KEGG   ORTHOLOGY: K03334
Entry
K03334                      KO                                     

Name
IL4I1
Definition
L-amino-acid oxidase [EC:1.4.3.2]
Pathway
ko00250  Alanine, aspartate and glutamate metabolism
ko00270  Cysteine and methionine metabolism
ko00280  Valine, leucine and isoleucine degradation
ko00350  Tyrosine metabolism
ko00360  Phenylalanine metabolism
ko00380  Tryptophan metabolism
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00950  Isoquinoline alkaloid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Module
M00044  Tyrosine degradation, tyrosine => homogentisate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K03334  IL4I1; L-amino-acid oxidase
   00270 Cysteine and methionine metabolism
    K03334  IL4I1; L-amino-acid oxidase
   00280 Valine, leucine and isoleucine degradation
    K03334  IL4I1; L-amino-acid oxidase
   00350 Tyrosine metabolism
    K03334  IL4I1; L-amino-acid oxidase
   00360 Phenylalanine metabolism
    K03334  IL4I1; L-amino-acid oxidase
   00380 Tryptophan metabolism
    K03334  IL4I1; L-amino-acid oxidase
   00400 Phenylalanine, tyrosine and tryptophan biosynthesis
    K03334  IL4I1; L-amino-acid oxidase
  09110 Biosynthesis of other secondary metabolites
   00950 Isoquinoline alkaloid biosynthesis
    K03334  IL4I1; L-amino-acid oxidase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.4  Acting on the CH-NH2 group of donors
   1.4.3  With oxygen as acceptor
    1.4.3.2  L-amino-acid oxidase
     K03334  IL4I1; L-amino-acid oxidase
Other DBs
RN: R00357 R00648 R00677 R00689 R00729 R02197
GO: 0001716
Genes
HSA: 259307(IL4I1)
PTR: 456223(IL4I1)
PPS: 100980850(IL4I1)
GGO: 101153847(IL4I1)
PON: 100936174(IL4I1)
NLE: 100588082(IL4I1)
MCC: 719114(IL4I1)
MCF: 102115096(IL4I1)
CSAB: 103225935 103235062(IL4I1)
RRO: 104667273(IL4I1)
RBB: 108535617 108535810(IL4I1)
CJC: 100393511(IL4I1)
SBQ: 101036047(IL4I1)
MMU: 100328588(Il4i1b) 100470(Lao1) 14204(Il4i1) 73988(4930438A08Rik)
RNO: 100360621(Il4i1) 287305(RGD1308564) 298483(Lao1)
HGL: 101710424(Il4i1)
TUP: 102481575 102484685(IL4I1)
CFA: 482436 484371(IL4I1)
VVP: 112908249 112931512(IL4I1)
AML: 100476680
UMR: 103657267(IL4I1) 103670918
UAH: 113243274(IL4I1) 113254224
ORO: 101367095(IL4I1) 101374427
FCA: 101100683(IL4I1) 111561629
PTG: 102958405(IL4I1) 107179172
PPAD: 109253035(IL4I1) 109254834
AJU: 106970164 106983121(IL4I1)
BTA: 104968452(IL4I1) 782545
BOM: 102265076(IL4I1) 102281829
BIU: 109556898 109572132(IL4I1)
BBUB: 102390358 102390534(IL4I1)
CHX: 102183203 102186899(IL4I1)
OAS: 101103614 105602079(IL4I1)
BACU: 103000198(IL4I1) 103011548
LVE: 103085233 103091507(IL4I1)
OOR: 101272245 101278148(IL4I1)
DLE: 111175407 111180588(IL4I1)
PCAD: 102976825(IL4I1) 102988769
MYD: 102756117
MNA: 107531789(IL4I1) 107544363
HAI: 109391026(IL4I1)
DRO: 112310093(IL4I1)
PALE: 102888858 102897392(IL4I1)
RAY: 107500425(IL4I1) 107508277
MJV: 108383350(IL4I1)
OAA: 100079395(IL4I1)
GGA: 417039(IL4I1)
MGP: 100540143(IL4I1)
CJO: 107321571(IL4I1)
NMEL: 110406676(IL4I1)
APLA: 101790142(IL4I1)
ACYG: 106049930(IL4I1)
TGU: 100222394(IL4I1)
SCAN: 103824938(IL4I1)
GFR: 102037637(IL4I1)
FAB: 101808392(IL4I1)
PHI: 102109935(IL4I1)
PMAJ: 107198862(IL4I1)
CCAE: 111936793(IL4I1)
FPG: 106112282(IL4I1)
FCH: 102046121(IL4I1)
CLV: 102086260(IL4I1)
EGZ: 104133949(IL4I1)
NNI: 104011855(IL4I1)
PADL: 103922928(IL4I1)
AAM: 106482065(IL4I1)
AMJ: 102565465 102573609(IL4I1)
XTR: 100493881(il4i1) 100496394
DRE: 337166(si:dkey-40g16.6)
IPU: 108277784(il4i1)
PHYP: 113532631(il4i1)
EEE: 113579601(il4i1)
TRU: 101072153 101072660(il4i1)
NCC: 104942625
CSEM: 103377764(il4i1)
HCQ: 109510681
BPEC: 110161951(il4i1)
MALB: 109954170(il4i1)
ELS: 105024042(il4i1)
SFM: 108928687(il4i1)
PKI: 111833916(il4i1)
 » show all
Reference
PMID:9122225
  Authors
Chu CC, Paul WE
  Title
Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis.
  Journal
Proc Natl Acad Sci U S A 94:2507-12 (1997)
DOI:10.1073/pnas.94.6.2507
  Sequence
Reference
  Authors
Mason JM, Naidu MD, Barcia M, Porti D, Chavan SS, Chu CC
  Title
IL-4-induced gene-1 is a leukocyte L-amino acid oxidase with an unusual acidic pH preference and lysosomal localization.
  Journal
J Immunol 173:4561-7 (2004)
DOI:10.4049/jimmunol.173.7.4561
LinkDB

