KEGG ORTHOLOGY: K03945

ORTHOLOGY: K03945

Entry

K03945                      KO

Symbol

NDUFA1

Name

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1

Pathway

map00190

Oxidative phosphorylation

map01100

Metabolic pathways

map04714

Thermogenesis

map04723

Retrograde endocannabinoid signaling

map04932

Non-alcoholic fatty liver disease

map05010

Alzheimer disease

map05012

Parkinson disease

map05014

Amyotrophic lateral sclerosis

map05016

Huntington disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05208

Chemical carcinogenesis - reactive oxygen species

map05415

Diabetic cardiomyopathy

Module

M00146

NADH dehydrogenase (ubiquinone) 1 alpha subcomplex

Disease

H00473

Mitochondrial complex I deficiency

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09102 Energy metabolism
   00190 Oxidative phosphorylation
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
09150 Organismal Systems
  09156 Nervous system
   04723 Retrograde endocannabinoid signaling
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
  09159 Environmental adaptation
   04714 Thermogenesis
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
   05012 Parkinson disease
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
   05014 Amyotrophic lateral sclerosis
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
   05016 Huntington disease
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
   05020 Prion disease
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
   05022 Pathways of neurodegeneration - multiple diseases
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K03945  NDUFA1; NADH dehydrogenase (ubiquinone) 1 alpha subcomplex subunit 1

Other DBs

TC:

3.D.1.6

Genes

HSA:	4694(NDUFA1)

PTR:	100608263(NDUFA1)

PPS:	100983914(NDUFA1)

GGO:	101144612(NDUFA1)

PON:	100173751(NDUFA1)

NLE:	115833278(NDUFA1)

HMH:	116811998(NDUFA1)

MCC:	694635(NDUFA1)

MCF:	102122243 102144790(NDUFA1)

MTHB:

126932207 126941467 126946139

MNI:	105468400(NDUFA1)

CSAB:

103247345(NDUFA1)

PANU:

101007924(NDUFA1)

TGE:	112615542(NDUFA1)

MLEU:

105537526(NDUFA1)

RRO:	104668090 115898726(NDUFA1)

RBB:	108526355 108536327

TFN:	117077312(NDUFA1) 117089611

PTEH:

111550654 113222333(NDUFA1)

CANG:

105513232(NDUFA1)

CJC:	100389053(NDUFA1) 108591917 108593294 118153983 128929002

SBQ:	101053450(NDUFA1)

CIMI:

108291046(NDUFA1) 108296115 108298418 108303153 108310744

CSYR:

103276211(NDUFA1) 110596544

MMUR:

105879883 109729268 109730235(NDUFA1) 109731114

LCAT:

123628789(NDUFA1) 123642737 123646445

PCOQ:

105826272(NDUFA1)

OGA:	111722776 111723421 111724308 111725086 111727526(NDUFA1)

MMU:	54405(Ndufa1)

MCAL:

110288945(Ndufa1)

MPAH:

110313685(Ndufa1)

RNO:	363441(Ndufa1)

MCOC:

116077484(Ndufa1)

ANU:	117695530(Ndufa1)

MUN:	110548267 110560771 110563820(Ndufa1)

CGE:	100689328(Ndufa1)

MAUA:

101823499(Ndufa1)

PLEU:

114702631 114705437(Ndufa1)

MORG:

121441690 121444726

MFOT:

126488457

AAMP:

119804764(Ndufa1)

NGI:	103742966(Ndufa1)

HGL:	106010407(Ndufa1)

CPOC:

100715717(Ndufa1)

CCAN:

109682051(Ndufa1)

DORD:

105988285(Ndufa1)

DSP:	122108040 122128220(Ndufa1)

PLOP:

125343518(Ndufa1) 125355778 125355998

NCAR:

124962734 124971899 124980697

MMMA:

107146270 107152995(Ndufa1)

OPI:	101525197(NDUFA1)

TUP:	102473868 102491460(NDUFA1) 102500068 102500778 102502899 106733410

GVR:	103605455(NDUFA1)

CFA:	102154025 102154035(NDUFA1) 106557778 481033

CLUD:

