KEGG ORTHOLOGY: K03998

ORTHOLOGY: K03998

Entry

K03998                      KO

Symbol

C8B

Name

complement component 8 subunit beta

Pathway

map04610

Complement and coagulation cascades

map04810

Regulation of actin cytoskeleton

map05020

Prion disease

map05146

Amoebiasis

map05171

Coronavirus disease - COVID-19

map05322

Systemic lupus erythematosus

Disease

H00103

Late complement pathway defects

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K03998  C8B; complement component 8 subunit beta
09150 Organismal Systems
  09151 Immune system
   04610 Complement and coagulation cascades
    K03998  C8B; complement component 8 subunit beta
09160 Human Diseases
  09172 Infectious disease: viral
   05171 Coronavirus disease - COVID-19
    K03998  C8B; complement component 8 subunit beta
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K03998  C8B; complement component 8 subunit beta
  09163 Immune disease
   05322 Systemic lupus erythematosus
    K03998  C8B; complement component 8 subunit beta
  09164 Neurodegenerative disease
   05020 Prion disease
    K03998  C8B; complement component 8 subunit beta

Genes

HSA:

732(C8B)

PTR:	456887(C8B)

PPS:	100976626(C8B)

GGO:	101138999(C8B)

PON:	100453748(C8B)

NLE:	100583059(C8B)

HMH:	116457266(C8B)

MCC:	716155(C8B)

MCF:	102133338(C8B)

MTHB:

126932947

MNI:	105495134(C8B)

CSAB:

103224737(C8B)

CATY:

105595979(C8B)

PANU:

101007717(C8B)

TGE:	112631480(C8B)

MLEU:

105534914(C8B)

RRO:	104664293(C8B)

RBB:	108532932(C8B)

TFN:	117091975(C8B)

PTEH:

111522650(C8B)

CANG:

105511278(C8B)

CJC:	100397653(C8B)

SBQ:	101047099(C8B)

CIMI:

108314883(C8B)

CSYR:

103255086(C8B)

MMUR:

105882579(C8B)

LCAT:

123635595(C8B)

PCOQ:

105806385(C8B)

OGA:	100963531(C8B)

MMU:	110382(C8b)

MCAL:

110292205(C8b)

MPAH:

110323447(C8b)

RNO:	313421(C8b)

MCOC:

116095468(C8b)

ANU:	117709108(C8b)

MUN:	110556362(C8b)

CGE:	100773949(C8b)

MAUA:

101822474(C8b)

PROB:

127224868(C8b)

PLEU:

114705806(C8b)

MORG:

121448571(C8b)

MFOT:

126497932

AAMP:

119817793(C8b)

NGI:	103732454(C8b)

HGL:	101696501(C8b)

CPOC:

100729610(C8b)

CCAN:

109676181(C8b)

DORD:

105989935(C8b)

DSP:	122124589(C8b)

PLOP:

125354308(C8b)

NCAR:

124963658

MMMA:

107141718(C8b)

OCU:	100009385(C8B)

OPI:	101530295(C8B)

TUP:	102498857(C8B)

GVR:	103603579(C8B)

CFA:	479555(C8B)

CLUD:

112647100(C8B)

VVP:	112926021(C8B)

VLG:	121500472(C8B)

NPO:	129496546(C8B)

AML:	100475113(C8B)

UMR:	103670671(C8B)

UAH:	113254615(C8B)

UAR:	123795381(C8B)

ELK:

111143455

LLV:

125099065

MPUF:

101676491(C8B)

MNP:	132000926(C8B)

MLK:	131809906(C8B)

NVS:	122898714(C8B)

ORO:	101380165(C8B)

EJU:	114212140(C8B)

ZCA:	113915754(C8B)

MLX:	118019364(C8B)

NSU:	110575078(C8B)

LWW:	102750453(C8B)

FCA:	101099229(C8B)

PYU:	121027201(C8B)

PCOO:

112872270(C8B)

PBG:	122480560(C8B)

PVIV:

125173579(C8B)

LRUF:

124514133

PTG:	102970545(C8B)

PPAD:

109266794(C8B)

PUC:

125912553

AJU:

106975061

HHV:	120235446(C8B)

BTA:	513217(C8B)

BOM:	102269851(C8B)

BIU:	109556241(C8B)

BBUB:

102402963(C8B)

BBIS:

105000170(C8B)

CHX:	102170749(C8B)

OAS:	101102522(C8B)

BTAX:

128045434(C8B)

ODA:	120856084(C8B)

CCAD:

122436899(C8B)

MBEZ:

129541518(C8B)

SSC:	100037954(C8B)

CFR:	102523940(C8B)

CBAI:

105071669(C8B)

CDK:	105092814(C8B)

VPC:	102540196(C8B)

BACU:

103017188(C8B)

BMUS:

118900259(C8B)

LVE:	103069755(C8B)

OOR:	101289903(C8B)

DLE:	111175865(C8B)

PCAD:

102976102(C8B)

PSIU:

116759774(C8B)

NASI:

112407075(C8B)

ECB:	100059423(C8B)

EPZ:	103564395(C8B)

EAI:	106833472(C8B)

MYB:	102263623(C8B)

MYD:	102751821(C8B)

MMYO:

118677617(C8B)

MLF:	102435040(C8B)

PKL:	118723456(C8B)

EFUS:

103284060(C8B)

MNA:	107530647(C8B)

DRO:	112314657(C8B)

SHON:

118984943(C8B)

AJM:	119051649(C8B)

PDIC:

114497529(C8B)

PHAS:

123830706(C8B)

MMF:	118626950(C8B)

PPAM:

129070709(C8B)

HAI:	109377006(C8B)

RFQ:	117027726(C8B)

PALE:

102894338(C8B)

PGIG:

120621766(C8B)

PVP:	105298995(C8B)

RAY:	107518331(C8B)

MJV:	108402388(C8B)

TOD:	119235912(C8B)

SARA:

101549550(C8B)

SETR:

126010982(C8B)

LAV:	100670998(C8B)

TMU:

101360625

ETF:	101659081(C8B)

DNM:	101423648(C8B)

MDO:	100032214(C8B)

GAS:	123245779(C8B)

OAA:	100081005(C8B)

GGA:	424669(C8B)

PCOC:

116236169(C8B)

MGP:	100547639(C8B)

CJO:	107317701(C8B)

TPAI:

128072437(C8B)

LMUT:

125693737(C8B)

NMEL:

110402367(C8B)

APLA:

101804949(C8B)

ACYG:

106032915(C8B)

CATA:

118243625(C8B)

AFUL:

116492071(C8B)

TGU:	100222207(C8B)

LSR:	110476848(C8B)

SCAN:

103815206(C8B)

PMOA:

120503349(C8B)

OTC:	121345108(C8B)

PRUF:

121362025(C8B)

GFR:	102032114(C8B)

FAB:	101814170(C8B)

OMA:	130256163(C8B)

PHI:	102114417(C8B)

PMAJ:

107208194(C8B)

CCAE:

111933008(C8B)

CCW:	104695507(C8B)

CBRC:

103615106(C8B)

ETL:	114055186(C8B)

ZAB:	102062280(C8B)

ACHL:

103798566(C8B)

SVG:	106849746(C8B)

MMEA:

130586013(C8B)

HRT:	120756565(C8B)

FPG:	101918957(C8B)

FCH:	102049711(C8B)

CLV:	102091236(C8B)

EGZ:	104123887(C8B)

NNI:	104009341(C8B)

PCRI:

104031880(C8B)

PLET:

104628871(C8B)

EHS:	104507945(C8B)

PCAO:

104053588(C8B)

ACUN:

113482673(C8B)

TALA:

104357650(C8B)

PADL:

103913362(C8B)

AFOR:

103905754(C8B)

ACHC:

115348778(C8B)

HALD:

104319324(C8B)

AGEN:

126042387

GCL:

127019270

CCRI:

104160740(C8B)

CSTI:

104553178(C8B)

CMAC:

104474285(C8B)

MUI:	104546002(C8B)

BREG:

104636493(C8B)

FGA:	104080012(C8B)

GSTE:

104264461(C8B)

LDI:	104350634(C8B)

MNB:	103776522(C8B)

OHA:	104328030(C8B)

SHAB:

115612048(C8B)

DPUB:

104301764(C8B)

PGUU:

104465803(C8B)

ACAR:

104521893(C8B)

CPEA:

104385190(C8B)

AVIT:

104274113(C8B)

CVF:	104286229(C8B)

RTD:	128913604(C8B)

CUCA:

104066578(C8B)

TEO:	104378449(C8B)

BRHI:

104492752

AAM:	106498961(C8B)

AROW:

112967658(C8B)

NPD:	112943485(C8B)

TGT:	104566118(C8B)

DNE:	112986615(C8B)

SCAM:

104149609(C8B)

ASN:	102372308(C8B)

AMJ:	102576131(C8B)

CPOO:

109307523(C8B)

GGN:	109286599(C8B)

PSS:	102453356(C8B)

CMY:	102940513(C8B)

CCAY:

125641820(C8B)

DCC:	119860370(C8B)

CPIC:

101939780(C8B)

TST:	117881530(C8B)

CABI:

116838120(C8B)

MRV:	120370994(C8B)

ACS:	100551539(c8b)

ASAO:

132773978(C8B)

PVT:	110077118(C8B)

SUND:

121928832(C8B)

PBI:	103058725(C8B)

