KEGG   ORTHOLOGY: K02620
Entry
K02620                      KO                                     

Name
TCF7, TCF-1
Definition
transcription factor 7
Pathway
map04310  Wnt signaling pathway
map04390  Hippo signaling pathway
map04520  Adherens junction
map04550  Signaling pathways regulating pluripotency of stem cells
map04916  Melanogenesis
map04934  Cushing syndrome
map05132  Salmonella infection
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05200  Pathways in cancer
map05210  Colorectal cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05221  Acute myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05412  Arrhythmogenic right ventricular cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K02620  TCF7, TCF-1; transcription factor 7
   04390 Hippo signaling pathway
    K02620  TCF7, TCF-1; transcription factor 7
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K02620  TCF7, TCF-1; transcription factor 7
   04550 Signaling pathways regulating pluripotency of stem cells
    K02620  TCF7, TCF-1; transcription factor 7
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K02620  TCF7, TCF-1; transcription factor 7
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02620  TCF7, TCF-1; transcription factor 7
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05225 Hepatocellular carcinoma
    K02620  TCF7, TCF-1; transcription factor 7
   05226 Gastric cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05216 Thyroid cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05221 Acute myeloid leukemia
    K02620  TCF7, TCF-1; transcription factor 7
   05217 Basal cell carcinoma
    K02620  TCF7, TCF-1; transcription factor 7
   05215 Prostate cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05213 Endometrial cancer
    K02620  TCF7, TCF-1; transcription factor 7
   05224 Breast cancer
    K02620  TCF7, TCF-1; transcription factor 7
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K02620  TCF7, TCF-1; transcription factor 7
   05165 Human papillomavirus infection
    K02620  TCF7, TCF-1; transcription factor 7
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K02620  TCF7, TCF-1; transcription factor 7
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K02620  TCF7, TCF-1; transcription factor 7
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K02620  TCF7, TCF-1; transcription factor 7
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K02620  TCF7, TCF-1; transcription factor 7
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K02620  TCF7, TCF-1; transcription factor 7
Genes
HSA: 6932(TCF7)
PTR: 745839(TCF7)
PPS: 100980839(TCF7)
GGO: 101149731(TCF7)
PON: 100461234(TCF7)
NLE: 100595737(TCF7)
MCC: 710234(TCF7)
MCF: 102142248(TCF7)
CSAB: 103244543(TCF7)
CATY: 105599768(TCF7)
PANU: 101024089(TCF7)
RRO: 104659811(TCF7)
RBB: 108529562(TCF7)
TFN: 117065864(TCF7)
PTEH: 111529175(TCF7)
CJC: 100399154(TCF7)
SBQ: 101029076(TCF7)
MMUR: 105869975(TCF7)
MMU: 21414(Tcf7)
MCAL: 110304948(Tcf7)
MPAH: 110332085(Tcf7)
RNO: 363595(Tcf7)
MCOC: 116077224(Tcf7)
MUN: 110549622(Tcf7)
CGE: 100757390(Tcf7)
PLEU: 114683055(Tcf7)
NGI: 103729786(Tcf7)
HGL: 101707882(Tcf7)
CCAN: 109689465(Tcf7)
OCU: 100339216(TCF7)
TUP: 102484318(TCF7)
CFA: 481506(TCF7)
VVP: 112917059(TCF7)
VLG: 121495797(TCF7)
AML: 100476528(TCF7)
UMR: 103663815(TCF7)
UAH: 113261735(TCF7)
ORO: 101376237(TCF7)
ELK: 111141244
MPUF: 101678117(TCF7)
EJU: 114209512(TCF7)
MLX: 118016638(TCF7)
FCA: 101098768(TCF7)
PTG: 102957988(TCF7)
PPAD: 109250863(TCF7)
