KEGG   ORTHOLOGY: K04346
Entry
K04346                      KO                                     

Name
GNA12
Definition
guanine nucleotide-binding protein subunit alpha-12
Pathway
map04010  MAPK signaling pathway
map04022  cGMP-PKG signaling pathway
map04071  Sphingolipid signaling pathway
map04072  Phospholipase D signaling pathway
map04270  Vascular smooth muscle contraction
map04361  Axon regeneration
map04730  Long-term depression
map04810  Regulation of actin cytoskeleton
map04928  Parathyroid hormone synthesis, secretion and action
map05130  Pathogenic Escherichia coli infection
map05163  Human cytomegalovirus infection
map05200  Pathways in cancer
Disease
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04072 Phospholipase D signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04071 Sphingolipid signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04022 cGMP-PKG signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09156 Nervous system
   04730 Long-term depression
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09158 Development and regeneration
   04361 Axon regeneration
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04031 GTP-binding proteins
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
Genes
HSA: 2768(GNA12)
PTR: 463234(GNA12)
PPS: 100979605(GNA12)
GGO: 101147243(GNA12)
PON: 100173387(GNA12)
NLE: 100591916(GNA12)
MCC: 100429106(GNA12)
MCF: 101867258(GNA12)
CSAB: 103246857(GNA12)
CATY: 105571739(GNA12)
PANU: 101015317(GNA12)
RRO: 104664964(GNA12)
RBB: 108543875(GNA12)
TFN: 117073210(GNA12)
PTEH: 111523703(GNA12)
CJC: 100387912(GNA12)
SBQ: 101042405(GNA12)
MMUR: 105868406(GNA12)
MMU: 14673(Gna12)
MCAL: 110295092(Gna12)
MPAH: 110312844(Gna12)
RNO: 81663(Gna12)
MCOC: 116068678(Gna12)
MUN: 110554732(Gna12)
CGE: 100760944(Gna12)
PLEU: 114705518(Gna12)
NGI: 103748670(Gna12)
HGL: 101697421(Gna12)
CCAN: 109683409(Gna12)
OCU: 100347293(GNA12)
TUP: 102501406(GNA12)
CFA: 102154318(GNA12)
VVP: 112929357(GNA12)
VLG: 121487216(GNA12)
AML: 100465369(GNA12)
UMR: 103669942(GNA12)
UAH: 113267979(GNA12)
ORO: 101371250(GNA12)
ELK: 111146098
MPUF: 101677577(GNA12)
EJU: 114199958(GNA12)
MLX: 117999301(GNA12)
FCA: 101093316(GNA12)
PTG: 102961052(GNA12)
PPAD: 109251142(GNA12)
AJU: 106984497(GNA12)
HHV: 120228022(GNA12)
BTA: 515159(GNA12)
BOM: 102265273(GNA12)
BIU: 109578204(GNA12)
BBUB: 102409709(GNA12)
CHX: 102185175(GNA12)
OAS: 101111070(GNA12)
ODA: 120882944(GNA12)
SSC: 100525156(GNA12)
CFR: 102524525(GNA12) 116666290
CDK: 105086681(GNA12)
BACU: 103009974(GNA12)
LVE: 103069136(GNA12)
OOR: 101281075(GNA12)
DLE: 111169388(GNA12)
PCAD: 102996723(GNA12)
ECB: 100060005(GNA12)
EPZ: 103549418(GNA12)
EAI: 106834780(GNA12)
MYB: 102260289(GNA12)
MYD: 102763801(GNA12)
MMYO: 118657873(GNA12)
MNA: 107541162(GNA12)
HAI: 109380223(GNA12)
DRO: 112319524(GNA12)
SHON: 118995031(GNA12)
AJM: 119037188 119043796(GNA12)
MMF: 118616426(GNA12)
PALE: 102891706(GNA12)
RAY: 107521430(GNA12)
MJV: 108383439(GNA12)
TOD: 119241629(GNA12)
LAV: 100676444(GNA12)
TMU: 101351796
MDO: 100010453(GNA12)
SHR: 100916443(GNA12)
PCW: 110200100(GNA12)
OAA: 100082592(GNA12)
GGA: 769924(GNA12)
PCOC: 116237643(GNA12)
MGP: 100550659(GNA12)
CJO: 107320696(GNA12)
NMEL: 110405782(GNA12)
APLA: 101798445(GNA12)
ACYG: 106032065(GNA12)
TGU: 100225137(GNA12)
LSR: 110480984(GNA12)
SCAN: 103817628(GNA12)
PMOA: 120513017(GNA12)
GFR: 102044790(GNA12)
FAB: 101818259(GNA12)
PHI: 102104762(GNA12)
PMAJ: 107211274(GNA12)
CCAE: 111936095(GNA12)
CCW: 104684810(GNA12)
ETL: 114060163(GNA12)
FPG: 101917262(GNA12)
FCH: 102059010(GNA12)
CLV: 102088372(GNA12)
EGZ: 104132621(GNA12)
NNI: 104015218(GNA12)
ACUN: 113485647(GNA12)
PADL: 103913532(GNA12)
AAM: 106483939(GNA12)
ASN: 102377286(GNA12)
AMJ: 102559993(GNA12)
CPOO: 109314716(GNA12)
GGN: 109294314(GNA12)
PSS: 102445616(GNA12)
CMY: 102931254(GNA12)
CPIC: 101947834(GNA12)
TST: 117884213(GNA12)
CABI: 116816726(GNA12)
ACS: 100564021(gna12)
PVT: 110083721(GNA12)
PBI: 103050241(GNA12)
PMUR: 107290610(GNA12)
TSR: 106543761(GNA12)
PGUT: 117659919(GNA12)
PMUA: 114584033(GNA12)
ZVI: 118092639(GNA12)
GJA: 107116703(GNA12)
DRE: 503589(gna12a)
SGH: 107581709(gna12) 107592501
IPU: 108257129(gna12)
PHYP: 113536042(gna12)
AMEX: 103024018(gna12)
EEE: 113581016(gna12)
TRU: 101078184(gna12)
LCO: 104929956(gna12)
NCC: 104953227(gna12)
ELY: 117255443(gna12a)
PLEP: 121941718(gna12a)
SLUC: 116042660(gna12a)
ECRA: 117957719(gna12a)
PFLV: 114568096(gna12)
GAT: 120825079(gna12a)
MSAM: 119898751(gna12a) 119898752
CUD: 121508158(gna12a)
MZE: 101473086(gna12)
ONL: 100695956(gna12)
OAU: 116312366(gna12a)
OLA: 101166935(gna12)
OML: 112137476(gna12a)
XMA: 102222306(gna12)
XCO: 114145506(gna12)
XHE: 116720292(gna12)
PRET: 103462653(gna12)
CVG: 107086421(gna12)
CTUL: 119783694(gna12a)
NFU: 107388805(gna12)
KMR: 108231102(gna12a)
ALIM: 106519647(gna12) 106535814
AOCE: 111579495(gna12)
CSEM: 103383240(gna12)
POV: 109639272(gna12)
LCF: 108888452(gna12)
SDU: 111216573(gna12)
SLAL: 111663289(gna12)
XGL: 120800111(gna12a)
HCQ: 109511425(gna12)
BPEC: 110153513(gna12)
MALB: 109968205(gna12)
SASA: 106593532
OMY: 110513250 110519706(gna12a)
ELS: 105006302(gna12)
SFM: 108927048(gna12)
LOC: 102693638(gna12)
LCM: 102367557(GNA12)
CMK: 103185131(gna12)
RTP: 109917843(gna12)
SPU: 414055
SKO: 100371005
DME: Dmel_CG17678(cta)
DER: 6548622
DSE: 6620479
DSI: Dsimw501_GD17672(Dsim_GD17672)
DYA: Dyak_GE22695(Dyak_cta)
DAN: 6498720
DSR: 110188780
DPE: 6597992
DMN: 108163668
DWI: 6642655
DGR: 6566635
DAZ: 108610046
DNV: 108649870
DHE: 111594096
DVI: 6633906
MDE: 101898580
LCQ: 111688751
ACOZ: 120955650
AARA: 120901285
AAG: 5570853
CPII: 120425173
AME: 410906
ACER: 108001125
BIM: 100745931
BTER: 100649951
CCAL: 108622504
OBB: 114871357
MGEN: 117220251
NMEA: 116435250
CGIG: 122400909
SOC: 105200292
MPHA: 105839168
AEC: 105147295
ACEP: 105624301
PBAR: 105431792
VEM: 105569521
HST: 105181192
DQU: 106742960
CFO: 105259283
FEX: 115234956
LHU: 105675078
PGC: 109863777
OBO: 105278292
PCF: 106784198
NVI: 100115318
CSOL: 105359649
MDL: 103572197
TCA: 661072
DPA: 109541992
AGB: 108913892
APLN: 108732666
PPYR: 116175451
OTU: 111420380
BMOR: 100862775(Galpha12)
BMAN: 114248860
MSEX: 115443118
BANY: 112043613
PMAC: 106720633
PPOT: 106109104
PXU: 106127207
PRAP: 111001958
ZCE: 119834786
HAW: 110369680
TNL: 113491781
PXY: 105391521
API: 100165181
DNX: 107169778
AGS: 114131159
RMD: 113552929
BTAB: 109044576
DCI: 103507297
CLEC: 106672229
NLU: 111051510
ZNE: 110838798
CSEC: 111865428
FCD: 110848091
DPX: DAPPUDRAFT_190301(Gna12)
PVM: 113811454
HAME: 121869372
EAF: 111712669
DSV: 119453135
RSAN: 119399997
RMP: 119180408
TUT: 107368817
CEL: CELE_F18G5.3(gpa-12)
CBR: CBG16182(Cbr-gpa-12)
BMY: BM_BM3442(Bma-gpa-12)
TSP: Tsp_00479
PCAN: 112573964
BGT: 106078602
GAE: 121380023
CRG: 105341702
MYI: 110465109
PMAX: 117325622
LAK: 106174984
NVE: 5520204
EPA: 110251752
ATEN: 116298423
ADF: 107350389
AMIL: 114947132
PDAM: 113680345
SPIS: 111329690
DGT: 114529102
HMG: 100192290(gna12)
 » show all
Reference
PMID:8423800
  Authors
Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA
  Title
Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.