112649282(NDUFA1) 112655613 112663986 112669712

VVP:	112910581(NDUFA1) 112930992

VLG:	121483574(NDUFA1) 121493526

NPO:	129509004 129518265(NDUFA1)

AML:	100479846(NDUFA1) 117801911

UMR:	103657024 103668224 103671508 103677743(NDUFA1) 121102487

UAH:	113241285(NDUFA1) 113251926

UAR:	123785620(NDUFA1) 123787661 123794646 123795955 123798818 123799762

ELK:

111157253

LLV:	125091362 125108496

MPUF:

101683103(NDUFA1)

MNP:	132007310(NDUFA1) 132022144 132022717

MLK:	131808139 131808426 131821701(NDUFA1)

NVS:	122897149(NDUFA1) 122915592

ORO:	101365928(NDUFA1) 101369899 101385824

EJU:	114197002(NDUFA1) 114207684 114225274

ZCA:	113908037 113909655 113914078 113917199 113917862 113918892 113920583 113920690 113922818 113929533 113931401(NDUFA1) 113934784 113937435 118356633 118356882

MLX:	117999192 118005005 118006077 118006627 118012420(NDUFA1) 118024594

NSU:	110571899 110572549 110576912(NDUFA1) 110582412 110584754 110592684

LWW:

102729606

FCA:	101085348 101085609(NDUFA1)

PYU:	121013658 121025390(NDUFA1)

PCOO:

112859395 112871256(NDUFA1)

PBG:	122476829(NDUFA1) 122479923 122495644

PVIV:

125150789 125157826(NDUFA1)

LRUF:

124510032 124513969

PTG:	102950382 102960858 102964097(NDUFA1)

PPAD:

109250759(NDUFA1)

PUC:

125932271

AJU:	106985705 113594233

HHV:	120222145(NDUFA1) 120228004 120238465 120245638

BTA:	101904690 327673(NDUFA1)

BOM:	102279499(NDUFA1) 102287341

BIU:	109556362(NDUFA1)

BBUB:

102393322(NDUFA1) 102397866 102399339 102403959

BBIS:

104994319(NDUFA1) 105005064

CHX:	102177419(NDUFA1)

OAS:	100216464(NDUFA1) 114113123 121815982

ODA:	120869008 120881459(NDUFA1)

CCAD:

122434193 122435278(NDUFA1) 122446206

SSC:	100515069(NDUFA1)

CFR:	116662114(NDUFA1)

CDK:	116150922(NDUFA1)

VPC:	116277276(NDUFA1)

BMUS:

118881812 118888446(NDUFA1) 118897264 118899930

LVE:

103091475

OOR:

117202624

PSIU:

116748141(NDUFA1) 116749003 116758484

NASI:

112404044(NDUFA1)

ECB:	100058835(NDUFA1)

EPZ:	103542030(NDUFA1)

EAI:	106845129(NDUFA1)

MYB:	102251359(NDUFA1) 102260520

MYD:	102754499(NDUFA1)

MMYO:

118653714 118653841(NDUFA1) 118658680

MLF:	102418704(NDUFA1)

PKL:	118722188(NDUFA1) 118729080

EFUS:

103303948(NDUFA1) 129150910 129151877

MNA:	107544459(NDUFA1)

DRO:	112303408 112310507(NDUFA1)

SHON:

118974657 119003015(NDUFA1)

AJM:	119060097(NDUFA1)

PDIC:

114505128(NDUFA1)

PHAS:

123805221(NDUFA1)

MMF:	118636240(NDUFA1)

PPAM:

129076111(NDUFA1)

HAI:	109396222(NDUFA1)

RFQ:	117013892 117020414(NDUFA1)

PALE:

102892221(NDUFA1)

PVP:	105305558(NDUFA1)

MJV:	108386549(NDUFA1)

TOD:	119246549(NDUFA1)

SETR:

125996596 125999564(NDUFA1) 126011490

LAV:	111751867(NDUFA1)

TMU:	111821167 111821539

ETF:	115871646(NDUFA1)

DNM:	111766325(NDUFA1)

MDO:	103100668(NDUFA1)

GAS:	123253370(NDUFA1) 123255009

SHR:	100933088(NDUFA1)