AJU: 106984911(TCF7)
HHV: 120238500(TCF7)
BTA: 782690(TCF7)
BOM: 102266633(TCF7)
BIU: 109562015(TCF7)
BBUB: 102408996(TCF7)
CHX: 102173736(TCF7)
OAS: 101101980(TCF7)
ODA: 120863661(TCF7)
SSC: 100512951(TCF7)
CFR: 102519063(TCF7)
CDK: 105090254(TCF7)
BACU: 103018264(TCF7)
LVE: 103074150(TCF7)
OOR: 101289599(TCF7)
DLE: 111182442(TCF7)
PCAD: 102992878(TCF7)
ECB: 100072786(TCF7)
EPZ: 103543120(TCF7)
EAI: 106834657(TCF7)
MYB: 102250528(TCF7)
MYD: 102757003(TCF7)
MMYO: 118657631(TCF7)
MNA: 107525397(TCF7)
HAI: 109382635(TCF7)
DRO: 112318180(TCF7)
SHON: 118990084(TCF7)
AJM: 119037608(TCF7)
MMF: 118643629(TCF7)
PALE: 102885788(TCF7)
RAY: 107506797(TCF7)
MJV: 108406081(TCF7)
TOD: 119243471(TCF7)
LAV: 100663559(TCF7)
TMU: 101350837
MDO: 100017589(TCF7)
SHR: 100930141(TCF7)
PCW: 110211723(TCF7)
OAA: 100082332(TCF7)
GGA: 395229(TCF7)
PCOC: 116232216(TCF7)
MGP: 100544924(TCF7)
CJO: 107320225(TCF7)
NMEL: 110405287(TCF7)
APLA: 101803610(TCF7)
ACYG: 106032766(TCF7)
TGU: 100221008(TCF7)
LSR: 110481074(TCF7)
SCAN: 103817470(TCF7)
PMOA: 120498623(TCF7)
GFR: 102036749(TCF7)
FAB: 101820491(TCF7)
PHI: 102110510(TCF7)
PMAJ: 107210639(TCF7)
CCAE: 111935599(TCF7)
CCW: 104683724(TCF7)
ETL: 114063910(TCF7)
FPG: 101919678(TCF7)
FCH: 102058554(TCF7)
CLV: 102094656(TCF7)
EGZ: 104133478(TCF7)
NNI: 104012004(TCF7)
ACUN: 113485114(TCF7)
PADL: 103915850(TCF7)
AAM: 106487174(TCF7)
ASN: 102383175(TCF7)
AMJ: 102576120(TCF7)
CPOO: 109310088(TCF7)
GGN: 109289961(TCF7)
PSS: 102446665(TCF7)
CMY: 102943166(TCF7)
CPIC: 101937399(TCF7)
TST: 117882270(TCF7)
CABI: 116826639(TCF7)
ACS: 100554608(tcf7)
PVT: 110079405(TCF7)
PBI: 103067042(TCF7)
PMUR: 107294908(TCF7)
TSR: 106542632(TCF7)
PGUT: 117656083(TCF7)
PMUA: 114591268(TCF7)
ZVI: 118080356(TCF7)
GJA: 107125983(TCF7)
XLA: 398658(tcf7.S)
XTR: 395061(tcf7)
NPR: 108792126(TCF7)
DRE: 497649(tcf7)
SRX: 107728269 107742437(tcf7)
SANH: 107661683(tcf7) 107692971
CCAR: 109048020
IPU: 108278866(tcf7)
PHYP: 113535749
AMEX: 103045826
EEE: 113578029(tcf7)
TRU: 101076516(tcf7)
LCO: 104924428
NCC: 104960861(tcf7)
ELY: 117245747 117268549(tcf7)
PLEP: 121952129(tcf7)
SLUC: 116055911(tcf7) 118493643
ECRA: 117955094(tcf7)
PFLV: 114566424(tcf7)
GAT: 120810826 120821561(tcf7)
MSAM: 119895287(tcf7)
CUD: 121518698(tcf7)
MZE: 101469770(tcf7)
ONL: 100710520(tcf7)
OAU: 116315805(tcf7)
OML: 112137216 112142310(tcf7)
XMA: 102221228(tcf7) 111610761
XCO: 114152465(tcf7) 114157642
XHE: 116728111(tcf7) 116732626
PRET: 103460015(tcf7) 103480959
CVG: 107085909(tcf7)
CTUL: 119797145 119797952(tcf7)
NFU: 107378492 107386837(tcf7)
KMR: 108238102(tcf7)
ALIM: 106524564(tcf7) 106532889
AOCE: 111566135
CSEM: 103394864(tcf7)
POV: 109635808(tcf7)
LCF: 108893669(tcf7)
SDU: 111234495(tcf7)
SLAL: 111659992(tcf7)
XGL: 120803038(tcf7)
MALB: 109966812(tcf7)
OMY: 101268913(tcf7) 110537729
ELS: 105026693
PKI: 111839551
LOC: 102694215(tcf7)
LCM: 102350321(TCF7)
CMK: 103183678(tcf7)
RTP: 109912241
ACER: 108000102
APLN: 108741021
VDE: 111250602
CBR: CBG11789
GAE: 121391070
MYI: 110453946
ATEN: 116297634
 » show all
Reference
PMID:1569101
  Authors
van de Wetering M, Oosterwegel M, Holstege F, Dooyes D, Suijkerbuijk R, Geurts van Kessel A, Clevers H
  Title
The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization.
  Journal
J Biol Chem 267:8530-6 (1992)
  Sequence
[hsa:6932]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
Reference
  Authors
Ioannidis V, Beermann F, Clevers H, Held W
  Title
The beta-catenin--TCF-1 pathway ensures CD4(+)CD8(+) thymocyte survival.
