KEGG   ORTHOLOGY: K03173
Entry
K03173                      KO                                     

Name
TRAF2
Definition
TNF receptor-associated factor 2 [EC:2.3.2.27]
Pathway
ko04010  MAPK signaling pathway
ko04064  NF-kappa B signaling pathway
ko04071  Sphingolipid signaling pathway
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04217  Necroptosis
ko04380  Osteoclast differentiation
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko04920  Adipocytokine signaling pathway
ko04932  Non-alcoholic fatty liver disease
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis
ko05016  Huntington disease
ko05017  Spinocerebellar ataxia
ko05022  Pathways of neurodegeneration - multiple diseases
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05135  Yersinia infection
ko05160  Hepatitis C
ko05163  Human cytomegalovirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03173  TRAF2; TNF receptor-associated factor 2
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04064 NF-kappa B signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04668 TNF signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04071 Sphingolipid signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K03173  TRAF2; TNF receptor-associated factor 2
   04217 Necroptosis
    K03173  TRAF2; TNF receptor-associated factor 2
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04622 RIG-I-like receptor signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
   04657 IL-17 signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K03173  TRAF2; TNF receptor-associated factor 2
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K03173  TRAF2; TNF receptor-associated factor 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03173  TRAF2; TNF receptor-associated factor 2
   05203 Viral carcinogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K03173  TRAF2; TNF receptor-associated factor 2
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03173  TRAF2; TNF receptor-associated factor 2
   05014 Amyotrophic lateral sclerosis
    K03173  TRAF2; TNF receptor-associated factor 2
   05016 Huntington disease
    K03173  TRAF2; TNF receptor-associated factor 2
   05017 Spinocerebellar ataxia
    K03173  TRAF2; TNF receptor-associated factor 2
   05022 Pathways of neurodegeneration - multiple diseases
    K03173  TRAF2; TNF receptor-associated factor 2
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K03173  TRAF2; TNF receptor-associated factor 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05132 Salmonella infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05131 Shigellosis
    K03173  TRAF2; TNF receptor-associated factor 2
   05135 Yersinia infection
    K03173  TRAF2; TNF receptor-associated factor 2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05160 Hepatitis C
    K03173  TRAF2; TNF receptor-associated factor 2
   05168 Herpes simplex virus 1 infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05163 Human cytomegalovirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05167 Kaposi sarcoma-associated herpesvirus infection
    K03173  TRAF2; TNF receptor-associated factor 2
   05169 Epstein-Barr virus infection
    K03173  TRAF2; TNF receptor-associated factor 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K03173  TRAF2; TNF receptor-associated factor 2
   04121 Ubiquitin system
