103394864(tcf7)
POV: 109635808(tcf7)
LCF: 108893669(tcf7)
SDU: 111234495(tcf7)
SLAL: 111659992(tcf7)
MALB: 109966812(tcf7)
ELS: 105026693
PKI: 111839551
LCM: 102350321(TCF7)
CMK: 103183678(tcf7)
RTP: 109912241
CBR: CBG11789
MYI: 110453946
 » show all
Reference
PMID:1569101
  Authors
van de Wetering M, Oosterwegel M, Holstege F, Dooyes D, Suijkerbuijk R, Geurts van Kessel A, Clevers H
  Title
The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
  Journal
J Biol Chem 267:8530-6 (1992)
  Sequence
[hsa:6932]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
Reference
  Authors
Ioannidis V, Beermann F, Clevers H, Held W
  Title
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.
  Journal
Nat Immunol 2:691-7 (2001)
DOI:10.1038/90623
  Sequence
[mmu:21414]
LinkDB

KEGG   ORTHOLOGY: K04490
Entry
K04490                      KO                                     

Name
TCF7L1
Definition
transcription factor 7-like 1
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04916  Melanogenesis
ko04934  Cushing syndrome
ko05132  Salmonella infection
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05412  Arrhythmogenic right ventricular cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
   04390 Hippo signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04490  TCF7L1; transcription factor 7-like 1
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04490  TCF7L1; transcription factor 7-like 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04490  TCF7L1; transcription factor 7-like 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05225 Hepatocellular carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05226 Gastric cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05216 Thyroid cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05221 Acute myeloid leukemia
    K04490  TCF7L1; transcription factor 7-like 1
   05217 Basal cell carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05215 Prostate cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05213 Endometrial cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05224 Breast cancer
    K04490  TCF7L1; transcription factor 7-like 1
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04490  TCF7L1; transcription factor 7-like 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04490  TCF7L1; transcription factor 7-like 1
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04490  TCF7L1; transcription factor 7-like 1
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04490  TCF7L1; transcription factor 7-like 1
   05165 Human papillomavirus infection
    K04490  TCF7L1; transcription factor 7-like 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04490  TCF7L1; transcription factor 7-like 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04490  TCF7L1; transcription factor 7-like 1
