KEGG   ORTHOLOGY: K03094
Entry
K03094                      KO                                     

Name
SKP1, CBF3D
Definition
S-phase kinase-associated protein 1
Pathway
ko04110  Cell cycle
ko04111  Cell cycle - yeast
ko04114  Oocyte meiosis
ko04120  Ubiquitin mediated proteolysis
ko04141  Protein processing in endoplasmic reticulum
ko04310  Wnt signaling pathway
ko04341  Hedgehog signaling pathway - fly
ko04350  TGF-beta signaling pathway
ko04710  Circadian rhythm
ko05131  Shigellosis
ko05132  Salmonella infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
   04120 Ubiquitin mediated proteolysis
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
   04341 Hedgehog signaling pathway - fly
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
   04350 TGF-beta signaling pathway
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
   04111 Cell cycle - yeast
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
   04114 Oocyte meiosis
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
 09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
   05131 Shigellosis
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
   03036 Chromosome and associated proteins
    K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   SCF complex
    Adaptor protein
     K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
   Cul7 complex
    Adaptor protein
     K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CBF3 complex
     K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
  Centrosome formation and ciliogenesis proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     K03094  SKP1, CBF3D; S-phase kinase-associated protein 1
Other DBs
COG: COG5201
Genes
HSA: 6500(SKP1)
PTR: 462063(SKP1)
PPS: 100981953(SKP1) 106635345
GGO: 101148010 101150703(SKP1)
PON: 100174716(SKP1) 112135798
NLE: 100596865(SKP1)
MCC: 100423634(SKP1)
MCF: 102142637(SKP1)
CSAB: 103244544(SKP1)
RRO: 104659810(SKP1) 104677263
CJC: 100398187(SKP1)
SBQ: 101030146(SKP1)
MMU: 21402(Skp1)
MCAL: 110305852(Skp1)
MPAH: 110331774(Skp1)
RNO: 287280(Skp1)
MUN: 110549633(Skp1)
CGE: 100757677(Skp1)
NGI: 103729775(Skp1)
HGL: 101704606(Skp1)
CCAN: 109689481(Skp1)
OCU: 100339463(SKP1)
TUP: 102483646(SKP1)
CFA: 474682(SKP1)
VVP: 112917057(SKP1)
AML: 100463880(SKP1)
UMR: 103663817(SKP1)
UAH: 113261736(SKP1)
ORO: 101374307 101386391(SKP1)
ELK: 111141245
FCA: 101099017(SKP1)
PTG: 102957702(SKP1)
PPAD: 109250862(SKP1) 109271783
AJU: 106984903(SKP1)
BTA: 615427(SKP1)
BOM: 102266347(SKP1)
BIU: 109562016(SKP1)
BBUB: 102408224(SKP1)
CHX: 102174738 108633185(SKP1)
OAS: 100240716(SKP1) 114108593(SKP1)
SSC: 100520183 110259483(SKP1)
CFR: 102519293(SKP1)
CDK: 105090262(SKP1)
BACU: 103011520 103018727(SKP1)
LVE: 103074429(SKP1) 103090703
OOR: 101289355(SKP1)
DLE: 111182443(SKP1)
ECB: 100062946(SKP1)
EPZ: 103543154(SKP1)
EAI: 106834656(SKP1)
MYB: 102251595(SKP1) 102251629
MYD: 102756513(SKP1)
MNA: 107525395(SKP1)
HAI: 109382554(SKP1)
DRO: 112318134(SKP1)
PALE: 102885538(SKP1)
RAY: 107506799(SKP1)
MJV: 108406083(SKP1)
LAV: 100663845(SKP1)
TMU: 101350591
MDO: 100014810(SKP1)
SHR: 100927300(SKP1)
PCW: 110211724(SKP1)
OAA: 100082731(SKP1)
GGA: 416319(SKP1)
MGP: 100544772(SKP1)
CJO: 107320209(SKP1)
NMEL: 110405291(SKP1)
APLA: 101803413(SKP1)
ACYG: 106032826(SKP1)