  Journal
Mol Cell Biol 13:762-8 (1993)
DOI:10.1128/MCB.13.2.762
  Sequence
[hsa:2768]
Reference
  Authors
Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D
  Title
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.
  Journal
Nat Cell Biol 14:686-96 (2012)
DOI:10.1038/ncb2507
  Sequence
[hsa:2768]
LinkDB

KEGG   ORTHOLOGY: K04534
Entry
K04534                      KO                                     

Name
GNAO, G-ALPHA-O
Definition
guanine nucleotide-binding protein G(o) subunit alpha
Pathway
map04015  Rap1 signaling pathway
map04361  Axon regeneration
map04713  Circadian entrainment
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04728  Dopaminergic synapse
map04730  Long-term depression
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04921  Oxytocin signaling pathway
map04926  Relaxin signaling pathway
map05032  Morphine addiction
map05034  Alcoholism
map05142  Chagas disease
map05145  Toxoplasmosis
map05163  Human cytomegalovirus infection
map05170  Human immunodeficiency virus 1 infection
Disease
H00606  Early infantile epileptic encephalopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04921 Oxytocin signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04926 Relaxin signaling pathway
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04916 Melanogenesis
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
  09156 Nervous system
   04724 Glutamatergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04727 GABAergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04725 Cholinergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04728 Dopaminergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04726 Serotonergic synapse
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04730 Long-term depression
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04723 Retrograde endocannabinoid signaling
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
  09158 Development and regeneration
   04361 Axon regeneration
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
 09160 Human Diseases
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   05163 Human cytomegalovirus infection
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   05142 Chagas disease
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
  09165 Substance dependence
   05032 Morphine addiction
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   05034 Alcoholism
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
   04031 GTP-binding proteins
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [OT]
    K04534  GNAO, G-ALPHA-O; guanine nucleotide-binding protein G(o) subunit alpha
Genes
HSA: 2775(GNAO1)
PTR: 450173(GNAO1)
PPS: 100991540(GNAO1)
GGO: 101150695(GNAO1)
PON: 100454626(GNAO1)
NLE: 100599912(GNAO1)
MCC: 574394(GNAO1)
MCF: 102131761(GNAO1)
CSAB: 103233012(GNAO1)
CATY: 105588486(GNAO1)
PANU: 101018328(GNAO1)
RRO: 104664017(GNAO1)
TFN: 117087809(GNAO1)
PTEH: 111541259(GNAO1)
CJC: 100389396(GNAO1)
SBQ: 101049046(GNAO1)
MMUR: 105866545(GNAO1)
MMU: 14681(Gnao1)
MCAL: 110299754(Gnao1)
MPAH: 110337832(Gnao1)
RNO: 50664(Gnao1)
MCOC: 116069889(Gnao1)
CGE: 100689069(Gnao1)
PLEU: 114694517(Gnao1)
NGI: 103749858(Gnao1)
HGL: 101723580(Gnao1)
OCU: 100342283(GNAO1)
TUP: 102483059(GNAO1)
CFA: 609157(GNAO1)
VVP: 112929627(GNAO1)
VLG: 121496666(GNAO1)
AML: 100466130(GNAO1)
UAH: 113252256(GNAO1)
ORO: 101376297(GNAO1)
ELK: 111157367
MPUF: 101677157(GNAO1)
EJU: 114203550(GNAO1)
MLX: 118023770(GNAO1)
FCA: 101101353(GNAO1)
PTG: 102958483(GNAO1)
PPAD: 109270899(GNAO1)
AJU: 106973284(GNAO1)
HHV: 120232146(GNAO1)
BTA: 281792(GNAO1)
BOM: 102280695(GNAO1)
BIU: 109572786(GNAO1)
BBUB: 102394976(GNAO1)
CHX: 102186145(GNAO1)
ODA: 120873213(GNAO1)
SSC: 100516976(GNAO1)
CFR: 102503533(GNAO1)
CDK: 105096168(GNAO1)
BACU: 103011674(GNAO1)
LVE: 103091025(GNAO1)
OOR: 101284566(GNAO1)
DLE: 111165310(GNAO1)
ECB: 100051282(GNAO1)
EPZ: 103555391(GNAO1)
EAI: 106822188(GNAO1)
MYB: 102263380(GNAO1)
MYD: 102765603(GNAO1)
MMYO: 118674453(GNAO1)
MNA: 107543463(GNAO1)
DRO: 112296672(GNAO1)
SHON: 118983964(GNAO1)
AJM: 119046437(GNAO1)
MMF: 118639180(GNAO1)
PALE: 102884654(GNAO1)
RAY: 107499654(GNAO1)
TOD: 119249230(GNAO1)
LAV: 100658419(GNAO1)
TMU: 101357613
MDO: 100015137(GNAO1)
SHR: 100914773(GNAO1)
PCW: 110193656(GNAO1)
OAA: 100079602(GNAO1)
GGA: 415698(GNAO1)
PCOC: 116243995(GNAO1)
CJO: 107319187(GNAO1)
NMEL: 110404455(GNAO1)
APLA: 101791437
ACYG: 106043102(GNAO1)
TGU: 100226617(GNAO1)
LSR: 110473008(GNAO1)
SCAN: 103816655(GNAO1)
PMOA: 120508016(GNAO1)
GFR: 102040380(GNAO1)
PHI: 102101605(GNAO1)
PMAJ: 107209802(GNAO1)
CCW: 104687499(GNAO1)
FPG: 101920934(GNAO1)
FCH: 102052678(GNAO1)
EGZ: 104130276(GNAO1)
AMJ: 102575346(GNAO1)
CPOO: 109310332
GGN: 109289648(GNAO1)
CMY: 102938723(GNAO1)
CPIC: 101939865(GNAO1)
TST: 117886587(GNAO1)
CABI: 116827902(GNAO1)
ACS: 100561396(gnao1) 103282364
PMUR: 107296063(GNAO1)
PGUT: 117670323
PMUA: 114601900(GNAO1)
ZVI: 118085957(GNAO1)
GJA: 107118988(GNAO1)
XLA: 108714022 397896(gnao1.S)
XTR: 549749(gnao1)
NPR: 108793915(GNAO1)
DRE: 393760(gnao1a) 393801(gnao1b)
AMEX: 103039135(gnao1) 111191720
EEE: 113573596(gnao1) 113579128
TRU: 101079681(gnao1)
NCC: 104965823(gnao1)
ELY: 117252760(gnao1b) 117262875(gnao1a)
PLEP: 121949902(gnao1a) 121950142(gnao1b)
SLUC: 116046502(gnao1a) 116060644(gnao1b)
ECRA: 117949807 117951216(gnao1b)
MSAM: 119889992 119893189(gnao1a)
CUD: 121508669(gnao1b) 121514716(gnao1a)
OAU: 116319550(gnao1a) 116334633(gnao1b)
OLA: 101166207(gnao1) 101167706
OML: 112152140 112160695(gnao1b)
CVG: 107103784
CTUL: 119789170(gnao1a) 119798936(gnao1b)
NFU: 107381402(gnao1) 107396198
KMR: 108228379(gnao1b) 108249535(gnao1a)
ALIM: 106532023(gnao1) 106536960
AOCE: 111571167 111579899(gnao1)
POV: 109636840(gnao1) 109638958
SLAL: 111646261(gnao1) 111666045
XGL: 120789882(gnao1b) 120793703(gnao1a)
BPEC: 110169647(gnao1) 110175486
SASA: 106560843(gnao1) 106562227 106573727(gnao1) 106587424
OMY: 110494881(gnao1a) 110506557(gnao1b) 110520292 110526435
ELS: 105016280 105018488(gnao1)
SFM: 108918980(gnao1)
PKI: 111848107 111851926(gnao1)
LOC: 102691646(gnao1)
ARUT: 117424108
CMK: 103185959
RTP: 109916540(gnao1)
BFO: 118417831
SCLV: 120332634
SPU: 576911
APLC: 110988978
SKO: 100377101
DME: Dmel_CG2204(Galphao)
DER: 6542262
DSE: 6608517
DSI: Dsimw501_GD10742(Dsim_GD10742)
DAN: 6496601
DSR: 110189779
DPE: 6592254
DWI: 6646234
DGR: 6560385
DAZ: 108615274
DNV: 108653373
DHE: 111599047
DVI: 6625542
MDE: 101887825
LCQ: 111688088
ACOZ: 120953849
AARA: 120898335
AAG: 5570867
AALB: 109411098
CPII: 120431056
AME: 102656465
ACER: 108001957
BIM: 100742795
BTER: 100642305
