KEGG   ORTHOLOGY: K03868
Entry
K03868                      KO                                     

Name
RBX1, ROC1
Definition
RING-box protein 1 [EC:2.3.2.32]
Pathway
ko03420  Nucleotide excision repair
ko04066  HIF-1 signaling pathway
ko04110  Cell cycle
ko04111  Cell cycle - yeast
ko04114  Oocyte meiosis
ko04120  Ubiquitin mediated proteolysis
ko04141  Protein processing in endoplasmic reticulum
ko04310  Wnt signaling pathway
ko04341  Hedgehog signaling pathway - fly
ko04350  TGF-beta signaling pathway
ko04710  Circadian rhythm
ko05131  Shigellosis
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05211  Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K03868  RBX1, ROC1; RING-box protein 1
   04120 Ubiquitin mediated proteolysis
    K03868  RBX1, ROC1; RING-box protein 1
  09124 Replication and repair
   03420 Nucleotide excision repair
    K03868  RBX1, ROC1; RING-box protein 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
   04341 Hedgehog signaling pathway - fly
    K03868  RBX1, ROC1; RING-box protein 1
   04350 TGF-beta signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
   04066 HIF-1 signaling pathway
    K03868  RBX1, ROC1; RING-box protein 1
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K03868  RBX1, ROC1; RING-box protein 1
   04111 Cell cycle - yeast
    K03868  RBX1, ROC1; RING-box protein 1
   04114 Oocyte meiosis
    K03868  RBX1, ROC1; RING-box protein 1
 09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    K03868  RBX1, ROC1; RING-box protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03868  RBX1, ROC1; RING-box protein 1
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K03868  RBX1, ROC1; RING-box protein 1
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K03868  RBX1, ROC1; RING-box protein 1
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K03868  RBX1, ROC1; RING-box protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03868  RBX1, ROC1; RING-box protein 1
   03400 DNA repair and recombination proteins
    K03868  RBX1, ROC1; RING-box protein 1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.32  cullin-RING-type E3 NEDD8 transferase
     K03868  RBX1, ROC1; RING-box protein 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  UBL E3 ligases
   K03868  RBX1, ROC1; RING-box protein 1
  Multi subunit Ring-finger type E3
   SCF complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   ECV complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul3 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul4 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul7 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
   Cul9 complex
    Ring finger protein
     K03868  RBX1, ROC1; RING-box protein 1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      K03868  RBX1, ROC1; RING-box protein 1
    TCR (transcription coupled repair) factors
     Cul4-CSA complex
      K03868  RBX1, ROC1; RING-box protein 1
Other DBs
COG: COG5194
GO: 0019788
Genes
HSA: 9978(RBX1)
PTR: 458860(RBX1)