  Journal
Nat Immunol 2:691-7 (2001)
DOI:10.1038/90623
  Sequence
[mmu:21414]
LinkDB

KEGG   ORTHOLOGY: K04490
Entry
K04490                      KO                                     

Name
TCF7L1
Definition
transcription factor 7-like 1
Pathway
map04310  Wnt signaling pathway
map04390  Hippo signaling pathway
map04520  Adherens junction
map04916  Melanogenesis
map04934  Cushing syndrome
map05132  Salmonella infection
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05200  Pathways in cancer
map05210  Colorectal cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05221  Acute myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05412  Arrhythmogenic right ventricular cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
   04390 Hippo signaling pathway
    K04490  TCF7L1; transcription factor 7-like 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04490  TCF7L1; transcription factor 7-like 1
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04490  TCF7L1; transcription factor 7-like 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04490  TCF7L1; transcription factor 7-like 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05225 Hepatocellular carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05226 Gastric cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05216 Thyroid cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05221 Acute myeloid leukemia
    K04490  TCF7L1; transcription factor 7-like 1
   05217 Basal cell carcinoma
    K04490  TCF7L1; transcription factor 7-like 1
   05215 Prostate cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05213 Endometrial cancer
    K04490  TCF7L1; transcription factor 7-like 1
   05224 Breast cancer
    K04490  TCF7L1; transcription factor 7-like 1
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04490  TCF7L1; transcription factor 7-like 1
   05165 Human papillomavirus infection
    K04490  TCF7L1; transcription factor 7-like 1
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04490  TCF7L1; transcription factor 7-like 1
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04490  TCF7L1; transcription factor 7-like 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04490  TCF7L1; transcription factor 7-like 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04490  TCF7L1; transcription factor 7-like 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04490  TCF7L1; transcription factor 7-like 1
Genes
HSA: 83439(TCF7L1)
PTR: 744526(TCF7L1)
PPS: 100968002(TCF7L1)
GGO: 101151621(TCF7L1)
PON: 100436197(TCF7L1)
NLE: 100601518(TCF7L1)
MCC: 694560(TCF7L1)
MCF: 102125513(TCF7L1)
CSAB: 103219950(TCF7L1)
CATY: 105587638(TCF7L1)
PANU: 101017547(TCF7L1)
RRO: 104659731(TCF7L1)
RBB: 108542809(TCF7L1)
TFN: 117062119(TCF7L1)
PTEH: 111551134(TCF7L1)
CJC: 100385633
SBQ: 101033762(TCF7L1)
MMUR: 105876584(TCF7L1)
MMU: 21415(Tcf7l1)
MCAL: 110296038(Tcf7l1)
MPAH: 110315696(Tcf7l1)
RNO: 312451(Tcf7l1)
MCOC: 116099088(Tcf7l1)
CGE: 100753225(Tcf7l1)
PLEU: 114681591(Tcf7l1)
NGI: 103739783(Tcf7l1)
HGL: 101699909(Tcf7l1)
CCAN: 109686184(Tcf7l1)
OCU: 100340471(TCF7L1)
TUP: 102481394(TCF7L1)
CFA: 612070(TCF7L1)
VVP: 112916685(TCF7L1)
VLG: 121490511(TCF7L1)
AML: 100480690(TCF7L1)
UMR: 103671448(TCF7L1)
UAH: 113243231(TCF7L1)
ORO: 101382778(TCF7L1)
ELK: 111148131
MPUF: 101670990(TCF7L1)
EJU: 114223462(TCF7L1)
MLX: 118007920(TCF7L1)
FCA: 101089850(TCF7L1)
PTG: 102958078(TCF7L1)
PPAD: 109263707(TCF7L1)
AJU: 106978197(TCF7L1)
HHV: 120220478(TCF7L1)
BTA: 515303(TCF7L1)
BOM: 102281039(TCF7L1)
BIU: 109565564(TCF7L1)
BBUB: 102410081(TCF7L1)
CHX: 102187776(TCF7L1)
OAS: 100913162(TCF7L1)
ODA: 120851515(TCF7L1)
