KEGG   ORTHOLOGY: K03083
Entry
K03083                      KO                                     

Name
GSK3B
Definition
glycogen synthase kinase 3 beta [EC:2.7.11.26]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04012  ErbB signaling pathway
map04062  Chemokine signaling pathway
map04110  Cell cycle
map04150  mTOR signaling pathway
map04151  PI3K-Akt signaling pathway
map04310  Wnt signaling pathway
map04340  Hedgehog signaling pathway
map04341  Hedgehog signaling pathway - fly
map04360  Axon guidance
map04390  Hippo signaling pathway
map04510  Focal adhesion
map04550  Signaling pathways regulating pluripotency of stem cells
map04657  IL-17 signaling pathway
map04660  T cell receptor signaling pathway
map04662  B cell receptor signaling pathway
map04711  Circadian rhythm - fly
map04722  Neurotrophin signaling pathway
map04728  Dopaminergic synapse
map04910  Insulin signaling pathway
map04916  Melanogenesis
map04917  Prolactin signaling pathway
map04919  Thyroid hormone signaling pathway
map04931  Insulin resistance
map04932  Non-alcoholic fatty liver disease
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map05010  Alzheimer disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05131  Shigellosis
map05135  Yersinia infection
map05160  Hepatitis C
map05162  Measles
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05200  Pathways in cancer
map05210  Colorectal cancer
map05213  Endometrial cancer
map05215  Prostate cancer
map05217  Basal cell carcinoma
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
map05415  Diabetic cardiomyopathy
map05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04310 Wnt signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04340 Hedgehog signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04341 Hedgehog signaling pathway - fly
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04390 Hippo signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04151 PI3K-Akt signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04150 mTOR signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04550 Signaling pathways regulating pluripotency of stem cells
    K03083  GSK3B; glycogen synthase kinase 3 beta
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04657 IL-17 signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04662 B cell receptor signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04062 Chemokine signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04917 Prolactin signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04935 Growth hormone synthesis, secretion and action
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04919 Thyroid hormone signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04916 Melanogenesis
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09156 Nervous system
   04728 Dopaminergic synapse
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04722 Neurotrophin signaling pathway
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09158 Development and regeneration
   04360 Axon guidance
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09159 Environmental adaptation
   04711 Circadian rhythm - fly
    K03083  GSK3B; glycogen synthase kinase 3 beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09162 Cancer: specific types