Genes
HSA: 83439(TCF7L1)
PTR: 744526(TCF7L1)
PPS: 100968002(TCF7L1)
GGO: 101151621(TCF7L1)
PON: 100436197(TCF7L1)
NLE: 100601518(TCF7L1)
MCC: 694560(TCF7L1)
MCF: 102125513(TCF7L1)
CSAB: 103219950(TCF7L1)
RRO: 104659731(TCF7L1)
RBB: 108542809(TCF7L1)
CJC: 100385633
SBQ: 101033762(TCF7L1)
MMU: 21415(Tcf7l1)
MCAL: 110296038(Tcf7l1)
MPAH: 110315696(Tcf7l1)
RNO: 312451(Tcf7l1)
CGE: 100753225(Tcf7l1)
NGI: 103739783(Tcf7l1)
HGL: 101699909(Tcf7l1)
CCAN: 109686184(Tcf7l1)
OCU: 100340471(TCF7L1)
TUP: 102481394(TCF7L1)
CFA: 612070(TCF7L1)
VVP: 112916685(TCF7L1)
AML: 100480690(TCF7L1)
UMR: 103671448(TCF7L1)
UAH: 113243231(TCF7L1)
ORO: 101382778(TCF7L1)
ELK: 111148131
FCA: 101089850(TCF7L1)
PTG: 102958078(TCF7L1)
PPAD: 109263707(TCF7L1)
AJU: 106978197(TCF7L1)
BTA: 515303(TCF7L1)
BOM: 102281039(TCF7L1)
BIU: 109565564(TCF7L1)
BBUB: 102410081(TCF7L1)
CHX: 102187776(TCF7L1)
OAS: 100913162(TCF7L1)
SSC: 100523899(TCF7L1)
CFR: 102516787(TCF7L1)
CDK: 105104146(TCF7L1)
BACU: 103010166(TCF7L1)
LVE: 103069353(TCF7L1)
OOR: 101287223(TCF7L1)
DLE: 111165393(TCF7L1)
PCAD: 102974053(TCF7L1)
ECB: 100067427(TCF7L1)
EPZ: 103548276(TCF7L1)
EAI: 106838609(TCF7L1)
MYB: 102240393(TCF7L1)
MYD: 102768915(TCF7L1)
MNA: 107528616(TCF7L1)
HAI: 109371340(TCF7L1)
DRO: 112302951(TCF7L1)
PALE: 102886093(TCF7L1)
RAY: 107506285(TCF7L1)
MJV: 108405898(TCF7L1)
TMU: 101341696
MDO: 100030368(TCF7L1)
SHR: 100922609(TCF7L1)
PCW: 110196343(TCF7L1)
OAA: 114817948(TCF7L1)
GGA: 395230(TCF7L1)
MGP: 104917108(TCF7L1)
CJO: 107323707(TCF7L1)
NMEL: 110387133(TCF7L1)
APLA: 101801135(TCF7L1)
TGU: 115498209(TCF7L1)
LSR: 110478270(TCF7L1)
GFR: 102039905(TCF7L1)
FAB: 101817952(TCF7L1)
PHI: 102105833(TCF7L1)
PMAJ: 107213891(TCF7L1)
CCAE: 111938914(TCF7L1)
ETL: 114070472(TCF7L1)
FPG: 101922879(TCF7L1)
FCH: 102051021(TCF7L1)
CLV: 102084814(TCF7L1)
NNI: 104022615(TCF7L1)
AAM: 106497459
ASN: 102382172(TCF7L1)
AMJ: 102559656(TCF7L1)
PSS: 102456229(TCF7L1)
CMY: 102947844(TCF7L1)
CPIC: 101943923(TCF7L1)
ACS: 100553130(tcf7l1)
PVT: 110084320(TCF7L1)
PBI: 103066724(TCF7L1)
PMUR: 107286235(TCF7L1)
TSR: 106539368(TCF7L1)
PMUA: 114585748(TCF7L1)
GJA: 107117396(TCF7L1)
XLA: 100329123(tcf7l1-d) 394281(tcf7l1.S) 397863(tcf7l1.L) 397969(tcf7l1-c)
XTR: 448107(tcf7l1)
NPR: 108792469
DRE: 30523(tcf7l1a) 30556(tcf7l1b)
IPU: 108265410
PHYP: 113546045
AMEX: 103022374
NCC: 104946533(tcf7l1)
MZE: 101466461 101481605(tcf7l1)
OLA: 100820729(tcf7l1) 111948314
NFU: 107393717(tcf7l1) 107395259
KMR: 108236527(tcf7l1) 108242566
ALIM: 106513792 106520143(tcf7l1)
MALB: 109954978
SFM: 108923598 108929514(tcf7l1)
PKI: 111837756 111857498(tcf7l1)
LCM: 102364488(TCF7L1)
 » show all
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
Reference
PMID:1741298
  Authors
Castrop J, van Norren K, Clevers H
  Title
A gene family of HMG-box transcription factors with homology to TCF-1.