CCAL: 108632785
OBB: 114871500
MGEN: 117222370
NMEA: 116425370
CGIG: 122402212
SOC: 105195608
MPHA: 105830461
AEC: 105144590
ACEP: 105618355
PBAR: 105431709
VEM: 105569773
HST: 105185321
DQU: 106750083
CFO: 105253347
FEX: 115234505
LHU: 105678675
PGC: 109854118
OBO: 105282401
PCF: 106791593
NVI: 100118592(Gnao)
CSOL: 105366809
MDL: 103569719
TCA: 655023
DPA: 109534130
ATD: 109599485
AGB: 108915123
NVL: 108568503
PPYR: 116159057
OTU: 111416000
BMOR: 692460(Go)
MSEX: 115444215
BANY: 112053280
PMAC: 106716736
PPOT: 106102374
PXU: 106114246
PRAP: 110995785
ZCE: 119831909
HAW: 110371260
TNL: 113494761
PXY: 105383314
API: 100168757(Gnao1)
AGS: 114125074
RMD: 113550390
BTAB: 109038493
DCI: 103507425
CLEC: 106661135
NLU: 111061900
ZNE: 110832380
CSEC: 111869440
FCD: 110863515
DPX: DAPPUDRAFT_59367(Gnao)
PVM: 113824421
HAME: 121875643
EAF: 111702108
DSV: 119436153
RSAN: 119371968
RMP: 119177116
VDE: 111243063
VJA: 111272392
TUT: 107359521
DPTE: 113798389
CSCU: 111620667
PTEP: 107443225
CEL: CELE_C26C6.2(goa-1) CELE_E02C12.5(gpa-3) CELE_F38E1.5(gpa-2) CELE_M04C7.1(gpa-15) CELE_R10H10.5(gpa-7) CELE_T19C4.6(gpa-1)
CBR: CBG08377(Cbr-gpa-7) CBG11277(Cbr-gpa-2) CBG19263(Cbr-gpa-3) CBG23127(Cbr-gpa-1) CBG24698(Cbr-goa-1)
BMY: BM_BM3092(Bma-gpa-3) BM_BM8284(Bma-goa-1)
PCAN: 112553462
CRG: 105346725
MYI: 110453591
PMAX: 117338230
OBI: 106882189
LAK: 106169108
EGL: EGR_07086
ATEN: 116298128
HMG: 100204078
TPS: THAPSDRAFT_264137(GPA2)
 » show all
Reference
PMID:1901650
  Authors
Tsukamoto T, Toyama R, Itoh H, Kozasa T, Matsuoka M, Kaziro Y
  Title
Structure of the human gene and two rat cDNAs encoding the alpha chain of GTP-binding regulatory protein Go: two different mRNAs are generated by alternative splicing.
  Journal
Proc Natl Acad Sci U S A 88:2974-8 (1991)
DOI:10.1073/pnas.88.8.2974
  Sequence
[hsa:2775]
LinkDB

KEGG   ORTHOLOGY: K04535
Entry
K04535                      KO                                     

Name
GNAZ
Definition
guanine nucleotide-binding protein G(z) subunit alpha
Pathway
map04730  Long-term depression
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09156 Nervous system
   04730 Long-term depression
    K04535  GNAZ; guanine nucleotide-binding protein G(z) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K04535  GNAZ; guanine nucleotide-binding protein G(z) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [OT]
    K04535  GNAZ; guanine nucleotide-binding protein G(z) subunit alpha
Genes
HSA: 2781(GNAZ)
PTR: 458693(GNAZ)
PPS: 100973910(GNAZ)
GGO: 101130405(GNAZ)
PON: 100461603(GNAZ)
NLE: 100592745(GNAZ)
MCC: 706704(GNAZ)
MCF: 102143621(GNAZ)
CSAB: 103222900(GNAZ)
CATY: 105599362(GNAZ)
PANU: 101013119(GNAZ)
RRO: 104672492(GNAZ)
RBB: 108540632(GNAZ)
TFN: 117095923(GNAZ)
PTEH: 111530540(GNAZ)
CJC: 100391403(GNAZ)
SBQ: 101043815(GNAZ)
MMU: 14687(Gnaz)
MCAL: 110303138(Gnaz)
MPAH: 110326251(Gnaz)
RNO: 25740(Gnaz)
MCOC: 116074526(Gnaz)
MUN: 110553860(Gnaz)
CGE: 100767381(Gnaz)
PLEU: 114696477(Gnaz)
NGI: 103734697(Gnaz)
HGL: 101714256(Gnaz)
CCAN: 109698317(Gnaz)
OCU: 100356759(GNAZ)
TUP: 102490381(GNAZ)
CFA: 607445(GNAZ)
VVP: 112907538(GNAZ)
VLG: 121475856(GNAZ)
AML: 100467701(GNAZ)
UMR: 103669195(GNAZ)
UAH: 113247070(GNAZ)
ORO: 101382032(GNAZ)
MPUF: 101676942(GNAZ)
EJU: 114201486(GNAZ)
MLX: 117999868(GNAZ)
FCA: 101100923(GNAZ)
PTG: 102956507(GNAZ)
PPAD: 109277432(GNAZ)
AJU: 106979694(GNAZ)
HHV: 120223937(GNAZ)
BTA: 112442078(GNAZ)
BOM: 102282969(GNAZ)
BBUB: 102397443(GNAZ)
CHX: 106501838(GNAZ)
OAS: 106991715(GNAZ)
ODA: 120871314(GNAZ)
SSC: 100151867(GNAZ)
CFR: 102510081(GNAZ)
CDK: 105095185(GNAZ)
BACU: 103009880(GNAZ)
LVE: 103078351(GNAZ)
OOR: 101279995(GNAZ)
DLE: 111162902(GNAZ)
PCAD: 102994046(GNAZ)
ECB: 100049992(GNAZ)
EPZ: 103560313(GNAZ)
EAI: 106847135(GNAZ)
MYB: 102242558(GNAZ)
MYD: 102759123(GNAZ)
MMYO: 118655528(GNAZ)
MNA: 107530516(GNAZ)
HAI: 109394891(GNAZ)
DRO: 112310808(GNAZ)
SHON: 119001818(GNAZ)
AJM: 119059207(GNAZ)
MMF: 118640045(GNAZ)
PALE: 107195444(GNAZ)
RAY: 107500686(GNAZ)
MJV: 108392015(GNAZ)
TOD: 119244489(GNAZ)
LAV: 100673517(GNAZ)
TMU: 101352149
MDO: 100016996(GNAZ)
SHR: 100916887(GNAZ)
PCW: 110215267(GNAZ)
OAA: 100088957(GNAZ)
GGA: 770226(GNAZ)
PCOC: 116228458(GNAZ)
MGP: 100547187(GNAZ)
CJO: 107321383(GNAZ)
NMEL: 110406402(GNAZ)
APLA: 101799262(GNAZ)
ACYG: 106031320(GNAZ)
TGU: 100227663(GNAZ)
LSR: 110481350(GNAZ)
SCAN: 103818016(GNAZ)
PMOA: 120510361(GNAZ)
GFR: 102041313(GNAZ)
FAB: 101813576(GNAZ)
PHI: 102100063(GNAZ)
PMAJ: 107211761(GNAZ)
CCAE: 111936624(GNAZ)
CCW: 104688566(GNAZ)
ETL: 114056650(GNAZ)
FPG: 101923915(GNAZ)
FCH: 102053137(GNAZ)
CLV: 102095261(GNAZ)
EGZ: 104130087(GNAZ)
NNI: 104011444(GNAZ)
ACUN: 113486090(GNAZ)
PADL: 103922619(GNAZ)
AAM: 106486304(GNAZ)
ASN: 102378442(GNAZ)
AMJ: 102560086(GNAZ)
CPOO: 109312842(GNAZ)
GGN: 109290378(GNAZ)
CMY: 102945651(GNAZ)
CPIC: 101945996(GNAZ)
TST: 117887948(GNAZ)
CABI: 116837125(GNAZ)
ACS: 100557798(gnaz)
PVT: 110081941(GNAZ)
PBI: 103053469(GNAZ)
PMUR: 107299455(GNAZ)
TSR: 106551860(GNAZ)
PGUT: 117677929(GNAZ)
PMUA: 114586097(GNAZ)
ZVI: 118075877(GNAZ)
GJA: 107115084(GNAZ)
XLA: 108707114(gnaz.S) 108716026(gnaz.L)
XTR: 780044(gnaz)
NPR: 108787775(GNAZ)
DRE: 564915(gnaz)
IPU: 108277250(gnaz)
PHYP: 113544026(gnaz)
AMEX: 103042294(gnaz)
EEE: 113575148(gnaz)
TRU: 101066109(gnaz)
LCO: 104923426(gnaz)
NCC: 104961029(gnaz)
ELY: 117269980(gnaz)
PLEP: 121959694(gnaz)
SLUC: 116035025(gnaz)
ECRA: 117958901(gnaz)
PFLV: 114570763(gnaz)
GAT: 120832271(gnaz)
MSAM: 119914809(gnaz)
CUD: 121524890(gnaz)
MZE: 101463857(gnaz)
ONL: 100699018(gnaz)
OAU: 116322450(gnaz)
OLA: 101167809(gnaz)
OML: 112163395(gnaz)
XMA: 102228140(gnaz)
XCO: 114149490(gnaz)
XHE: 116724207(gnaz)
PRET: 103473672(gnaz)
CVG: 107092701(gnaz)
CTUL: 119771590(gnaz)
NFU: 107372764(gnaz)
KMR: 108232719(gnaz)
ALIM: 106514523(gnaz)
AOCE: 111568360(gnaz)
CSEM: 103389074(gnaz)
POV: 109626531(gnaz)
LCF: 108879282(gnaz)
SDU: 111234166(gnaz)
SLAL: 111668088(gnaz)
XGL: 120806847(gnaz)
HCQ: 109517063(gnaz)
BPEC: 110174131(gnaz)
MALB: 109963489(gnaz)
OMY: 110509886 110523678(gnaz)
ELS: 105014976(gnaz)
LOC: 102694902(gnaz)
LCM: 102353158(GNAZ)
CMK: 103188671(gnaz)
RTP: 109916923(gnaz)
 » show all
Reference
  Authors
Milligan G, Kostenis E
  Title
Heterotrimeric G-proteins: a short history.
  Journal
Br J Pharmacol 147 Suppl 1:S46-55 (2006)
DOI:10.1038/sj.bjp.0706405
Reference
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)
DOI:10.1152/physrev.00003.2005
LinkDB

KEGG   ORTHOLOGY: K04630
Entry
K04630                      KO                                     

Name
GNAI
Definition
guanine nucleotide-binding protein G(i) subunit alpha