TGU: 100225726(SKP1)
LSR: 110481076(SKP1)
SCAN: 103817252(SKP1)
GFR: 102038546(SKP1)
FAB: 101813841(SKP1)
PHI: 102099878(SKP1)
PMAJ: 107210641(SKP1)
CCAE: 111935605(SKP1)
CCW: 104683717(SKP1)
ETL: 114063912(SKP1)
FPG: 101911889(SKP1)
FCH: 102046372(SKP1)
CLV: 102094112(SKP1)
EGZ: 104133458(SKP1)
NNI: 104012003(SKP1)
ACUN: 113485113(SKP1)
PADL: 103915789(SKP1)
AAM: 106487187(SKP1)
ASN: 102382934(SKP1)
AMJ: 102576679(SKP1)
PSS: 102446427(SKP1)
CMY: 102935126(SKP1)
CPIC: 101936963(SKP1)
ACS: 100568037(skp1)
PVT: 110079401(SKP1)
PBI: 103066791(SKP1)
PMUR: 107294918(SKP1)
TSR: 106542624(SKP1)
PMUA: 114591269(SKP1) 114604549
GJA: 107125984(SKP1)
XLA: 108712619 380538(skp1.S)
XTR: 549273(skp1)
NPR: 108792127(SKP1)
DRE: 393716(skp1)
SRX: 107728271 107742439(skp1)
SANH: 107661767(skp1) 107692975
SGH: 107603266(skp1)
CCAR: 109048021(skp1) 109067897
IPU: 100528639(skp1)
PHYP: 113535613(skp1)
AMEX: 103045526(skp1)
EEE: 113578037(skp1)
TRU: 101068627(skp1)
LCO: 104924374(skp1)
NCC: 104957032(skp1)
MZE: 101469121(skp1)
ONL: 100697275(skp1)
OLA: 101173567(skp1)
XMA: 102221489(skp1)
XCO: 114152468(skp1)
PRET: 103459979(skp1)
CVG: 107085893(skp1)
NFU: 107386838(skp1)
KMR: 108238075(skp1)
ALIM: 106524567(skp1)
AOCE: 111583951(skp1)
CSEM: 103394863(skp1)
POV: 109635809(skp1)
LCF: 108893670(skp1)
SDU: 111234629(skp1)
SLAL: 111645238 111659985(skp1)
HCQ: 109515642(skp1)
BPEC: 110153983(skp1)
MALB: 109966791(skp1)
SASA: 100195936(skp1) 106567526(SKP1)
ELS: 105026694(skp1)
PKI: 111839552 111847937(skp1)
LCM: 102350053(SKP1)
CMK: 103182116 103183679(skp1)
BFO: 118411438
CIN: 100181511
SPU: 594639
APLC: 110980531
SKO: 100313722
DME: Dmel_CG11941(SkpC) Dmel_CG11942(SkpE) Dmel_CG12227(SkpF) Dmel_CG12700(SkpD) Dmel_CG15800(CG15800) Dmel_CG16983(SkpA) Dmel_CG43089(CG43089) Dmel_CG8881(SkpB)
DSI: Dsimw501_GD16521(Dsim_GD16521) Dsimw501_GD17469(Dsim_GD17469) Dsimw501_GD25016(Dsim_GD25016) Dsimw501_GD25046(Dsim_GD25046) Dsimw501_GD25859(Dsim_GD25859) Dsimw501_GD29572(Dsim_GD29572)
MDE: 101898001
LCQ: 111679592
AAG: 5571571
AME: 409234
BIM: 100743026
BTER: 100651427
CCAL: 108624497
OBB: 114881063
SOC: 105195125
MPHA: 105833585
ACEP: 105626331
PBAR: 105427532
VEM: 105568886
HST: 105187367
DQU: 106749170
LHU: 105672747
PGC: 109853127
OBO: 105280685
PCF: 106787535
TCA: 663380(skp1)
DPA: 109545243
NVL: 108559854
BMOR: 733106
BMAN: 114248511
PMAC: 106708696
PRAP: 110992864
HAW: 110372361
TNL: 113508299
PXY: 105397971
DNX: 107161275
AGS: 114126975
RMD: 113561270
BTAB: 109042339
CLEC: 106666260
ZNE: 110835390
PVM: 113812043
TUT: 107361622
DPTE: 113795476
PTEP: 107441722
CEL: CELE_C06A8.4(skr-17) CELE_C42D4.6(skr-16) CELE_C52D10.6(skr-12) CELE_C52D10.7(skr-9) CELE_C52D10.8(skr-13) CELE_C52D10.9(skr-8) CELE_F44G3.6(skr-3) CELE_F46A9.4(skr-2) CELE_F46A9.5(skr-1) CELE_F47H4.10(skr-5) CELE_F54D10.1(skr-15) CELE_F56B3.12(skr-18) CELE_K08H2.1(skr-21) CELE_R12H7.3(skr-19) CELE_R12H7.5(skr-20) CELE_Y105C5B.13(skr-10) CELE_Y37H2C.2(skr-6) CELE_Y47D7A.1(skr-7) CELE_Y47D7A.8(skr-14) CELE_Y60A3A.18(skr-4)
PCAN: 112560103
CRG: 105325178
MYI: 110444357
OBI: 106875753
LAK: 106181029
SHX: MS3_04896
NVE: 5514721
EPA: 110242232
PDAM: 113678011
SPIS: 111347008
DGT: 114527624