   05210 Colorectal cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05225 Hepatocellular carcinoma
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05226 Gastric cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05217 Basal cell carcinoma
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05215 Prostate cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05213 Endometrial cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05224 Breast cancer
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09172 Infectious disease: viral
   05160 Hepatitis C
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05162 Measles
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05163 Human cytomegalovirus infection
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05165 Human papillomavirus infection
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05135 Yersinia infection
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05020 Prion disease
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05022 Pathways of neurodegeneration - multiple diseases
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K03083  GSK3B; glycogen synthase kinase 3 beta
   05415 Diabetic cardiomyopathy
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04931 Insulin resistance
    K03083  GSK3B; glycogen synthase kinase 3 beta
   04934 Cushing syndrome
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K03083  GSK3B; glycogen synthase kinase 3 beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K03083  GSK3B; glycogen synthase kinase 3 beta
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K03083  GSK3B; glycogen synthase kinase 3 beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.26  tau-protein kinase
     K03083  GSK3B; glycogen synthase kinase 3 beta
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CMGC group
  GSK family [OT]
   K03083  GSK3B; glycogen synthase kinase 3 beta
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K03083  GSK3B; glycogen synthase kinase 3 beta
Other DBs
GO: 0050321
Genes
HSA: 2932(GSK3B)
PTR: 100616510(GSK3B)
PPS: 100972306(GSK3B)
GGO: 101125534(GSK3B)
PON: 100447772(GSK3B)
NLE: 100606885(GSK3B)
MCC: 713114(GSK3B)
MCF: 102133756(GSK3B)
CSAB: 103228213(GSK3B)
CATY: 105589738(GSK3B)
PANU: 100998800(GSK3B)
RRO: 104680990(GSK3B)
RBB: 108541757(GSK3B)
TFN: 117083458(GSK3B)
PTEH: 111543871(GSK3B) 113221483
CJC: 100387683(GSK3B)
SBQ: 101051107(GSK3B)
MMUR: 105879917(GSK3B)
MMU: 56637(Gsk3b)
MCAL: 110311365(Gsk3b)
MPAH: 110329614(Gsk3b)
RNO: 84027(Gsk3b)
MCOC: 116085894(Gsk3b)
MUN: 110555390(Gsk3b)
CGE: 100760865(Gsk3b)
PLEU: 114701479(Gsk3b)
NGI: 103741948(Gsk3b)
HGL: 101701301(Gsk3b)
CCAN: 109685333(Gsk3b)
OCU: 100348842(GSK3B)
TUP: 102476038(GSK3B)
CFA: 478575(GSK3B)
VVP: 112913469(GSK3B)
VLG: 121489623(GSK3B)
AML: 100479224(GSK3B)
UMR: 103678785(GSK3B)
UAH: 113251972(GSK3B)
ORO: 101365718(GSK3B)
ELK: 111149921
MPUF: 101692999(GSK3B)
EJU: 114214730(GSK3B)
MLX: 118007057(GSK3B)
FCA: 101081660(GSK3B)
PTG: 102961382(GSK3B)
PPAD: 109266441(GSK3B)
AJU: 106968274(GSK3B)
HHV: 120242922(GSK3B)
BTA: 790875(GSK3B)
BOM: 102275260(GSK3B)
BBUB: 102401080(GSK3B)
CHX: 102176363(GSK3B)
OAS: 100169938(GSK3B)
ODA: 120871233(GSK3B)
SSC: 100126852(GSK3B)
CFR: 102504696(GSK3B)
CDK: 105090321(GSK3B)