Pathway
map04015  Rap1 signaling pathway
map04022  cGMP-PKG signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04071  Sphingolipid signaling pathway
map04113  Meiosis - yeast
map04261  Adrenergic signaling in cardiomyocytes
map04360  Axon guidance
map04371  Apelin signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04670  Leukocyte transendothelial migration
map04713  Circadian entrainment
map04723  Retrograde endocannabinoid signaling
map04724  Glutamatergic synapse
map04725  Cholinergic synapse
map04726  Serotonergic synapse
map04727  GABAergic synapse
map04728  Dopaminergic synapse
map04730  Long-term depression
map04914  Progesterone-mediated oocyte maturation
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04921  Oxytocin signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04924  Renin secretion
map04926  Relaxin signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04971  Gastric acid secretion
map05012  Parkinson disease
map05030  Cocaine addiction
map05032  Morphine addiction
map05034  Alcoholism
map05133  Pertussis
map05142  Chagas disease
map05145  Toxoplasmosis
map05163  Human cytomegalovirus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
Disease
H00033  Adrenal carcinoma
H01884  Auriculocondylar syndrome
H02269  Familial ventricular tachycardia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04371 Apelin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04071 Sphingolipid signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04024 cAMP signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04022 cGMP-PKG signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09140 Cellular Processes
  09143 Cell growth and death
   04113 Meiosis - yeast
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04670 Leukocyte transendothelial migration
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04062 Chemokine signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04915 Estrogen signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04914 Progesterone-mediated oocyte maturation
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04921 Oxytocin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04926 Relaxin signaling pathway
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04935 Growth hormone synthesis, secretion and action
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04928 Parathyroid hormone synthesis, secretion and action
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04916 Melanogenesis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04924 Renin secretion
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09154 Digestive system
   04971 Gastric acid secretion
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09156 Nervous system
   04724 Glutamatergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04727 GABAergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04725 Cholinergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04728 Dopaminergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04726 Serotonergic synapse
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04730 Long-term depression
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04723 Retrograde endocannabinoid signaling
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09158 Development and regeneration
   04360 Axon guidance
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05207 Chemical carcinogenesis - receptor activation
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05163 Human cytomegalovirus infection
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09171 Infectious disease: bacterial
   05133 Pertussis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05142 Chagas disease
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09165 Substance dependence
   05030 Cocaine addiction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05032 Morphine addiction
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   05034 Alcoholism
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
   04031 GTP-binding proteins
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Proteins found in most exosomes
   K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 1 (Gi/o) [OT]
    K04630  GNAI; guanine nucleotide-binding protein G(i) subunit alpha
Genes
HSA: 2770(GNAI1) 2771(GNAI2) 2773(GNAI3)
PTR: 457093(GNAI3) 472425(GNAI1) 744773(GNAI2)
PPS: 100968961(GNAI3) 100974334(GNAI2) 100985590(GNAI1)
GGO: 101125616(GNAI3) 101154597(GNAI1)
PON: 100172679(GNAI1) 100456074(GNAI3) 100458137(GNAI2)
NLE: 100583621(GNAI3) 100588993(GNAI2) 100604896(GNAI1)
MCC: 699310(GNAI3) 703780(GNAI2) 708940(GNAI1)
MCF: 101926144(GNAI2) 102119905(GNAI3) 102140224(GNAI1)
CSAB: 103224284(GNAI3) 103226652(GNAI1) 103227664(GNAI2)
CATY: 105573715(GNAI2) 105583233(GNAI1) 105594342(GNAI3)
PANU: 101011013(GNAI3) 101011251(GNAI2) 101020528(GNAI1)
RRO: 104655987(GNAI3) 104667102(GNAI2) 104673307(GNAI1)
RBB: 108519632(GNAI3) 108526962(GNAI2) 108534866(GNAI1)
TFN: 117072581(GNAI1) 117075132(GNAI3) 117081788(GNAI2)
PTEH: 111552452(GNAI1) 111555442(GNAI2) 111556065(GNAI3)
CJC: 100388113(GNAI1) 100404474(GNAI2) 100405745(GNAI3)
SBQ: 101032105(GNAI3) 101041681(GNAI2) 101042629(GNAI1)
MMUR: 105864008(GNAI3) 105874990(GNAI2) 105879338(GNAI1)
MMU: 14677(Gnai1) 14678(Gnai2) 14679(Gnai3)
MCAL: 110290775(Gnai3) 110294623(Gnai1) 110301809(Gnai2)
MPAH: 110314435 110319821(Gnai3) 110327202(Gnai2)
RNO: 25643(Gnai3) 25686(Gnai1) 81664(Gnai2)
MCOC: 116072321(Gnai2) 116093617(Gnai3) 116097497
MUN: 110539607 110545517(Gnai3) 110564775(Gnai2)
CGE: 100689068(Gnai2) 100689070(Gnai1) 100689072(Gnai3)
PLEU: 114699988(Gnai3) 114708228(Gnai1) 114710969(Gnai2)
NGI: 103724646 103732220(Gnai1) 103747835(Gnai3) 103750163(Gnai2)
HGL: 101698645(Gnai2) 101702965(Gnai1) 101703043(Gnai3)
CCAN: 109688838(Gnai3) 109693226(Gnai2) 109702253(Gnai1)
OCU: 100338391(GNAI1) 100339066(GNAI2) 100359147(GNAI3)
TUP: 102475420(GNAI2) 102476737(GNAI3) 102479323(GNAI1)
CFA: 442957(GNAI2) 478227(GNAI1) 611810(GNAI3)
VVP: 112911158(GNAI2) 112918267(GNAI3) 112925393(GNAI1)
VLG: 121471255(GNAI1) 121487463(GNAI3) 121495419(GNAI2)
AML: 100466408(GNAI3) 100471767(GNAI2) 100484933(GNAI1)
UMR: 103658775(GNAI1) 103674803(GNAI2) 103675000(GNAI3)
UAH: 113244920(GNAI3) 113256902(GNAI2) 113259201(GNAI1)
ORO: 101367568(GNAI3) 101367936(GNAI2) 101376186(GNAI1)
MPUF: 101674354(GNAI1) 101687914(GNAI2) 101691741(GNAI3)
EJU: 114207900(GNAI3) 114222284(GNAI1) 114225129(GNAI2)
MLX: 118005775(GNAI2) 118019030(GNAI3) 118020679(GNAI1)
FCA: 101089679(GNAI2) 101092837(GNAI1) 101100320(GNAI3)