ATH: AT1G10230(SK18) AT1G20140(SK4) AT1G75950(SKP1) AT2G03160(SK19) AT2G03170(SK14) AT2G03190(SK16) AT2G20160(MEO) AT2G25700(SK3) AT3G21830(SK8) AT3G21840(SK7) AT3G21850(SK9) AT3G21860(SK10) AT3G25650(SK15) AT3G53060(SK6) AT3G60010(SK13) AT3G60020(SK5) AT4G34210(SK11) AT4G34470(SK12) AT5G42190
LJA: Lj0g3v0079709.1(Lj0g3v0079709.1) Lj0g3v0106769.1(Lj0g3v0106769.1) Lj0g3v0259179.1(Lj0g3v0259179.1) Lj0g3v0261809.1(Lj0g3v0261809.1) Lj0g3v0349889.1(Lj0g3v0349889.1) Lj2g3v1267140.1(Lj2g3v1267140.1) Lj2g3v1670950.1(Lj2g3v1670950.1) Lj4g3v2366270.2(Lj4g3v2366270.2) Lj5g3v0186670.1(Lj5g3v0186670.1) Lj5g3v0186680.1(Lj5g3v0186680.1) Lj5g3v2242520.1(Lj5g3v2242520.1) Lj5g3v2243530.1(Lj5g3v2243530.1)
DOSA: Os02t0101600-00(Os02g0101600) Os02t0225100-00(Os02g0225100) Os06t0113800-00(Os06g0113800) Os07t0409500-01(Os07g0409500) Os07t0624900-00(Os07g0624900) Os07t0625400-01(Os07g0625400) Os07t0625500-01(Os07g0625500) Os07t0625600-00(Os07g0625600) Os08t0375500-00(Os08g0375500) Os08t0375700-00(Os08g0375700) Os09t0272900-01(Os09g0272900) Os09t0273800-01(Os09g0273800) Os09t0274800-00(Os09g0274800) Os09t0275200-01(Os09g0275200) Os09t0412050-00(Os09g0412050) Os09t0539500-01(Os09g0539500) Os10t0438100-00(Os10g0438100) Os11t0456300-01(Os11g0456300)
ATS: 109731751(LOC109731751) 109731752(LOC109731752) 109736328(LOC109736328) 109736331(LOC109736331) 109736344(LOC109736344) 109738030(LOC109738030) 109738826(LOC109738826) 109739276(LOC109739276) 109739861(LOC109739861) 109739863(LOC109739863) 109741013(LOC109741013) 109741575(LOC109741575) 109745567(LOC109745567) 109747449(LOC109747449) 109757294(LOC109757294) 109765120(LOC109765120) 109765502(LOC109765502) 109765503(LOC109765503) 109765504(LOC109765504) 109765505(LOC109765505) 109765506(LOC109765506) 109767474(LOC109767474) 109767932(LOC109767932) 109768388(LOC109768388) 109772398(LOC109772398) 109773898(LOC109773898) 109777844(LOC109777844) 109777845(LOC109777845) 109777916(LOC109777916) 109778508(LOC109778508) 109778923(LOC109778923) 109779096(LOC109779096) 109780380(LOC109780380) 109783394(LOC109783394) 109784277(LOC109784277) 109786254(LOC109786254)
CRE: CHLREDRAFT_128004(SKP1)
MNG: MNEG_0264
SCE: YDR328C(SKP1)
ERC: Ecym_8162
KMX: KLMA_60103(SKP1)
NCS: NCAS_0F02970(NCAS0F02970)
NDI: NDAI_0C04420(NDAI0C04420)
TPF: TPHA_0D02190(TPHA0D02190)
TBL: TBLA_0H01860(TBLA0H01860)
TDL: TDEL_0E02570(TDEL0E02570)
KAF: KAFR_0D04400(KAFR0D04400)
CAL: CAALFM_C107410CA(SKP1)
NCR: NCU08991(scon-3)
NTE: NEUTE1DRAFT117111(NEUTE1DRAFT_117111)
MGR: MGG_04978
SSCK: SPSK_09816
TRE: TRIREDRAFT_73823(skp1)
MAW: MAC_03119
MAJ: MAA_05788
CMT: CCM_02669
BFU: BCIN_03g01890(Bcskp1)
MBE: MBM_03677
ANI: AN2302.2
ABE: ARB_06761
TVE: TRV_03348
PTE: PTT_18813
SPO: SPBC409.05(skp1)
CNE: CNA08080
CNB: CNBA7900
TASA: A1Q1_01005
ABP: AGABI1DRAFT111082(AGABI1DRAFT_111082)
ABV: AGABI2DRAFT190295(AGABI2DRAFT_190295)
MGL: MGL_3474
MRT: MRET_2107
DDI: DDB_G0269230(fpaA) DDB_G0273251(fpaB-1) DDB_G0273615(fpaB-2)
DFA: DFA_07127(fpaA) DFA_12090
EHI: EHI_065310 EHI_066770(181.t00006) EHI_118670(62.t00027) EHI_134960(153.t00018) EHI_174130(116.t00012) EHI_174180(116.t00016)
PCB: PCHAS_114240(PC302606.00.0)
TAN: TA03425
TPV: TP03_0225
BBO: BBOV_IV006860(23.m05921)
CPV: cgd7_2500
PTI: PHATRDRAFT_17276(Skp1_1)
VG: 16512567(pdul_cds_894) 16607219(psal_cds_1160)
 » show all
Reference
  Authors
Petroski MD, Deshaies RJ.
