KEGG   ORTHOLOGY: K03914
Entry
K03914                      KO                                     

Name
F2R, PAR1
Definition
coagulation factor II (thrombin) receptor
Pathway
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04610  Complement and coagulation cascades
ko04611  Platelet activation
ko04810  Regulation of actin cytoskeleton
ko05130  Pathogenic Escherichia coli infection
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
   04020 Calcium signaling pathway
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
   04072 Phospholipase D signaling pathway
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
   04024 cAMP signaling pathway
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
   04151 PI3K-Akt signaling pathway
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
   04611 Platelet activation
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Peptide
   Thrombin
    K03914  F2R, PAR1; coagulation factor II (thrombin) receptor
Other DBs
GO: 0015057
Genes
HSA: 2149(F2R)
PTR: 471510(F2R)
PPS: 100986369(F2R)
GGO: 101144448(F2R)
PON: 100447792(F2R)
NLE: 100607663(F2R)
MCC: 707370(F2R)
MCF: 102137130(F2R)
CSAB: 103223358(F2R)
RRO: 104655485(F2R)
RBB: 108513076(F2R)
CJC: 100400356(F2R)
SBQ: 101048036(F2R)
MMU: 14062(F2r)
MCAL: 110308051(F2r)
MPAH: 110328985(F2r)
RNO: 25439(F2r)
MUN: 110551097(F2r)
CGE: 100758351(F2r)
NGI: 103752270(F2r)
HGL: 101708544(F2r)
CCAN: 109701102(F2r)
OCU: 100351711(F2R)
TUP: 102485895(F2R)
CFA: 488942(F2R)
VVP: 112919743(F2R)
AML: 105240499(F2R)
UMR: 103663554(F2R)
UAH: 113255187
ORO: 101364644(F2R)
ELK: 111148319
FCA: 101100861(F2R)
PTG: 102964799(F2R)
PPAD: 109274968(F2R)
BTA: 526585(F2R)
BOM: 102272347(F2R)
BIU: 109564649(F2R)
BBUB: 102407393(F2R)
CHX: 102187491(F2R)
OAS: 101105757(F2R)
SSC: 100521609(F2R)
CFR: 102506154(F2R)
CDK: 105084810(F2R)
BACU: 103006270(F2R)
LVE: 103078013(F2R)
OOR: 101278325(F2R)
DLE: 111185188(F2R)
PCAD: 102983891(F2R)
ECB: 100073278(F2R)
EPZ: 103540011(F2R)
EAI: 106824041(F2R)
MYB: 102249171(F2R)
MYD: 102770826(F2R)
MNA: 107531201(F2R)
HAI: 109381883(F2R)
DRO: 112307510(F2R)
PALE: 102886001(F2R)
RAY: 107501531(F2R)
MJV: 108383641(F2R) 108389995
LAV: 100668995(F2R)
TMU: 101358047
MDO: 100010071(F2R)
SHR: 100934757(F2R)
PCW: 110216589(F2R)
OAA: 114813183(F2R)
GGA: 427212(F2R)
MGP: 100543186(F2R)
CJO: 107306072(F2R)
NMEL: 110390007(F2R)
ACYG: 106042104(F2R)
TGU: 100220661(F2R)
LSR: 110471304(F2R)
SCAN: 103819537(F2R)
GFR: 102045591(F2R)
FAB: 101809495(F2R)
PHI: 102108910(F2R)
PMAJ: 107215843(F2R)
CCAE: 111940635(F2R)
CCW: 104698561(F2R)
ETL: 114057079(F2R)
FPG: 101917626(F2R)
FCH: 102055206(F2R)
CLV: 102096136(F2R)
EGZ: 104124890(F2R)
NNI: 104013343(F2R)
ACUN: 113489757(F2R)
PADL: 103919756(F2R)
AAM: 106489297(F2R) 106496616
ASN: 102371571(F2R)
AMJ: 102559171(F2R)
PSS: 102462418(F2R)
CMY: 102932450(F2R)
CPIC: 101935056(F2R)
ACS: 100566666(f2r) 107982334
PVT: 110084596 110084597(F2R)
PBI: 103063671(F2R) 103064541
XLA: 108707268(f2r.S) 378526(f2r.L)
XTR: 100493325(f2r)
DRE: 100124597(f2r2.1) 100149161 558477(f2r) 794215 794278(si:dkey-163m14.6) 794365(si:dkey-163m14.7) 799082(si:dkey-163m14.2) 799156 799227
IPU: 108255687(f2r)
PHYP: 113537012(f2r)
EEE: 113568043 113580495(f2r)
TRU: 101072420(f2r) 101078307
NCC: 104954982(f2r)
PRET: 103470430(f2r) 103473499
CVG: 107084527(f2r) 107090355
NFU: 107374832 107393891(f2r)
KMR: 108234532(f2r) 108244740
ALIM: 106517457(f2r)
AOCE: 111572634 111576016(f2r)
CSEM: 103389897 103398127(f2r)
POV: 109626040 109638049(f2r)
LCF: 108873765 108878175(f2r)
SDU: 111228371(f2r) 111239586
SLAL: 111660342(f2r) 111666761
HCQ: 109514170(f2r) 109529262
BPEC: 110156751(f2r) 110157418
MALB: 109957034(f2r) 109967793
ELS: 105014292
PKI: 111836076 111849769(f2r)
LCM: 102349897(F2R) 102362466
 » show all
Reference
  Authors
Kahn ML, Nakanishi-Matsui M, Shapiro MJ, Ishihara H, Coughlin SR
  Title
Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin.
  Journal
J Clin Invest 103:879-87 (1999)
DOI:10.1172/JCI6042
  Sequence
[hsa:2149]
LinkDB