PTG: 102951159(GNAI3) 102954501(GNAI1) 102962946(GNAI2)
PPAD: 109247840(GNAI2) 109268145(GNAI1) 109272000(GNAI3)
AJU: 106977809(GNAI3) 106979196(GNAI2) 106982494(GNAI1)
HHV: 120229291(GNAI2) 120244506(GNAI3) 120245414(GNAI1)
BTA: 281790(GNAI1) 281791(GNAI2) 539521(GNAI3)
BOM: 102273920(GNAI1) 102274651(GNAI2) 102285228(GNAI3)
BIU: 109555970(GNAI3) 109557337(GNAI1) 109576257(GNAI2)
BBUB: 102401306(GNAI1) 102409247(GNAI3) 102413668(GNAI2)
CHX: 100860765(GNAI2) 102185804(GNAI1) 108635583(GNAI3)
OAS: 100302341(GNAI2) 101103693(GNAI3) 101116393(GNAI1)
ODA: 120856729(GNAI3) 120868293(GNAI2) 120878127(GNAI1)
SSC: 100144419(GNAI1) 100144421(GNAI3) 397523(GNAI2)
CFR: 102504487(GNAI3) 102518290(GNAI1) 102522331(GNAI2)
CDK: 105085647(GNAI3) 105087520(GNAI2) 105100375(GNAI1)
BACU: 103008589(GNAI3) 103010531(GNAI2) 103017385(GNAI1)
LVE: 103077308(GNAI2) 103080185(GNAI3) 103081367(GNAI1)
OOR: 101271719(GNAI1) 101276500(GNAI2) 101277471(GNAI3)
DLE: 111164599(GNAI1) 111174368(GNAI2) 111180070(GNAI3)
PCAD: 102996618(GNAI2) 102996666(GNAI1) 102997009(GNAI3)
ECB: 100055673(GNAI1) 100058238(GNAI3) 100062085(GNAI2)
EPZ: 103552141 103553052(GNAI3) 103557343(GNAI2)
EAI: 106827362(GNAI3) 106830727(GNAI2) 106833450(GNAI1)
MYB: 102239557(GNAI3) 102249318(GNAI2) 102256872(GNAI1)
MYD: 102754275(GNAI2) 102765504(GNAI3) 102766400(GNAI1)
MMYO: 118666051(GNAI1) 118668456(GNAI2) 118673502(GNAI3) 118675794
MNA: 107540752(GNAI1) 107545079(GNAI2) 107545320(GNAI3)
HAI: 109375288(GNAI3) 109377665(GNAI2) 109392892(GNAI1)
DRO: 112303430(GNAI1) 112309828(GNAI2) 112313520(GNAI3)
SHON: 118989455(GNAI2) 118990034(GNAI3) 119000994(GNAI1)
AJM: 119036589(GNAI2) 119040343(GNAI1) 119054511(GNAI3)
MMF: 118620140(GNAI1) 118632994(GNAI2) 118637975(GNAI3)
PALE: 102885642(GNAI1) 102892785(GNAI3) 102898665(GNAI2)
RAY: 107513376(GNAI2) 107516134(GNAI3) 107518173(GNAI1)
MJV: 108388509 108400984(GNAI3) 108402874(GNAI2)
TOD: 119235137(GNAI3) 119244853(GNAI1) 119260497(GNAI2)
LAV: 100666344(GNAI1) 100667957(GNAI3) 100670234(GNAI2)
MDO: 100013052(GNAI1) 100030095(GNAI3) 100032986(GNAI2)
SHR: 100914706(GNAI2) 100916740(GNAI1) 100928725(GNAI3)
PCW: 110206959(GNAI1) 110216929(GNAI2) 110218213(GNAI3)
OAA: 100075665(GNAI1) 100077742(GNAI2) 100089995(GNAI3)
GGA: 374097(GNAI3) 396367(GNAI2) 396368(GNAI1)
PCOC: 116228502 116238696(GNAI3) 116241052(GNAI2)
CJO: 107319651(GNAI2) 107320948 107324730(GNAI3)
NMEL: 110388080(GNAI3) 110392326(GNAI1) 110404852(GNAI2)
APLA: 101797591 101798529(GNAI2) 101803759(GNAI3)
ACYG: 106035549(GNAI1) 106042860 106049766(GNAI3)
TGU: 100219656(GNAI1) 100225910(GNAI2) 100232622(GNAI3)
LSR: 110469148(GNAI3) 110469766 110472079(GNAI2)
SCAN: 103813540 103822350(GNAI3) 103824284(GNAI2)
PMOA: 120495618(GNAI2) 120503423(GNAI3) 120509259
GFR: 102034568(GNAI2) 102042928(GNAI1) 102045421(GNAI3)
FAB: 101806522(GNAI3) 101807650(GNAI2) 101818889(GNAI1)
PHI: 102100320(GNAI3) 102105798(GNAI2) 102111212(GNAI1)
PMAJ: 107204764 107210461(GNAI2) 107214903(GNAI3)
CCAE: 111923276 111935142(GNAI2) 111939887(GNAI3)
CCW: 104683249(GNAI2) 104686889 104692441(GNAI3)
FPG: 101917880(GNAI1) 101918521(GNAI3) 101924920(GNAI2)
FCH: 102051232(GNAI2) 102056299(GNAI3) 102059982
CLV: 102086179(GNAI1) 102095096(GNAI2) 102096204(GNAI3)
EGZ: 104126738(GNAI2) 104127759(GNAI3) 104132374(GNAI1)
NNI: 104008688(GNAI2) 104010747(GNAI1) 104014537(GNAI3)
ACUN: 113490430(GNAI3) 113491350(GNAI1)
AAM: 106485672(GNAI1) 106495133(GNAI2) 106496939
ASN: 102377099(GNAI2) 102379966(GNAI3) 102383800(GNAI1)
AMJ: 102567683(GNAI3) 102571369(GNAI1) 106737098(GNAI2)
CPOO: 109315765(GNAI1) 109317544(GNAI3)
GGN: 109292178(GNAI1) 109295174(GNAI3)
PSS: 102452618(GNAI1) 102453613(GNAI3)
CMY: 102932239(GNAI3) 102934526(GNAI2) 102948273(GNAI1)
CPIC: 101941167(GNAI3) 101946186(GNAI2) 101948588(GNAI1)
TST: 117874953(GNAI1) 117876049(GNAI3) 117879831(GNAI2)
CABI: 116836010(GNAI2) 116836173(GNAI3) 116837565
ACS: 100553120(gnai3) 100559069(gnai1) 100562211(gnai2)
PVT: 110076779(GNAI2) 110077193(GNAI1) 110085272(GNAI3)
TSR: 106539143(GNAI2) 106543690 106556950(GNAI3)
PGUT: 117657564 117664049(GNAI3) 117679120(GNAI2)
PMUA: 114591516(GNAI2) 114599173(GNAI3) 114605041(GNAI1)
GJA: 107118867(GNAI2) 107120788(GNAI3) 107121247(GNAI1)
XLA: 108714595 379236(gnai3.S) 380034(gnai1.L) 399463(gnai1.S) 779438(gnai2.S)
XTR: 100038283(gnai1) 394861(gnai2) 496962(gnai3)
NPR: 108795703(GNAI3) 108796157(GNAI1) 108803716
DRE: 100006888(gnai3) 323509(gnaia) 327650(gnai2b) 336421(gnai2a) 393946(gnai1)
IPU: 100526828(gnai1) 108254730(gnai2) 108265813(GNAI3) 108271854(GNAI2) 108279833(Gnai1)
ELY: 117249363(gnai1) 117257011 117257351(gnai2b) 117258430(gnai3) 117262337
PLEP: 121946439(gnai3) 121949708 121956064 121958365(gnai2b) 121961132(gnai1)
SLUC: 116040886(gnai3) 116041528 116051241(gnai2b) 116060043(gnai1) 116063082
ECRA: 117938819(gnai1) 117942988(gnai2b) 117944074 117947971(gnai3) 117949581
MSAM: 119885750 119886624(gnai2b) 119893459 119905591(gnai3) 119918406(gnai1)
OAU: 116309713(gnai3) 116317093(gnai1) 116318291 116333879 116334221(gnai2b)
OML: 112144555 112145165(gnai2b) 112152429 112158166(gnai1) 112158895(gnai3)
CTUL: 119775114(gnai2b) 119776661 119781033(gnai1) 119782225(gnai3) 119793087
KMR: 108231398(gnai2b) 108233300(gnai1) 108235740 108236783(gnai3) 108239985
LCM: 102361424(GNAI2) 102362833(GNAI3) 102364585
CMK: 103176615(gnai2) 103176999(gnai1) 103182452
DME: Dmel_CG10060(Galphai)
DER: 6544798
DSE: 6611081
DSI: Dsimw501_GD13099(Dsim_GD13099)
DAN: 6493746
DSR: 110188750
DPE: 6603026
DMN: 108152293
DWI: 6639222
DGR: 6557478
DAZ: 108613557
DNV: 108650434
DHE: 111601063
DVI: 6624094
LCQ: 111685718
ACOZ: 120961679
AARA: 120899676
AAG: 5574452
CPII: 120413245
AME: 411704
ACER: 108003667
BIM: 100749490
BTER: 100649199
CCAL: 108625145
OBB: 114879790
MGEN: 117229222
NMEA: 116430025
CGIG: 122399744
SOC: 105199791
MPHA: 105835934
AEC: 105148007
ACEP: 105623462
PBAR: 105427877
VEM: 105563807
HST: 105190201
DQU: 106747758
CFO: 105250004
LHU: 105676136
PGC: 109852600
OBO: 105280787
PCF: 106785141
TCA: 103314873
DPA: 109537189
ATD: 109596384
AGB: 108906281
NVL: 108565005
APLN: 108735245
PPYR: 116165885
OTU: 111424926
API: 100164033
DNX: 107166241
AGS: 114121439
RMD: 113555545
BTAB: 109038871
DCI: 103518442
CLEC: 106666884
NLU: 111045229
ZNE: 110827220
CSEC: 111866176
FCD: 110856662
DPX: DAPPUDRAFT_193276(Gnai)
HAME: 121878373
DSV: 119461834
RMP: 119174082
VDE: 111248312
VJA: 111265503
TUT: 107365545
DPTE: 113789883
CSCU: 111612958
PTEP: 107443828
SDM: 118181883
CEL: CELE_T07A9.7(gpa-4) CELE_Y95B8A.5(gpa-16)
CBR: CBG13491(Cbr-gpa-4) CBG18548(Cbr-gpa-16) CBG18556 CBG20108(Cbr-gpa-18)
BMY: BM_BM5631(Bm5631)