  Title
Function and regulation of cullin-RING ubiquitin ligases.
  Journal
Nat Rev Mol Cell Biol 6:9-20 (2005)
DOI:10.1038/nrm1547
Reference
PMID:8706131
  Authors
Bai C, Sen P, Hofmann K, Ma L, Goebl M, Harper JW, Elledge SJ
  Title
SKP1 connects cell cycle regulators to the ubiquitin proteolysis machinery through a novel motif, the F-box.
  Journal
Cell 86:263-74 (1996)
DOI:10.1016/S0092-8674(00)80098-7
  Sequence
[sce:YDR328C]
LinkDB

KEGG   ORTHOLOGY: K03347
Entry
K03347                      KO                                     

Name
CUL1, CDC53
Definition
cullin 1
Pathway
ko04110  Cell cycle
ko04111  Cell cycle - yeast
ko04114  Oocyte meiosis
ko04120  Ubiquitin mediated proteolysis
ko04141  Protein processing in endoplasmic reticulum
ko04310  Wnt signaling pathway
ko04340  Hedgehog signaling pathway
ko04341  Hedgehog signaling pathway - fly
ko04350  TGF-beta signaling pathway
ko04710  Circadian rhythm
ko05131  Shigellosis
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03347  CUL1, CDC53; cullin 1
   04120 Ubiquitin mediated proteolysis
    K03347  CUL1, CDC53; cullin 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K03347  CUL1, CDC53; cullin 1
   04340 Hedgehog signaling pathway
    K03347  CUL1, CDC53; cullin 1
   04341 Hedgehog signaling pathway - fly
    K03347  CUL1, CDC53; cullin 1
   04350 TGF-beta signaling pathway
    K03347  CUL1, CDC53; cullin 1
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K03347  CUL1, CDC53; cullin 1
   04111 Cell cycle - yeast
    K03347  CUL1, CDC53; cullin 1
   04114 Oocyte meiosis
    K03347  CUL1, CDC53; cullin 1
 09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    K03347  CUL1, CDC53; cullin 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03347  CUL1, CDC53; cullin 1
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K03347  CUL1, CDC53; cullin 1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03347  CUL1, CDC53; cullin 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03347  CUL1, CDC53; cullin 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   SCF complex
    Cullin
     K03347  CUL1, CDC53; cullin 1
Other DBs
COG: COG5647
Genes
HSA: 8454(CUL1)
PTR: 463821(CUL1)
PPS: 100972042(CUL1)
GGO: 109025459(CUL1)
NLE: 100580180(CUL1)
MCC: 710581(CUL1)
MCF: 101867010(CUL1)
CSAB: 103227180(CUL1)
RRO: 104667014(CUL1)
RBB: 108522304(CUL1)
CJC: 100395702(CUL1)
SBQ: 101051291(CUL1)
MMU: 26965(Cul1)
MCAL: 110296040(Cul1)
MPAH: 110316251(Cul1)
RNO: 362356(Cul1)
MUN: 110547501(Cul1)
CGE: 100757763(Cul1)
NGI: 103731381(Cul1)
HGL: 101703786(Cul1)
CCAN: 109695511(Cul1)
OCU: 100345752(CUL1)
TUP: 102497446(CUL1)
CFA: 475512(CUL1)
VVP: 112934801(CUL1)
AML: 100466596(CUL1)
UMR: 103668956(CUL1)
UAH: 113241451(CUL1)
ORO: 101369645(CUL1)
ELK: 111154336
FCA: 101087051(CUL1)
PTG: 102957061(CUL1)
PPAD: 109269217(CUL1)
AJU: 106981418(CUL1)
BTA: 407228(CUL1)
BOM: 102277514
BIU: 109557757(CUL1)
BBUB: 102400493(CUL1)
CHX: 102189276(CUL1)
OAS: 101106584(CUL1)
SSC: 100524037(CUL1)
CFR: 102517054(CUL1)
CDK: 105085195(CUL1)
BACU: 103011656(CUL1)
LVE: 103070988(CUL1)
OOR: 101280362(CUL1)
DLE: 111177194(CUL1)
ECB: 100051217(CUL1)
EPZ: 103553705(CUL1)
EAI: 106842121(CUL1)
MYB: 102245795(CUL1)
MYD: 102771406(CUL1)
MNA: 107523767(CUL1)
HAI: 109395450(CUL1)
DRO: 112308266(CUL1)
PALE: 102887109(CUL1)
RAY: 107500535(CUL1)
MJV: 108386656(CUL1)
LAV: 100664600(CUL1)
TMU: 101360163
MDO: 100013348(CUL1)
SHR: 100926417(CUL1)
PCW: 110201672(CUL1)
OAA: 100073945(CUL1)
GGA: 420783(CUL1)
MGP: 100540218(CUL1)
CJO: 107309836(CUL1)
NMEL: 110390791(CUL1)