AFZ:	127542527 127552431

PCW:	110196432 110200038(NDUFA1)

OAA:	100078945(NDUFA1)

GGA:	772150(NDUFA1)

PCOC:

116234887(NDUFA1)

MGP:	100543163(NDUFA1)

CJO:	107312913(NDUFA1)

TPAI:

128075831(NDUFA1)

LMUT:

125699840(NDUFA1)

NMEL:

110403184(NDUFA1)

ACYG:

106037647(NDUFA1)

CATA:

118245276(NDUFA1)

AFUL:

116494419(NDUFA1)

TGU:	100227546(NDUFA1)

LSR:	110480438(NDUFA1)

SCAN:

103816398(NDUFA1)

PMOA:

120506186(NDUFA1)

OTC:	121331734(NDUFA1)

PRUF:

121363060(NDUFA1)

GFR:	102039347(NDUFA1)

OMA:	130253147(NDUFA1)

PHI:	102112253(NDUFA1)

PMAJ:

107204009(NDUFA1)

CCAE:

111928660(NDUFA1)

CCW:	120412036(NDUFA1)

CBRC:

103621669(NDUFA1)

ETL:	114064966(NDUFA1)

ZAB:	102070586(NDUFA1)

SVG:	106859405(NDUFA1)

MMEA:

130573296(NDUFA1)

HRT:	120764884(NDUFA1)

FCH:	102053450(NDUFA1)

CLV:	102091183(NDUFA1)

NNI:	104021393(NDUFA1)

PLET:

104623975(NDUFA1)

ACHC:

115333808(NDUFA1)

HLE:	104832667(NDUFA1)

AGEN:

126050231

GCL:

127019705

CCRI:

104164941(NDUFA1)

CMAC:

104476192(NDUFA1)

MUI:	104545355(NDUFA1)

FGA:	104077881(NDUFA1)

LDI:	104342649(NDUFA1)

NNT:	104411214(NDUFA1)

SHAB:

115613341(NDUFA1)

DPUB:

104301189(NDUFA1)

CPEA:

104388362(NDUFA1)

RTD:	128914499(NDUFA1)

CUCA:

104064032(NDUFA1)

BRHI:

104494693(NDUFA1)

NPD:	112947088(NDUFA1)

DNE:	112997194(NDUFA1)

AMJ:	102564782(NDUFA1)

CPOO:

109313585(NDUFA1)

GGN:	109300780(NDUFA1)

PSS:	102454034(NDUFA1)

CMY:

102930727

CCAY:

125624611 125642191(NDUFA1)

DCC:	119845487 119861131(NDUFA1)

CPIC:

101944836(NDUFA1)

TST:	117882672(NDUFA1)

CABI:

116817187(NDUFA1)

MRV:	120371799(NDUFA1)

ACS:	100558312(ndufa1)

ASAO:

132762848(NDUFA1)

PVT:	110090266(NDUFA1)

SUND:

121936219(NDUFA1)

PBI:	103052933(NDUFA1)

VKO:	123022116(NDUFA1)

PMUA:

114587333 114589076(NDUFA1)

PRAF:

128404693 128406864(NDUFA1) 128412322

ZVI:	118084498(NDUFA1) 118090292 118097549

HCG:	128335551(NDUFA1)

GJA:	107123735(NDUFA1)

STOW:

125436232 125442600(NDUFA1)

EMC:	129341295(NDUFA1)

XLA:	108698442(ndufa1.L) 108700140(ndufa1.S)

XTR:	100135137(ndufa1)

NPR:	108799962(NDUFA1)

RTEM:

120913701(NDUFA1) 120928534

BBUF:

120977376(NDUFA1)

BGAR:

122946032(NDUFA1)

MUO:	115474698(NDUFA1)

GSH:	117360918(NDUFA1)

DRE:	415243(ndufa1)

SRX:	107744539 107752088

SANH:

107658147 107664341

SGH:	107550767 107561495

CCAR:

109102961 109108779

CAUA:

113057882 113058154 113113932

CGIB:

127971979 128027212

PTET:

122357718(ndufa1)

LROH:

127176244(ndufa1)

OMC:	131553548(ndufa1)

PPRM:

120474416(ndufa1)