TSP: Tsp_07815
BGT: 106070347
GAE: 121367598
CRG: 105342518
LAK: 106151815
NVE: 5522111
ATEN: 116305144
AMIL: 114976014
PDAM: 113684972
SPIS: 111343192
DGT: 114524442
HMG: 100192225(gnai4)
SCE: YER020W(GPA2)
ERC: Ecym_7187
NCS: NCAS_0A14970(NCAS0A14970)
NDI: NDAI_0J00490(NDAI0J00490)
TPF: TPHA_0I02990(TPHA0I02990)
TBL: TBLA_0J00340(TBLA0J00340)
TDL: TDEL_0H00740(TDEL0H00740)
KAF: KAFR_0B00560(KAFR0B00560)
CAL: CAALFM_C302240CA(GPA2)
SLB: AWJ20_2465(GPA2)
BBRX: BRETT_002852(GPA2)
NCR: NCU05206(gna-3) NCU06493(gna-1)
NTE: NEUTE1DRAFT62526(NEUTE1DRAFT_62526) NEUTE1DRAFT80570(NEUTE1DRAFT_80570)
SMP: SMAC_05328 SMAC_07195(putative gna3)
BFU: BCIN_05g06770(bcg1) BCIN_15g03610(bcg3)
ANG: ANI_1_824074(An08g05820) ANI_1_860074(An08g06130)
PNO: SNOG_06158(SNOG_06157) SNOG_10086(AY327542)
SPO: SPAC23H3.13c(gpa2)
ABP: AGABI1DRAFT102615(AGABI1DRAFT_102615) AGABI1DRAFT116493(AGABI1DRAFT_116493) AGABI1DRAFT123478(AGABI1DRAFT_123478) AGABI1DRAFT132402(AGABI1DRAFT_132402) AGABI1DRAFT36876(AGABI1DRAFT_36876)
ABV: AGABI2DRAFT150479(AGABI2DRAFT_150479) AGABI2DRAFT151207(AGABI2DRAFT_151207) AGABI2DRAFT188871(AGABI2DRAFT_188871) AGABI2DRAFT196019(AGABI2DRAFT_196019) AGABI2DRAFT211352(AGABI2DRAFT_211352)
MGL: MGL_0613
MRT: MRET_2482
DDI: DDB_G0276267(gpaB) DDB_G0283349(gpaA)
DFA: DFA_02716(gpaG) DFA_03705(gpaA) DFA_06634(gpaI) DFA_07593 DFA_08287(gpaB)
EHI: EHI_140350(150.t00020)
 » show all
Reference
PMID:3110783
  Authors
Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M
  Title
Human cDNA clones for an alpha subunit of Gi signal-transduction protein.
  Journal
Proc Natl Acad Sci U S A 84:5115-9 (1987)
DOI:10.1073/pnas.84.15.5115
  Sequence
[hsa:2770]
Reference
PMID:3120178
  Authors
Beals CR, Wilson CB, Perlmutter RM
  Title
A small multigene family encodes Gi signal-transduction proteins.
  Journal
Proc Natl Acad Sci U S A 84:7886-90 (1987)
DOI:10.1073/pnas.84.22.7886
  Sequence
[hsa:2771 2773]
LinkDB

KEGG   ORTHOLOGY: K04632
Entry
K04632                      KO                                     

Name
GNAS
Definition
guanine nucleotide-binding protein G(s) subunit alpha
Pathway
map01522  Endocrine resistance
map04015  Rap1 signaling pathway
map04020  Calcium signaling pathway
map04024  cAMP signaling pathway
map04072  Phospholipase D signaling pathway
map04261  Adrenergic signaling in cardiomyocytes
map04270  Vascular smooth muscle contraction
map04361  Axon regeneration
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04724  Glutamatergic synapse
map04726  Serotonergic synapse
map04728  Dopaminergic synapse
map04730  Long-term depression
map04750  Inflammatory mediator regulation of TRP channels
map04911  Insulin secretion
map04912  GnRH signaling pathway
map04913  Ovarian steroidogenesis
map04915  Estrogen signaling pathway
map04916  Melanogenesis
map04918  Thyroid hormone synthesis
map04921  Oxytocin signaling pathway
map04922  Glucagon signaling pathway
map04923  Regulation of lipolysis in adipocytes
map04924  Renin secretion
map04925  Aldosterone synthesis and secretion
map04926  Relaxin signaling pathway
map04927  Cortisol synthesis and secretion
map04928  Parathyroid hormone synthesis, secretion and action
map04934  Cushing syndrome
map04935  Growth hormone synthesis, secretion and action
map04961  Endocrine and other factor-regulated calcium reabsorption
map04962  Vasopressin-regulated water reabsorption
map04970  Salivary secretion
map04971  Gastric acid secretion
map04972  Pancreatic secretion
map04976  Bile secretion
map05012  Parkinson disease
map05030  Cocaine addiction
map05031  Amphetamine addiction
map05032  Morphine addiction
map05034  Alcoholism
map05110  Vibrio cholerae infection
map05142  Chagas disease
map05146  Amoebiasis
map05163  Human cytomegalovirus infection
map05165  Human papillomavirus infection
map05200  Pathways in cancer
map05207  Chemical carcinogenesis - receptor activation
map05414  Dilated cardiomyopathy
Disease
H00244  Pseudohypoparathyroidism
H00441  Progressive osseous heteroplasia
H00501  Fibrous dysplasia, polyostotic
H01102  Pituitary adenomas
H01431  Cushing syndrome
H01483  Acromegaly
H02049  Bilateral macronodular adrenal hyperplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04020 Calcium signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04072 Phospholipase D signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04024 cAMP signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09152 Endocrine system
   04911 Insulin secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04922 Glucagon signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04923 Regulation of lipolysis in adipocytes
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04912 GnRH signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04913 Ovarian steroidogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04915 Estrogen signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04921 Oxytocin signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04926 Relaxin signaling pathway
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04935 Growth hormone synthesis, secretion and action
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04918 Thyroid hormone synthesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04928 Parathyroid hormone synthesis, secretion and action
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04916 Melanogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04924 Renin secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04925 Aldosterone synthesis and secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04927 Cortisol synthesis and secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04270 Vascular smooth muscle contraction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09154 Digestive system
   04970 Salivary secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04971 Gastric acid secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04972 Pancreatic secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04976 Bile secretion
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04961 Endocrine and other factor-regulated calcium reabsorption
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09156 Nervous system
   04724 Glutamatergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04728 Dopaminergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04726 Serotonergic synapse
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04730 Long-term depression
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09158 Development and regeneration
   04361 Axon regeneration
