| Entry |
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| Name |
O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase;
MMPSepSecS;
SepSecS;
SLA/LP;
O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase;
O-phospho-L-seryl-tRNA:L-selenocysteinyl-tRNA synthase
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| Class |
Transferases;
Transferring selenium-containing groups;
Selenotransferases
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| Sysname |
selenophosphate:O-phospho-L-seryl-tRNASec selenium transferase
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| Reaction(IUBMB) |
O-phospho-L-seryl-tRNASec + selenophosphate + H2O = L-selenocysteinyl-tRNASec + 2 phosphate [RN: R08224]
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| Reaction(KEGG) |
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| Substrate |
O-phospho-L-seryl-tRNASec;
selenophosphate [CPD: C05172];
H2O [CPD: C00001]
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| Product |
L-selenocysteinyl-tRNA(Sec) [CPD: C06482];
phosphate [CPD: C00009]
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| Comment |
A pyridoxal-phosphate protein [4]. In archaea and eukarya selenocysteine formation is achieved by a two-step process: EC 2.7.1.164 (O-phosphoseryl-tRNASec kinase) phosphorylates the endogenous L-seryl-tRNASec to O-phospho-L-seryl-tRNASec, and then this misacylated amino acid-tRNA species is converted to L-selenocysteinyl-tRNASec by Sep-tRNA:Sec-tRNA synthase.
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| History |
EC 2.9.1.2 created 2009, modified 2014
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| Pathway |
| ec00970 | Aminoacyl-tRNA biosynthesis |
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| Orthology |
| K03341 | O-phospho-L-seryl-tRNASec:L-selenocysteinyl-tRNA synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Palioura S, Sherrer RL, Steitz TA, Soll D, Simonovic M |
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| Title |
The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Araiso Y, Palioura S, Ishitani R, Sherrer RL, O'Donoghue P, Yuan J, Oshikane H, Domae N, Defranco J, Soll D, Nureki O |
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| Title |
Structural insights into RNA-dependent eukaryal and archaeal selenocysteine formation. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Aeby E, Palioura S, Pusnik M, Marazzi J, Lieberman A, Ullu E, Soll D, Schneider A |
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| Title |
The canonical pathway for selenocysteine insertion is dispensable in Trypanosomes. |
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| Journal |
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| Reference |
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| Authors |
Yuan J, Palioura S, Salazar JC, Su D, O'Donoghue P, Hohn MJ, Cardoso AM, Whitman WB, Soll D |
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| Title |
RNA-dependent conversion of phosphoserine forms selenocysteine in eukaryotes and archaea. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.9.1.2 |
| ExPASy - ENZYME nomenclature database: | 2.9.1.2 |
| BRENDA, the Enzyme Database: | 2.9.1.2 |
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| LinkDB |
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