    K03173  TRAF2; TNF receptor-associated factor 2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K03173  TRAF2; TNF receptor-associated factor 2
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA surveillance and transport factors
   mRNA cycle factors
    Stress granule specific factors
     K03173  TRAF2; TNF receptor-associated factor 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K03173  TRAF2; TNF receptor-associated factor 2
Genes
HSA: 7186(TRAF2)
PTR: 464876(TRAF2)
PPS: 100982095(TRAF2)
GGO: 101144745(TRAF2)
PON: 100458089(TRAF2)
NLE: 100590721(TRAF2)
MCC: 708391(TRAF2)
MCF: 101925175(TRAF2)
CSAB: 103239600(TRAF2)
RRO: 104669650(TRAF2)
RBB: 108542901(TRAF2)
CJC: 100404226(TRAF2)
SBQ: 101035434(TRAF2)
MMU: 22030(Traf2)
MCAL: 110289986(Traf2)
MPAH: 110318405(Traf2)
RNO: 311786(Traf2)
MUN: 110557003(Traf2)
CGE: 100762099(Traf2)
NGI: 103741188(Traf2)
HGL: 101705156(Traf2)
CCAN: 109699331(Traf2)
TUP: 102473925(C8G)
CFA: 480673(TRAF2)
VVP: 112906881(TRAF2)
AML: 100474087(TRAF2)
UMR: 103675245(TRAF2)
ORO: 101371938(TRAF2)
FCA: 101096363(TRAF2)
PTG: 102966802(TRAF2)
PPAD: 109258781(TRAF2)
AJU: 106989490(TRAF2)
BTA: 512355(TRAF2)
BOM: 102275265(TRAF2)
BIU: 109566626(TRAF2)
BBUB: 102395129 112577610(TRAF2)
CHX: 102184255(TRAF2)
OAS: 101105235(TRAF2)
SSC: 100513840(TRAF2)
CFR: 102511649(TRAF2)
CDK: 105106196(TRAF2)
BACU: 103013880(TRAF2)
LVE: 103088738(TRAF2)
OOR: 101281303(TRAF2)
DLE: 111177009(TRAF2)
PCAD: 102996185(TRAF2)
ECB: 100068006(TRAF2)
EPZ: 103567822(TRAF2)
EAI: 106845532(TRAF2)
MYB: 102263277(TRAF2)
MYD: 102772361(TRAF2)
MNA: 107536208(TRAF2)
HAI: 109381672(TRAF2)
DRO: 112306448(TRAF2)
PALE: 102889343(TRAF2)
RAY: 107503081(TRAF2)
MJV: 108406827(TRAF2)
LAV: 100670400(TRAF2)
TMU: 101354911
MDO: 100017243(TRAF2)
SHR: 100934749(TRAF2)
PCW: 110205309(TRAF2)
OAA: 100681066 100681935(TRAF2)
GGA: 417287(TRAF2)
MGP: 100545697(TRAF2)
CJO: 107321623(TRAF2)
NMEL: 110406784(TRAF2)
APLA: 101798982(TRAF2)
ACYG: 106037085(TRAF2)
TGU: 100223400(TRAF2)
LSR: 110472193(TRAF2)
SCAN: 103819084(TRAF2)
GFR: 102033115(TRAF2)
FAB: 101807272(TRAF2)
PHI: 102106384(TRAF2)
PMAJ: 107212160(TRAF2)
CCAE: 111936895(TRAF2)
CCW: 104688205(TRAF2)
ETL: 114064144(TRAF2)
FPG: 101911961(TRAF2)
FCH: 102059920(TRAF2)
CLV: 102095289(TRAF2)
EGZ: 104124021(TRAF2)
NNI: 104018369(TRAF2)
ACUN: 113486502(TRAF2)
PADL: 103921138(TRAF2)
AAM: 106494252(TRAF2)
ASN: 102384689(TRAF2)
AMJ: 102564363(TRAF2)
PSS: 102449635(TRAF2)
CMY: 102941067(TRAF2)
CPIC: 101933518(TRAF2) 101946577
ACS: 100561141(traf2) 100566904
PVT: 110087462(TRAF2)
PBI: 103050015 103066991(TRAF2)
PMUR: 107296550 107302543(TRAF2)
TSR: 106541963(TRAF2)
GJA: 107115164(TRAF2) 107118266
XLA: 108698135(traf2.L) 431974(traf2.S)
XTR: 100494415(traf2)
NPR: 108787259(TRAF2)
DRE: 100005446 557526(traf2b) 564295(traf2a)
IPU: 108255825 108259928(traf2)
PHYP: 113531130(traf2) 113537061
AMEX: 103028261(traf2) 103036375
CMK: 103183006(traf2) 103184612
APLC: 110981046
MYI: 110464971
OBI: 106879639
HMG: 100213781
 » show all
Reference
  Authors
He L, Grammer AC, Wu X, Lipsky PE
  Title
TRAF3 forms heterotrimers with TRAF2 and modulates its ability to mediate NF-{kappa}B activation.
  Journal
J Biol Chem 279:55855-65 (2004)
DOI:10.1074/jbc.M407284200
Reference
  Authors
Mauro C, Crescenzi E, De Mattia R, Pacifico F, Mellone S, Salzano S, de Luca C, D'Adamio L, Palumbo G, Formisano S, Vito P, Leonardi A
  Title
Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis.