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04714 Thermogenesis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05207 Chemical carcinogenesis - receptor activation
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05165 Human papillomavirus infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05142 Chagas disease
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09165 Substance dependence
   05030 Cocaine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05031 Amphetamine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05032 Morphine addiction
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   05034 Alcoholism
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
   04031 GTP-binding proteins
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of other body fluids (saliva and urine)
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of colorectal cancer cells
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
  Exosomal proteins of bladder cancer cells
   K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 2 (Gs)
    K04632  GNAS; guanine nucleotide-binding protein G(s) subunit alpha
Genes
HSA: 2778(GNAS)
PTR: 104003639 469986(GNAS)
PPS: 100978090 100990650
GGO: 101132215 109023045(GNAS)
PON: 100442753(GNAS) 103888841
NLE: 101176289(GNAS) 115830355
MCC: 100424899 694289
MCF: 102145630(GNAS) 107126444
CSAB: 103243499 103243509(GNAS)
CATY: 105585318 105585319
PANU: 103887915
RRO: 104663797(GNAS) 104663799
RBB: 108541624(GNAS) 108541626
PTEH: 111555637(GNAS) 111555638
CJC: 100408515(GNAS) 103787209
SBQ: 101043452(GNAS) 104652116
MMU: 14683(Gnas)
RNO: 24896(Gnas)
CGE: 100689067(Gnas) 103158534
NGI: 103741466 103741475(Gnas)
HGL: 101705689 101716905(Gnas)
CCAN: 109692784(Gnas) 109692786
OCU: 100008904(GNAS) 100346323
TUP: 102489563(GNAS) 102501321
CFA: 403943(GNAS)
ORO: 101364060(GNAS) 105757053
EJU: 114197913(GNAS) 114197962
PTG: 102964541(GNAS)
HHV: 120234858(GNAS) 120234860
BTA: 281793(GNAS)
CHX: 102188874(GNAS) 108633189
SSC: 100049657(GNAS)
BACU: 103004158 103004432(GNAS)
LVE: 103085385 103089051(GNAS)
DLE: 111186741(GNAS) 111186746
PCAD: 102987258 102993267(GNAS)
MMYO: 118662565(GNAS) 118663143
MNA: 107529329(GNAS) 107529353
AJM: 119055313(GNAS) 119055349
MMF: 118618303(GNAS) 118618304
RAY: 107500067(GNAS) 107500068
TOD: 119236970
MDO: 100021523(GNAS) 100029582
SHR: 100930666(GNAS)
PCW: 110205152(GNAS)
OAA: 100080392(GNAS)
GGA: 419313(GNAS)
MGP: 100550361(GNAS)
CJO: 107323051(GNAS)
NMEL: 110408305(GNAS)
APLA: 101791631(GNAS)
ACYG: 106042176(GNAS)
TGU: 100232476(GNAS)
LSR: 110483601(GNAS)
SCAN: 103818880(GNAS)
PMOA: 120506987(GNAS)
GFR: 102041915(GNAS)
FAB: 101810765(GNAS)
PHI: 102103803(GNAS)
PMAJ: 107213286(GNAS)
CCAE: 111938030(GNAS)
CCW: 104687623(GNAS)
ETL: 114056214(GNAS)
FPG: 101922321(GNAS)
FCH: 102059934(GNAS)
CLV: 102095310(GNAS)
EGZ: 104130645(GNAS)
NNI: 104013042(GNAS)
ACUN: 113487624(GNAS)
PADL: 103919293(GNAS)
AAM: 106492804
ASN: 102384106(GNAS)
AMJ: 102563836(GNAS)
CPOO: 109318799(GNAS)
GGN: 109292369(GNAS)
PSS: 102447036
CMY: 102934181(GNAS)
CPIC: 101939195(GNAS)
TST: 117885759(GNAS)
CABI: 116816696 116826053(GNAS)
PVT: 110084741(GNAS)
PMUR: 107295540(GNAS)
TSR: 106537887(GNAS)
PGUT: 117674882(GNAS)
PMUA: 114599685(GNAS)
ZVI: 118089017(GNAS)
GJA: 107119835(GNAS)
XLA: 394414(gnas.S) 399059(gnas.L)
XTR: 407931(gnas)
NPR: 108784456 108802775(GNAS)
DRE: 557353(gnas)
PHYP: 113533656 113545913(gnas)
EEE: 113577854(gnas) 113578881
TRU: 101064507(gnas) 101065996
LCO: 104933618 104936173(gnas)
NCC: 104943626(gnas) 104961555
ELY: 117257069 117258383(gnas)
PLEP: 121946698(gnas) 121957044
SLUC: 116040638(gnas) 116051389
ECRA: 117943482 117948265(gnas)
PFLV: 114554090 114558379(gnas)
GAT: 120829642(gnas) 120835150
MSAM: 119886579 119905691(gnas)
CUD: 121506863(gnas)
MZE: 101467861 101481065(gnas)
ONL: 100710082 100712365(gnas)
OAU: 116318971(gnas) 116320732
OLA: 101163657(gnas) 101166373
OML: 112145513 112158811(gnas)
XMA: 102220069(gnas) 102237275
XCO: 114134934 114143677(gnas)
XHE: 116711262
PRET: 103464384 103468030(gnas)
CVG: 107086678(gnas) 107103230
CTUL: 119789225(gnas) 119793801
NFU: 107385351 107390594(gnas)
KMR: 108231696 108236834(gnas)
ALIM: 106513057(gnas) 106515123
CSEM: 103384508(gnas) 103386688
POV: 109630898(gnas) 109635337
LCF: 108884112 108891667(gnas)
SDU: 111218983(gnas) 111223941
SLAL: 111650977 111670700(gnas)
XGL: 120783487 120803856(gnas)
HCQ: 109517765(gnas) 109529200
BPEC: 110170217 110174705(gnas)
MALB: 109970020(gnas) 109970238
SASA: 106566693 106571962(gnas)
SALP: 111966254 111976616(gnas)
SFM: 108928411(gnas) 108930457
PKI: 111835288(gnas) 111844707
LOC: 102686575(gnas)
LCM: 102352483(GNAS)
CMK: 103171631(gnas)
CIN: 100185405
SCLV: 120338525
DME: Dmel_CG2835(Galphas)
DER: 6548006
DSE: 6615810
DSI: Dsimw501_GD11812(Dsim_GD11812)
DAN: 6495724
DSR: 110191496
DPE: 6590492
DWI: 6641002
DGR: 6559122
DAZ: 108616844
DNV: 108657668
DHE: 111600016
DVI: 6625437
MDE: 101899076
LCQ: 111681898
AGA: AgaP_AGAP012095(GNAS_ANOGA)
ACOZ: 120959132
AARA: 120904596
AAG: 5563900
AME: 411011
ACER: 107996056
BIM: 100743421
BTER: 100642353
CCAL: 108623734
OBB: 114877664
MGEN: 117226544
NMEA: 116432566
CGIG: 122395728
SOC: 105205688
MPHA: 105839094
AEC: 105148870
ACEP: 105625855
PBAR: 105431600
VEM: 105560140
HST: 105187166
DQU: 106742205
CFO: 105255386
FEX: 115241541
LHU: 105677705
PGC: 109860532
OBO: 105283208
PCF: 106790564
NVI: 100122520
CSOL: 105363913
MDL: 103572952
DPA: 109544329
AGB: 108911374
NVL: 108560534
APLN: 108735478
OTU: 111418834
MSEX: 115442987
BANY: 112057121
PMAC: 106714942
PPOT: 106103158
PXU: 106128743
ZCE: 119836894
HAW: 110379546
TNL: 113494278
PXY: 105388866
API: 100159067
DNX: 107166913
AGS: 114120428
RMD: 113548464
BTAB: 109042160
DCI: 103505624
CLEC: 106662310
NLU: 111059791
ZNE: 110833990
CSEC: 111872188
FCD: 110848319
DPX: DAPPUDRAFT_191575(Gnas)
HAME: 121864680
EAF: 111707508
DSV: 119432526
RSAN: 119374703
RMP: 119176172
VDE: 111245999
VJA: 111264679
TUT: 107371146
DPTE: 113793105
CSCU: 111620663
PTEP: 107439392
SDM: 118205626
CEL: CELE_R06A10.2(gsa-1)
CBR: CBG22078(Cbr-gsa-1)
BMY: BM_BM5243(Bma-gsa-1)
TSP: Tsp_05311
BGT: 106078284
GAE: 121388111
PMAX: 117338168
OBI: 106869212
EGL: EGR_04343
NVE: 5521470
EPA: 110248771
ADF: 107348778
AMIL: 114968530
PDAM: 113680839
SPIS: 111335857
DGT: 114516946
HMG: 100192291(gnal) 100200225
 » show all
Reference
PMID:3093273
  Authors
Mattera R, Codina J, Crozat A, Kidd V, Woo SL, Birnbaumer L
  Title
Identification by molecular cloning of two forms of the alpha-subunit of the human liver stimulatory (GS) regulatory component of adenylyl cyclase.