SSC: 100523899(TCF7L1)
CFR: 102516787(TCF7L1)
CDK: 105104146(TCF7L1)
BACU: 103010166(TCF7L1)
LVE: 103069353(TCF7L1)
OOR: 101287223(TCF7L1)
DLE: 111165393(TCF7L1)
PCAD: 102974053(TCF7L1)
ECB: 100067427(TCF7L1)
EPZ: 103548276(TCF7L1)
EAI: 106838609(TCF7L1)
MYB: 102240393(TCF7L1)
MYD: 102768915(TCF7L1)
MMYO: 118668800(TCF7L1)
MNA: 107528616(TCF7L1)
HAI: 109371340(TCF7L1)
DRO: 112302951(TCF7L1)
SHON: 118982463(TCF7L1) 118989528
AJM: 119059869(TCF7L1)
MMF: 118630569(TCF7L1)
PALE: 102886093(TCF7L1)
RAY: 107506285(TCF7L1)
MJV: 108405898(TCF7L1)
TOD: 119259123(TCF7L1)
TMU: 101341696
MDO: 100030368(TCF7L1)
SHR: 100922609(TCF7L1)
PCW: 110196343(TCF7L1)
OAA: 114817948(TCF7L1)
GGA: 395230(TCF7L1)
PCOC: 116231327(TCF7L1)
MGP: 104917108(TCF7L1)
CJO: 107323707(TCF7L1)
NMEL: 110387133(TCF7L1)
APLA: 101801135(TCF7L1)
TGU: 115498209(TCF7L1)
LSR: 110478270(TCF7L1)
PMOA: 120505008(TCF7L1)
GFR: 102039905(TCF7L1)
FAB: 101817952(TCF7L1)
PHI: 102105833(TCF7L1)
PMAJ: 107213891(TCF7L1)
CCAE: 111938914(TCF7L1)
ETL: 114070472(TCF7L1)
FPG: 101922879(TCF7L1)
FCH: 102051021(TCF7L1)
CLV: 102084814(TCF7L1)
NNI: 104022615(TCF7L1)
AAM: 106497459
ASN: 102382172(TCF7L1)
AMJ: 102559656(TCF7L1)
CPOO: 109324635(TCF7L1)
GGN: 109286704(TCF7L1)
PSS: 102456229(TCF7L1)
CMY: 102947844(TCF7L1)
CPIC: 101943923(TCF7L1)
TST: 117872874(TCF7L1)
CABI: 116820735(TCF7L1)
ACS: 100553130(tcf7l1)
PVT: 110084320(TCF7L1)
PBI: 103066724(TCF7L1)
PMUR: 107286235(TCF7L1)
TSR: 106539368(TCF7L1)
PGUT: 117677059(TCF7L1)
PMUA: 114585748(TCF7L1)
ZVI: 118097303(TCF7L1)
GJA: 107117396(TCF7L1)
XLA: 394281(tcf7l1.S) 397863(tcf7l1.L)
XTR: 448107(tcf7l1)
NPR: 108792469
DRE: 30523(tcf7l1a) 30556(tcf7l1b)
IPU: 108265410
PHYP: 113546045
AMEX: 103022374
NCC: 104946533(tcf7l1)
PLEP: 121938910 121944425(tcf7l1b)
SLUC: 116041786 116053887(tcf7l1b)
MZE: 101466461 101481605(tcf7l1)
OLA: 100820729(tcf7l1) 111948314
OML: 112148818(tcf7l1b) 112162929
CTUL: 119783953(tcf7l1b)
NFU: 107393717(tcf7l1) 107395259
KMR: 108236527(tcf7l1b) 108242566
ALIM: 106513792 106520143(tcf7l1)
XGL: 120805718(tcf7l1b) 120806258
MALB: 109954978
SFM: 108923598 108929514(tcf7l1)
PKI: 111837756 111857498(tcf7l1)
LOC: 102692120(tcf7l1)
LCM: 102364488(TCF7L1)
 » show all
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
Reference
PMID:1741298
  Authors
Castrop J, van Norren K, Clevers H
  Title
A gene family of HMG-box transcription factors with homology to TCF-1.
  Journal
Nucleic Acids Res 20:611 (1992)
DOI:10.1093/nar/20.3.611
  Sequence
[hsa:83439]
LinkDB

KEGG   ORTHOLOGY: K04491
Entry
K04491                      KO                                     

Name
TCF7L2
Definition
transcription factor 7-like 2
Pathway
map04310  Wnt signaling pathway
map04390  Hippo signaling pathway
map04520  Adherens junction
map04916  Melanogenesis
map04934  Cushing syndrome
map05132  Salmonella infection
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05200  Pathways in cancer
map05210  Colorectal cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05221  Acute myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05412  Arrhythmogenic right ventricular cardiomyopathy
Disease
H00409  Type 2 diabetes mellitus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04491  TCF7L2; transcription factor 7-like 2
   04390 Hippo signaling pathway
    K04491  TCF7L2; transcription factor 7-like 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04491  TCF7L2; transcription factor 7-like 2
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04491  TCF7L2; transcription factor 7-like 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04491  TCF7L2; transcription factor 7-like 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05225 Hepatocellular carcinoma
