KEGG   ORTHOLOGY: K03989Help
Entry
K03989                      KO                                     

Name
C4
Definition
complement component 4
Pathway
ko04610  Complement and coagulation cascades
ko05133  Pertussis
ko05150  Staphylococcus aureus infection
ko05322  Systemic lupus erythematosus
Disease
H00080  Systemic lupus erythematosus
H00102  Classic complement pathway component defects
H01649  Schizophrenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03989  C4; complement component 4
 09160 Human Diseases
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K03989  C4; complement component 4
  09171 Infectious disease: bacterial
   05133 Pertussis
    K03989  C4; complement component 4
   05150 Staphylococcus aureus infection
    K03989  C4; complement component 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K03989  C4; complement component 4
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K03989  C4; complement component 4
Peptidases and inhibitors [BR:ko01002]
 Peptidase inhibitors
  Family I39: alpha2M family
   K03989  C4; complement component 4
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K03989  C4; complement component 4
  Exosomal proteins of other cancer cells
   K03989  C4; complement component 4
BRITE hierarchy
Genes
HSA: 720(C4A) 721(C4B)
PTR: 100616513 462577
PPS: 100988452(C4A)
GGO: 101146168 101148680
PON: 100171517(C4B)
NLE: 100596445
MCC: 721200 723314
MCF: 102132156(C4B)
CSAB: 103221723(C4B) 103221732
RRO: 104659391(C4A) 104678146
CJC: 100411501(C4A)
SBQ: 101045782(C4A)
MMU: 12268(C4b)
MCAL: 110283979
MPAH: 110335909(C4a)
RNO: 24233(C4a)
MUN: 110560118(C4a)
CGE: 100767983(C4a)
NGI: 103724415
HGL: 101719002(C4a)
CCAN: 109689567
OCU: 100356976(C4A)
TUP: 102483263(C4A)
CFA: 481722
VVP: 112913631
AML: 100475765(C4B)
UMR: 103682335(C4A)
UAH: 113243734
ORO: 101380173
ELK: 111152244
FCA: 101094346
PTG: 102967020(C4A)
PPAD: 109260502
AJU: 106983498
BTA: 280678(C4A) 781663
BOM: 102269445(C4A) 102280288
SSC: 445467(C4A)
CFR: 102521056
CDK: 105087437(C4A)
BACU: 103015179(C4A)
LVE: 103087928(C4A)
OOR: 101279376
DLE: 111170700
PCAD: 102989916
ECB: 100059239
EPZ: 103563298(C4A)
EAI: 106831006
MYB: 102254455(C4A)
MYD: 102774999(C4A)
MNA: 107538990
HAI: 109373128
DRO: 112302138
PALE: 102898626(C4A)
RAY: 107498435(C4A)
MJV: 108393997(C4A)
LAV: 100667171(C4A)
TMU: 101351736
MDO: 100025543(C4A)
SHR: 100923960
PCW: 110199439(C4A)
OAA: 103165320(C4A)
GGA: 418892(C4A) 426611(C4)
TGU: 100231134
LSR: 110468582
SCAN: 103827373
GFR: 102032664(C4A)
FAB: 101810518(C4A)
PHI: 102114525(C4A)
PMAJ: 107210755
CCAE: 111945366
CCW: 104689934
ETL: 114063749
FPG: 101924008(C4B)
FCH: 102048743
CLV: 102094160
EGZ: 104131486
NNI: 104010873
ACUN: 113484218
PADL: 103913434
ASN: 102383747
AMJ: 102568973
PSS: 102454722
CMY: 102944866(C4A)
CPIC: 101939210(C4A) 101951165
ACS: 100554736(c4b)
PVT: 110089773
PBI: 103063425
PMUR: 107297122
TSR: 106545859
XLA: 394275(c4a.L)
XTR: 100135012(c4a)
DRE: 566261(c4) 794635(c4b)
TRU: 101065354
LCO: 104922750
NCC: 104965571
OLA: 100049261(c4b) 110016646
XMA: 102220196
XCO: 114140756
PRET: 103478546
NFU: 107372375
AOCE: 111588842
POV: 109633561
LCF: 108891077
SDU: 111238774
SLAL: 111668799
MALB: 109971691
LCM: 102346391
RTP: 109927203
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2395880
  Authors
Carroll MC, Fathallah DM, Bergamaschini L, Alicot EM, Isenman DE
  Title
Substitution of a single amino acid (aspartic acid for histidine) converts the functional activity of human complement C4B to C4A.
  Journal
Proc Natl Acad Sci U S A 87:6868-72 (1990)
DOI:10.1073/pnas.87.17.6868
  Sequence
[hsa:720 721]
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