BACU: 102998893(GSK3B)
LVE: 103074757(GSK3B)
OOR: 101283259(GSK3B)
DLE: 111168040(GSK3B)
PCAD: 102978702(GSK3B)
ECB: 100061033(GSK3B)
EPZ: 103547424(GSK3B)
EAI: 106829188(GSK3B)
MYB: 102248758(GSK3B)
MYD: 102751662(GSK3B)
MMYO: 118675932(GSK3B)
MNA: 107527219(GSK3B)
HAI: 109388396(GSK3B)
DRO: 112320540(GSK3B)
SHON: 118986594(GSK3B)
AJM: 119059198(GSK3B)
MMF: 118617870(GSK3B)
PALE: 102882441(GSK3B)
RAY: 107517741(GSK3B)
MJV: 108389003(GSK3B)
TOD: 119257489(GSK3B)
LAV: 100675105(GSK3B)
TMU: 101349186
MDO: 100012447(GSK3B)
SHR: 100920192(GSK3B)
PCW: 110208073(GSK3B)
OAA: 100092089(GSK3B)
GGA: 418335(GSK3B)
PCOC: 116242399(GSK3B)
MGP: 100545864(GSK3B)
CJO: 107319718(GSK3B)
NMEL: 110399222(GSK3B)
APLA: 101802112(GSK3B)
TGU: 100224604(GSK3B)
LSR: 110480689(GSK3B)
SCAN: 103827115(GSK3B)
PMOA: 120506458(GSK3B)
GFR: 102034944(GSK3B)
FAB: 101807423(GSK3B)
PHI: 102105491(GSK3B)
PMAJ: 107205227(GSK3B)
CCAE: 111938905(GSK3B)
CCW: 104687192(GSK3B)
ETL: 114055112(GSK3B)
FCH: 102059271(GSK3B)
CLV: 102090893(GSK3B)
EGZ: 104126562(GSK3B)
NNI: 104008666(GSK3B)
ACUN: 113479281(GSK3B)
PADL: 103922243(GSK3B)
AAM: 106497256(GSK3B)
ASN: 102387985(GSK3B)
AMJ: 106737044(GSK3B)
CPOO: 109319208(GSK3B)
GGN: 109304193(GSK3B)
PSS: 102461748(GSK3B)
CMY: 102935600(GSK3B)
CPIC: 101935079(GSK3B)
TST: 117886617(GSK3B)
CABI: 116836359(GSK3B)
ACS: 100564023(gsk3b)
PVT: 110076947(GSK3B)
PBI: 103066659(GSK3B)
PMUR: 107286129(GSK3B)
TSR: 106549019(GSK3B)
PGUT: 117661883(GSK3B)
PMUA: 114587589(GSK3B)
ZVI: 118097518(GSK3B)
GJA: 107109342(GSK3B)
XLA: 399097(gsk3b.L) 779056
XTR: 100489648(gsk3b)
NPR: 108801162(GSK3B)
DRE: 30654(gsk3ba) 557882(gsk3bb)
IPU: 108258646 108266408(gsk3b)
PHYP: 113537726
AMEX: 103021870(gsk3b) 103043574
EEE: 113578561(gsk3b)
TRU: 101067898
LCO: 104936875(gsk3b)
NCC: 104952807(gsk3b)
ELY: 117251073(gsk3ba)
PLEP: 121948765(gsk3ba)
SLUC: 116046905(gsk3ba)
ECRA: 117952380(gsk3ba)
PFLV: 114563778(gsk3b)
GAT: 120833868(gsk3ba)
MSAM: 119904210(gsk3ba)
CUD: 121522620(gsk3ba)
MZE: 101487930(gsk3b)
ONL: 100712404(gsk3b)
OAU: 116316075(gsk3ba)
OLA: 101174787(gsk3b)
OML: 112155060(gsk3ba)
XMA: 102224919(gsk3b)
XCO: 114147695(gsk3b)
XHE: 116722565(gsk3b)
PRET: 103459583(gsk3b)
CVG: 107092050(gsk3b)
CTUL: 119798510(gsk3ba)
NFU: 107389867(gsk3b)
KMR: 108232478(gsk3ba)
ALIM: 106535279
AOCE: 111578103(gsk3b)
CSEM: 103392124(gsk3b)
POV: 109631323(gsk3b)
LCF: 108884414(gsk3b)
SDU: 111218261(gsk3b)
SLAL: 111662131(gsk3b)
XGL: 120801452(gsk3ba)
HCQ: 109531284(gsk3b)
BPEC: 110166530(gsk3b)
MALB: 109965436(gsk3b)
ELS: 105027876(gsk3b) 105031009
LOC: 102692161(gsk3b)
PSPA: 121320753(gsk3ba) 121327778
LCM: 102350787(GSK3B)
CMK: 103180204(gsk3b)
RTP: 109910841
BFO: 118415612
CIN: 445595(gsk)
SCLV: 120325724
SKO: 100303595(gsk3b)
DME: Dmel_CG2621(sgg) Dmel_CG31003(gskt)
DSI: Dsimw501_GD21574(Dsim_GD21574)
DSR: 110182587
DWI: 6648991
ACOZ: 120949236
AARA: 120893758
AAG: 5566167
AALB: 109415782
CPII: 120415202
AME: 408976
ACER: 108000569
BIM: 100747625
BTER: 100645880
OBB: 114872947
MGEN: 117221214
NMEA: 116431418
CGIG: 122396924
SOC: 105193199
MPHA: 105830340
AEC: 105152459
ACEP: 105620830
PBAR: 105429295
VEM: 105563629
HST: 105188825
DQU: 106748316
CFO: 105258655
FEX: 115244661
LHU: 105675406
PGC: 109852652
OBO: 105287738
PCF: 106787307
NVI: 100117808