    K04491  TCF7L2; transcription factor 7-like 2
   05226 Gastric cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05216 Thyroid cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05221 Acute myeloid leukemia
    K04491  TCF7L2; transcription factor 7-like 2
   05217 Basal cell carcinoma
    K04491  TCF7L2; transcription factor 7-like 2
   05215 Prostate cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05213 Endometrial cancer
    K04491  TCF7L2; transcription factor 7-like 2
   05224 Breast cancer
    K04491  TCF7L2; transcription factor 7-like 2
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04491  TCF7L2; transcription factor 7-like 2
   05165 Human papillomavirus infection
    K04491  TCF7L2; transcription factor 7-like 2
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04491  TCF7L2; transcription factor 7-like 2
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04491  TCF7L2; transcription factor 7-like 2
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04491  TCF7L2; transcription factor 7-like 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04491  TCF7L2; transcription factor 7-like 2
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04491  TCF7L2; transcription factor 7-like 2
Genes
HSA: 6934(TCF7L2)
PTR: 450743(TCF7L2)
PPS: 100978424(TCF7L2)
GGO: 109025238(TCF7L2)
PON: 100434811(TCF7L2)
NLE: 100605701(TCF7L2)
MCC: 701759(TCF7L2)
MCF: 102116470(TCF7L2)
CSAB: 103216817(TCF7L2)
CATY: 105577906(TCF7L2)
PANU: 101026705(TCF7L2)
RRO: 104664436(TCF7L2)
RBB: 108542456(TCF7L2)
TFN: 117066750(TCF7L2)
PTEH: 111538904(TCF7L2)
CJC: 100406757(TCF7L2)
SBQ: 101037011(TCF7L2)
MMUR: 105875160(TCF7L2)
MMU: 21416(Tcf7l2)
MCAL: 110285273(Tcf7l2)
MPAH: 110313411(Tcf7l2)
RNO: 679869(Tcf7l2)
MCOC: 116104020(Tcf7l2)
MUN: 110545126(Tcf7l2)
CGE: 100758400(Tcf7l2)
PLEU: 114697060(Tcf7l2)
NGI: 103731749(Tcf7l2)
HGL: 101710380(Tcf7l2)
CCAN: 109688561(Tcf7l2)
OCU: 100358378(TCF7L2)
TUP: 102472810(TCF7L2)
CFA: 486894(TCF7L2)
VVP: 112916157(TCF7L2)
VLG: 121485032(TCF7L2)
AML: 100467719(TCF7L2)
UMR: 103657263(TCF7L2)
UAH: 113251942(TCF7L2)
ORO: 101385846(TCF7L2)
ELK: 111145217
MPUF: 101676452(TCF7L2)
MLX: 118026323(TCF7L2)
FCA: 101095618(TCF7L2)
PTG: 102961321(TCF7L2)
PPAD: 109272915(TCF7L2)
AJU: 106974119(TCF7L2)
HHV: 120235337(TCF7L2)
BTA: 540481(TCF7L2)
BOM: 102272230(TCF7L2)
BIU: 109553057(TCF7L2)
BBUB: 102393101(TCF7L2)
CHX: 102180102(TCF7L2)
OAS: 101118068(TCF7L2)
ODA: 120873902(TCF7L2)
SSC: 100153922(TCF7L2)
CFR: 102510763(TCF7L2)
CDK: 105091689(TCF7L2)
BACU: 103010923(TCF7L2)
LVE: 103068781(TCF7L2)
OOR: 101288107(TCF7L2)
DLE: 111172300(TCF7L2)
PCAD: 102987858(TCF7L2)
ECB: 100059146(TCF7L2)
EPZ: 103564289(TCF7L2)
EAI: 106848101(TCF7L2)
MYB: 102245737(TCF7L2)
MYD: 102767014(TCF7L2)
MMYO: 118669739(TCF7L2)
MNA: 107536455(TCF7L2)
HAI: 109384898(TCF7L2)
DRO: 112300313(TCF7L2)
SHON: 118999410(TCF7L2)
AJM: 119040094(TCF7L2)
MMF: 118632022(TCF7L2)
PALE: 102880370(TCF7L2)
RAY: 107511705(TCF7L2)
MJV: 108408173(TCF7L2)
TOD: 119234547(TCF7L2)
LAV: 100656106(TCF7L2)
TMU: 101345532
MDO: 100021451(TCF7L2)
SHR: 100922675(TCF7L2)
PCW: 110209517(TCF7L2)
OAA: 100080633(TCF7L2)
GGA: 395508(TCF7L2)
PCOC: 116231615(TCF7L2)
MGP: 100545943
CJO: 107316122(TCF7L2)
NMEL: 110399432(TCF7L2)
APLA: 101790790(TCF7L2)
ACYG: 106031894(TCF7L2)
TGU: 100229459(TCF7L2)
LSR: 110468252(TCF7L2)
SCAN: 103814128(TCF7L2)
PMOA: 120501961(TCF7L2)
GFR: 102035103(TCF7L2)
FAB: 101808150(TCF7L2)
PHI: 102110960(TCF7L2)
PMAJ: 107206579(TCF7L2)
CCAE: 111930957(TCF7L2)
CCW: 104695213(TCF7L2)
ETL: 114057387(TCF7L2)