KEGG   ORTHOLOGY: K04129
Entry
K04129                      KO                                     

Name
CHRM1
Definition
muscarinic acetylcholine receptor M1
Pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04725  Cholinergic synapse
ko04810  Regulation of actin cytoskeleton
ko05010  Alzheimer disease
ko05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04129  CHRM1; muscarinic acetylcholine receptor M1
   04024 cAMP signaling pathway
    K04129  CHRM1; muscarinic acetylcholine receptor M1
   04151 PI3K-Akt signaling pathway
    K04129  CHRM1; muscarinic acetylcholine receptor M1
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04129  CHRM1; muscarinic acetylcholine receptor M1
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04129  CHRM1; muscarinic acetylcholine receptor M1
 09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    K04129  CHRM1; muscarinic acetylcholine receptor M1
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04129  CHRM1; muscarinic acetylcholine receptor M1
   05022 Pathways of neurodegeneration - multiple diseases
    K04129  CHRM1; muscarinic acetylcholine receptor M1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04129  CHRM1; muscarinic acetylcholine receptor M1
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    K04129  CHRM1; muscarinic acetylcholine receptor M1
Other DBs
GO: 0016907
TC: 9.A.14.3.2
Genes
HSA: 1128(CHRM1)
PTR: 451272(CHRM1)
PPS: 100970743(CHRM1)
GGO: 101131622(CHRM1)
PON: 100172935(CHRM1)
NLE: 100586653(CHRM1)
MCC: 574362(CHRM1)
MCF: 102119626(CHRM1)
CSAB: 103233802(CHRM1)
RRO: 104672686(CHRM1)
RBB: 108536133(CHRM1)
CJC: 100401418(CHRM1)
SBQ: 101035927(CHRM1)
MMU: 12669(Chrm1)
MCAL: 110285542(Chrm1)
MPAH: 110331831(Chrm1)
RNO: 25229(Chrm1)
MUN: 110557477(Chrm1)
CGE: 100755522(Chrm1)
NGI: 103737656(Chrm1)
HGL: 101702102(Chrm1)
CCAN: 109693848(Chrm1)
OCU: 100346573(CHRM1)
TUP: 102486224(CHRM1)
CFA: 483776(CHRM1)
VVP: 112924347(CHRM1)
AML: 100481445(CHRM1)
UMR: 103678244(CHRM1)
UAH: 113246917(CHRM1)
ORO: 101380644(CHRM1)
ELK: 111150081
FCA: 101093801(CHRM1)
PTG: 102964850(CHRM1)
PPAD: 109246616(CHRM1)
AJU: 106981762(CHRM1)
BTA: 281684(CHRM1)
BOM: 102275926(CHRM1)
BIU: 109554719(CHRM1)
BBUB: 102412288(CHRM1)
CHX: 102187843(CHRM1)
OAS: 101117029(CHRM1)
SSC: 397099(CHRM1)
CFR: 102523660(CHRM1)
CDK: 105091516(CHRM1)
BACU: 103019287(CHRM1)
LVE: 103070656(CHRM1)
OOR: 101285827(CHRM1)
DLE: 111183839(CHRM1)
PCAD: 102982691(CHRM1)
ECB: 100064117(CHRM1)
EPZ: 103558955(CHRM1)
EAI: 106822085(CHRM1)
MYB: 102238610(CHRM1)
MYD: 102754848(CHRM1)
MNA: 107539778(CHRM1)
HAI: 109384108(CHRM1)
DRO: 112317249(CHRM1)
PALE: 102885993(CHRM1)
RAY: 107501614(CHRM1)
MJV: 108397051(CHRM1)
LAV: 100674374(CHRM1)
TMU: 101360696
MDO: 100013112(CHRM1)
SHR: 100919191(CHRM1)
PCW: 110195377(CHRM1)
OAA: 100086064(CHRM1) 114815970(CHRM5)
ASN: 102379641(CHRM1)
AMJ: 102572624(CHRM1)
PSS: 102460077(CHRM1)
CMY: 102939400
CPIC: 101933014(CHRM1)
ACS: 100565611(chrm1)
PVT: 110070209(CHRM1)
PBI: 103053243
PMUA: 114586618(CHRM1)
GJA: 107111024(CHRM1)
XTR: 100490434(chrm1)
NPR: 108785248(CHRM1)
DRE: 792708(chrm1a) 794658(chrm1b)
OLA: 101171981
SASA: 106603122
OTW: 112228842
SALP: 111950043
ELS: 105010913
LCM: 102366576(CHRM1)
RTP: 109921872
SHX: MS3_02170
 » show all
Reference
PMID:2848036
  Authors
Shapiro RA, Scherer NM, Habecker BA, Subers EM, Nathanson NM
  Title
Isolation, sequence, and functional expression of the mouse M1 muscarinic acetylcholine receptor gene.
  Journal
J Biol Chem 263:18397-403 (1988)
  Sequence
[mmu:12669]
LinkDB