CSOL: 105361003
MDL: 103568284
TCA: 664299(sgg)
DPA: 109543135
AGB: 108911124
APLN: 108740221
PPYR: 116168407
OTU: 111425073
BMOR: 100862751
BMAN: 114248216
MSEX: 115442364
BANY: 112053924
PPOT: 106104377
ZCE: 119832823
BTAB: 109032346
DCI: 103505841
CLEC: 106665236
NLU: 111053552
ZNE: 110828127
CSEC: 111863303
DPX: DAPPUDRAFT_299658(GSK-3B)
HAME: 121854880
EAF: 111716558
CEL: CELE_C44H4.6(C44H4.6) CELE_R03D7.5(R03D7.5) CELE_Y18D10A.5(gsk-3)
CBR: CBG07972(Cbr-gsk-3) CBG20633
BMY: BM_BM17519(Bm17519)
PCAN: 112569067
BGT: 106055186
GAE: 121385789
PMAX: 117341186
LAK: 106175040
NVE: 5507789
EPA: 110246760
ATEN: 116304269
ADF: 107338367
AMIL: 114955121
PDAM: 113676171
SPIS: 111331568
DGT: 114524427
ATH: AT1G09840(SK41) AT1G57870(SK42)
ALY: 9322792
BRP: 103836306
BNA: 106362385
BOE: 106307426
RSZ: 108806577
THJ: 104816818
CIT: 102626568
PVY: 116142755
TCC: 18607133
GRA: 105786117
GAB: 108456590
EGR: 104420009
GMX: 100799387
GSJ: 114380038
VRA: 106775854
VAR: 108330760
VUN: 114188155
CCAJ: 109803441
APRC: 113853270
CAM: 101499607
ADU: 107482736
AIP: 107638504
LANG: 109345710
FVE: 101304291
PPER: 18790812
PMUM: 103319001
PAVI: 110765669
PDUL: 117616242
MDM: 103430103
PXB: 103946372
ZJU: 107412572
MNT: 21396301
CSV: 101208983
CMO: 103491156
BHJ: 120073748
MCHA: 111019443
CMAX: 111478245
CMOS: 111453385
CPEP: 111803783
RCU: 8263267
JCU: 105629676
HBR: 110635663
MESC: 110619390
PEU: 105128406
QLO: 115977572
VVI: 100252299
VRI: 117926425
SLY: 101265073
SPEN: 107007726
SOT: 102587166
CANN: 107839861
NTA: 107817080
NSY: 104225019
NTO: 104094374
SIND: 105172522
OEU: 111375622
EGT: 105962552
HAN: 110929045
LSV: 111878994
CCAV: 112512659
DCR: 108208830
CSIN: 114302940
BVG: 104896931
SOE: 110797331
NNU: 104589033
MING: 122081300
NCOL: 116258048
OSA: 4334738
DOSA: Os03t0841800-01(Os03g0841800)
OBR: 102707105
BDI: 100825794
ATS: 109766472
SBI: 8079643
ZMA: 542518
SITA: 101775242
PHAI: 112874314
EGU: 105036107
MUS: 103981797
AOF: 109827173
ATR: 18448458
PIC: PICST_77550(RIM11)
CAL: CAALFM_C204280WA(CaO19.792) CAALFM_C204290WA(RIM11)
SLB: AWJ20_1413(RIM11)
NCR: NCU04185(prk-1)
NTE: NEUTE1DRAFT115704(NEUTE1DRAFT_115704)
SMP: SMAC_04408(putative rim11)
MGR: MGG_12122
SSCK: SPSK_04178
TRE: TRIREDRAFT_74400(gsk3)
MAJ: MAA_07562
CMT: CCM_03795
MBE: MBM_03205
ANI: AN6508.2
ANG: ANI_1_32134(An15g00170)
ABE: ARB_04291
TVE: TRV_06272
PTE: PTT_18800
ZTR: MYCGRDRAFT_100881(GSK3)
PFJ: MYCFIDRAFT_50287(GSK3)
SPO: SPAC1687.15(gsk3) SPBC8D2.01(gsk31)
CNE: CNB00720
CNB: CNBB4980
TASA: A1Q1_05162
ABP: AGABI1DRAFT111475(AGABI1DRAFT_111475)
ABV: AGABI2DRAFT190701(AGABI2DRAFT_190701)
MGL: MGL_1055
MRT: MRET_3099
DDI: DDB_G0270218(glkA) DDB_G0272110(gskA)
EHI: EHI_003900(370.t00002) EHI_121880(147.t00016)
TAN: TA02550
CPV: cgd4_240
TPS: THAPSDRAFT_38559(GSK-3)
 » show all
Reference
PMID:7980435
  Authors
Stambolic V, Woodgett JR
  Title
Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation.
  Journal
Biochem J 303 ( Pt 3):701-4 (1994)
DOI:10.1042/bj3030701
  Sequence
[hsa:2932]
Reference
  Authors
Bobinnec Y, Morin X, Debec A
  Title
Shaggy/GSK-3beta kinase localizes to the centrosome and to specialized cytoskeletal structures in Drosophila.
  Journal
Cell Motil Cytoskeleton 63:313-20 (2006)
DOI:10.1002/cm.20128
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