FPG: 101911463(TCF7L2)
FCH: 102053252(TCF7L2)
CLV: 102092542(TCF7L2)
EGZ: 104130428(TCF7L2)
NNI: 104022375(TCF7L2)
ACUN: 113481635(TCF7L2)
PADL: 103918670(TCF7L2)
AAM: 106483723(TCF7L2)
ASN: 102373887(TCF7L2)
AMJ: 102558653(TCF7L2)
CPOO: 109324083(TCF7L2)
GGN: 109287622(TCF7L2)
PSS: 102459521(TCF7L2)
CMY: 102935138(TCF7L2)
CPIC: 101938831(TCF7L2)
TST: 117879792(TCF7L2)
CABI: 116832677(TCF7L2)
ACS: 100561311(tcf7l2) 100563899
PVT: 110071969(TCF7L2)
PBI: 103067231(TCF7L2)
PMUR: 107286251(TCF7L2)
TSR: 106550184(TCF7L2)
PGUT: 117678715(TCF7L2)
PMUA: 114597477(TCF7L2)
ZVI: 118093455(TCF7L2)
GJA: 107121002(TCF7L2)
XLA: 108697306 399164(tcf7l2.L)
XTR: 100101719(tcf7l2)
NPR: 108793512(TCF7L2)
DRE: 30510(tcf7l2)
IPU: 108274114(tcf7l2)
PHYP: 113527302(tcf7l2)
AMEX: 103031257(tcf7l2)
EEE: 113577640
TRU: 101067664(tcf7l2) 115250775
LCO: 104932553(tcf7l2)
NCC: 104943463(tcf7l2)
ELY: 117247028(tcf7l2)
PLEP: 121958519(tcf7l2)
SLUC: 116061043(tcf7l2)
ECRA: 117936627(tcf7l2)
PFLV: 114547666(tcf7l2)
GAT: 120819326(tcf7l2)
MSAM: 119911965 119915700(tcf7l2)
CUD: 121528169(tcf7l2)
MZE: 101472434 101473558(tcf7l2)
OLA: 101169492(tcf7l2)
OML: 112154020(tcf7l2)
XMA: 102216716(tcf7l2)
XCO: 114151877(tcf7l2)
XHE: 116726851(tcf7l2)
PRET: 103473336 103481429(tcf7l2)
CVG: 107090000(tcf7l2)
CTUL: 119774953(tcf7l2)
NFU: 107387573(tcf7l2) 107396480
KMR: 108248252(tcf7l2)
ALIM: 106534544(tcf7l2)
AOCE: 111579048(tcf7l2)
CSEM: 103381486(tcf7l2) 103385014
POV: 109627028(tcf7l2)
LCF: 108901696(tcf7l2)
SDU: 111219725(tcf7l2)
SLAL: 111657117(tcf7l2)
XGL: 120794076(tcf7l2)
HCQ: 109513392(tcf7l2)
BPEC: 110154410(tcf7l2)
MALB: 109962891(tcf7l2)
OTW: 112223237 112224184(tcf7l2)
ELS: 105007703(tcf7l2)
SFM: 108932732 108940446(tcf7l2)
PKI: 111858155(tcf7l2)
LOC: 102691677(tcf7l2)
LCM: 102346208(TCF7L2)
CMK: 103186546(tcf7l2)
RTP: 109926936(tcf7l2)
BFO: 118412533
CIN: 778773(tcf/lef)
SPU: 373203(Tcf/Lef)
APLC: 110984316
SKO: 100303556(tcf7l)
DME: Dmel_CG34403(pan)
DER: 6555877
DSI: Dsimw501_GD17850(Dsim_pan)
DSR: 110185475
DPE: 6602541
DMN: 108164406
DWI: 6650061
DAZ: 108617901
DHE: 111597895
LCQ: 111687000
AME: 726671
BIM: 100745788
BTER: 100643645
CCAL: 108623756
OBB: 114877554
MGEN: 117223795
NMEA: 116427844
CGIG: 122404573
SOC: 105198489
MPHA: 105837174
AEC: 105151104
ACEP: 105619854
PBAR: 105424403
VEM: 105566494
HST: 105186992
DQU: 106742176
CFO: 105253941
LHU: 105675787
PGC: 109859232
OBO: 105281955
PCF: 106793924
NVI: 100120687
CSOL: 105360929
MDL: 103575344
TCA: 641465(Pan)
DPA: 109535398
ATD: 109595558
AGB: 108911640
NVL: 108564096
PPYR: 116175025
OTU: 111424736
BMOR: 101742450
BMAN: 114239539
MSEX: 115453597
BANY: 112058326
PMAC: 106719867
PPOT: 106111393
PXU: 106123142
PRAP: 110998995
ZCE: 119837715
HAW: 110372629
TNL: 113497924
PXY: 105381194
API: 100161896
AGS: 114118917
RMD: 113550243
BTAB: 109030753
DCI: 103521547
CLEC: 106664004
NLU: 111047051
ZNE: 110830984
CSEC: 111867222
FCD: 110843907
PVM: 113807509
HAME: 121861552
EAF: 111718027
DSV: 119437031
RSAN: 119393871
RMP: 119161120
VJA: 111267083
DPTE: 113799178
CEL: CELE_W10C8.2(pop-1)
TSP: Tsp_02818
PCAN: 112561450
BGT: 106050505
GAE: 121379435
CRG: 105329818
MYI: 110453906
PMAX: 117329520
OBI: 106876393
LAK: 106155607
NVE: 5503766
ADF: 107340855
AMIL: 114964939
PDAM: 113677974
SPIS: 111346760
DGT: 114528487
HMG: 100199257
AQU: 100641322(Tcf)
 » show all
Reference
  Authors
Prokunina-Olsson L, Welch C, Hansson O, Adhikari N, Scott LJ, Usher N, Tong M, Sprau A, Swift A, Bonnycastle LL, Erdos MR, He Z, Saxena R, Harmon B, Kotova O, Hoffman EP, Altshuler D, Groop L, Boehnke M, Collins FS, Hall JL
  Title
Tissue-specific alternative splicing of TCF7L2.
