KEGG   ORTHOLOGY: K04344
Entry
K04344                      KO                                     

Name
CACNA1A, CAV2.1
Definition
voltage-dependent calcium channel P/Q type alpha-1A
Pathway
map04010  MAPK signaling pathway
map04020  Calcium signaling pathway
map04721  Synaptic vesicle cycle
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04728  Dopaminergic synapse
map04730  Long-term depression
map04742  Taste transduction
map04930  Type II diabetes mellitus
map05017  Spinocerebellar ataxia
map05032  Morphine addiction
map05033  Nicotine addiction
map05207  Chemical carcinogenesis - receptor activation
Disease
H00063  Spinocerebellar ataxia (SCA)
H00606  Early infantile epileptic encephalopathy
H00749  Episodic ataxias
H00775  Hemiplegic migraine
H01808  Hemiconvulsion-hemiplegia-epilepsy syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04020 Calcium signaling pathway
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
 09150 Organismal Systems
  09156 Nervous system
   04724 Glutamatergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04727 GABAergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04725 Cholinergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04728 Dopaminergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04726 Serotonergic synapse
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04730 Long-term depression
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04723 Retrograde endocannabinoid signaling
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   04721 Synaptic vesicle cycle
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09157 Sensory system
   04742 Taste transduction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09165 Substance dependence
   05032 Morphine addiction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
   05033 Nicotine addiction
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04344  CACNA1A, CAV2.1; voltage-dependent calcium channel P/Q type alpha-1A
Other DBs
GO: 0005245
TC: 1.A.1.11.8 1.A.1.11.27
Genes
HSA: 773(CACNA1A)
PTR: 455766(CACNA1A)
PPS: 100971898(CACNA1A)
GGO: 101127257(CACNA1A)
PON: 100458387(CACNA1A)
NLE: 100602682(CACNA1A)
MCC: 718291(CACNA1A)
MCF: 102130052(CACNA1A)
CSAB: 103234371(CACNA1A)
CATY: 105601562(CACNA1A)
PANU: 101013922(CACNA1A)
RRO: 104661142(CACNA1A)
RBB: 108544091(CACNA1A)
TFN: 117075607(CACNA1A)
PTEH: 111523866(CACNA1A)
CJC: 100390599(CACNA1A)
SBQ: 101046396(CACNA1A)
MMUR: 105885431(CACNA1A)
MMU: 12286(Cacna1a)
MCAL: 110299941(Cacna1a)
MPAH: 110337404(Cacna1a)
RNO: 25398(Cacna1a)
MCOC: 116067850
MUN: 110545836(Cacna1a)
CGE: 100758171(Cacna1a)
PLEU: 114684157(Cacna1a)
NGI: 103751913(Cacna1a)
HGL: 101725815(Cacna1a)
CCAN: 109681262(Cacna1a)
OCU: 100009265(CACNA1A)
TUP: 102473903(CACNA1A)
CFA: 100686650(CACNA1A)
VVP: 112908114(CACNA1A)
VLG: 121495291(CACNA1A)
AML: 100473951(CACNA1A)
UMR: 103682191
UAH: 113247199(CACNA1A)
ORO: 101378448(CACNA1A)
ELK: 111162543
MPUF: 101674676(CACNA1A)
EJU: 114197735(CACNA1A)
MLX: 118005966(CACNA1A)
FCA: 101094827(CACNA1A)
PTG: 102962991(CACNA1A)
PPAD: 109254011(CACNA1A)
AJU: 106986103(CACNA1A)