PPS: 100981636(RBX1)
GGO: 101151577(RBX1)
PON: 100441665(RBX1)
NLE: 100596079(RBX1)
MCC: 710252(RBX1)
MCF: 102132483(RBX1)
CSAB: 103223367(RBX1)
RRO: 104673455(RBX1)
RBB: 108528465(RBX1)
CJC: 100391523(RBX1)
SBQ: 101031903(RBX1)
MMU: 56438(Rbx1)
MCAL: 110310464(Rbx1)
MPAH: 110334961(Rbx1)
RNO: 300084(Rbx1)
MUN: 110550435(Rbx1)
CGE: 100762556(Rbx1)
NGI: 103743488(Rbx1)
HGL: 101712475(Rbx1)
CCAN: 109686914(Rbx1)
OCU: 103352470(RBX1)
TUP: 102468598(RBX1)
CFA: 474494(RBX1)
VVP: 112934005(RBX1)
UMR: 103674160(RBX1)
UAH: 113241739(RBX1)
ORO: 101363104(RBX1)
ELK: 111157501
FCA: 101087758(RBX1)
PTG: 102955881(RBX1)
PPAD: 109265611(RBX1)
AJU: 113602716(RBX1)
BTA: 518880(RBX1) 780968
BOM: 102272719(RBX1)
BIU: 109559850(RBX1)
BBUB: 102414522(RBX1)
CHX: 102187112(RBX1) 102188771
OAS: 101109871(RBX1)
SSC: 110260638(RBX1)
CFR: 102515877(RBX1)
CDK: 105091911(RBX1)
BACU: 102998295(RBX1)
LVE: 103090829(RBX1)
OOR: 101287254(RBX1) 101289349
DLE: 111186303(RBX1)
PCAD: 102983946(RBX1)
ECB: 100055581(RBX1)
EPZ: 103556120(RBX1)
EAI: 106842455(RBX1)
MYD: 102760790(RBX1)
MNA: 107531277(RBX1)
HAI: 109392275(RBX1)
DRO: 112321770(RBX1)
PALE: 102893437(RBX1)
RAY: 107519712(RBX1)
MJV: 108394317(RBX1)
LAV: 100657479(RBX1)
TMU: 101349359
MDO: 100013521(RBX1)
SHR: 100918404(RBX1)
PCW: 110205825(RBX1)
OAA: 100076928(RBX1)
GGA: 418001(RBX1)
MGP: 100543550(RBX1)
CJO: 107312930(RBX1)
NMEL: 110392307(RBX1)
APLA: 101796040(RBX1)
ACYG: 106035919(RBX1)
TGU: 100190092(RBX1)
LSR: 110483089(RBX1)
SCAN: 103813288(RBX1)
GFR: 102037823(RBX1)
FAB: 101806409(RBX1)
PHI: 102102832(RBX1)
PMAJ: 107204430(RBX1)
CCAE: 111934630(RBX1)
CCW: 104696532(RBX1)
ETL: 114058064(RBX1)
FPG: 101916874(RBX1)
FCH: 102049129(RBX1)
CLV: 102095842(RBX1)
ACUN: 113488055(RBX1)
PADL: 103915729(RBX1)
AAM: 106488968(RBX1)
ASN: 102372162(RBX1)
AMJ: 102571619(RBX1)
PSS: 102451113(RBX1)
CMY: 102943754(RBX1)
CPIC: 101936281(RBX1)
ACS: 100566553(rbx1)
PVT: 110076073(RBX1)
PBI: 103065423(RBX1)
PMUR: 107285413(RBX1)
TSR: 106537822(RBX1) 106553210
PMUA: 114605459(RBX1)
GJA: 107117140(RBX1)
XLA: 108714482(rbx1.L) 108715730(rbx1.S)
XTR: 100379935(rbx1)
NPR: 108788200(RBX1)
DRE: 449846(rbx1)
SANH: 107672143(rbx1) 107695112
SGH: 107580054 107602336(rbx1)
CCAR: 109076699(rbx1)
PHYP: 113524074(rbx1)
AMEX: 107197156(rbx1)
EEE: 113583718(rbx1)
LCO: 104932083(rbx1)
NCC: 104945083(rbx1)
MZE: 101480103(rbx1)
ONL: 100696705(rbx1)
OLA: 101170590(rbx1)
XMA: 102233269(rbx1)
XCO: 114160562(rbx1)
PRET: 103468459(rbx1)
CVG: 107093096(rbx1)
NFU: 107376330(rbx1)
KMR: 108236172(rbx1)
ALIM: 106520678(rbx1)
AOCE: 111570331(rbx1)
CSEM: 103393328(rbx1)
POV: 109643626(rbx1)
LCF: 108877581(rbx1)
SDU: 111230345(rbx1)
SLAL: 111645594 111647571(rbx1)
HCQ: 109514860(rbx1)
BPEC: 110162377(rbx1)
MALB: 109952664(rbx1)
SASA: 100136424(rbx1) 106601243(rbx1)
ELS: 105025789(rbx1)
PKI: 111845210(rbx1) 111853244
LCM: 102352187(RBX1)
CMK: 103189242(rbx1)
RTP: 109921792(rbx1)
BFO: 118419573
CIN: 100182516
APLC: 110984414
DME: Dmel_CG16982(Roc1a) Dmel_CG16988(Roc1b)