APLA: 101793264(CUL1)
ACYG: 106048734(CUL1)
TGU: 100223849(CUL1)
LSR: 110479185(CUL1)
SCAN: 103819366(CUL1)
GFR: 102038503(CUL1)
FAB: 101810352(CUL1)
PHI: 102100590(CUL1)
PMAJ: 107200314(CUL1)
CCAE: 111923644(CUL1)
CCW: 104688924(CUL1)
ETL: 114063866(CUL1)
FPG: 101911159(CUL1)
FCH: 102056187(CUL1)
CLV: 102093584(CUL1)
EGZ: 104124772(CUL1)
NNI: 104015389(CUL1)
ACUN: 113477562(CUL1)
PADL: 103916089(CUL1)
AAM: 106495275(CUL1)
ASN: 102371987(CUL1)
AMJ: 102562508(CUL1)
PSS: 102452815(CUL1)
CMY: 102932876(CUL1)
CPIC: 101938030(CUL1)
ACS: 100563024(cul1)
PVT: 110088676(CUL1)
PBI: 103051969(CUL1)
PMUR: 107288848
TSR: 106547022(CUL1)
PMUA: 114607913(CUL1)
GJA: 107119625(CUL1)
XLA: 734414(cul1.S) 734526
XTR: 734121(cul1)
NPR: 108794363(CUL1)
DRE: 323883(cul1a) 406816(cul1b)
IPU: 108256454(cul1) 108280768
AMEX: 103026940(cul1) 111194478
EEE: 113584345
TRU: 101068951(cul1)
NCC: 104940785(cul1)
MZE: 101485891(cul1)
ONL: 100699353(cul1)
OLA: 101155471(cul1)
XMA: 102238349(cul1)
XCO: 114136425(cul1)
PRET: 103457010(cul1)
CVG: 107097881(cul1)
NFU: 107383137(cul1)
KMR: 108249552(cul1)
ALIM: 106531655(cul1)
AOCE: 111571338(cul1)
CSEM: 103377187(cul1)
POV: 109645364(cul1)
LCF: 108885000(cul1)
SDU: 111238316(cul1)
SLAL: 111647272(cul1)
HCQ: 109530293(cul1)
BPEC: 110158319(cul1)
MALB: 109951060(cul1)
ELS: 105022041(cul1) 105024245
SFM: 108919683(cul1) 108935504
LCM: 102360768(CUL1)
CMK: 103187003(cul1)
RTP: 109916300(cul1)
BFO: 118403913
SPU: 589630
APLC: 110975971
DME: Dmel_CG11261(Cul6) Dmel_CG1877(Cul1)
DSI: Dsimw501_GD10516(Dsim_GD10516) Dsimw501_GD12683(Dsim_GD12683)
DPE: 6590465
DWI: 6640400
DAZ: 108616909
DNV: 108654970
DHE: 111599944
DVI: 6635882
MDE: 101893739
LCQ: 111682503
AAG: 5578149
AALB: 115258731
PVM: 113816603
TUT: 107366218
CEL: CELE_D2045.6(cul-1) CELE_K08E7.7(cul-6)
PCAN: 112557063
CRG: 105325130
MYI: 110451924
NVE: 5509071
AMIL: 114977368
DGT: 114517451
HMG: 101238456
ALY: 9310976
CRB: 17884026
BRP: 103836734
CPAP: 110821436
VRA: 106768610
VAR: 108346100
CCAJ: 109807764
LJA: Lj0g3v0209709.2(Lj0g3v0209709.2)
FVE: 101303474
RCN: 112197743
CSV: 101216323
CMO: 103497868
MCHA: 111009631
CPEP: 111806899
RCU: 8262419
VVI: 100233054(CUL1) 100261361
SLY: 101249757
SPEN: 107006861
CANN: 107842772
NTA: 107770609 107807954(cul1C)
NSY: 104229650
NTO: 104090935
NAU: 109223502
CCAV: 112529394
BVG: 104886440
SOE: 110791258
DOSA: Os01t0369000-01(Os01g0369000) Os01t0369200-01(Os01g0369200)
ATS: 109738966(LOC109738966) 109765974(LOC109765974)
PDA: 103716049
EGU: 105045249
MUS: 103974412
DCT: 110116436
PEQ: 110037334
AOF: 109849771
ATR: 18422906
SMO: SELMODRAFT_158171(CUL1-2) SELMODRAFT_173394(CUL1-1)
CRE: CHLREDRAFT_116937(CUL3)
APRO: F751_6385
SCE: YDL132W(CDC53)
ERC: Ecym_8046
KMX: KLMA_60494(CDC53)
NCS: NCAS_0A13810(NCAS0A13810)
NDI: NDAI_0A02230(NDAI0A02230)
TPF: TPHA_0P00850(TPHA0P00850)
TBL: TBLA_0A05930(TBLA0A05930)
TDL: TDEL_0H01480(TDEL0H01480)
KAF: KAFR_0B01150(KAFR0B01150)
PIC: PICST_29770(CDC53)
CAL: CAALFM_C301700WA(CDC53)
NCR: NCU05204(cul-1)
NTE: NEUTE1DRAFT80573(NEUTE1DRAFT_80573)
MGR: MGG_07145
SSCK: SPSK_07032
MAW: MAC_08080
MAJ: MAA_05122
CMT: CCM_04213
MBE: MBM_02956
ANI: AN1019.2
ANG: ANI_1_830074(An08g05870)
PBN: PADG_11387(PADG_02155)
ABE: ARB_01462
TVE: TRV_05741
PTE: PTT_04953
SPO: SPAC17G6.12(cul1)
CNE: CNN01140
CNB: CNBN1130
TASA: A1Q1_03354
DDI: DDB_G0267384(culB) DDB_G0278991(culE) DDB_G0291972(culA)
DFA: DFA_09462(culA)
EHI: EHI_156450(100.t00027)
SMIN: v1.2.024830.t1(symbB.v1.2.024830.t1)
PTI: PHATRDRAFT_29317(CUL1_3)
SPAR: SPRG_01077
 » show all
Reference
  Authors
Petroski MD, Deshaies RJ.