HHV: 120245276(CACNA1A)
BTA: 282648(CACNA1A)
BOM: 102266763(CACNA1A)
BIU: 109560900(CACNA1A)
BBUB: 102404131(CACNA1A)
CHX: 102168441(CACNA1A)
OAS: 101120920(CACNA1A)
ODA: 120864066(CACNA1A)
SSC: 100525387(CACNA1A)
CFR: 102516820(CACNA1A)
CDK: 105100784(CACNA1A)
BACU: 103007483(CACNA1A)
LVE: 103068318(CACNA1A)
OOR: 101275783(CACNA1A)
DLE: 111166727(CACNA1A)
PCAD: 102977865(CACNA1A)
ECB: 100063873(CACNA1A)
EPZ: 103566268(CACNA1A)
EAI: 106844288(CACNA1A)
MYB: 102257882(CACNA1A)
MYD: 102771143(CACNA1A)
MMYO: 118652720(CACNA1A)
MNA: 107541038(CACNA1A)
HAI: 109394251(CACNA1A)
DRO: 112301443(CACNA1A)
SHON: 118984103(CACNA1A)
AJM: 119049676(CACNA1A)
MMF: 118615449(CACNA1A)
PALE: 102891789(CACNA1A)
RAY: 107519399(CACNA1A)
MJV: 108399643(CACNA1A)
TOD: 119241018(CACNA1A)
LAV: 100655176(CACNA1A)
TMU: 101341628
MDO: 100021108(CACNA1A)
SHR: 100925240(CACNA1A)
PCW: 110214234(CACNA1A)
OAA: 100078981(CACNA1A)
GGA: 107049790
LSR: 110481525(CACNA1A)
PMOA: 120506097(CACNA1A)
PHI: 102099919(CACNA1A)
ETL: 114072531(CACNA1A)
FPG: 101919186(CACNA1A)
ASN: 102376033(CACNA1A)
AMJ: 102564806(CACNA1A)
CMY: 102933709(CACNA1A)
CPIC: 101943820(CACNA1A)
TST: 117888655(CACNA1A)
CABI: 116817734(CACNA1A)
ACS: 100557580(cacna1a)
PVT: 110082653(CACNA1A)
PBI: 103050605(CACNA1A)
PMUR: 107286895(CACNA1A)
TSR: 106547348(CACNA1A)
PGUT: 117658819(CACNA1A)
PMUA: 114590816(CACNA1A)
ZVI: 118079990(CACNA1A)
GJA: 107116856(CACNA1A)
XLA: 108710372 373828(cacna1a.S)
XTR: 100492135(cacna1a)
NPR: 108794965(CACNA1A)
DRE: 562059(cacna1aa) 569528(cacna1ab)
CCAR: 109060317
PHYP: 113523781(cacna1a) 113525358
TRU: 101065285 101072720(cacna1a)
LCO: 104936743 109138994(cacna1a)
ELY: 117254987(cacna1ab) 117268021(cacna1aa)
PLEP: 121942442(cacna1ab) 121956459(cacna1aa)
SLUC: 116042548(cacna1ab) 116051851(cacna1aa)
ECRA: 117958666(cacna1aa) 117961643(cacna1ab)
PFLV: 114546705(cacna1a) 114569401
GAT: 120827313(cacna1aa)
MSAM: 119887893(cacna1aa) 119898592(cacna1ab)
CUD: 121503961(cacna1aa) 121508767(cacna1ab)
MZE: 101480217 101484868(cacna1a)
ONL: 100694261 100709811(cacna1a)
OAU: 116326122(cacna1ab) 116329204
OLA: 101170273 105357443(cacna1a)
OML: 112141681(cacna1ab) 112146767(cacna1aa)
XMA: 102225112 102236322(cacna1a)
XCO: 114145343(cacna1a) 114159632
XHE: 116720012(cacna1a) 116735966
PRET: 103462507(cacna1a) 103468620
CTUL: 119772641(cacna1aa) 119786986(cacna1ab)
NFU: 107376625 107391184(cacna1a)
KMR: 108239282(cacna1aa) 108247309(cacna1ab)
ALIM: 106527230(cacna1a) 106535455
CSEM: 103383187(cacna1a) 103392961
LCF: 108880719 108880807(cacna1a)
SDU: 111227043 111235833(cacna1a)
XGL: 120785766(cacna1aa) 120800346(cacna1ab)
BPEC: 110156590(cacna1a)
MALB: 109970352(cacna1a)
ELS: 105012190(cacna1a) 105024166
SFM: 108927499(cacna1a) 108930696
PKI: 111843226 111845281(cacna1a)
LOC: 102693691(cacna1a)
PSPA: 121304484(cacna1ab)
LCM: 102354855(CACNA1A)
RTP: 109912552
SPU: 574743
SKO: 100373523
DER: 6551177
PGC: 109856977
CRG: 105322251
 » show all
Reference
  Authors
Rose SJ, Kriener LH, Heinzer AK, Fan X, Raike RS, van den Maagdenberg AM, Hess EJ
  Title
The first knockin mouse model of episodic ataxia type 2.