KEGG   ORTHOLOGY: K04130
Entry
K04130                      KO                                     

Name
CHRM2
Definition
muscarinic acetylcholine receptor M2
Pathway
ko04020  Calcium signaling pathway
ko04024  cAMP signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04725  Cholinergic synapse
ko04810  Regulation of actin cytoskeleton
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04130  CHRM2; muscarinic acetylcholine receptor M2
   04024 cAMP signaling pathway
    K04130  CHRM2; muscarinic acetylcholine receptor M2
   04151 PI3K-Akt signaling pathway
    K04130  CHRM2; muscarinic acetylcholine receptor M2
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04130  CHRM2; muscarinic acetylcholine receptor M2
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04130  CHRM2; muscarinic acetylcholine receptor M2
 09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    K04130  CHRM2; muscarinic acetylcholine receptor M2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04130  CHRM2; muscarinic acetylcholine receptor M2
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    K04130  CHRM2; muscarinic acetylcholine receptor M2
Other DBs
GO: 0016907
Genes
HSA: 1129(CHRM2)
PTR: 463758(CHRM2)
PPS: 103782638(CHRM2)
GGO: 101124976(CHRM2)
PON: 100450243(CHRM2)
NLE: 100593190(CHRM2)
MCC: 714780(CHRM2)
MCF: 102141940(CHRM2)
CSAB: 103226965(CHRM2)
RRO: 104668941(CHRM2)
RBB: 108532444(CHRM2)
CJC: 100411083(CHRM2)
SBQ: 104649836(CHRM2)
MMU: 243764(Chrm2)
MCAL: 110296617(Chrm2)
MPAH: 110316713(Chrm2)
RNO: 81645(Chrm2)
MUN: 110557978(Chrm2)
CGE: 100770997(Chrm2)
NGI: 103726078(Chrm2)
HGL: 101714286(Chrm2)
CCAN: 109677776(Chrm2)
OCU: 100342878(CHRM2)
TUP: 102470522(CHRM2)
CFA: 403858(CHRM2)
VVP: 112908890(CHRM2)
AML: 100483729(CHRM2)
UMR: 103669054(CHRM2)
UAH: 113266585(CHRM2)
ORO: 101386108(CHRM2)
ELK: 111152067
FCA: 101099790(CHRM2)
PTG: 102950279(CHRM2)
PPAD: 109269060(CHRM2)
AJU: 106975696(CHRM2)
BTA: 522170(CHRM2)
BOM: 102288004(CHRM2)
BIU: 109557673(CHRM2)
BBUB: 102412001(CHRM2)
CHX: 102169456(CHRM2)
OAS: 101102897(CHRM2)
SSC: 397498(CHRM2)
CFR: 102509282(CHRM2)
CDK: 105091619(CHRM2)
BACU: 103000729(CHRM2)
LVE: 103070593(CHRM2)
OOR: 101284832(CHRM2)
DLE: 111182727(CHRM2)
PCAD: 102984774(CHRM2)
ECB: 100064906(CHRM2)
EPZ: 103561369(CHRM2)
EAI: 106829990(CHRM2)
MYB: 102244198(CHRM2)
MYD: 102774659(CHRM2)
MNA: 107544520(CHRM2)
HAI: 109388540(CHRM2)
DRO: 112299910(CHRM2)
PALE: 102883382(CHRM2)
RAY: 107499062(CHRM2)
MJV: 108391646(CHRM2)
LAV: 100666496(CHRM2)
TMU: 101349646
MDO: 100017080(CHRM2)
SHR: 100925629(CHRM2)
PCW: 110216282(CHRM2)
OAA: 100075952(CHRM2)
GGA: 418126(CHRM2)
MGP: 100538353(CHRM2)
CJO: 107315784(CHRM2)
NMEL: 110394649(CHRM2)
APLA: 101792126(CHRM2)
ACYG: 106030984(CHRM2)
TGU: 100220676(CHRM2)
LSR: 110482597(CHRM2)
SCAN: 103819622(CHRM2)
GFR: 102032522(CHRM2)
FAB: 101811127(CHRM2)
PHI: 102103691(CHRM2)
PMAJ: 107205035(CHRM2)
CCAE: 111936668(CHRM2)
CCW: 104696199(CHRM2)
ETL: 114064295(CHRM2)
FPG: 101919158(CHRM2)
FCH: 102054742(CHRM2)
CLV: 102098670(CHRM2)
EGZ: 104126091(CHRM2)
NNI: 104012391(CHRM2)
ACUN: 113491545(CHRM2)
PADL: 103924397(CHRM2)
AAM: 106488476(CHRM2)
ASN: 102382805(CHRM2)
AMJ: 102575025(CHRM2)
PSS: 102445606(CHRM2)
CMY: 102940353(CHRM2)
CPIC: 101940030(CHRM2)
ACS: 100560735(chrm2)
PVT: 110078260(CHRM2)
PBI: 103050753(CHRM2)
PMUR: 107294180(CHRM2)
TSR: 106542367(CHRM2)
PMUA: 114605279(CHRM2)
GJA: 107119224(CHRM2)
XLA: 108704358(chrm2.L) 108712545(chrm2.S)
XTR: 100485603(chrm2)
NPR: 108788723(CHRM2)
DRE: 352938(chrm2a) 555516(chrm2b)
IPU: 108268785 108274455(chrm2)
PHYP: 113528685 113529780(chrm2)
AMEX: 103021745 103039136(chrm2)
EEE: 113573657(chrm2) 113579735
TRU: 101064044(chrm2) 101067250
LCO: 104935830(chrm2) 104940443
OLA: 101157989(chrm2) 101163735
PRET: 103459119(chrm2) 103466077
CVG: 107085326(chrm2) 107103804
KMR: 108233278(chrm2) 108239971
AOCE: 111565671(chrm2) 111585437
POV: 109624680 109632850(chrm2)
SDU: 111224678(chrm2) 111228487
SLAL: 111660037(chrm2) 111671210
HCQ: 109523706(chrm2) 109526789
BPEC: 110161877(chrm2) 110166866
ELS: 105018412 105023422(chrm2)
SFM: 108920765(chrm2)
LCM: 102351552(CHRM2)
CMK: 103185606(chrm2)
BFO: 118427742
APLC: 110976217
DSR: 110180416
DMN: 108164553
PMAC: 106721485
 » show all
Reference
PMID:2825184
  Authors
Gocayne J, Robinson DA, FitzGerald MG, Chung FZ, Kerlavage AR, Lentes KU, Lai J, Wang CD, Fraser CM, Venter JC
  Title
Primary structure of rat cardiac beta-adrenergic and muscarinic cholinergic receptors obtained by automated DNA sequence analysis: further evidence for a multigene family.
  Journal
Proc Natl Acad Sci U S A 84:8296-300 (1987)
DOI:10.1073/pnas.84.23.8296
  Sequence
[rno:81645]
LinkDB