  Journal
Nucleic Acids Res 20:611 (1992)
DOI:10.1093/nar/20.3.611
  Sequence
[hsa:83439]
LinkDB

KEGG   ORTHOLOGY: K04491
Entry
K04491                      KO                                     

Name
TCF7L2
Definition
transcription factor 7-like 2
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04916  Melanogenesis
ko04934  Cushing syndrome
ko05132  Salmonella infection
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05412  Arrhythmogenic right ventricular cardiomyopathy
Disease
H00409  Type 2 diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04491  TCF7L2; transcription factor 7-like 2
   04390 Hippo signaling pathway
    K04491  TCF7L2; transcription factor 7-like 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04491  TCF7L2; transcription factor 7-like 2
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04491  TCF7L2; transcription factor 7-like 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04491  TCF7L2; transcription factor 7-like 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05225 Hepatocellular carcinoma
    K04491  TCF7L2; transcription factor 7-like 2
   05226 Gastric cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05216 Thyroid cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05221 Acute myeloid leukemia
    K04491  TCF7L2; transcription factor 7-like 2
   05217 Basal cell carcinoma
    K04491  TCF7L2; transcription factor 7-like 2
   05215 Prostate cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05213 Endometrial cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05224 Breast cancer
    K04491  TCF7L2; transcription factor 7-like 2
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04491  TCF7L2; transcription factor 7-like 2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04491  TCF7L2; transcription factor 7-like 2
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04491  TCF7L2; transcription factor 7-like 2
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04491  TCF7L2; transcription factor 7-like 2
   05165 Human papillomavirus infection
    K04491  TCF7L2; transcription factor 7-like 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04491  TCF7L2; transcription factor 7-like 2
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04491  TCF7L2; transcription factor 7-like 2
Genes
HSA: 6934(TCF7L2)
PTR: 450743(TCF7L2)
PPS: 100978424(TCF7L2)
GGO: 109025238(TCF7L2)
PON: 100434811(TCF7L2)
NLE: 100605701(TCF7L2)
MCC: 701759(TCF7L2)
MCF: 102116470(TCF7L2)
CSAB: 103216817(TCF7L2)
RRO: 104664436(TCF7L2)
RBB: 108542456(TCF7L2)
CJC: 100406757(TCF7L2)
SBQ: 101037011(TCF7L2)
MMU: 21416(Tcf7l2)
MCAL: 110285273(Tcf7l2)
MPAH: 110313411(Tcf7l2)
RNO: 679869(Tcf7l2)
MUN: 110545126(Tcf7l2)
CGE: 100758400(Tcf7l2)
NGI: 103731749(Tcf7l2)
HGL: 101710380(Tcf7l2)
CCAN: 109688561(Tcf7l2)
OCU: 100358378(TCF7L2)
TUP: 102472810(TCF7L2)
CFA: 486894(TCF7L2)
VVP: 112916157(TCF7L2)
AML: 100467719(TCF7L2)
UMR: 103657263(TCF7L2)
UAH: 113251942(TCF7L2)
ORO: 101385846(TCF7L2)
ELK: 111145217