KEGG   ENZYME: 1.4.3.2
Entry
EC 1.4.3.2                  Enzyme                                 

Name
L-amino-acid oxidase;
ophio-amino-acid oxidase
Class
Oxidoreductases;
Acting on the CH-NH2 group of donors;
With oxygen as acceptor
Sysname
L-amino-acid:oxygen oxidoreductase (deaminating)
Reaction(IUBMB)
an L-amino acid + H2O + O2 = a 2-oxo carboxylate + NH3 + H2O2 [RN:R01259]
Reaction(KEGG)
Substrate
L-amino acid [CPD:C00151];
H2O [CPD:C00001];
O2 [CPD:C00007]
Product
2-oxo carboxylate [CPD:C00161];
NH3 [CPD:C00014];
H2O2 [CPD:C00027]
Comment
A flavoprotein (FAD).
History
EC 1.4.3.2 created 1961
Pathway
ec00250  Alanine, aspartate and glutamate metabolism
ec00270  Cysteine and methionine metabolism
ec00280  Valine, leucine and isoleucine degradation
ec00350  Tyrosine metabolism
ec00360  Phenylalanine metabolism
ec00380  Tryptophan metabolism
ec00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ec00950  Isoquinoline alkaloid biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K03334  L-amino-acid oxidase
Genes
HSA: 259307(IL4I1)
PTR: 456223(IL4I1)
PPS: 100980850(IL4I1)
GGO: 101153847(IL4I1)
PON: 100936174(IL4I1)
NLE: 100588082(IL4I1)
MCC: 719114(IL4I1)
MCF: 102115096(IL4I1)
CSAB: 103225935 103235062(IL4I1)
RRO: 104667273(IL4I1)
RBB: 108535617 108535810(IL4I1)
CJC: 100393511(IL4I1)
SBQ: 101036047(IL4I1)
MMU: 100328588(Il4i1b) 100470(Lao1) 14204(Il4i1) 73988(4930438A08Rik)
RNO: 100360621(Il4i1) 287305(RGD1308564) 298483(Lao1)
HGL: 101710424(Il4i1)
TUP: 102481575 102484685(IL4I1)
CFA: 482436 484371(IL4I1)
VVP: 112908249 112931512(IL4I1)
AML: 100476680
UMR: 103657267(IL4I1) 103670918
UAH: 113243274(IL4I1) 113254224
ORO: 101367095(IL4I1) 101374427
FCA: 101100683(IL4I1) 111561629
PTG: 102958405(IL4I1) 107179172
PPAD: 109253035(IL4I1) 109254834
AJU: 106970164 106983121(IL4I1)
BTA: 104968452(IL4I1) 782545
BOM: 102265076(IL4I1) 102281829
BIU: 109556898 109572132(IL4I1)
BBUB: 102390358 102390534(IL4I1)
CHX: 102183203 102186899(IL4I1)
OAS: 101103614 105602079(IL4I1)
BACU: 103000198(IL4I1) 103011548
LVE: 103085233 103091507(IL4I1)
OOR: 101272245 101278148(IL4I1)
DLE: 111175407 111180588(IL4I1)
PCAD: 102976825(IL4I1) 102988769
MYD: 102756117