RKG:	130072986(ndufa1)

MAMB:

125258894(ndufa1)

CIDE:

127494627

MASI:

127417716

TROS:

130563719(ndufa1)

TDW:	130438079(ndufa1)

MANU:

129422741(ndufa1)

IPU:

108269237

IFU:	128611836(ndufa1)

PHYP:

113528929(ndufa1)

SMEO:

124386374(ndufa1)

TFD:	113636086(ndufa1)

TVC:	132856384(ndufa1)

AMEX:

103045774(ndufa1)

CMAO:

118807162(ndufa1)

EEE:	113582665(ndufa1)

CHAR:

105913093(ndufa1)

TRU:	101079005(ndufa1)

TFS:	130531426(ndufa1)

TNG:	GSTEN00029314G001

NCC:	104965904(ndufa1)

TBEN:

117489091(ndufa1)

CGOB:

115014967(ndufa1)

PGEO:

117454125(ndufa1)

GACU:

117543492(ndufa1)

EMAC:

134859540(ndufa1)

ELY:	117260727(ndufa1)

EFO:	125894604(ndufa1)

SLUC:

116052293(ndufa1)

ECRA:

117951754(ndufa1)

ESP:	116696761(ndufa1)

PFLV:

114562662(ndufa1)

GAT:	120817292(ndufa1)

PPUG:

119211594(ndufa1)

AFB:	129090073(ndufa1)

CLUM:

117738005(ndufa1)

PSWI:

130209548(ndufa1)

MSAM:

119888751(ndufa1)

SCHU:

122880112(ndufa1)

CUD:	121516522(ndufa1)

ALAT:

119007804(ndufa1)

MZE:	101485144(ndufa1)

ONL:	100692526(ndufa1)

OAU:	116317574(ndufa1)

OLA:	101160172(ndufa1)

OML:	112153404(ndufa1)

CSAI:

133447175(ndufa1)

XMA:	102217006(ndufa1)

XCO:	114138883(ndufa1)

XHE:	116714151(ndufa1)

PRET:

103471547(ndufa1)

PFOR:

103133038 103150198

PLAI:

106940250 106945471(ndufa1)

PMEI:

106915310(ndufa1)

GAF:	122837488(ndufa1)

PPRL:

129360759 129360761

CVG:	107093301(ndufa1)

CTUL:

119786298(ndufa1)

GMU:	124860114(ndufa1)

NFU:	107378079(ndufa1)

KMR:	108231275(ndufa1)

ALIM:

106514641(ndufa1)

NWH:	119408862(ndufa1)

AOCE:

111570116(ndufa1)

CSEM:

103390559(ndufa1)

POV:	109624375(ndufa1)

SSEN:

122778567(ndufa1)

HHIP:

117769179(ndufa1)

HSP:	118112571(ndufa1)

SMAU:

118319138(ndufa1)

LCF:	108879924 108895399(ndufa1)

SDU:	111232658(ndufa1)

SLAL:

111648191(ndufa1)

XGL:	120785380(ndufa1)

HCQ:	109518710(ndufa1)

SSCV:

125989887

SBIA:

133508894(ndufa1)

PEE:	133407572(ndufa1)

PTAO:

133484685(ndufa1)

BPEC:

110159004(ndufa1)

MALB:

109955818(ndufa1)

BSPL:

114863900(ndufa1)

SJO:	128363047(ndufa1)

SASA:

106604444(ndua1) 106611562(NDUA1)

STRU:

115170022(ndufa1) 115205062

OTW:	112220656(ndufa1)

OMY:	100301838(ndufa1)

OGO:	123993544(ndufa1)

ONE:	115130856(ndufa1)

OKI:	109910239(ndufa1)

OKE:	118380283(ndufa1)

SALP:

111965874(ndufa1) 111967622

SNH:	120048009 120061973

CCLU:

121537243 121540348(ndufa1)

ELS:	105025504(ndufa1)

SFM:	108923206(ndufa1)

PKI:	111835070(ndufa1)

AANG:

118222591(ndufa1)

LOC:	102696258(ndufa1)

PSPA:

121307592 121317918

ARUT:

117412640 117430935

PSEX:

120537275(ndufa1)