KEGG   ORTHOLOGY: K04289
Entry
K04289                      KO                                     

Name
LPAR1, EDG2
Definition
lysophosphatidic acid receptor 1
Pathway
ko04015  Rap1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04540  Gap junction
ko04810  Regulation of actin cytoskeleton
ko05130  Pathogenic Escherichia coli infection
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
   04072 Phospholipase D signaling pathway
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
   04151 PI3K-Akt signaling pathway
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Lipid
   Lysophosphatidic acid
    K04289  LPAR1, EDG2; lysophosphatidic acid receptor 1
Other DBs
GO: 0070915
Genes
HSA: 1902(LPAR1)
PTR: 464655(LPAR1)
PPS: 100981266(LPAR1)
GGO: 101144872(LPAR1)
PON: 100458931(LPAR1)
NLE: 100589911(LPAR1)
MCC: 709208(LPAR1)
MCF: 101864894(LPAR1) 102125640
CSAB: 103219021(LPAR1)
RRO: 104664137(LPAR1)
RBB: 108513979
CJC: 100414340(LPAR1)
SBQ: 101035023(LPAR1)
MMU: 14745(Lpar1)
MCAL: 110292580(Lpar1)
MPAH: 110322872(Lpar1)
RNO: 116744(Lpar1)
MUN: 110554214(Lpar1)
CGE: 100757522(Lpar1)
NGI: 103732526(Lpar1)
HGL: 101713333(Lpar1)
CCAN: 109692877(Lpar1)
OCU: 100355169(LPAR1)
TUP: 102503029(LPAR1)
CFA: 474800(LPAR1)
VVP: 112923052(LPAR1)
AML: 100479569(LPAR1)
UMR: 103678568(LPAR1)
UAH: 113260324(LPAR1)
ORO: 101371767(LPAR1)
ELK: 111145805
FCA: 101092556(LPAR1)
PTG: 102968521(LPAR1)
PPAD: 109269980(LPAR1)
AJU: 106971772(LPAR1)
BTA: 281136(LPAR1)
BOM: 102273019(LPAR1)
BIU: 109563336(LPAR1) 109563337
BBUB: 102406108(LPAR1)
CHX: 102189399(LPAR1)
OAS: 443346(LPAR1)
SSC: 100512581(LPAR1)
CFR: 102522277(LPAR1)
CDK: 105096434
BACU: 103015300(LPAR1)
LVE: 103091078(LPAR1)
OOR: 101274338(LPAR1)
DLE: 111177336(LPAR1)
PCAD: 102992144(LPAR1)
ECB: 100053797(LPAR1)
EPZ: 103546686(LPAR1)
EAI: 106826903(LPAR1)
MYB: 102258769(LPAR1)
MYD: 102762844(LPAR1)
MNA: 107537650(LPAR1)
HAI: 109379349(LPAR1)
DRO: 112304468(LPAR1)
PALE: 102891503(LPAR1)
RAY: 107502626(LPAR1)
MJV: 108408598(LPAR1)
LAV: 100668056(LPAR1)
TMU: 101344103
MDO: 100016607(LPAR1) 103103209
SHR: 100928953(LPAR1) 100932534
OAA: 100077696(LPAR1)
GGA: 427339(LPAR1)
MGP: 100541536(LPAR1) 109363681
CJO: 107306591(LPAR1)
NMEL: 110389432(LPAR1) 110407913
APLA: 101796868 101802482(LPAR1)
ACYG: 106043035(LPAR1) 106046837
TGU: 100223722(LPAR1) 115497772
LSR: 110467706 110467746(LPAR1)
SCAN: 103820340 103821825(LPAR1)
GFR: 102032612 102038748(LPAR1)
FAB: 101814928 101819651(LPAR1)
PHI: 102105561 102111782(LPAR1)
PMAJ: 107198333(LPAR1) 107212973
CCAE: 111937972 111941320(LPAR1)
CCW: 104690481(LPAR1) 104690993
ETL: 114069483 114072958(LPAR1)
FPG: 101920309(LPAR1) 106112258
FCH: 102050804 102058846(LPAR1)
CLV: 102084885(LPAR1) 102089623
EGZ: 104121830 104123052(LPAR1)
NNI: 104017012 104019835(LPAR1)
ACUN: 113487191 113490290(LPAR1)
PADL: 103917222 103921055(LPAR1)
AAM: 106494707 106499585(LPAR1)
ASN: 102382491(LPAR1) 112551204
AMJ: 102563758(LPAR1)
PSS: 102445645(LPAR1) 102453320
CMY: 102929826 102935396(LPAR1)
CPIC: 101932155(LPAR1) 101940038
ACS: 100565601(lpar1)
PVT: 110075502 110077739(LPAR1)
PBI: 103053763(LPAR1) 103055321
TSR: 106544059(LPAR1) 106555676
PMUA: 114585716 114587543(LPAR1)
GJA: 107108929 107114523(LPAR1)
XLA: 373591(lpar1.L) 379403(lpar1.S)
XTR: 100124893(lpar1) 116408597
NPR: 108787629(LPAR1)
DRE: 368461(lpar1)
SANH: 107653498(lpar1)
IPU: 108277333(lpar1)
PHYP: 113544013
EEE: 113577615(lpar1)
TRU: 101075588
LCO: 104927704(lpar1)
NCC: 104964645(lpar1)
MZE: 101487294(lpar1)
ONL: 100691976(lpar1)
OLA: 101164735(lpar1)
XMA: 102222146(lpar1)
XCO: 114149710(lpar1)
PRET: 103473989(lpar1)
CVG: 107091062(lpar1)
NFU: 107396668(lpar1)
KMR: 108232758(lpar1)
ALIM: 106513587(lpar1)
AOCE: 111581611(lpar1)
CSEM: 103390307(lpar1) 103399363
POV: 109646242(lpar1)
LCF: 108880309(lpar1)
SDU: 111237500
SLAL: 111655943
HCQ: 109530147(lpar1)
BPEC: 110166379
MALB: 109960839(lpar1)
ELS: 105026669
SFM: 108936306
PKI: 111842175
LCM: 102349282(LPAR1)
CMK: 103187154(lpar1)
RTP: 109929476
CIN: 100182538
ADF: 107357274
 » show all
Reference
PMID:9070858
  Authors
An S, Dickens MA, Bleu T, Hallmark OG, Goetzl EJ
  Title
Molecular cloning of the human Edg2 protein and its identification as a functional cellular receptor for lysophosphatidic acid.
  Journal
Biochem Biophys Res Commun 231:619-22 (1997)
DOI:10.1006/bbrc.1997.6150
  Sequence
[hsa:1902]
LinkDB

