KEGG   ORTHOLOGY: K03871Help
Entry
K03871                      KO                                     

Name
VHL
Definition
von Hippel-Lindau disease tumor supressor
Pathway
ko04066  HIF-1 signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04212  Longevity regulating pathway - worm
ko05200  Pathways in cancer
ko05211  Renal cell carcinoma
Disease
H00021  Renal cell carcinoma
H00236  Congenital polycythemia
H00559  von Hippel-Lindau syndrome
H01510  Malignant paraganglioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K03871  VHL; von Hippel-Lindau disease tumor supressor
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    K03871  VHL; von Hippel-Lindau disease tumor supressor
 09150 Organismal Systems
  09149 Aging
   04212 Longevity regulating pathway - worm
    K03871  VHL; von Hippel-Lindau disease tumor supressor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03871  VHL; von Hippel-Lindau disease tumor supressor
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K03871  VHL; von Hippel-Lindau disease tumor supressor
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K03871  VHL; von Hippel-Lindau disease tumor supressor
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   ECV complex
    Target recognizing subunit (VHL box)
     K03871  VHL; von Hippel-Lindau disease tumor supressor
BRITE hierarchy
Genes
HSA: 7428(VHL)
PTR: 749769(VHL)
PPS: 100986949(VHL)
GGO: 101149351(VHL)
PON: 100173372(VHL)
NLE: 100600696(VHL)
MCC: 106996285(VHL)
MCF: 102137687(VHLL) 107128974(VHL)
CSAB: 103223849(VHLL) 103227999(VHL)
RRO: 104667143(VHL)
RBB: 108512296(VHL) 108515508(VHLL)
CJC: 103788323(VHL)
SBQ: 104651216(VHL)
MMU: 22346(Vhl)
MCAL: 110296136(Vhl)
MPAH: 110316548(Vhl)
RNO: 24874(Vhl)
MUN: 110548945(Vhl)
CGE: 100751916(Vhl)
NGI: 103751433(Vhl)
HGL: 101697654(Vhl) 101705641
CCAN: 109688948(Vhl)
OCU: 100350053(VHL)
TUP: 102486323(VHL)
CFA: 494000(VHL)
VVP: 112933697(VHL)
AML: 100473201(VHL)
UMR: 103669642(VHL)
UAH: 113257162(VHL)
ORO: 101370163(VHL)
FCA: 101092590(VHL)
PTG: 102955568(VHL)
PPAD: 109254368(VHL)
AJU: 106972341(VHL)
BTA: 540957(VHL)
BOM: 102274048(VHL)
BIU: 109576248(VHL)
BBUB: 102411667(VHL)
CHX: 102182921(VHL)
OAS: 101122897(VHL)
SSC: 100739306(VHL)
CDK: 105093118(VHL)
BACU: 103007825(VHL)
LVE: 103080565(VHL)
OOR: 101272871(VHL)
DLE: 111169978
PCAD: 102978007 102997043(VHL)
ECB: 100058139(VHL)
EPZ: 103561463(VHL)
EAI: 106835626(VHL)
MYB: 102255400(VHL)
MNA: 107534686(VHL)
DRO: 112301235(VHL)
PALE: 102884716
RAY: 107498366(VHL)
LAV: 111750613(VHL)
TMU: 101352062
MDO: 100024305(VHL)
SHR: 111719447(VHL)
PCW: 110204865(VHL)
OAA: 114806529(VHL)
GGA: 416117(VHL)
MGP: 109369884(VHL)
NMEL: 110405041(VHL)
APLA: 110351418
TGU: 100231028(VHL)
LSR: 110477103(VHL)
SCAN: 115484105
GFR: 102035931(VHL)
FAB: 101814622(VHL)
PHI: 102106299(VHL)
PMAJ: 107210253(VHL)
CCAE: 111935274
CCW: 104683399
ETL: 114067683(VHL)
FPG: 101921920(VHL)
CLV: 102086490(VHL)