  Title
Function and regulation of cullin-RING ubiquitin ligases.
  Journal
Nat Rev Mol Cell Biol 6:9-20 (2005)
DOI:10.1038/nrm1547
Reference
PMID:9499404
  Authors
Patton EE, Willems AR, Sa D, Kuras L, Thomas D, Craig KL, Tyers M
  Title
Cdc53 is a scaffold protein for multiple Cdc34/Skp1/F-box proteincomplexes that regulate cell division and methionine biosynthesis in yeast.
  Journal
Genes Dev 12:692-705 (1998)
DOI:10.1101/gad.12.5.692
  Sequence
[sce:YDL132W]
Reference
PMID:8681378
  Authors
Kipreos ET, Lander LE, Wing JP, He WW, Hedgecock EM
  Title
cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family.
  Journal
Cell 85:829-39 (1996)
DOI:10.1016/S0092-8674(00)81267-2
  Sequence
[hsa:8454]
LinkDB

KEGG   ORTHOLOGY: K03868
Entry
K03868                      KO                                     

Name
RBX1, ROC1
Definition
RING-box protein 1 [EC:2.3.2.32]
Pathway
ko03420  Nucleotide excision repair
ko04066  HIF-1 signaling pathway
ko04110  Cell cycle
ko04111  Cell cycle - yeast
ko04114  Oocyte meiosis
ko04120  Ubiquitin mediated proteolysis
ko04141  Protein processing in endoplasmic reticulum
ko04310  Wnt signaling pathway
ko04341  Hedgehog signaling pathway - fly
ko04350  TGF-beta signaling pathway
ko04710  Circadian rhythm
ko05131  Shigellosis
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03868  RBX1, ROC1; RING-box protein 1
   04120 Ubiquitin mediated proteolysis
    K03868  RBX1, ROC1; RING-box protein 1
  09124 Replication and repair
   03420 Nucleotide excision repair
    K03868  RBX1, ROC1; RING-box protein 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
   04341 Hedgehog signaling pathway - fly
    K03868  RBX1, ROC1; RING-box protein 1
   04350 TGF-beta signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
   04066 HIF-1 signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K03868  RBX1, ROC1; RING-box protein 1
   04111 Cell cycle - yeast
    K03868  RBX1, ROC1; RING-box protein 1
   04114 Oocyte meiosis
    K03868  RBX1, ROC1; RING-box protein 1
 09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    K03868  RBX1, ROC1; RING-box protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03868  RBX1, ROC1; RING-box protein 1
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K03868  RBX1, ROC1; RING-box protein 1
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K03868  RBX1, ROC1; RING-box protein 1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03868  RBX1, ROC1; RING-box protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03868  RBX1, ROC1; RING-box protein 1
   03400 DNA repair and recombination proteins
    K03868  RBX1, ROC1; RING-box protein 1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.32  cullin-RING-type E3 NEDD8 transferase
     K03868  RBX1, ROC1; RING-box protein 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  UBL E3 ligases
   K03868  RBX1, ROC1; RING-box protein 1
  Multi subunit Ring-finger type E3
   SCF complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   ECV complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul3 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul4 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul7 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul9 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      K03868  RBX1, ROC1; RING-box protein 1