KEGG   ORTHOLOGY: K04291
Entry
K04291                      KO                                     

Name
LPAR2, EDG4
Definition
lysophosphatidic acid receptor 2
Pathway
ko04015  Rap1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05130  Pathogenic Escherichia coli infection
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
   04072 Phospholipase D signaling pathway
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
   04151 PI3K-Akt signaling pathway
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Lipid
   Lysophosphatidic acid
    K04291  LPAR2, EDG4; lysophosphatidic acid receptor 2
Other DBs
GO: 0070915
TC: 9.A.14.2.5
Genes
HSA: 9170(LPAR2)
PTR: 455878(LPAR2)
PPS: 100988354(LPAR2)
GGO: 101126528(LPAR2)
PON: 100458628(LPAR2)
NLE: 100587344(LPAR2)
MCC: 719844(LPAR2)
MCF: 102120852(LPAR2)
CSAB: 103234222(LPAR2)
RRO: 104680662(LPAR2)
RBB: 108515641(LPAR2)
CJC: 100391457(LPAR2)
SBQ: 101048307(LPAR2)
MMU: 53978(Lpar2)
MCAL: 110300387(Lpar2)
MPAH: 110336830(Lpar2)
RNO: 498609(Lpar2)
MUN: 110549164(Lpar2)
CGE: 100753903(Lpar2)
NGI: 103726831(Lpar2)
HGL: 101721970(Lpar2)
CCAN: 109687178(Lpar2)
OCU: 100343700(LPAR2)
TUP: 102502351(LPAR2)
CFA: 484802(LPAR2)
VVP: 112912747(LPAR2)
AML: 100483313(LPAR2)
UMR: 103675138(LPAR2)
UAH: 113256760(LPAR2)
ORO: 101363634(LPAR2)
ELK: 111144147
FCA: 101100950(LPAR2)
PTG: 102966758(LPAR2)
PPAD: 109247675(LPAR2)
AJU: 106969061(LPAR2)
BTA: 509748(LPAR2)
BOM: 102268794(LPAR2)
BIU: 109561368(LPAR2)
BBUB: 102411165(LPAR2)
CHX: 102187119(LPAR2)
OAS: 101104572(LPAR2)
SSC: 100038015(LPAR2)
CFR: 102504628(LPAR2)
CDK: 105103737(LPAR2)
BACU: 103016779(LPAR2)
LVE: 103074802(LPAR2)
OOR: 101287741(LPAR2)
DLE: 111166724(LPAR2)
PCAD: 102986483(LPAR2)
ECB: 102147510(LPAR2)
EPZ: 103561322(LPAR2)
EAI: 106825461(LPAR2)
MYB: 102246865(LPAR2)
MYD: 102761006(LPAR2)
MNA: 107535357(LPAR2)
HAI: 109382376(LPAR2)
DRO: 112305257(LPAR2)
PALE: 102891807(LPAR2)
RAY: 107503740(LPAR2)
MJV: 108401369(LPAR2)
LAV: 100674529(LPAR2)
TMU: 101360086
MDO: 100014105(LPAR2)
SHR: 100915220(LPAR2)
PCW: 110214461(LPAR2)
GGA: 426086(LPAR2)
MGP: 100550166(LPAR2)
CJO: 107307021(LPAR2)
NMEL: 110391060(LPAR2)
APLA: 101789658(LPAR2)
ACYG: 106049475(LPAR2)
TGU: 115491626(LPAR2)
LSR: 110479080(LPAR2)
SCAN: 103825056(LPAR2)
GFR: 102032251(LPAR2)
PHI: 102112903(LPAR2)
PMAJ: 107199132(LPAR2)
CCAE: 111945421(LPAR2)
ETL: 114072973(LPAR2)
FPG: 101923045(LPAR2)
FCH: 102058075(LPAR2)
EGZ: 104135290(LPAR2)
NNI: 104013846(LPAR2)
ACUN: 113490929(LPAR2)
PADL: 103920849(LPAR2)
AAM: 106500202(LPAR2)
ASN: 102369379(LPAR2)
AMJ: 102561509(LPAR2)
PSS: 102447107
CMY: 102942984(LPAR2)
CPIC: 101951112(LPAR2)
ACS: 100565184(lpar2)
PVT: 110071644(LPAR2)
PBI: 103067510(LPAR2)
PMUR: 107287233(LPAR2)
TSR: 106539958(LPAR2)
PMUA: 114592871(LPAR2)
GJA: 107124321(LPAR2)
XLA: 108711685(lpar2.L) 447460(lpar2.S)
XTR: 493190(lpar2)
NPR: 108800357(LPAR2)
DRE: 445184(lpar2a) 567956(lpar2b)
IPU: 108257275(lpar2) 108258779(LPAR2)
AMEX: 103027992 103037183(lpar2)
NCC: 104952496(lpar2)
PRET: 103468756(lpar2) 103474898
CVG: 107090067 107093411(lpar2)
NFU: 107378328(lpar2) 107389755
ALIM: 106522697 106529464(lpar2)
HCQ: 109511043(lpar2)
ELS: 105005707 105023381(lpar2)
LCM: 102356779
CMK: 103174454
LAK: 106163074
 » show all
Reference
PMID:9525886
  Authors
An S, Bleu T, Hallmark OG, Goetzl EJ
  Title
Characterization of a novel subtype of human G protein-coupled receptor for lysophosphatidic acid.
  Journal
J Biol Chem 273:7906-10 (1998)
DOI:10.1074/jbc.273.14.7906
  Sequence
[hsa:9170]
LinkDB

KEGG   ORTHOLOGY: K04294
Entry
K04294                      KO                                     

Name
LPAR3, EDG7
Definition
lysophosphatidic acid receptor 3
Pathway
ko04015  Rap1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04151  PI3K-Akt signaling pathway
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
   04072 Phospholipase D signaling pathway
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
   04151 PI3K-Akt signaling pathway
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Lipid
   Lysophosphatidic acid
    K04294  LPAR3, EDG7; lysophosphatidic acid receptor 3
Other DBs
GO: 0070915
Genes
HSA: 23566(LPAR3)
PTR: 736110(LPAR3)
PPS: 100975023(LPAR3)
GGO: 101142058(LPAR3)
PON: 100448001(LPAR3)
NLE: 100590490(LPAR3)
MCC: 710828(LPAR3)
MCF: 102142911(LPAR3)
CSAB: 103224524(LPAR3)
RRO: 104677501(LPAR3)
RBB: 108527700(LPAR3)
CJC: 100392576(LPAR3)
SBQ: 101044775(LPAR3)
MMU: 65086(Lpar3)
MCAL: 110291198(Lpar3)
MPAH: 110320673(Lpar3)
RNO: 66025(Lpar3)
MUN: 110558300(Lpar3)
CGE: 100759265(Lpar3)
NGI: 103728104(Lpar3)
HGL: 101716212(Lpar3)
CCAN: 109699400(Lpar3)
OCU: 100009484(LPAR3)
TUP: 102495978(LPAR3)
CFA: 490187(LPAR3)
VVP: 112924485(LPAR3)
AML: 100474288(LPAR3)
UMR: 103662965(LPAR3)
ORO: 101363176(LPAR3)
ELK: 111143684
FCA: 101097996(LPAR3)
PTG: 102968459(LPAR3)
PPAD: 109246190(LPAR3)
AJU: 106973342(LPAR3)
BTA: 532829(LPAR3)
BOM: 102268179(LPAR3)
BIU: 109556129(LPAR3)
BBUB: 102388933(LPAR3)
CHX: 102186820(LPAR3)
OAS: 101111138(LPAR3)
SSC: 100113360(LPAR3)
CFR: 102508154(LPAR3)
CDK: 105095047(LPAR3)
BACU: 103013128(LPAR3)
LVE: 103073033(LPAR3)
OOR: 101278115(LPAR3)
DLE: 111178371(LPAR3)
PCAD: 102995933(LPAR3)
ECB: 100052775(LPAR3)
EPZ: 103562992(LPAR3)
EAI: 106824051(LPAR3)
MYB: 102242469(LPAR3)
MYD: 102753374(LPAR3)
MNA: 107543205(LPAR3)
HAI: 109372903(LPAR3)
DRO: 112309315(LPAR3)
PALE: 102880785(LPAR3)
RAY: 107511577(LPAR3)
MJV: 108403785(LPAR3)
LAV: 100655832(LPAR3)
TMU: 101346095
MDO: 100012415(LPAR3)
SHR: 100915601(LPAR3)
PCW: 110209937(LPAR3)
OAA: 100079033(LPAR3)
GGA: 771215(LPAR3)
MGP: 100547842(LPAR3)
CJO: 107317576(LPAR3)
NMEL: 110391062(LPAR3)
APLA: 101793595(LPAR3)
ACYG: 106034114(LPAR3)
TGU: 100225154(LPAR3)
LSR: 110470419(LPAR3)
SCAN: 103814917(LPAR3)
GFR: 102041393(LPAR3)
FAB: 101808273(LPAR3)
PHI: 102111144(LPAR3)
PMAJ: 107208287(LPAR3)
CCAE: 111932850(LPAR3)
CCW: 104695306(LPAR3)
ETL: 114057094(LPAR3)
FPG: 101922607(LPAR3)
FCH: 102053547(LPAR3)
CLV: 102095525(LPAR3)
EGZ: 104122897(LPAR3)
NNI: 104015469(LPAR3)
ACUN: 113483118(LPAR3)
PADL: 103925143(LPAR3)
AAM: 106499684(LPAR3)
ASN: 102368731(LPAR3)
AMJ: 102559286(LPAR3)
PSS: 102451255(LPAR3)
CMY: 102944638(LPAR3)
CPIC: 101939177(LPAR3)
ACS: 100554366(lpar3)
PVT: 110079734(LPAR3)
PBI: 103060593(LPAR3)
PMUR: 107285247(LPAR3)
TSR: 106538543(LPAR3)
PMUA: 114598805(LPAR3)
GJA: 107117296(LPAR3)
XLA: 108714179(lpar3.L) 108715493(lpar3.S)
XTR: 100494791(lpar3)
NPR: 108791384(LPAR3)
DRE: 102216338(lpar3)
SRX: 107715712 107741531(lpar3)
IPU: 108271040
PHYP: 113532147(lpar3)
AMEX: 103032282(lpar3)
EEE: 113586108(lpar3)
TRU: 101073172(lpar3)
LCO: 104931932(lpar3)
NCC: 104954258(lpar3)
MZE: 101478332(lpar3)
ONL: 100698163(lpar3)
OLA: 101172645(lpar3)
XMA: 102221110(lpar3)
XCO: 114151282(lpar3)
PRET: 103464145(lpar3)
CVG: 107087234(lpar3)
NFU: 107392693(lpar3)
KMR: 108230661(lpar3)
ALIM: 106511447(lpar3)
AOCE: 111586262(lpar3)
CSEM: 103393145
POV: 109625857(lpar3)
LCF: 108881288(lpar3)
SDU: 111227715(lpar3)
SLAL: 111650243(lpar3)
HCQ: 109522048(lpar3)
BPEC: 110160088(lpar3)
MALB: 109958221(lpar3)
SASA: 106613437(lpar3)
SALP: 111963165(lpar3)
ELS: 114839650(lpar3)
SFM: 108923470(lpar3) 108935081
LCM: 102355524 102362131(LPAR3)
CMK: 103174698(lpar3) 103180702
RTP: 109924871
CIN: 100186784
EPA: 110240338
SPIS: 111329595
 » show all
Reference
  Authors
Bandoh K, Aoki J, Hosono H, Kobayashi S, Kobayashi T, Murakami-Murofushi K, Tsujimoto M, Arai H, Inoue K
  Title
Molecular cloning and characterization of a novel human G-protein-coupled receptor, EDG7, for lysophosphatidic acid.
  Journal
J Biol Chem 274:27776-85 (1999)
DOI:10.1074/jbc.274.39.27776
  Sequence
[hsa:23566]
LinkDB