  Journal
Hum Mol Genet 18:3795-804 (2009)
DOI:10.1093/hmg/ddp321
  Sequence
[hsa:6934]
Reference
PMID:9065401
  Authors
Korinek V, Barker N, Morin PJ, van Wichen D, de Weger R, Kinzler KW, Vogelstein B, Clevers H
  Title
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma.
  Journal
Science 275:1784-7 (1997)
DOI:10.1126/science.275.5307.1784
  Sequence
[hsa:6934]
LinkDB

KEGG   ORTHOLOGY: K04492
Entry
K04492                      KO                                     

Name
LEF1
Definition
lymphoid enhancer-binding factor 1
Pathway
map04310  Wnt signaling pathway
map04390  Hippo signaling pathway
map04520  Adherens junction
map04916  Melanogenesis
map04934  Cushing syndrome
map05132  Salmonella infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05200  Pathways in cancer
map05210  Colorectal cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05221  Acute myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05412  Arrhythmogenic right ventricular cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
   04390 Hippo signaling pathway
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09150 Organismal Systems
  09152 Endocrine system
   04916 Melanogenesis
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09162 Cancer: specific types
   05210 Colorectal cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05225 Hepatocellular carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05226 Gastric cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05216 Thyroid cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05221 Acute myeloid leukemia
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05217 Basal cell carcinoma
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05215 Prostate cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05213 Endometrial cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
   05224 Breast cancer
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09166 Cardiovascular disease
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04492  LEF1; lymphoid enhancer-binding factor 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04492  LEF1; lymphoid enhancer-binding factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K04492  LEF1; lymphoid enhancer-binding factor 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   HMG TCF-1
    K04492  LEF1; lymphoid enhancer-binding factor 1
Genes
HSA: 51176(LEF1)
PTR: 461425(LEF1)
PPS: 100995847(LEF1)
GGO: 101140253(LEF1)
PON: 100447785(LEF1)
NLE: 100593051(LEF1)
MCC: 695776(LEF1)
MCF: 101925349(LEF1)
CSAB: 103236088(LEF1)
CATY: 105571411(LEF1)
PANU: 101017352(LEF1)
RRO: 104670045(LEF1)
RBB: 108515891(LEF1)
TFN: 117085762(LEF1)
PTEH: 111547880(LEF1)
CJC: 100399759(LEF1)
SBQ: 101047688(LEF1)
MMUR: 105872329(LEF1)
MMU: 16842(Lef1)
MCAL: 110290892(Lef1)
MPAH: 110319903(Lef1)
RNO: 161452(Lef1)
MCOC: 116093789(Lef1)
MUN: 110553391(Lef1)
CGE: 100761200(Lef1)
PLEU: 114682816(Lef1)
NGI: 103742515(Lef1)
HGL: 101711023(Lef1)
CCAN: 109688935
OCU: 100352691(LEF1)
TUP: 102474621(LEF1)
CFA: 478507(LEF1)
VVP: 112934208(LEF1)
VLG: 121493895(LEF1)
AML: 100465982(LEF1)
UMR: 103661728(LEF1)
UAH: 113255544(LEF1)
ORO: 101372325(LEF1)
ELK: 111154120
MPUF: 101689480(LEF1)
EJU: 114222653(LEF1)
MLX: 118027079(LEF1)
FCA: 101088077(LEF1)
PTG: 102970026(LEF1)
PPAD: 109247814(LEF1)
AJU: 106983664(LEF1)
HHV: 120236146(LEF1)
BTA: 535399(LEF1)
BOM: 102266946(LEF1)