EGZ: 104121781(VHL)
NNI: 104017014(VHL) 104021398
PADL: 103913610(VHL)
AAM: 106494625(VHL)
ASN: 102378530(VHL)
AMJ: 102557707(VHL)
PSS: 102455661(VHL)
CMY: 102935375(VHL)
CPIC: 101937051(VHL)
ACS: 100560920(vhl)
PVT: 110077876(VHL)
PBI: 103056649
PMUR: 107298606(VHL)
TSR: 106556309
PMUA: 114591793(VHL)
GJA: 107122229(VHL)
XLA: 108714636(vhl.L)
XTR: 549121(vhl)
NPR: 108786037(VHL)
DRE: 791202(vhl) 795635(vhll)
IPU: 108271809(vhl)
PHYP: 113545808(vhl)
TRU: 101068717
LCO: 104933452(vhl)
NCC: 104941408
MZE: 101468402(vhl)
ONL: 100699102(vhl)
OLA: 101157853(vhl)
XMA: 102232438(vhl)
XCO: 114135786(vhl)
PRET: 103465255
CVG: 107094015(vhl)
NFU: 107385700
KMR: 108235772(vhl)
ALIM: 106518020(vhl)
AOCE: 111566652(vhl)
CSEM: 103385940
POV: 109628898(vhl)
LCF: 108881483(vhl)
SDU: 111221786(vhl)
SLAL: 111667871(vhl)
HCQ: 109522503(vhl)
BPEC: 110168396(vhl)
MALB: 109964425(vhl)
SASA: 100380306(vhl)
OTW: 112217436(vhl) 112239307
SALP: 111966645(vhl) 112078081
ELS: 105017201(vhl) 105027074
PKI: 111839852
LCM: 102364581
RTP: 109933532
SPU: 594647
APLC: 110980219
SKO: 100366296
DME: Dmel_CG13221(Vhl)
DER: 6547113
DSI: Dsimw501_GD10785(Dsim_GD10785)
DSR: 110179360
DPE: 6593058
DMN: 108159835
DWI: 6640477
DAZ: 108617486
DNV: 108654268
DHE: 111605236
MDE: 101892847
LCQ: 111682321
AAG: 5568564
BIM: 100740557
BTER: 100646034
CCAL: 108625034
OBB: 114875832
SOC: 105195691
MPHA: 105837273
AEC: 105144469
ACEP: 105622523
PBAR: 105431774
VEM: 105569551
HST: 112588761
CFO: 105252255
LHU: 105670331
PGC: 109852109
OBO: 105282073
NVI: 103315787
CSOL: 105363445
MDL: 103576738
TCA: 103313576(Vhl) 657278
DPA: 109536001
NVL: 108566355
BMOR: 101739221
PRAP: 110996398
HAW: 110379515
TNL: 113494439
API: 100163806
DNX: 107165969
AGS: 114123739
RMD: 113561024
BTAB: 109034176
CLEC: 106670596
ZNE: 110830843
FCD: 110846190
PVM: 113813057
DPTE: 113793700
PTEP: 107455579
CEL: CELE_F08G12.4(vhl-1)
CBR: CBG17370(Cbr-vhl-1)
CRG: 105330196
OBI: 106868400
ADF: 107333799
PDAM: 113683172
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Mahrour N, Redwine WB, Florens L, Swanson SK, Martin-Brown S, Bradford WD, Staehling-Hampton K, Washburn MP, Conaway RC, Conaway JW
  Title
Characterization of Cullin-box sequences that direct recruitment of Cul2-Rbx1 and Cul5-Rbx2 modules to Elongin BC-based ubiquitin ligases.
  Journal
J Biol Chem 283:8005-13 (2008)
DOI:10.1074/jbc.M706987200
  Sequence
[hsa:7428]
Reference
  Authors
Kamura T, Maenaka K, Kotoshiba S, Matsumoto M, Kohda D, Conaway RC, Conaway JW, Nakayama KI.
  Title
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
  Journal
Genes Dev 18:3055-65 (2004)
DOI:10.1101/gad.1252404
  Sequence
[hsa:7428]
Reference
  Authors
Adryan B, Decker HJ, Papas TS, Hsu T
  Title
Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila.
  Journal
Oncogene 19:2803-11 (2000)
DOI:10.1038/sj.onc.1203611
  Sequence
LinkDB All DBs

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