    TCR (transcription coupled repair) factors
     Cul4-CSA complex
      K03868  RBX1, ROC1; RING-box protein 1
Other DBs
COG: COG5194
GO: 0019788
Genes
HSA: 9978(RBX1)
PTR: 458860(RBX1)
PPS: 100981636(RBX1)
GGO: 101151577(RBX1)
PON: 100441665(RBX1)
NLE: 100596079(RBX1)
MCC: 710252(RBX1)
MCF: 102132483(RBX1)
CSAB: 103223367(RBX1)
RRO: 104673455(RBX1)
RBB: 108528465(RBX1)
CJC: 100391523(RBX1)
SBQ: 101031903(RBX1)
MMU: 56438(Rbx1)
MCAL: 110310464(Rbx1)
MPAH: 110334961(Rbx1)
RNO: 300084(Rbx1)
MUN: 110550435(Rbx1)
CGE: 100762556(Rbx1)
NGI: 103743488(Rbx1)
HGL: 101712475(Rbx1)
CCAN: 109686914(Rbx1)
OCU: 103352470(RBX1)
TUP: 102468598(RBX1)
CFA: 474494(RBX1)
VVP: 112934005(RBX1)
UMR: 103674160(RBX1)
UAH: 113241739(RBX1)
ORO: 101363104(RBX1)
ELK: 111157501
FCA: 101087758(RBX1)
PTG: 102955881(RBX1)
PPAD: 109265611(RBX1)
AJU: 113602716(RBX1)
BTA: 518880(RBX1) 780968
BOM: 102272719(RBX1)
BIU: 109559850(RBX1)
BBUB: 102414522(RBX1)
CHX: 102187112(RBX1) 102188771
OAS: 101109871(RBX1)
SSC: 110260638(RBX1)
CFR: 102515877(RBX1)
CDK: 105091911(RBX1)
BACU: 102998295(RBX1)
LVE: 103090829(RBX1)
OOR: 101287254(RBX1) 101289349
DLE: 111186303(RBX1)
PCAD: 102983946(RBX1)
ECB: 100055581(RBX1)
EPZ: 103556120(RBX1)
EAI: 106842455(RBX1)
MYD: 102760790(RBX1)
MNA: 107531277(RBX1)
HAI: 109392275(RBX1)
DRO: 112321770(RBX1)
PALE: 102893437(RBX1)
RAY: 107519712(RBX1)
MJV: 108394317(RBX1)
LAV: 100657479(RBX1)
TMU: 101349359
MDO: 100013521(RBX1)
SHR: 100918404(RBX1)
PCW: 110205825(RBX1)
OAA: 100076928(RBX1)
GGA: 418001(RBX1)
MGP: 100543550(RBX1)
CJO: 107312930(RBX1)
NMEL: 110392307(RBX1)
APLA: 101796040(RBX1)
ACYG: 106035919(RBX1)
TGU: 100190092(RBX1)
LSR: 110483089(RBX1)
SCAN: 103813288(RBX1)
GFR: 102037823(RBX1)
FAB: 101806409(RBX1)
PHI: 102102832(RBX1)
PMAJ: 107204430(RBX1)
CCAE: 111934630(RBX1)
CCW: 104696532(RBX1)
ETL: 114058064(RBX1)
FPG: 101916874(RBX1)
FCH: 102049129(RBX1)
CLV: 102095842(RBX1)
ACUN: 113488055(RBX1)
PADL: 103915729(RBX1)
AAM: 106488968(RBX1)
ASN: 102372162(RBX1)
AMJ: 102571619(RBX1)
PSS: 102451113(RBX1)
CMY: 102943754(RBX1)
CPIC: 101936281(RBX1)
ACS: 100566553(rbx1)
PVT: 110076073(RBX1)
PBI: 103065423(RBX1)
PMUR: 107285413(RBX1)
TSR: 106537822(RBX1) 106553210
PMUA: 114605459(RBX1)
GJA: 107117140(RBX1)
XLA: 108714482(rbx1.L) 108715730(rbx1.S)
XTR: 100379935(rbx1)
NPR: 108788200(RBX1)
DRE: 449846(rbx1)
SANH: 107672143(rbx1) 107695112
SGH: 107580054 107602336(rbx1)
CCAR: 109076699(rbx1)
PHYP: 113524074(rbx1)
AMEX: 107197156(rbx1)
EEE: 113583718(rbx1)
LCO: 104932083(rbx1)
NCC: 104945083(rbx1)
MZE: 101480103(rbx1)
ONL: 100696705(rbx1)
OLA: 101170590(rbx1)
XMA: 102233269(rbx1)
XCO: 114160562(rbx1)
PRET: 103468459(rbx1)
CVG: 107093096(rbx1)
NFU: 107376330(rbx1)
KMR: 108236172(rbx1)
ALIM: 106520678(rbx1)
AOCE: 111570331(rbx1)
CSEM: 103393328(rbx1)
POV: 109643626(rbx1)
LCF: 108877581(rbx1)
SDU: 111230345(rbx1)
SLAL: 111645594 111647571(rbx1)
HCQ: 109514860(rbx1)
BPEC: 110162377(rbx1)
MALB: 109952664(rbx1)
SASA: 100136424(rbx1) 106601243(rbx1)
ELS: 105025789(rbx1)