  Journal
J Biol Chem 281:2631-8 (2006)
DOI:10.1074/jbc.M502181200
Reference
  Authors
Zhou AY, Shen RR, Kim E, Lock YJ, Xu M, Chen ZJ, Hahn WC
  Title
IKKepsilon-mediated tumorigenesis requires K63-linked polyubiquitination by a cIAP1/cIAP2/TRAF2 E3 ubiquitin ligase complex.
  Journal
Cell Rep 3:724-33 (2013)
DOI:10.1016/j.celrep.2013.01.031
Reference
PMID:7639698
  Authors
Song HY, Donner DB
  Title
Association of a RING finger protein with the cytoplasmic domain of the human type-2 tumour necrosis factor receptor.
  Journal
Biochem J 309 ( Pt 3):825-9 (1995)
DOI:10.1042/bj3090825
  Sequence
[hsa:7186]
LinkDB

KEGG   ORTHOLOGY: K09849
Entry
K09849                      KO                                     

Name
TRAF5
Definition
TNF receptor-associated factor 5
Pathway
ko04064  NF-kappa B signaling pathway
ko04217  Necroptosis
ko04621  NOD-like receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04668  TNF signaling pathway
ko05131  Shigellosis
ko05163  Human cytomegalovirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05222  Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
   04668 TNF signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K09849  TRAF5; TNF receptor-associated factor 5
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
   04657 IL-17 signaling pathway
    K09849  TRAF5; TNF receptor-associated factor 5
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K09849  TRAF5; TNF receptor-associated factor 5
   05203 Viral carcinogenesis
    K09849  TRAF5; TNF receptor-associated factor 5
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K09849  TRAF5; TNF receptor-associated factor 5
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K09849  TRAF5; TNF receptor-associated factor 5
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K09849  TRAF5; TNF receptor-associated factor 5
   05168 Herpes simplex virus 1 infection
    K09849  TRAF5; TNF receptor-associated factor 5
   05163 Human cytomegalovirus infection
    K09849  TRAF5; TNF receptor-associated factor 5
   05169 Epstein-Barr virus infection
    K09849  TRAF5; TNF receptor-associated factor 5
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K09849  TRAF5; TNF receptor-associated factor 5
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRAF proteins
    K09849  TRAF5; TNF receptor-associated factor 5
Genes
HSA: 7188(TRAF5)
PTR: 457711(TRAF5)
PPS: 100978119(TRAF5)
GGO: 101130440(TRAF5)
PON: 100453867(TRAF5)
NLE: 100601779(TRAF5)
MCC: 711879(TRAF5)
MCF: 102142772(TRAF5)
CSAB: 103230138(TRAF5)
RRO: 104669508(TRAF5)
RBB: 108515877(TRAF5)
CJC: 100388423(TRAF5)
SBQ: 101031994(TRAF5)
MMU: 22033(Traf5)
MCAL: 110296886(Traf5)
MPAH: 110322137(Traf5)
RNO: 684173(Traf5)
MUN: 110566223(Traf5)
CGE: 100760758(Traf5)
NGI: 103727039(Traf5)
HGL: 101704164(Traf5)
CCAN: 109692314(Traf5)
OCU: 100340005(TRAF5)
TUP: 102478124(TRAF5)
CFA: 480019(TRAF5)
VVP: 112907150(TRAF5)