LCM:	102366199(NDUFA1)

CMK:	103178436(ndufa1)

RTP:	109925916(ndufa1)

CPLA:

122557404(ndufa1)

HOC:	132820116(ndufa1)

LERI:

129702326 129703694

PMRN:

116944597(NDUFA1)

LRJ:	133341324(NDUFA1)

BBEL:

109463860

DME:	Dmel_CG34439(ND-MWFE)

DER:

26526085

DSE:

116800491

DSI:	Dsimw501_GD29026(Dsim_GD29026)

DYA:	Dyak_GE29044

DAN:

DSR:

DPO:

DPE:

DMN:	108158974 117189443

DWI:

26528843

DMO:	Dmoj_GI19985

DAZ:

DHE:

DVI:

CCAT:

BOD:

BDR:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ014797

CPII:

CNS:

BCOO:

FVI:

OBB:

SOC:

MPHA:

HST:

DQU:

OBO:

NVI:

TPRE:

LBD:

MDL:

FAS:

DAM:

CINS:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	100142126 656487

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

NVL:	108557158 108568238

APLN:

OTU:

BMOR:

BMAN:

DPL:	KGM_202942

MJU:	123867711 123870621

NIQ:

PXU:

ZCE:

CCRC:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

HHAL:

NLU:

HVI:

ZNE:

CSEC:

SGRE:

IEL:

DPX:	DAPPUDRAFT_322524

PCLA:

HAZT:

PPOI:

DSV:

RSAN:

RMP:

PMEO:

CEL:	CELE_F31D4.9(ndua-1)

CRQ:	GCK72_021960

BMY:	BM_BM3728(Bm3728)

LOA:	LOAG_12302

TSP:

GAE:

RPHI:

ATH:

ALY:

CRB:

CSAT:

104743472 104745012 104764549

EUS:	EUTSA_v10021979mg

BRP:	103848838 103859337 103870609

BNA:	106353008 106397172 106427973 106439242 106452849 125580420

BOE:	106324825 106332522

THJ:	104816152 104820511

CPAP:

CIT:

PVY:

MINC:

TCC:

GRA:

GHI:

GAB:

HSYR:

DZI:	111280092 111287444 111307595

EGR:

120290058

GMX:	100500566 100816948

GSJ:	114394965 114425292

PVU:	PHAVU_008G079100g

VRA:

106758834

VAR:	108321315 108321316

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:	Lj3g3v0461220.1(Lj3g3v0461220.1)

ADU:

107485404

AIP:

107639739

AHF:	112743889 112797260

PCIN:

129291365 129300164

QSA:	O6P43_016438 O6P43_020552

FVE:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:	110661518 110667716

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

QSU:

QLO:

TWL:	119994284 120011836

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107779548 107797538

NSY:

NTO:

NAU:

SIND:

OEU:	111374774 111381799 111384754 111398619

EGT:

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

DCR:

CSIN:

RVL:

AEW:

BVG:

CQI:

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os05t0481600-01(Os05g0481600)

BDI:

100844878

ATS:

109743427

TDC:	119284082 119348710

TAES:

123060260 123137180 123182384

LPER:

LRD:

SBI:

ZMA:

PVIR:

PHAI:

PDA:	103702165 103705921

EGU:

105046022

MUS:

103992501

ZOF:	121971693 122030375

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

CSL:	COCSUDRAFT_53289

CVR:	CHLNCDRAFT_139713

OLU:	OSTLU_31430

OTA:	OT_ostta04g05090

BPG:	Bathy08g04730

MIS:	MICPUN_108714

MPP:	MICPUCDRAFT_59145(JGI:MicpuC2_59145)

CME:	CYME_CMK135C

DPP:	DICPUDRAFT_154324

DFA:

DFA_10874

» show all

Reference

PMID:8938439

Authors

Zhuchenko O, Wehnert M, Bailey J, Sun ZS, Lee CC

Title

Isolation, mapping, and genomic structure of an X-linked gene for a subunit of human mitochondrial complex I.

Journal

Genomics 37:281-8 (1996)
DOI:10.1006/geno.1996.0561

Sequence

[hsa:4694]

LinkDB

DBGET integrated database retrieval system