KEGG   ORTHOLOGY: K04346
Entry
K04346                      KO                                     

Name
GNA12
Definition
guanine nucleotide-binding protein subunit alpha-12
Pathway
ko04010  MAPK signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04270  Vascular smooth muscle contraction
ko04361  Axon regeneration
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04928  Parathyroid hormone synthesis, secretion and action
ko05130  Pathogenic Escherichia coli infection
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
Disease
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04072 Phospholipase D signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04071 Sphingolipid signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04022 cGMP-PKG signaling pathway
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09156 Nervous system
   04730 Long-term depression
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09158 Development and regeneration
   04361 Axon regeneration
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
   04031 GTP-binding proteins
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of hepatic cells
   K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04346  GNA12; guanine nucleotide-binding protein subunit alpha-12
Genes
HSA: 2768(GNA12)
PTR: 463234(GNA12)
PPS: 100979605(GNA12)
GGO: 101147243(GNA12)
PON: 100173387(GNA12)
NLE: 100591916(GNA12)
MCC: 100429106(GNA12)
MCF: 101867258(GNA12)
CSAB: 103246857(GNA12)
RRO: 104664964(GNA12)
RBB: 108543875(GNA12)
CJC: 100387912(GNA12)
SBQ: 101042405(GNA12)
MMU: 14673(Gna12)
MCAL: 110295092(Gna12)
MPAH: 110312844(Gna12)
RNO: 81663(Gna12)
MUN: 110554732(Gna12)
CGE: 100760944(Gna12)
NGI: 103748670(Gna12)
HGL: 101697421(Gna12)
CCAN: 109683409(Gna12)
OCU: 100347293(GNA12)
TUP: 102501406(GNA12)
CFA: 102154318(GNA12)
VVP: 112929357(GNA12)
AML: 100465369(GNA12)
UMR: 103669942(GNA12)
UAH: 113267979(GNA12)
ORO: 101371250(GNA12)
ELK: 111146098
FCA: 101093316(GNA12)
PTG: 102961052(GNA12)
PPAD: 109251142(GNA12)
AJU: 106984497(GNA12)
BTA: 515159(GNA12)
BOM: 102265273(GNA12)
BIU: 109578204(GNA12)
BBUB: 102409709(GNA12)
CHX: 102185175(GNA12)
OAS: 101111070(GNA12)
SSC: 100525156(GNA12)
CFR: 102524525(GNA12) 116666290
CDK: 105086681(GNA12)
BACU: 103009974(GNA12)
LVE: 103069136(GNA12)
OOR: 101281075(GNA12)
DLE: 111169388(GNA12)
PCAD: 102996723(GNA12)
ECB: 100060005(GNA12)
EPZ: 103549418(GNA12)
EAI: 106834780(GNA12)
MYB: 102260289(GNA12)
MYD: 102763801(GNA12)
MNA: 107541162(GNA12)
HAI: 109380223(GNA12)
DRO: 112319524(GNA12)
PALE: 102891706(GNA12)
RAY: 107521430(GNA12)
MJV: 108383439(GNA12)
LAV: 100676444(GNA12)
TMU: 101351796
MDO: 100010453(GNA12)
SHR: 100916443(GNA12)
PCW: 110200100(GNA12)
OAA: 100082592(GNA12)
GGA: 769924(GNA12)
MGP: 100550659(GNA12)
CJO: 107320696(GNA12)
NMEL: 110405782(GNA12)
APLA: 101798445(GNA12)
ACYG: 106032065(GNA12)
TGU: 100225137(GNA12)
LSR: 110480984(GNA12)
SCAN: 103817628(GNA12)
GFR: 102044790(GNA12)
FAB: 101818259(GNA12)
PHI: 102104762(GNA12)