  Journal
Exp Neurol 261:553-62 (2014)
DOI:10.1016/j.expneurol.2014.08.001
  Sequence
[hsa:773]
Reference
  Authors
Hans M, Urrutia A, Deal C, Brust PF, Stauderman K, Ellis SB, Harpold MM, Johnson EC, Williams ME
  Title
Structural elements in domain IV that influence biophysical and pharmacological properties of human alpha1A-containing high-voltage-activated calcium channels.
  Journal
Biophys J 76:1384-400 (1999)
DOI:10.1016/S0006-3495(99)77300-5
LinkDB

KEGG   ORTHOLOGY: K04849
Entry
K04849                      KO                                     

Name
CACNA1B, CAV2.2
Definition
voltage-dependent calcium channel N type alpha-1B
Pathway
map04010  MAPK signaling pathway
map04020  Calcium signaling pathway
map04721  Synaptic vesicle cycle
map04723  Retrograde endocannabinoid signaling
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04728  Dopaminergic synapse
map04930  Type II diabetes mellitus
map05016  Huntington disease
map05020  Prion disease
map05022  Pathways of neurodegeneration - multiple diseases
map05032  Morphine addiction
map05033  Nicotine addiction
map05207  Chemical carcinogenesis - receptor activation
Disease
H00831  Primary dystonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04020 Calcium signaling pathway
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
 09150 Organismal Systems
  09156 Nervous system
   04727 GABAergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04725 Cholinergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04728 Dopaminergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04726 Serotonergic synapse
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04723 Retrograde endocannabinoid signaling
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   04721 Synaptic vesicle cycle
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
 09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
  09164 Neurodegenerative disease
   05016 Huntington disease
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   05020 Prion disease
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   05022 Pathways of neurodegeneration - multiple diseases
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
  09165 Substance dependence
   05032 Morphine addiction
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
   05033 Nicotine addiction
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
Ion channels [BR:ko04040]
 Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04849  CACNA1B, CAV2.2; voltage-dependent calcium channel N type alpha-1B
Other DBs
GO: 0005245
TC: 1.A.1.11.9
Genes
HSA: 774(CACNA1B)
PTR: 464893(CACNA1B)
PPS: 100979369(CACNA1B)
GGO: 101123776(CACNA1B)