  Journal
FEBS Lett 206:36-42 (1986)
DOI:10.1016/0014-5793(86)81336-9
  Sequence
[hsa:2778]
Reference
  Authors
Wettschureck N, Offermanns S.
  Title
Mammalian G proteins and their cell type specific functions.
  Journal
Physiol Rev 85:1159-204 (2005)
DOI:10.1152/physrev.00003.2005
LinkDB

KEGG   ORTHOLOGY: K04639
Entry
K04639                      KO                                     

Name
GNA13
Definition
guanine nucleotide-binding protein subunit alpha-13
Pathway
map04022  cGMP-PKG signaling pathway
map04071  Sphingolipid signaling pathway
map04072  Phospholipase D signaling pathway
map04270  Vascular smooth muscle contraction
map04371  Apelin signaling pathway
map04611  Platelet activation
map04730  Long-term depression
map04810  Regulation of actin cytoskeleton
map04928  Parathyroid hormone synthesis, secretion and action
map05130  Pathogenic Escherichia coli infection
map05163  Human cytomegalovirus infection
map05200  Pathways in cancer
Disease
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04072 Phospholipase D signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04071 Sphingolipid signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04022 cGMP-PKG signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09156 Nervous system
   04730 Long-term depression
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04031 GTP-binding proteins
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  Exosomal proteins of colorectal cancer cells
   K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
Genes
HSA: 10672(GNA13)
PTR: 454827(GNA13)
PPS: 100988877(GNA13)
GGO: 101152866(GNA13)
PON: 100461065(GNA13)
NLE: 100589821(GNA13)
MCC: 718144(GNA13)
MCF: 102127819(GNA13)
CSAB: 103243186(GNA13)
CATY: 105573047(GNA13)
PANU: 101010815(GNA13)
RRO: 104675436(GNA13)
RBB: 108517753(GNA13)
TFN: 117067409(GNA13)
PTEH: 111542515(GNA13)
CJC: 100394016(GNA13)
SBQ: 101034540(GNA13)
MMUR: 105861706(GNA13)
MMU: 14674(Gna13)
MCAL: 110304818(Gna13)
MPAH: 110331761(Gna13)
RNO: 303634(Gna13)
MCOC: 116076843(Gna13)
MUN: 110560037(Gna13)
CGE: 100689071(Gna13)
PLEU: 114690445(Gna13)
NGI: 103742208(Gna13)
HGL: 101719378(Gna13)
CCAN: 109696711(Gna13)
OCU: 100352794(GNA13)
TUP: 102488219(GNA13)
CFA: 490901(GNA13)
VVP: 112920734(GNA13)
VLG: 121473119(GNA13)
AML: 100474482(GNA13)
UMR: 103665670(GNA13)
UAH: 113265242(GNA13)
ORO: 101386508(GNA13)
ELK: 111158131
MPUF: 101676878(GNA13)
EJU: 114216074(GNA13)
MLX: 118024340(GNA13)
FCA: 101087625(GNA13)
PTG: 102964498(GNA13)
PPAD: 109277047(GNA13)
AJU: 106975340(GNA13)
HHV: 120230247(GNA13)
BTA: 505611(GNA13)
BOM: 102275435(GNA13)
BIU: 109573379(GNA13)
BBUB: 102390212(GNA13)
CHX: 102170818(GNA13)
OAS: 101117003(GNA13)
ODA: 120866595(GNA13)
SSC: 100522824(GNA13)
CFR: 102523556(GNA13)
CDK: 105085708(GNA13)
BACU: 103007094(GNA13)
LVE: 103071564(GNA13)
OOR: 101277931(GNA13)
DLE: 111182908(GNA13)
PCAD: 102989616(GNA13)
ECB: 100062972(GNA13)
EPZ: 103553497(GNA13)
EAI: 106835353(GNA13)
MYB: 102252423(GNA13)
MYD: 102764420(GNA13)
MMYO: 118671564(GNA13)
MNA: 107538305(GNA13)
HAI: 109380315(GNA13)
DRO: 112316266(GNA13)
SHON: 119003776(GNA13)
AJM: 119036264(GNA13)
MMF: 118633864(GNA13)
PALE: 102891607(GNA13)
RAY: 107510298(GNA13)
MJV: 108392407(GNA13)
TOD: 119233057(GNA13)
LAV: 100664965(GNA13)
TMU: 101346987
MDO: 100024566(GNA13)
SHR: 100932191(GNA13)
PCW: 110218195(GNA13)
OAA: 103166871(GNA13)
GGA: 417434(GNA13)
PCOC: 116232471(GNA13)
MGP: 100540964(GNA13)
CJO: 107322109(GNA13)
NMEL: 110407202(GNA13)
APLA: 101801355(GNA13)
ACYG: 106034698(GNA13)
TGU: 100223985(GNA13)
LSR: 110473974(GNA13)
SCAN: 103819970(GNA13)
PMOA: 120505454(GNA13)
GFR: 102040291(GNA13)
FAB: 101812192(GNA13)
PHI: 102099584(GNA13)
PMAJ: 107212551(GNA13)
CCAE: 111937573(GNA13)
CCW: 104696029(GNA13)
ETL: 114060688(GNA13)
FPG: 101922831(GNA13)
FCH: 102052233(GNA13)
CLV: 102084052(GNA13)
EGZ: 104132822(GNA13)
NNI: 104014357(GNA13)
ACUN: 113486831(GNA13)
PADL: 103916715(GNA13)
AAM: 106493143(GNA13)
ASN: 102376261(GNA13)
AMJ: 102568562(GNA13)
CPOO: 109314956(GNA13)
GGN: 109296855(GNA13)
PSS: 102458860(GNA13)
CMY: 102940587(GNA13)
CPIC: 101953084(GNA13)
TST: 117887642(GNA13)
CABI: 116822478(GNA13)
ACS: 100554119(gna13)
PVT: 110085885(GNA13)
PBI: 103050681(GNA13)
PMUR: 107282571(GNA13)
TSR: 106553054(GNA13)
PGUT: 117662931(GNA13)
PMUA: 114588210(GNA13)
ZVI: 118079645(GNA13)
GJA: 107105951(GNA13)
XLA: 108701204(gna13.L) 496349(gna13.S)
XTR: 100145489(gna13)
NPR: 108802992(GNA13)
DRE: 326825(gna13a) 336333(gna13b)
IPU: 108273768(GNA13) 108278714
NCC: 104946516
ELY: 117247232 117268272(gna13b)
PLEP: 121957290(gna13b) 121958546
SLUC: 116045102(gna13b) 116061103
ECRA: 117937186 117958637(gna13b)
GAT: 120819191 120827658(gna13b)
MSAM: 119915709 119918667(gna13b)
CUD: 121528175 121529287(gna13b)
OAU: 116325955 116332737(gna13b)
OML: 112154003 112157938(gna13b)
XMA: 102222912 102227062(gna13)
XCO: 114148609 114151980(gna13)
XHE: 116726921(gna13) 116735936
XGL: 120794244 120806440(gna13b)
BPEC: 110164386(gna13)
SALP: 111967821
PKI: 111848291 111856756(gna13)
LOC: 102687288(gna13)
LCM: 102364864(GNA13)
CMK: 103175515(gna13)
RTP: 109931209(gna13)
CIN: 100180076
SCLV: 120333469
SPU: 115918012
APLC: 110980280
VDE: 111250444
VJA: 111272399
PCAN: 112567820
AQU: 105312217
 » show all
Reference
PMID:2508088
  Authors
Strathmann M, Wilkie TM, Simon MI
  Title
Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.
  Journal
Proc Natl Acad Sci U S A 86:7407-9 (1989)
DOI:10.1073/pnas.86.19.7407
Reference
PMID:7791744
  Authors
Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD
  Title
Expression of GTP-binding protein alpha subunits in human thymocytes.
  Journal
Mol Cell Biochem 144:45-51 (1995)
DOI:10.1007/bf00926739
  Sequence
[hsa:10672]
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