FCA: 101095618(TCF7L2)
PTG: 102961321(TCF7L2)
PPAD: 109272915(TCF7L2)
AJU: 106974119(TCF7L2)
BTA: 540481(TCF7L2)
BOM: 102272230(TCF7L2)
BIU: 109553057(TCF7L2)
BBUB: 102393101(TCF7L2)
CHX: 102180102(TCF7L2)
OAS: 101118068(TCF7L2)
SSC: 100153922(TCF7L2)
CFR: 102510763(TCF7L2)
CDK: 105091689(TCF7L2)
BACU: 103010923(TCF7L2)
LVE: 103068781(TCF7L2)
OOR: 101288107(TCF7L2)
DLE: 111172300(TCF7L2)
PCAD: 102987858(TCF7L2)
ECB: 100059146(TCF7L2)
EPZ: 103564289(TCF7L2)
EAI: 106848101(TCF7L2)
MYB: 102245737(TCF7L2)
MYD: 102767014(TCF7L2)
MNA: 107536455(TCF7L2)
HAI: 109384898(TCF7L2)
DRO: 112300313(TCF7L2)
PALE: 102880370(TCF7L2)
RAY: 107511705(TCF7L2)
MJV: 108408173(TCF7L2)
LAV: 100656106(TCF7L2)
TMU: 101345532
MDO: 100021451(TCF7L2)
SHR: 100922675(TCF7L2)
PCW: 110209517(TCF7L2)
OAA: 100080633(TCF7L2)
GGA: 395508(TCF7L2)
MGP: 100545943
CJO: 107316122(TCF7L2)
NMEL: 110399432(TCF7L2)
APLA: 101790790(TCF7L2)
ACYG: 106031894(TCF7L2)
TGU: 100229459(TCF7L2)
LSR: 110468252(TCF7L2)
SCAN: 103814128(TCF7L2)
GFR: 102035103(TCF7L2)
FAB: 101808150(TCF7L2)
PHI: 102110960(TCF7L2)
PMAJ: 107206579(TCF7L2)
CCAE: 111930957(TCF7L2)
CCW: 104695213(TCF7L2)
ETL: 114057387(TCF7L2)
FPG: 101911463(TCF7L2)
FCH: 102053252(TCF7L2)
CLV: 102092542(TCF7L2)
EGZ: 104130428(TCF7L2)
NNI: 104022375(TCF7L2)
ACUN: 113481635(TCF7L2)
PADL: 103918670(TCF7L2)
AAM: 106483723(TCF7L2)
ASN: 102373887(TCF7L2)
AMJ: 102558653(TCF7L2)
PSS: 102459521(TCF7L2)
CMY: 102935138(TCF7L2)
CPIC: 101938831(TCF7L2)
ACS: 100561311(tcf7l2) 100563899
PVT: 110071969(TCF7L2)
PBI: 103067231(TCF7L2)
PMUR: 107286251(TCF7L2)
TSR: 106550184(TCF7L2)
PMUA: 114597477(TCF7L2)
GJA: 107121002(TCF7L2)
XLA: 108697306 399164(tcf7l2.L)
XTR: 100101719(tcf7l2)
NPR: 108793512(TCF7L2)
DRE: 30510(tcf7l2)
IPU: 108274114(tcf7l2)
PHYP: 113527302(tcf7l2)
AMEX: 103031257(tcf7l2)
EEE: 113577640
TRU: 101067664(tcf7l2) 115250775
LCO: 104932553(tcf7l2)
NCC: 104943463(tcf7l2)
MZE: 101472434 101473558(tcf7l2)
OLA: 101169492(tcf7l2)
XMA: 102216716(tcf7l2)
XCO: 114151877(tcf7l2)
PRET: 103473336 103481429(tcf7l2)
CVG: 107090000(tcf7l2)
NFU: 107387573(tcf7l2) 107396480
KMR: 108248252(tcf7l2)
ALIM: 106534544(tcf7l2)
AOCE: 111579048(tcf7l2)
CSEM: 103381486(tcf7l2) 103385014
POV: 109627028(tcf7l2)
LCF: 108901696(tcf7l2)
SDU: 111219725(tcf7l2)
SLAL: 111657117(tcf7l2)
HCQ: 109513392(tcf7l2)
BPEC: 110154410(tcf7l2)
MALB: 109962891(tcf7l2)
OTW: 112223237 112224184(tcf7l2)
ELS: 105007703(tcf7l2)
SFM: 108932732 108940446(tcf7l2)
PKI: 111858155(tcf7l2)
LCM: 102346208(TCF7L2)
CMK: 103186546(tcf7l2)
RTP: 109926936(tcf7l2)
BFO: 118412533
CIN: 778773(tcf/lef)
SPU: 373203(Tcf/Lef)
APLC: 110984316
SKO: 100303556(tcf7l)
DME: Dmel_CG34403(pan)
DER: 6555877
DSI: Dsimw501_GD17850(Dsim_pan)
DSR: 110185475
DPE: 6602541
DMN: 108164406
DWI: 6650061
DAZ: 108617901
DHE: 111597895
LCQ: 111687000
AME: 726671
BIM: 100745788
BTER: 100643645
CCAL: 108623756
OBB: 114877554
SOC: 105198489
MPHA: 105837174
AEC: 105151104
ACEP: 105619854
PBAR: 105424403
VEM: 105566494
HST: 105186992
DQU: 106742176