KEGG   ORTHOLOGY: K04275
Entry
K04275                      KO                                     

Name
LPAR4, GPR23
Definition
lysophosphatidic acid receptor 4
Pathway
ko04015  Rap1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04151  PI3K-Akt signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05130  Pathogenic Escherichia coli infection
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
   04072 Phospholipase D signaling pathway
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
   04151 PI3K-Akt signaling pathway
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Lipid
   Lysophosphatidic acid
    K04275  LPAR4, GPR23; lysophosphatidic acid receptor 4
Other DBs
GO: 0070915
TC: 9.A.14.13.9
Genes
HSA: 2846(LPAR4)
PTR: 465729(LPAR4)
PPS: 100989638(LPAR4)
GGO: 101150616(LPAR4)
PON: 100459511(LPAR4)
NLE: 100588179(LPAR4)
MCC: 707170(LPAR4)
MCF: 101864899(LPAR4)
CSAB: 103232244(LPAR4)
RRO: 104654349(LPAR4)
RBB: 108529808(LPAR4)
CJC: 100395819(LPAR4)
SBQ: 101044548(LPAR4)
MMU: 78134(Lpar4)
MCAL: 110287196(Lpar4)
MPAH: 110313491(Lpar4)
RNO: 302378(Lpar4)
MUN: 110541171(Lpar4)
CGE: 100752179(Lpar4)
NGI: 103737817(Lpar4)
OCU: 100344512(LPAR4)
TUP: 102500888(LPAR4)
CFA: 491978(LPAR4)
VVP: 112909196(LPAR4)
AML: 100477865(LPAR4)
UMR: 103675824(LPAR4)
UAH: 113242104(LPAR4)
ORO: 101363180(LPAR4)
ELK: 111160942
FCA: 101087973(LPAR4)
PTG: 102962731(LPAR4)
PPAD: 109260287(LPAR4)
AJU: 106987200(LPAR4)
BTA: 539738(LPAR4)
BOM: 102277938(LPAR4)
BBUB: 102411978(LPAR4)
CHX: 102184511(LPAR4)
OAS: 101118506(LPAR4)
SSC: 100038017(LPAR4)
CFR: 102505523(LPAR4)
CDK: 105090092(LPAR4)
BACU: 103017315
LVE: 103078023(LPAR4)
OOR: 101276625(LPAR4)
DLE: 111178180(LPAR4)
PCAD: 102976773(LPAR4)
ECB: 100071749(LPAR4)
EPZ: 103561874(LPAR4)
EAI: 106827637(LPAR4)
MYB: 102246973(LPAR4)
MYD: 102762209(LPAR4)
MNA: 107537244(LPAR4)
HAI: 109385677(LPAR4)
DRO: 112317954(LPAR4)
PALE: 102881134(LPAR4)
RAY: 107500228(LPAR4)
LAV: 100656506(LPAR4)
TMU: 101346400
MDO: 100020275(LPAR4)
SHR: 100914083(LPAR4)
PCW: 110193052(LPAR4)
OAA: 114812808(LPAR4)
GGA: 422149(LPAR4)
MGP: 100539306(LPAR4)
CJO: 107312621(LPAR4)
NMEL: 110403160(LPAR4)
ACYG: 106042983(LPAR4)
TGU: 100226504(LPAR4)
LSR: 110474370(LPAR4)
SCAN: 103816438(LPAR4)
GFR: 102036590(LPAR4)
FAB: 101818510(LPAR4)
PHI: 102099403(LPAR4)
PMAJ: 107203848(LPAR4)
CCAE: 111928583(LPAR4)
CCW: 104691290(LPAR4)
ETL: 114065169(LPAR4)
FPG: 101916616(LPAR4)
FCH: 102058845(LPAR4)
CLV: 102084800(LPAR4)
EGZ: 104135969(LPAR4)
NNI: 104012845(LPAR4)
ACUN: 113479996(LPAR4)
PADL: 103919177(LPAR4)
AAM: 106482083(LPAR4)
ASN: 102377038(LPAR4)
AMJ: 102566056(LPAR4)
PSS: 102445780(LPAR4)
CMY: 102946452(LPAR4)
CPIC: 101944244(LPAR4)
ACS: 100556160 100562456(lpar4)
PVT: 110086630(LPAR4)
PBI: 103065158(LPAR4) 103067277(HCAR1)
PMUR: 107289964(LPAR4) 107296113
TSR: 106549815(LPAR4) 106553862
PMUA: 114589214(LPAR4) 114599968
GJA: 107121365(LPAR4) 107125005
XLA: 108700165(lpar4.S) 779407(lpar4.L)
XTR: 780308(lpar4)
NPR: 108795346(LPAR4)
DRE: 794698(lpar4)
IPU: 108268431(lpar4)
PHYP: 113542682(lpar4)
AMEX: 103042068
EEE: 113570362 113574177(lpar4)
LCO: 104920594(lpar4)
NCC: 104946178(lpar4)
MZE: 101469114 101482060(lpar4)
XCO: 114139701
NFU: 107375389
KMR: 108237951
ALIM: 106518132(lpar4)
AOCE: 111562742 111569862(lpar4)
CSEM: 103391316(lpar4)
POV: 109630081(lpar4) 109634450
LCF: 108882745(lpar4)
SDU: 111226560(lpar4)
SLAL: 111668872
HCQ: 109524498(lpar4)
BPEC: 110153794(lpar4)
MALB: 109957477(lpar4)
ELS: 105007557(lpar4)
SFM: 108922905 108925231(lpar4)
LCM: 102353655(LPAR4)
CMK: 103176311 103177830(lpar4)
RTP: 109912325(lpar4) 109927492
MYI: 110442869
DGT: 114517624
 » show all
Reference
  Authors
Noguchi K, Ishii S, Shimizu T
  Title
Identification of p2y9/GPR23 as a novel G protein-coupled receptor for lysophosphatidic acid, structurally distant from the Edg family.
  Journal
J Biol Chem 278:25600-6 (2003)
DOI:10.1074/jbc.M302648200
  Sequence
[hsa:2846]
LinkDB