PMAJ: 107211274(GNA12)
CCAE: 111936095(GNA12)
CCW: 104684810(GNA12)
ETL: 114060163(GNA12)
FPG: 101917262(GNA12)
FCH: 102059010(GNA12)
CLV: 102088372(GNA12)
EGZ: 104132621(GNA12)
NNI: 104015218(GNA12)
ACUN: 113485647(GNA12)
PADL: 103913532(GNA12)
AAM: 106483939(GNA12)
ASN: 102377286(GNA12)
AMJ: 102559993(GNA12)
PSS: 102445616(GNA12)
CMY: 102931254(GNA12)
CPIC: 101947834(GNA12)
ACS: 100564021(gna12)
PVT: 110083721(GNA12)
PBI: 103050241(GNA12)
PMUR: 107290610(GNA12)
TSR: 106543761(GNA12)
PMUA: 114584033(GNA12)
GJA: 107116703(GNA12)
DRE: 503589(gna12a)
SGH: 107581709(gna12) 107592501
IPU: 108257129(gna12)
PHYP: 113536042(gna12)
AMEX: 103024018(gna12)
EEE: 113581016(gna12)
TRU: 101078184(gna12)
LCO: 104929956(gna12)
NCC: 104953227(gna12)
MZE: 101473086(gna12)
ONL: 100695956(gna12)
OLA: 101166935(gna12)
XMA: 102222306(gna12)
XCO: 114145506(gna12)
PRET: 103462653(gna12)
CVG: 107086421(gna12)
NFU: 107388805(gna12)
KMR: 108231102(gna12)
ALIM: 106519647(gna12) 106535814
AOCE: 111579495(gna12)
CSEM: 103383240(gna12)
POV: 109639272(gna12)
LCF: 108888452(gna12)
SDU: 111216573(gna12)
SLAL: 111663289(gna12)
HCQ: 109511425(gna12)
BPEC: 110153513(gna12)
MALB: 109968205(gna12)
SASA: 106593532
ELS: 105006302(gna12)
SFM: 108927048(gna12)
LCM: 102367557(GNA12)
CMK: 103185131(gna12)
RTP: 109917843(gna12)
SPU: 414055
SKO: 100371005
DME: Dmel_CG17678(cta)
DER: 6548622
DSE: 6620479
DSI: Dsimw501_GD17672(Dsim_GD17672)
DYA: Dyak_GE22695(Dyak_cta)
DAN: 6498720
DSR: 110188780
DPE: 6597992
DMN: 108163668
DWI: 6642655
DAZ: 108610046
DNV: 108649870
DHE: 111594096
DVI: 6633906
MDE: 101898580
LCQ: 111688751
AAG: 5570853
AME: 410906
BIM: 100745931
BTER: 100649951
CCAL: 108622504
OBB: 114871357
SOC: 105200292
MPHA: 105839168
AEC: 105147295
ACEP: 105624301
PBAR: 105431792
VEM: 105569521
HST: 105181192
DQU: 106742960
CFO: 105259283
LHU: 105675078
PGC: 109863777
OBO: 105278292
PCF: 106784198
NVI: 100115318
CSOL: 105359649
MDL: 103572197
TCA: 661072
DPA: 109541992
BMOR: 100862775(Galpha12)
BMAN: 114248860
PMAC: 106720633
PRAP: 111001958
HAW: 110369680
TNL: 113491781
PXY: 105391521
API: 100165181
DNX: 107169778
AGS: 114131159
RMD: 113552929
BTAB: 109044576
CLEC: 106672229
ZNE: 110838798
FCD: 110848091
DPX: DAPPUDRAFT_190301(Gna12)
PVM: 113811454
TUT: 107368817
CEL: CELE_F18G5.3(gpa-12)
CBR: CBG16182(Cbr-gpa-12)
BMY: Bm1_00355
TSP: Tsp_00479
PCAN: 112573964
CRG: 105341702
MYI: 110465109
LAK: 106174984
NVE: 5520204
EPA: 110251752
ADF: 107350389
AMIL: 114947132
PDAM: 113680345
SPIS: 111329690
DGT: 114529102
HMG: 100192290(gna12)
 » show all
Reference
PMID:8423800
  Authors
Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA
  Title
Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product.
  Journal
Mol Cell Biol 13:762-8 (1993)
DOI:10.1128/MCB.13.2.762
  Sequence
[hsa:2768]
Reference
  Authors
Gan X, Wang J, Wang C, Sommer E, Kozasa T, Srinivasula S, Alessi D, Offermanns S, Simon MI, Wu D
  Title
PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12.