CFO: 105253941
LHU: 105675787
PGC: 109859232
OBO: 105281955
PCF: 106793924
NVI: 100120687
CSOL: 105360929
MDL: 103575344
TCA: 641465(Pan)
DPA: 109535398
ATD: 109595558
NVL: 108564096
BMOR: 101742450
BMAN: 114239539
PMAC: 106719867
PRAP: 110998995
HAW: 110372629
TNL: 113497924
PXY: 105381194
API: 100161896
AGS: 114118917
RMD: 113550243
BTAB: 109030753
CLEC: 106664004
ZNE: 110830984
FCD: 110843907
PVM: 113807509
DPTE: 113799178
CEL: CELE_W10C8.2(pop-1)
BMY: Bm1_47615
TSP: Tsp_02818
PCAN: 112561450
CRG: 105329818
MYI: 110453906
OBI: 106876393
LAK: 106155607
NVE: 5503766
ADF: 107340855
AMIL: 114964939
PDAM: 113677974
SPIS: 111346760
DGT: 114528487
HMG: 100199257
AQU: 100641322(Tcf)
 » show all
Reference
  Authors
Prokunina-Olsson L, Welch C, Hansson O, Adhikari N, Scott LJ, Usher N, Tong M, Sprau A, Swift A, Bonnycastle LL, Erdos MR, He Z, Saxena R, Harmon B, Kotova O, Hoffman EP, Altshuler D, Groop L, Boehnke M, Collins FS, Hall JL
  Title
Tissue-specific alternative splicing of TCF7L2.
  Journal
Hum Mol Genet 18:3795-804 (2009)
DOI:10.1093/hmg/ddp321
  Sequence
[hsa:6934]
Reference
PMID:9065401
  Authors
Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H
  Title
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
  Journal
Science 275:1784-7 (1997)
DOI:10.1126/science.275.5307.1784
  Sequence
[hsa:6934]
LinkDB

KEGG   ORTHOLOGY: K04492
Entry
K04492                      KO                                     

Name
LEF1
Definition
lymphoid enhancer-binding factor 1
Pathway
ko04310  Wnt signaling pathway
ko04390  Hippo signaling pathway
ko04520  Adherens junction
ko04916  Melanogenesis
ko04934  Cushing syndrome
ko05132  Salmonella infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05200  Pathways in cancer
ko05210  Colorectal cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05412  Arrhythmogenic right ventricular cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
   04390 Hippo signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05225 Hepatocellular carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05226 Gastric cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05216 Thyroid cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05221 Acute myeloid leukemia
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05217 Basal cell carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05215 Prostate cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05213 Endometrial cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05224 Breast cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04492  LEF1; lymphoid enhancer-binding factor 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04492  LEF1; lymphoid enhancer-binding factor 1
Genes
HSA: 51176(LEF1)
PTR: 461425(LEF1)
PPS: 100995847(LEF1)
GGO: 101140253(LEF1)
PON: 100447785(LEF1)
NLE: 100593051(LEF1)
MCC: 695776(LEF1)
MCF: 101925349(LEF1)
CSAB: 103236088(LEF1)
RRO: 104670045(LEF1)
RBB: 108515891(LEF1)
CJC: 100399759(LEF1)
SBQ: 101047688(LEF1)
MMU: 16842(Lef1)