MNA: 107531789(IL4I1) 107544363
HAI: 109391026(IL4I1)
DRO: 112310093(IL4I1)
PALE: 102888858 102897392(IL4I1)
RAY: 107500425(IL4I1) 107508277
MJV: 108383350(IL4I1)
OAA: 100079395(IL4I1)
GGA: 417039(IL4I1)
MGP: 100540143(IL4I1)
CJO: 107321571(IL4I1)
NMEL: 110406676(IL4I1)
APLA: 101790142(IL4I1)
ACYG: 106049930(IL4I1)
TGU: 100222394(IL4I1)
SCAN: 103824938(IL4I1)
GFR: 102037637(IL4I1)
FAB: 101808392(IL4I1)
PHI: 102109935(IL4I1)
PMAJ: 107198862(IL4I1)
CCAE: 111936793(IL4I1)
FPG: 106112282(IL4I1)
FCH: 102046121(IL4I1)
CLV: 102086260(IL4I1)
EGZ: 104133949(IL4I1)
NNI: 104011855(IL4I1)
PADL: 103922928(IL4I1)
AAM: 106482065(IL4I1)
AMJ: 102565465 102573609(IL4I1)
XTR: 100493881(il4i1) 100496394
DRE: 337166(si:dkey-40g16.6)
IPU: 108277784(il4i1)
PHYP: 113532631(il4i1)
EEE: 113579601(il4i1)
TRU: 101072153 101072660(il4i1)
NCC: 104942625
CSEM: 103377764(il4i1)
HCQ: 109510681
BPEC: 110161951(il4i1)
MALB: 109954170(il4i1)
ELS: 105024042(il4i1)
SFM: 108928687(il4i1)
PKI: 111833916(il4i1)
 » show all
Reference
1
  Authors
Meister, A. and Wellner, D.
  Title
Flavoprotein amino acid oxidase.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 609-648.
Reference
2  [PMID:13843884]
  Authors
WELLNER D, MEISTER A.
  Title
Crystalline L-amino acid oxidase of Crotalus adamanteus.
  Journal
J Biol Chem 235:2013-8 (1960)
Other DBs
ExplorEnz - The Enzyme Database: 1.4.3.2
IUBMB Enzyme Nomenclature: 1.4.3.2
ExPASy - ENZYME nomenclature database: 1.4.3.2
BRENDA, the Enzyme Database: 1.4.3.2
CAS: 9000-89-9
LinkDB

KEGG   REACTION: R00729
Entry
R00729                      Reaction                               

Name
L-Tyrosine:oxygen oxidoreductase (deaminating)
Definition
L-Tyrosine + H2O + Oxygen <=> 3-(4-Hydroxyphenyl)pyruvate + Ammonia + Hydrogen peroxide
Equation
Reaction class
RC00006  C00082_C01179
RC02755  C00007_C00027
Enzyme
Pathway
rn00350  Tyrosine metabolism
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00950  Isoquinoline alkaloid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00044  Tyrosine degradation, tyrosine => homogentisate
Orthology
K03334  L-amino-acid oxidase [EC:1.4.3.2]
Other DBs
RHEA: 61251
LinkDB

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