  Journal
Nat Cell Biol 14:686-96 (2012)
DOI:10.1038/ncb2507
  Sequence
[hsa:2768]
LinkDB

KEGG   ORTHOLOGY: K04639
Entry
K04639                      KO                                     

Name
GNA13
Definition
guanine nucleotide-binding protein subunit alpha-13
Pathway
ko04022  cGMP-PKG signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04611  Platelet activation
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04928  Parathyroid hormone synthesis, secretion and action
ko05130  Pathogenic Escherichia coli infection
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
Disease
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04072 Phospholipase D signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04071 Sphingolipid signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04022 cGMP-PKG signaling pathway
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09156 Nervous system
   04730 Long-term depression
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
   04031 GTP-binding proteins
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
  Exosomal proteins of colorectal cancer cells
   K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
GTP-binding proteins [BR:ko04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 4 (G12/13)
    K04639  GNA13; guanine nucleotide-binding protein subunit alpha-13
Genes
HSA: 10672(GNA13)
PTR: 454827(GNA13)
PPS: 100988877(GNA13)
GGO: 101152866(GNA13)
PON: 100461065(GNA13)
NLE: 100589821(GNA13)
MCC: 718144(GNA13)
MCF: 102127819(GNA13)
CSAB: 103243186(GNA13)
RRO: 104675436(GNA13)
RBB: 108517753(GNA13)
CJC: 100394016(GNA13)
SBQ: 101034540(GNA13)
MMU: 14674(Gna13)
MCAL: 110304818(Gna13)
MPAH: 110331761(Gna13)
RNO: 303634(Gna13)
MUN: 110560037(Gna13)
CGE: 100689071(Gna13)
NGI: 103742208(Gna13)
HGL: 101719378(Gna13)
CCAN: 109696711(Gna13)
OCU: 100352794(GNA13)
TUP: 102488219(GNA13)
CFA: 490901(GNA13)
VVP: 112920734(GNA13)
AML: 100474482(GNA13)
UMR: 103665670(GNA13)
UAH: 113265242(GNA13)
ORO: 101386508(GNA13)
ELK: 111158131
FCA: 101087625(GNA13)
PTG: 102964498(GNA13)
PPAD: 109277047(GNA13)
AJU: 106975340(GNA13)
BTA: 505611(GNA13)
BOM: 102275435(GNA13)
BIU: 109573379(GNA13)
BBUB: 102390212(GNA13)
CHX: 102170818(GNA13)
OAS: 101117003(GNA13)
SSC: 100522824(GNA13)
CFR: 102523556(GNA13)
CDK: 105085708(GNA13)
BACU: 103007094(GNA13)
LVE: 103071564(GNA13)
OOR: 101277931(GNA13)
DLE: 111182908(GNA13)
PCAD: 102989616(GNA13)
ECB: 100062972(GNA13)
EPZ: 103553497(GNA13)
EAI: 106835353(GNA13)
MYB: 102252423(GNA13)
MYD: 102764420(GNA13)
MNA: 107538305(GNA13)
HAI: 109380315(GNA13)
DRO: 112316266(GNA13)
PALE: 102891607(GNA13)
RAY: 107510298(GNA13)
MJV: 108392407(GNA13)
LAV: 100664965(GNA13)
TMU: 101346987
MDO: 100024566(GNA13)
SHR: 100932191(GNA13)
PCW: 110218195(GNA13)
OAA: 103166871(GNA13)
GGA: 417434(GNA13)
MGP: 100540964(GNA13)
CJO: 107322109(GNA13)
NMEL: 110407202(GNA13)
APLA: 101801355(GNA13)
ACYG: 106034698(GNA13)
TGU: 100223985(GNA13)
LSR: 110473974(GNA13)
SCAN: 103819970(GNA13)
GFR: 102040291(GNA13)
FAB: 101812192(GNA13)
PHI: 102099584(GNA13)
PMAJ: 107212551(GNA13)
CCAE: 111937573(GNA13)
CCW: 104696029(GNA13)
ETL: 114060688(GNA13)
FPG: 101922831(GNA13)
FCH: 102052233(GNA13)
CLV: 102084052(GNA13)
EGZ: 104132822(GNA13)
NNI: 104014357(GNA13)
ACUN: 113486831(GNA13)
PADL: 103916715(GNA13)
AAM: 106493143(GNA13)
ASN: 102376261(GNA13)
AMJ: 102568562(GNA13)
PSS: 102458860(GNA13)
CMY: 102940587(GNA13)
CPIC: 101953084(GNA13)
ACS: 100554119(gna13)
PVT: 110085885(GNA13)
PBI: 103050681(GNA13)
PMUR: 107282571(GNA13)
TSR: 106553054(GNA13)
PMUA: 114588210(GNA13)
GJA: 107105951(GNA13)
XLA: 108701204(gna13.L) 496349(gna13.S)
XTR: 100145489(gna13)
NPR: 108802992(GNA13)
DRE: 326825(gna13a) 336333(gna13b)
IPU: 108273768(GNA13) 108278714
NCC: 104946516
XMA: 102222912 102227062(gna13)
XCO: 114148609 114151980(gna13)
KMR: 108228367 108248446(gna13)
BPEC: 110164386(gna13)
SALP: 111967821
PKI: 111848291 111856756(gna13)
LCM: 102364864(GNA13)
CMK: 103175515(gna13)
RTP: 109931209(gna13)
CIN: 100180076
SPU: 115918012
APLC: 110980280
PCAN: 112567820
AQU: 105312217
 » show all
Reference
PMID:2508088
  Authors
Strathmann M, Wilkie TM, Simon MI
  Title
Diversity of the G-protein family: sequences from five additional alpha subunits in the mouse.
  Journal
Proc Natl Acad Sci U S A 86:7407-9 (1989)
DOI:10.1073/pnas.86.19.7407
Reference
PMID:7791744
  Authors
Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD
  Title
Expression of GTP-binding protein alpha subunits in human thymocytes.
  Journal
Mol Cell Biochem 144:45-51 (1995)
DOI:10.1007/bf00926739
  Sequence
[hsa:10672]
LinkDB

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