DSI: Dsimw501_GD11014(Dsim_GD11014) Dsimw501_GD16520(Dsim_GD16520)
AAG: 5565270
AME: 408691
BIM: 100750218
BTER: 100643234
CCAL: 108631453
OBB: 114871947
SOC: 105195164
MPHA: 105839647
AEC: 105148347
ACEP: 105626311
PBAR: 105432274
VEM: 105568857
HST: 105188519
DQU: 106740675
CFO: 105252239
LHU: 105674184
PGC: 109852514
OBO: 105284276
PCF: 106787165
NVI: 100115578
CSOL: 105361251
MDL: 103578781
TCA: 655935
DPA: 109536288
NVL: 108557707
BMOR: 692971
BMAN: 114248509
PMAC: 106708735
PRAP: 110992851
HAW: 110372277
TNL: 113508302
PXY: 105397966
DNX: 107162314
BTAB: 109044484
CLEC: 106666282
ZNE: 110832453
FCD: 110848901
PVM: 113818542
TUT: 107362230
DPTE: 113789362
PTEP: 107454093
CEL: CELE_ZK287.5(rbx-1)
CBR: CBG19342(Cbr-rbx-1)
BMY: Bm1_05985
PCAN: 112559116
CRG: 105317988
MYI: 110455961
OBI: 106882699
LAK: 106150763
SHX: MS3_02947
NVE: 5509443
EPA: 110249442
ADF: 107349974
AMIL: 114969829
PDAM: 113677930
SPIS: 111341613
DGT: 114530307
HMG: 100204043
AQU: 100636037
ATH: AT3G42830 AT5G20570(RBX1)
ALY: 9308017
CPAP: 110817690
TCC: 18588272
LJA: Lj0g3v0042719.1(Lj0g3v0042719.1) Lj0g3v0262469.1(Lj0g3v0262469.1) Lj3g3v1339080.1(Lj3g3v1339080.1)
ZJU: 107423885
NNU: 104600540
DOSA: Os01t0106800-01(Os01g0106800) Os02t0708300-01(Os02g0708300)
ATS: 109737146(LOC109737146) 109777151(LOC109777151)
PEQ: 110019661
CRE: CHLREDRAFT_79815(RBX1)
MNG: MNEG_4176
APRO: F751_6626
OLU: OSTLU_119493(rbx1)
MIS: MICPUN_113936(RBX1)
SCE: YOL133W(HRT1)
ERC: Ecym_2029
KMX: KLMA_70161(HRT1)
NCS: NCAS_0C04480(NCAS0C04480)
NDI: NDAI_0G03860(NDAI0G03860)
TPF: TPHA_0P01470(TPHA0P01470)
TBL: TBLA_0B08710(TBLA0B08710)
TDL: TDEL_0A00470(TDEL0A00470)
KAF: KAFR_0C01780(KAFR0C01780)
PIC: PICST_37145(HRT1)
CAL: CAALFM_C302450WA(HRT1)
NTE: NEUTE1DRAFT116888(NEUTE1DRAFT_116888)
MGR: MGG_08844
SSCK: SPSK_02774
MAW: MAC_01896
MAJ: MAA_00593
CMT: CCM_05836
BFU: BCIN_03g07500(Bchrt1)
MBE: MBM_08230
ANI: AN8844.2
ANG: ANI_1_294154(An17g02100)
ABE: ARB_07022
TVE: TRV_07648
PTE: PTT_16968
SPO: SPAC23H4.18c(rbx1)
CNE: CNB03140
CNB: CNBB2560
ABP: AGABI1DRAFT130185(AGABI1DRAFT_130185)
ABV: AGABI2DRAFT139777(AGABI2DRAFT_139777)
MGL: MGL_0788
MRT: MRET_0028
DDI: DDB_G0287629(rbx1)
EHI: EHI_151630(2.t00108)
PCB: PCHAS_080650(PC000269.01.0)
TAN: TA10565
TPV: TP04_0669
BBO: BBOV_III007590(17.m07664)
CPV: cgd8_930
SMIN: v1.2.005788.t1(symbB.v1.2.005788.t1)
PTI: PHATRDRAFT_39090(Rbx1)
NGD: NGA_0441600(RBX1)
SPAR: SPRG_11654
 » show all
Reference
  Authors
Kamura T, Koepp DM, Conrad MN, Skowyra D, Moreland RJ, Iliopoulos O, Lane WS, Kaelin WG Jr, Elledge SJ, Conaway RC, Harper JW, Conaway JW
  Title
Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase.
  Journal
Science 284:657-61 (1999)
DOI:10.1126/science.284.5414.657
  Sequence
[sce:YOL133W]
Reference
  Authors
Kamura T, Conrad MN, Yan Q, Conaway RC, Conaway JW
  Title
The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2.
  Journal
Genes Dev 13:2928-33 (1999)
DOI:10.1101/gad.13.22.2928
  Sequence
[hsa:9978] [sce:YOL133W]
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