PON: 100450868(CACNA1B)
NLE: 100584807(CACNA1B)
MCC: 721452(CACNA1B)
MCF: 101925455
CSAB: 103239541(CACNA1B)
CATY: 105580650(CACNA1B)
RRO: 104669605(CACNA1B)
RBB: 108542921(CACNA1B)
TFN: 117099070(CACNA1B)
PTEH: 111553106(CACNA1B)
CJC: 100390442(CACNA1B)
SBQ: 101049976(CACNA1B)
MMUR: 105882232(CACNA1B)
MMU: 12287(Cacna1b)
MCAL: 110289304(Cacna1b)
MPAH: 110318209(Cacna1b)
RNO: 257648(Cacna1b)
MCOC: 116089786(Cacna1b)
CGE: 100770495(Cacna1b)
PLEU: 114692733(Cacna1b)
NGI: 103732608(Cacna1b)
HGL: 101697609(Cacna1b)
CCAN: 109693749
OCU: 100008979(CACNA1B)
TUP: 102498317(CACNA1B)
CFA: 480660(CACNA1B)
VVP: 112911427(CACNA1B)
VLG: 121473438(CACNA1B)
AML: 100466608(CACNA1B)
UMR: 103675324(CACNA1B)
ORO: 105758129
ELK: 111145672
MPUF: 101673094(CACNA1B)
EJU: 114201734(CACNA1B)
MLX: 118017467(CACNA1B)
FCA: 101087362(CACNA1B)
PTG: 102954775(CACNA1B)
PPAD: 109260261(CACNA1B)
AJU: 106986735(CACNA1B)
HHV: 120222772(CACNA1B)
BTA: 282410(CACNA1B)
BOM: 102266839(CACNA1B)
BBUB: 102395660(CACNA1B)
CHX: 102189138(CACNA1B)
OAS: 101122774(CACNA1B)
ODA: 120852240(CACNA1B)
SSC: 102164336(CACNA1B)
CFR: 102521766(CACNA1B)
CDK: 105102103(CACNA1B)
BACU: 103004988(CACNA1B)
LVE: 103073411(CACNA1B)
OOR: 101272416(CACNA1B)
DLE: 111176963(CACNA1B)
PCAD: 102983972(CACNA1B)
ECB: 100058760(CACNA1B)
EPZ: 103554173(CACNA1B)
EAI: 106822757(CACNA1B)
MYB: 102245786(CACNA1B)
MYD: 102756826(CACNA1B)
MMYO: 118655312(CACNA1B)
MNA: 107536136(CACNA1B)
HAI: 109382541(CACNA1B)
DRO: 112306604(CACNA1B)
SHON: 118980179(CACNA1B)
AJM: 119036142(CACNA1B)
MMF: 118629754(CACNA1B)
PALE: 102877847(CACNA1B)
RAY: 107505355(CACNA1B)
MJV: 108404638(CACNA1B)
TOD: 119230884(CACNA1B)
LAV: 100660444(CACNA1B)
TMU: 101351661
MDO: 100023896(CACNA1B)
SHR: 100933192(CACNA1B)
PCW: 110205247(CACNA1B)
OAA: 100681261(CACNA1B)
GGA: 374169(CACNA1B)
PCOC: 116234164(CACNA1B)
MGP: 100539318(CACNA1B)
CJO: 107321666(CACNA1B)
NMEL: 110407048(CACNA1B)
APLA: 101794161
ACYG: 106037093(CACNA1B)
TGU: 100230125(CACNA1B)
LSR: 110476962
SCAN: 103819171(CACNA1B)
PMOA: 120507440(CACNA1B)
GFR: 102043304(CACNA1B)
FAB: 101812454(CACNA1B)
PHI: 102107124(CACNA1B)
PMAJ: 107211935(CACNA1B)
CCAE: 111936929(CACNA1B)
CCW: 104688232
ETL: 114071402(CACNA1B)
FPG: 101922058(CACNA1B)
FCH: 102058219(CACNA1B)
CLV: 102086328(CACNA1B)
EGZ: 104124015(CACNA1B)
NNI: 104022209(CACNA1B)
ACUN: 113486402(CACNA1B)
PADL: 103918950(CACNA1B)
AAM: 106497478(CACNA1B)
ASN: 102374664(CACNA1B)
AMJ: 102564626(CACNA1B)
CPOO: 109313839(CACNA1B)
GGN: 109292863(CACNA1B)
PSS: 102452356(CACNA1B)
CMY: 102935334(CACNA1B)
CPIC: 101941901(CACNA1B)
TST: 117889392(CACNA1B)
CABI: 116816175(CACNA1B)
ACS: 100565533(cacna1b)
PVT: 110089800(CACNA1B)