PMUR:

107286642(C8B)

CTIG:

120297393(C8B)

TSR:	106540407(C8B) 106556020

PGUT:

117664287(C8B)

APRI:

131194840(C8B)

PTEX:

113440698(C8B)

NSS:	113411059(C8B)

VKO:	123023440(C8B)

PMUA:

114598937(C8B)

PRAF:

128415710(C8B)

ZVI:	118088924(C8B)

HCG:	128325206(C8B)

GJA:	107118034(C8B)

STOW:

125433978(C8B)

EMC:	129330624(C8B)

XLA:	108714245(c8b.L)

XTR:	100380076(c8b)

NPR:	108788158(C8B)

RTEM:

120946248(C8B)

BBUF:

120978797(C8B)

BGAR:

122943530(C8B)

MUO:	115472167 115472315(C8B)

GSH:	117346862(C8B)

DRE:	793127(c8b)

SRX:	107705128(c8b)

SANH:

107693591(c8b)

SGH:	107600305(c8b)

CCAR:

109054712(c8b)

CAUA:

113046139(c8b)

CGIB:

PTET:

LROH:

OMC:

RKG:	130100385(c8b)

MAMB:

125250468

CIDE:

127506438

MASI:

127441944

TROS:

130553858(c8b)

TDW:

130415385

MANU:

129443139(c8b)

IPU:

108268226

IFU:	128610742(c8b)

PHYP:

113547243(c8b)

SMEO:

124386952(c8b)

TFD:	113648499(c8b)

TVC:	132849073(c8b)

AMEX:

103022810(c8b)

CMAO:

118825952(c8b)

EEE:	113591036(c8b)

TRU:	101064587(c8b)

TNG:	GSTEN00015039G001

LCO:	104932764(c8b)

NCC:	104945626(c8b)

CGOB:

115022050(c8b)

PGEO:

117462183(c8b)

GACU:

117545463(c8b)

EMAC:

134866512(c8b)

ELY:	117271831(c8b)

EFO:	125901577(c8b)

SLUC:

116045616

ECRA:

117953979

ESP:

116699328

PFLV:

114565561(c8b)

GAT:	120815687(c8b)

AFB:	129114285(c8b)

PSWI:

130198193(c8b)

MSAM:

119902405(c8b)

SCHU:

122886710

ALAT:

119011506(c8b)

MZE:	101481990(c8b)

ONL:	100693988(c8b)

OAU:

116314279

OLA:	101171863(c8b)

OML:	112147659(dab1b)

CSAI:

133452259

XMA:	102229009(c8b)

XCO:	114145902(c8b)

XHE:	116721134(c8b)

PRET:

103478980(c8b)

PFOR:

103140040(c8b)

PLAI:

106946522(c8b)

PMEI:

106929344(c8b)

PPRL:

129361629(c8b)

CVG:	107083631(c8b)

GMU:

124869793

NFU:	107384384(c8b)

ALIM:

106521303(c8b)

NWH:	119414905(c8b)

AOCE:

111587313(c8b)

CSEM:

103396190

POV:	109637277(c8b)

SSEN:

122781797

LCF:

108883845

SDU:	111228965(c8b)

SLAL:

111666489(c8b)

XGL:	120798736(c8b)

HCQ:	109520612(c8b)

SSCV:

SBIA:

PEE:

BPEC:

MALB:

109970668(c8b)

SJO:	128368549(c8b)

SASA:

106600417(c8b)

STRU:

115169541(c8b)

OTW:

112226757

OMY:	100136625(c8b)

ONE:	115102916(c8b)

SALP:

111979436(c8b)

SNH:	120020240(c8b)

ELS:	105020147(c8b)

SFM:	108935186(c8b)

PKI:	111847575(c8b)

AANG:

118230166(c8b)

LOC:	102696332(c8b)

PSPA:

121330973(c8b)

ARUT:

117411336

LCM:	102346549(C8B)

CMK:	103185299(c8b)

CPLA:

122554381

» show all

Reference

PMID:12220191

Authors

Musingarimi P1, Plumb ME, Sodetz JM.

Title

Interaction between the C8 alpha-gamma and C8 beta subunits of human complement C8: role of the C8 beta N-terminal thrombospondin type 1 module and membrane attack complex/perforin domain.

Journal

Biochemistry 41:11255-60 (2002)
DOI:10.1021/bi026207h

Sequence

[hsa:732]

Reference

PMID:2820472

Authors

Howard OM, Rao AG, Sodetz JM

Title

Complementary DNA and derived amino acid sequence of the beta subunit of human complement protein C8: identification of a close structural and ancestral relationship to the alpha subunit and C9.

Journal

Biochemistry 26:3565-70 (1987)
DOI:10.1021/bi00386a047

Sequence

[hsa:732]

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