KEGG   ORTHOLOGY: K08390
Entry
K08390                      KO                                     

Name
LPAR5, GPR92
Definition
lysophosphatidic acid receptor 5
Pathway
ko04015  Rap1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05130  Pathogenic Escherichia coli infection
ko05200  Pathways in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
   04072 Phospholipase D signaling pathway
    K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
   04151 PI3K-Akt signaling pathway
    K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Lipid
   Lysophosphatidic acid
    K08390  LPAR5, GPR92; lysophosphatidic acid receptor 5
Genes
HSA: 57121(LPAR5)
PTR: 747759(LPAR5)
PPS: 100974345(LPAR5)
GGO: 101126364(LPAR5)
PON: 100444153(LPAR5)
NLE: 100586980(LPAR5)
MCC: 713283(LPAR5)
MCF: 102146767(LPAR5)
CSAB: 103218464(LPAR5)
RRO: 104680109(LPAR5)
RBB: 108542054(LPAR5)
CJC: 100413340(LPAR5)
SBQ: 101037682(LPAR5)
MMU: 381810(Lpar5)
MCAL: 110297038(Lpar5)
MPAH: 110317128(Lpar5)
RNO: 500317(Lpar5)
MUN: 110548577(Lpar5)
CGE: 100765885(Lpar5)
NGI: 103727518(Lpar5)
HGL: 101716148(Lpar5)
CCAN: 109682765(Lpar5)
OCU: 100347657(LPAR5)
TUP: 102491630(LPAR5)
CFA: 486724(LPAR5)
VVP: 112917350(LPAR5)
AML: 100477983(LPAR5)
UAH: 113257973(LPAR5)
ORO: 101377363(LPAR5)
ELK: 111159825
FCA: 102899848(LPAR5)
PPAD: 109276125(LPAR5)
AJU: 106965444(LPAR5)
BTA: 507598(LPAR5)
BOM: 102276877(LPAR5)
BIU: 109558930(LPAR5)
BBUB: 102407059(LPAR5)
CHX: 102189196(LPAR5)
OAS: 101109610(LPAR5)
SSC: 102161415(LPAR5)
CFR: 102524474(LPAR5)
CDK: 105098214(LPAR5)
BACU: 103015627(LPAR5)
LVE: 103071546(LPAR5)
OOR: 101281432(LPAR5)
PCAD: 102981443(LPAR5)
ECB: 100147585(LPAR5)
EPZ: 103547006(LPAR5)
EAI: 106847340(LPAR5)
MYB: 102250139(LPAR5)
MYD: 102756094(LPAR5)
MNA: 107544026(LPAR5)
HAI: 109373640(LPAR5)
DRO: 112321636(LPAR5)
PALE: 102892521(LPAR5)
RAY: 107519844(LPAR5)
MJV: 108387620(LPAR5)
LAV: 100674432(LPAR5)
TMU: 101343136
MDO: 100015472(LPAR5)
SHR: 100922143(LPAR5)
PCW: 110213879(LPAR5)
OAA: 114807801(LPAR5)
GGA: 418279(LPAR5)
MGP: 100547557(LPAR5)
CJO: 107318862(LPAR5)
NMEL: 110398598(LPAR5)
APLA: 101804147(LPAR5)
ACYG: 106047848(LPAR5)
TGU: 100229694(LPAR5)
LSR: 110480807(LPAR5)
SCAN: 103827152(LPAR5)
GFR: 102041046(LPAR5)
FAB: 101812796(LPAR5)
PHI: 102113993(LPAR5)
PMAJ: 107212790(LPAR5)
CCAE: 111938362(LPAR5)
CCW: 104687119(LPAR5)
ETL: 114058191(LPAR5)
FPG: 101917980(LPAR5)
FCH: 102057164(LPAR5)
CLV: 102090478(LPAR5)
EGZ: 104126530(LPAR5)
NNI: 104009404(LPAR5)
ACUN: 113486812(LPAR5)
PADL: 103922014(LPAR5)
AAM: 106497200(LPAR5)
ASN: 102383882(LPAR5)
AMJ: 102573900(LPAR5)
PSS: 102456044(LPAR5)
CMY: 102947899(LPAR5)
CPIC: 101935808(LPAR5)
ACS: 100566703(lpar5)
PVT: 110084627(LPAR5)
PBI: 103048306(LPAR5)
PMUR: 107285764(LPAR5)
TSR: 106548359(LPAR5)
PMUA: 114588139(LPAR5)
GJA: 107118407(LPAR5)
XLA: 108696063(lpar5.L) 108697350(lpar5.S)
XTR: 100216171(lpar5)
NPR: 108784390(LPAR5)
OTW: 112260400
LCM: 102346747(LPAR5)
RTP: 109925950(lpar5)
 » show all
Reference
  Authors
Hu J, Oda SK, Shotts K, Donovan EE, Strauch P, Pujanauski LM, Victorino F, Al-Shami A, Fujiwara Y, Tigyi G, Oravecz T, Pelanda R, Torres RM
  Title
Lysophosphatidic acid receptor 5 inhibits B cell antigen receptor signaling and antibody response.
  Journal
J Immunol 193:85-95 (2014)
DOI:10.4049/jimmunol.1300429
  Sequence
[mmu:381810]
LinkDB