AML: 100475872(TRAF5)
UMR: 103672476(TRAF5)
UAH: 113262665(TRAF5)
ORO: 101373241(TRAF5)
ELK: 111150675
FCA: 101086032(TRAF5)
PTG: 102972430(TRAF5)
PPAD: 109254870(TRAF5)
AJU: 106966776(TRAF5)
BTA: 507234(TRAF5)
BOM: 102266053(TRAF5)
BIU: 109570606(TRAF5)
BBUB: 102413198(TRAF5)
CHX: 102188243(TRAF5)
OAS: 101119408(TRAF5)
SSC: 396616(TRAF5)
CFR: 102507430(TRAF5)
CDK: 105099319(TRAF5)
BACU: 103010499(TRAF5)
LVE: 103075051(TRAF5)
OOR: 101280074(TRAF5)
DLE: 111184706(TRAF5)
PCAD: 102986959(TRAF5)
ECB: 100055119(TRAF5)
EPZ: 103551972(TRAF5)
EAI: 106827146(TRAF5)
MYB: 102243439(TRAF5)
MYD: 102764568(TRAF5)
MNA: 107538857(TRAF5)
HAI: 109379157(TRAF5)
DRO: 112296542(TRAF5)
PALE: 102879730(TRAF5)
RAY: 107521637(TRAF5)
MJV: 108385436(TRAF5)
LAV: 100663885(TRAF5)
TMU: 101358050
MDO: 100022268(TRAF5)
SHR: 100926831(TRAF5)
PCW: 110222706(TRAF5)
OAA: 100078367(TRAF5)
GGA: 374055(TRAF5)
MGP: 100541595(TRAF5)
CJO: 107311111(TRAF5)
NMEL: 110396762(TRAF5)
APLA: 101797384(TRAF5)
ACYG: 106031523(TRAF5)
TGU: 100219054(TRAF5)
LSR: 110479943(TRAF5)
SCAN: 103821528(TRAF5)
GFR: 102042050(TRAF5)
FAB: 101821791(TRAF5)
PHI: 102104462(TRAF5)
PMAJ: 107201904(TRAF5)
CCAE: 111926165(TRAF5)
CCW: 104685651(TRAF5)
ETL: 114066923(TRAF5)
FPG: 101921400(TRAF5)
FCH: 102053015(TRAF5)
CLV: 102088528(TRAF5)
EGZ: 104128738(TRAF5)
NNI: 104019677(TRAF5)
ACUN: 113478255(TRAF5)
PADL: 103922096(TRAF5)
AAM: 106490486(TRAF5)
ASN: 102370403(TRAF5)
AMJ: 102564531(TRAF5)
PSS: 102459505(TRAF5)
CMY: 102929887(TRAF5)
CPIC: 101933745(TRAF5)
ACS: 100555319(traf5)
PVT: 110079501(TRAF5)
PBI: 103064879(TRAF5)
PMUR: 107288580(TRAF5)
TSR: 106552805(TRAF5)
PMUA: 114594702(TRAF5)
GJA: 107124212(TRAF5)
XLA: 108716445(traf5.L)
XTR: 100491604(traf5)
NPR: 108784349(TRAF5)
DRE: 563887(traf5)
IPU: 108271110
PHYP: 113534779
AMEX: 103031120
EEE: 113569092
LCO: 104936671
NCC: 104947442
MZE: 101481248
ONL: 100697176
OLA: 101170323
KMR: 108249386
AOCE: 111563258
CSEM: 103383406
LCF: 108892171
SDU: 111232930
SLAL: 111649752
MALB: 109971816
SASA: 106564804 106585043(TRAF5)
ELS: 105026840
SFM: 108933531(traf5)
PKI: 111853469(traf5)
LCM: 102355485(TRAF5)
CMK: 103178011(traf5)
RTP: 109920924
BTER: 105665677
SOC: 105193485
OBO: 113562238
PCF: 106791776
DPA: 109544114
TUT: 107368829
EPA: 110251088
AMIL: 114969979
DFA: DFA_02794
 » show all
Reference
  Authors
Sun D, Novotny M, Bulek K, Liu C, Li X, Hamilton T
  Title
Treatment with IL-17 prolongs the half-life of chemokine CXCL1 mRNA via the adaptor TRAF5 and the splicing-regulatory factor SF2 (ASF).
  Journal
Nat Immunol 12:853-60 (2011)
DOI:10.1038/ni.2081
Reference
PMID:9511754
  Authors
Mizushima S, Fujita M, Ishida T, Azuma S, Kato K, Hirai M, Otsuka M, Yamamoto T, Inoue J
  Title
Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5).
  Journal
Gene 207:135-40 (1998)
DOI:10.1016/S0378-1119(97)00616-1
  Sequence
[hsa:7188]
LinkDB

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