PBI: 103051885
PMUR: 107297756
PGUT: 117676312
PMUA: 114588906(CACNA1B)
ZVI: 118083834(CACNA1B)
GJA: 107118784(CACNA1B)
XLA: 100462926(cacna1b.S) 108699890
XTR: 100489231(cacna1b)
NPR: 108794388(CACNA1B)
DRE: 555941(cacna1ba) 562796(cacna1bb)
TRU: 101072690
ELY: 117252457 117269803(cacna1bb)
PLEP: 121959764(cacna1bb)
SLUC: 116034744(cacna1bb) 116050657(cacna1ba)
ECRA: 117944726(cacna1ba) 117958822(cacna1bb)
GAT: 120830281(cacna1ba) 120831493(cacna1bb)
MSAM: 119892109(cacna1ba) 119914522(cacna1bb)
CUD: 121509592(cacna1ba) 121525018(cacna1bb)
OAU: 116319585(cacna1bb) 116334933(cacna1ba)
OML: 112137703(cacna1ba) 112162903(cacna1bb)
CVG: 107083739
CTUL: 119772035(cacna1bb)
KMR: 108245630(cacna1ba) 108251447(cacna1bb)
LCF: 108878412(cacna1b) 108889014
XGL: 120805259(cacna1ba) 120806204(cacna1bb)
HCQ: 109527074
OMY: 100136656(cacna1b) 110509332(cacna1bb) 110525473(cacna1ba) 118936269
LOC: 102696482
PSPA: 121306674
LCM: 102345610(CACNA1B)
CMK: 103180424(cacna1b)
RTP: 109926711
BFO: 118421257
CIN: 100184382
SCLV: 120344323
DSI: Dsimw501_GD15954(Dsim_GD15954)
DSR: 110182064
DPE: 6599410
DMN: 108156392
DWI: 6649112
DAZ: 108618327
DNV: 108656582
DHE: 111592349
MDE: 101889994
LCQ: 111681125
AARA: 120896627
AME: 408764(Cac)
BIM: 100746463
BTER: 100647135
CCAL: 108623463
OBB: 114873253
MPHA: 105833674
ACEP: 105620023
PBAR: 105425824
HST: 105185443
DQU: 106745520
CFO: 105258693
OBO: 105285138
PCF: 106791166
NVI: 100121288
CSOL: 105368770
MDL: 103576100
TCA: 661666(Cac)
DPA: 109540220
ATD: 109596221
NVL: 108565398
BMOR: 100306947
BMAN: 114245534
MSEX: 115447928
PMAC: 106719701
PRAP: 111001832
ZCE: 119829899
HAW: 110379158
TNL: 113494500
PXY: 105386568
API: 100164406
DNX: 107174009
AGS: 114121456
RMD: 113550723
BTAB: 109032851
CLEC: 106666338
NLU: 111054487
ZNE: 110836626
CSEC: 111875626
TUT: 107372220
DPTE: 113799879
CSCU: 111625859
TSP: Tsp_10911
PCAN: 112574940
MYI: 110467402
LAK: 106170041
NVE: 5515227
ATEN: 116303749
ADF: 107352390
DGT: 114533568
 » show all
Reference
PMID:1321501
  Authors
Williams ME, Brust PF, Feldman DH, Patthi S, Simerson S, Maroufi A, McCue AF, Velicelebi G, Ellis SB, Harpold MM
  Title
Structure and functional expression of an omega-conotoxin-sensitive human N-type calcium channel.
  Journal
Science 257:389-95 (1992)
DOI:10.1126/science.1321501
  Sequence
[hsa:774]
Reference
  Authors
Keum D, Baek C, Kim DI, Kweon HJ, Suh BC
  Title
Voltage-dependent regulation of CaV2.2 channels by Gq-coupled receptor is facilitated by membrane-localized beta subunit.
  Journal
J Gen Physiol 144:297-309 (2014)
DOI:10.1085/jgp.201411245
  Sequence
[hsa:774]
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