KEGG   ORTHOLOGY: K04273
Entry
K04273                      KO                                     

Name
LPAR6, P2RY5
Definition
lysophosphatidic acid receptor 6
Pathway
ko04072  Phospholipase D signaling pathway
ko04080  Neuroactive ligand-receptor interaction
ko04151  PI3K-Akt signaling pathway
ko05200  Pathways in cancer
Disease
H00667  Woolly hair
H00784  Localized autosomal recessive hypotrichosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
   04151 PI3K-Akt signaling pathway
    K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
G protein-coupled receptors [BR:ko04030]
 Rhodopsin family
  Lipid
   Lysophosphatidic acid
    K04273  LPAR6, P2RY5; lysophosphatidic acid receptor 6
Other DBs
GO: 0070915
Genes
HSA: 10161(LPAR6)
PTR: 741241(LPAR6)
PPS: 100974511(LPAR6)
GGO: 101132139(LPAR6)
PON: 100432438(LPAR6)
NLE: 100588296(LPAR6)
MCC: 705081(LPAR6)
MCF: 102145478(LPAR6)
CSAB: 103214404(LPAR6)
RRO: 104662759(LPAR6)
RBB: 108530743(LPAR6)
CJC: 100398639(LPAR6)
SBQ: 101038623(LPAR6)
MMU: 67168(Lpar6)
MCAL: 110309180(Lpar6)
MPAH: 110325234(Lpar6)
RNO: 691774(Lpar6)
MUN: 110553593(Lpar6)
CGE: 100750873(Lpar6)
NGI: 103726741(Lpar6)
HGL: 101703338(Lpar6)
CCAN: 109691097(Lpar6)
OCU: 103352130(LPAR6)
TUP: 102494278(LPAR6)
CFA: 100856069(LPAR6)
VVP: 112933949(LPAR6)
AML: 100475559(LPAR6)
UMR: 103677601(LPAR6)
UAH: 113251326(LPAR6)
ORO: 101386667(LPAR6)
ELK: 111146912
FCA: 101095629(LPAR6)
PTG: 102965799(LPAR6)
PPAD: 109265953(LPAR6)
AJU: 106971998(LPAR6)
BTA: 782518(LPAR6)
BOM: 102285753(LPAR6)
BIU: 109566714(LPAR6)
BBUB: 102399806(LPAR6)
CHX: 102183611(LPAR6)
OAS: 101114118(LPAR6)
SSC: 100738399(LPAR6)
CFR: 102516623(LPAR6)
CDK: 105101802(LPAR6)
BACU: 103013481(LPAR6)
LVE: 103071883(LPAR6)
OOR: 101273284(LPAR6)
DLE: 111175320(LPAR6)
PCAD: 102994918(LPAR6)
ECB: 100629781(LPAR6)
EPZ: 103549434(LPAR6)
EAI: 106829683(LPAR6)
MYB: 102251488(LPAR6)
MYD: 102765968(LPAR6)
MNA: 107531401(LPAR6)
HAI: 109387139(LPAR6)
DRO: 112313055(LPAR6)
PALE: 102892775(LPAR6)
RAY: 107520928(LPAR6)
MJV: 108384784(LPAR6)
LAV: 100669291(LPAR6)
TMU: 101356213
MDO: 103102093(LPAR6)
SHR: 105749898(LPAR6)
PCW: 110213449(LPAR6)
OAA: 103170464(LPAR6)
GGA: 396118(LPAR6)
MGP: 100541942(PUSL1) 100548273(LPAR6) 116216169
CJO: 107308153(LPAR6) 107323273
NMEL: 110387731(LPAR6) 110408725
APLA: 101792915(LPAR6) 101794174
ACYG: 106035041(LPAR6) 106044634
TGU: 101233928(LPAR6)
LSR: 110469559(LPAR6)
SCAN: 103827407(LPAR6)
GFR: 102042956(LPAR6)
FAB: 101810970(LPAR6)
PHI: 102104985(LPAR6)
PMAJ: 107203091(LPAR6)
CCAE: 111939055(LPAR6)
CCW: 104689971(LPAR6) 104693316
ETL: 114060930(LPAR6) 114071275
FPG: 101912931(LPAR6) 101922080
FCH: 102049640 102051394(LPAR6)
CLV: 102086710(LPAR6) 102097365(PUSL1)
EGZ: 104131601(LPAR6) 104133372
NNI: 104009057 104010902(LPAR6)
ACUN: 113486889(LPAR6) 113487787
PADL: 103913464(LPAR6) 103917946
AAM: 106489230(LPAR6) 106495565
CMY: 102932175 102933729(LPAR6)
ACS: 100553477 103279739(lpar6)
PVT: 110073288
PMUR: 107284300(LPAR6) 107287530
TSR: 106543704(LPAR6) 106547704
PMUA: 114582719(LPAR6) 114595052 114602514(PUSL1)
XLA: 100036865(LOC100497020.L) 101243551(lpar6.L) 108703519 108709805(lpar6.S) 108711753
DRE: 101884764(lpar6b) 110437788 571773(lpar6a)
RTP: 109922608 109937909(lpar6)
SOC: 105203641
AEC: 105143286
ACEP: 105625488
LHU: 105678724
OBO: 105278269
EPA: 110243809
PDAM: 113683977
HMG: 101236394
 » show all
Reference
  Authors
Pasternack SM, von Kugelgen I, Aboud KA, Lee YA, Ruschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nurnberg P, Nothen MM, Betz RC
  Title
G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth.
  Journal
Nat Genet 40:329-34 (2008)
DOI:10.1038/ng.84
  Sequence
[hsa:10161]
LinkDB

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