BIU: 109560266(LEF1)
BBUB: 102409520(LEF1)
CHX: 100860901(LEF1)
OAS: 780521(LEF1)
ODA: 120861741(LEF1)
SSC: 100170126(LEF1)
CFR: 102510619(LEF1)
CDK: 105105289(LEF1)
BACU: 103020844(LEF1)
LVE: 103068879(LEF1)
OOR: 101287631(LEF1)
DLE: 111171490(LEF1)
PCAD: 102996605(LEF1)
ECB: 100072938(LEF1)
EPZ: 103557035(LEF1)
EAI: 106829814(LEF1)
MYB: 102255910(LEF1)
MYD: 102767379(LEF1)
MMYO: 118673131(LEF1)
MNA: 107538292(LEF1)
HAI: 109379461(LEF1)
DRO: 112321441(LEF1)
SHON: 118977082(LEF1)
AJM: 119061436(LEF1)
MMF: 118637343(LEF1)
PALE: 102886933(LEF1)
RAY: 107511497(LEF1)
MJV: 108405595(LEF1)
TOD: 119242944(LEF1)
LAV: 100658960(LEF1)
TMU: 101345125
MDO: 100011783(LEF1)
SHR: 100934638(LEF1)
PCW: 110218610(LEF1)
OAA: 100079818(LEF1)
GGA: 395865(LEF1)
PCOC: 116238078(LEF1)
MGP: 100542839(LEF1)
CJO: 107313267(LEF1)
NMEL: 110398346(LEF1)
APLA: 101792052(LEF1)
ACYG: 106038656(LEF1)
TGU: 100228376(LEF1)
LSR: 110468005(LEF1)
SCAN: 103826009(LEF1)
PMOA: 120502824(LEF1)
GFR: 102034937(LEF1)
FAB: 101821185(LEF1)
PHI: 102109576(LEF1)
PMAJ: 107203557(LEF1)
CCAE: 111928334(LEF1)
CCW: 104697293(LEF1)
ETL: 114057906(LEF1)
FPG: 101917929(LEF1)
FCH: 102050307(LEF1)
CLV: 102084626(LEF1)
EGZ: 104135527(LEF1)
NNI: 104021166(LEF1)
ACUN: 113479673(LEF1)
PADL: 103919538(LEF1)
AAM: 106491833(LEF1)
ASN: 102385539(LEF1)
AMJ: 102560337(LEF1)
CPOO: 109309400(LEF1)
GGN: 109301061(LEF1)
PSS: 102456780(LEF1)
CMY: 102930185(LEF1)
CPIC: 101953582(LEF1)
TST: 117878225(LEF1)
CABI: 116837678(LEF1)
ACS: 100556215(lef1)
PVT: 110080460(LEF1)
PBI: 103064656(LEF1)
PMUR: 107302616(LEF1)
TSR: 106556004(LEF1)
PGUT: 117679923(LEF1)
PMUA: 114603846(LEF1)
ZVI: 118083338(LEF1)
GJA: 107123114(LEF1)
XLA: 398238(lef1.L) 779101(lef1.S)
XTR: 100493178(lef1)
NPR: 108785415(LEF1) 108801973
DRE: 30701(lef1)
SGH: 107583218(lef1) 107594427
CCAR: 109046851
IPU: 108262963(lef1)
PHYP: 113538151(lef1)
AMEX: 103033630(lef1)
EEE: 113568617(lef1)
TRU: 101064872(lef1) 115251054
LCO: 104927262(lef1)
NCC: 104953587
ELY: 117255366(lef1)
PLEP: 121942444(lef1) 121959099
SLUC: 116034295(lef1)
ECRA: 117957879(lef1)
PFLV: 114567774(lef1)
GAT: 120825743(lef1)
MSAM: 119898915(lef1) 119898916
CUD: 121508857(lef1)
MZE: 101464688(lef1)
ONL: 100704365(lef1)
OAU: 116330136(lef1)
OLA: 101167344(lef1)
OML: 112157252(lef1)
XMA: 102226301(lef1) 111609564
XCO: 114144420(lef1) 114149416
XHE: 116719693(lef1)
PRET: 103472749(lef1)
CVG: 107094620(lef1)
CTUL: 119779063(lef1)
NFU: 107375038(lef1)
KMR: 108230929(lef1)
ALIM: 106517066(lef1)
AOCE: 111586156(lef1)
LCF: 108888246(lef1)
SDU: 111236636(lef1)
SLAL: 111671174(lef1)
XGL: 120800237(lef1)
BPEC: 110165341(lef1)
MALB: 109955531(lef1) 109972141
SASA: 106602294 106610340(lef1)
OTW: 112238204
ELS: 105020989(lef1)
PKI: 111837376(lef1) 111852095
LOC: 102686059(lef1)
PSPA: 121296434 121321759(lef1)
LCM: 102354030(LEF1)
CMK: 103182161
 » show all
Reference
  Authors
Hovanes K, Li TW, Waterman ML
  Title
The human LEF-1 gene contains a promoter preferentially active in lymphocytes and encodes multiple isoforms derived from alternative splicing.
  Journal
Nucleic Acids Res 28:1994-2003 (2000)
DOI:10.1093/nar/28.9.1994
  Sequence
[hsa:51176]
Reference
  Authors
Arce L, Yokoyama NN, Waterman ML
  Title
Diversity of LEF/TCF action in development and disease.
  Journal
Oncogene 25:7492-504 (2006)
DOI:10.1038/sj.onc.1210056
LinkDB

DBGET integrated database retrieval system