PKI: 111845210(rbx1) 111853244
LCM: 102352187(RBX1)
CMK: 103189242(rbx1)
RTP: 109921792(rbx1)
BFO: 118419573
CIN: 100182516
APLC: 110984414
DME: Dmel_CG16982(Roc1a) Dmel_CG16988(Roc1b)
DSI: Dsimw501_GD11014(Dsim_GD11014) Dsimw501_GD16520(Dsim_GD16520)
AAG: 5565270
AME: 408691
BIM: 100750218
BTER: 100643234
CCAL: 108631453
OBB: 114871947
SOC: 105195164
MPHA: 105839647
AEC: 105148347
ACEP: 105626311
PBAR: 105432274
VEM: 105568857
HST: 105188519
DQU: 106740675
CFO: 105252239
LHU: 105674184
PGC: 109852514
OBO: 105284276
PCF: 106787165
NVI: 100115578
CSOL: 105361251
MDL: 103578781
TCA: 655935
DPA: 109536288
NVL: 108557707
BMOR: 692971
BMAN: 114248509
PMAC: 106708735
PRAP: 110992851
HAW: 110372277
TNL: 113508302
PXY: 105397966
DNX: 107162314
BTAB: 109044484
CLEC: 106666282
ZNE: 110832453
FCD: 110848901
PVM: 113818542
TUT: 107362230
DPTE: 113789362
PTEP: 107454093
CEL: CELE_ZK287.5(rbx-1)
CBR: CBG19342(Cbr-rbx-1)
BMY: Bm1_05985
PCAN: 112559116
CRG: 105317988
MYI: 110455961
OBI: 106882699
LAK: 106150763
SHX: MS3_02947
NVE: 5509443
EPA: 110249442
ADF: 107349974
AMIL: 114969829
PDAM: 113677930
SPIS: 111341613
DGT: 114530307
HMG: 100204043
AQU: 100636037
ATH: AT3G42830 AT5G20570(RBX1)
ALY: 9308017
CPAP: 110817690
TCC: 18588272
LJA: Lj0g3v0042719.1(Lj0g3v0042719.1) Lj0g3v0262469.1(Lj0g3v0262469.1) Lj3g3v1339080.1(Lj3g3v1339080.1)
ZJU: 107423885
NNU: 104600540
DOSA: Os01t0106800-01(Os01g0106800) Os02t0708300-01(Os02g0708300)
ATS: 109737146(LOC109737146) 109777151(LOC109777151)
PEQ: 110019661
CRE: CHLREDRAFT_79815(RBX1)
MNG: MNEG_4176
APRO: F751_6626
OLU: OSTLU_119493(rbx1)
MIS: MICPUN_113936(RBX1)
SCE: YOL133W(HRT1)
ERC: Ecym_2029
KMX: KLMA_70161(HRT1)
NCS: NCAS_0C04480(NCAS0C04480)
NDI: NDAI_0G03860(NDAI0G03860)
TPF: TPHA_0P01470(TPHA0P01470)
TBL: TBLA_0B08710(TBLA0B08710)
TDL: TDEL_0A00470(TDEL0A00470)
KAF: KAFR_0C01780(KAFR0C01780)
PIC: PICST_37145(HRT1)
CAL: CAALFM_C302450WA(HRT1)
NTE: NEUTE1DRAFT116888(NEUTE1DRAFT_116888)
MGR: MGG_08844
SSCK: SPSK_02774
MAW: MAC_01896
MAJ: MAA_00593
CMT: CCM_05836
BFU: BCIN_03g07500(Bchrt1)
MBE: MBM_08230
ANI: AN8844.2
ANG: ANI_1_294154(An17g02100)
ABE: ARB_07022
TVE: TRV_07648
PTE: PTT_16968
SPO: SPAC23H4.18c(rbx1)
CNE: CNB03140
CNB: CNBB2560
ABP: AGABI1DRAFT130185(AGABI1DRAFT_130185)
ABV: AGABI2DRAFT139777(AGABI2DRAFT_139777)
MGL: MGL_0788
MRT: MRET_0028
DDI: DDB_G0287629(rbx1)
EHI: EHI_151630(2.t00108)
PCB: PCHAS_080650(PC000269.01.0)
TAN: TA10565
TPV: TP04_0669
BBO: BBOV_III007590(17.m07664)
CPV: cgd8_930
SMIN: v1.2.005788.t1(symbB.v1.2.005788.t1)
PTI: PHATRDRAFT_39090(Rbx1)
NGD: NGA_0441600(RBX1)
SPAR: SPRG_11654
 » show all
Reference
  Authors
Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG Jr, Elledge SJ, Conaway RC, Harper JW, Conaway JW
  Title
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
  Journal
Science 284:657-61 (1999)
DOI:10.1126/science.284.5414.657
  Sequence
[sce:YOL133W]
Reference
  Authors
Kamura T, Conrad MN, Yan Q, Conaway RC, Conaway JW
  Title
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.
  Journal
Genes Dev 13:2928-33 (1999)
DOI:10.1101/gad.13.22.2928
  Sequence
[hsa:9978] [sce:YOL133W]
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