MCAL: 110290892(Lef1)
MPAH: 110319903(Lef1)
RNO: 161452(Lef1)
MUN: 110553391(Lef1)
CGE: 100761200(Lef1)
NGI: 103742515(Lef1)
HGL: 101711023(Lef1)
CCAN: 109688935
OCU: 100352691(LEF1)
TUP: 102474621(LEF1)
CFA: 478507(LEF1)
VVP: 112934208(LEF1)
AML: 100465982(LEF1)
UMR: 103661728(LEF1)
UAH: 113255544(LEF1)
ORO: 101372325(LEF1)
ELK: 111154120
FCA: 101088077(LEF1)
PTG: 102970026(LEF1)
PPAD: 109247814(LEF1)
AJU: 106983664(LEF1)
BTA: 535399(LEF1)
BOM: 102266946(LEF1)
BIU: 109560266(LEF1)
BBUB: 102409520(LEF1)
CHX: 100860901(LEF1)
OAS: 780521(LEF1)
SSC: 100170126(LEF1)
CFR: 102510619(LEF1)
CDK: 105105289(LEF1)
BACU: 103020844(LEF1)
LVE: 103068879(LEF1)
OOR: 101287631(LEF1)
DLE: 111171490(LEF1)
PCAD: 102996605(LEF1)
ECB: 100072938(LEF1)
EPZ: 103557035(LEF1)
EAI: 106829814(LEF1)
MYB: 102255910(LEF1)
MYD: 102767379(LEF1)
MNA: 107538292(LEF1)
HAI: 109379461(LEF1)
DRO: 112321441(LEF1)
PALE: 102886933(LEF1)
RAY: 107511497(LEF1)
MJV: 108405595(LEF1)
LAV: 100658960(LEF1)
TMU: 101345125
MDO: 100011783(LEF1)
SHR: 100934638(LEF1)
PCW: 110218610(LEF1)
OAA: 100079818(LEF1)
GGA: 395865(LEF1)
MGP: 100542839(LEF1)
CJO: 107313267(LEF1)
NMEL: 110398346(LEF1)
APLA: 101792052(LEF1)
ACYG: 106038656(LEF1)
TGU: 100228376(LEF1)
LSR: 110468005(LEF1)
SCAN: 103826009(LEF1)
GFR: 102034937(LEF1)
FAB: 101821185(LEF1)
PHI: 102109576(LEF1)
PMAJ: 107203557(LEF1)
CCAE: 111928334(LEF1)
CCW: 104697293(LEF1)
ETL: 114057906(LEF1)
FPG: 101917929(LEF1)
FCH: 102050307(LEF1)
CLV: 102084626(LEF1)
EGZ: 104135527(LEF1)
NNI: 104021166(LEF1)
ACUN: 113479673(LEF1)
PADL: 103919538(LEF1)
AAM: 106491833(LEF1)
ASN: 102385539(LEF1)
AMJ: 102560337(LEF1)
PSS: 102456780(LEF1)
CMY: 102930185(LEF1)
CPIC: 101953582(LEF1)
ACS: 100556215(lef1)
PVT: 110080460(LEF1)
PBI: 103064656(LEF1)
PMUR: 107302616(LEF1)
TSR: 106556004(LEF1)
PMUA: 114603846(LEF1)
GJA: 107123114(LEF1)
XLA: 100337575(lef-1) 398238(lef1.L) 779101(lef1)
XTR: 100493178(lef1)
NPR: 108785415(LEF1) 108801973
DRE: 30701(lef1)
SGH: 107583218(lef1) 107594427
CCAR: 109046851
IPU: 108262963(lef1)
PHYP: 113538151(lef1)
AMEX: 103033630(lef1)
EEE: 113568617(lef1)
TRU: 101064872(lef1) 115251054
LCO: 104927262(lef1)
NCC: 104953587
MZE: 101464688(lef1)
ONL: 100704365(lef1)
OLA: 101167344(lef1)
XMA: 102226301(lef1) 111609564
XCO: 114144420(lef1) 114149416
PRET: 103472749(lef1)
CVG: 107094620(lef1)
NFU: 107375038(lef1)
KMR: 108230929(lef1)
ALIM: 106517066(lef1)
AOCE: 111586156(lef1)
LCF: 108888246(lef1)
SDU: 111236636(lef1)
SLAL: 111671174(lef1)
BPEC: 110165341(lef1)
MALB: 109955531(lef1) 109972141
SASA: 106602294 106610340(lef1)
OTW: 112238204
ELS: 105020989(lef1)
PKI: 111837376(lef1) 111852095
LCM: 102354030(LEF1)
CMK: 103182161
 » show all
Reference
  Authors
Hovanes K, Li TW, Waterman ML
  Title
The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.
  Journal
Nucleic Acids Res 28:1994-2003 (2000)
DOI:10.1093/nar/28.9.1994
  Sequence
[hsa:51176]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
LinkDB

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